Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3] triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT 6 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 14, 2010, Pages 5282-5290

  Ivachtchenko, Alexandre V ^a,b   Golovina, Elena S ^a   Kadieva, Madina G ^a   Koryakova, Angela G ^a   Kovalenko, Sergiy M ^c   Mitkin, Oleg D ^a   Okun, Ilya M ^b   Ravnyeyko, Irina M ^d   Tkachenko, Sergey E ^b   Zaremba, Oleg V ^d  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

^c Institute of Combinatorial Organic Chemistry   (Ukraine)

^d NATIONAL UNIVERSITY OF PHARMACY   (Ukraine)

Author keywords

5 HT6 Antagonist; 5 HT6 Receptor; Thieno 2,3 e 1,2,3 triazolo 1,5 a pyrimidines

Indexed keywords

3 (PHENYLSULFONYL) N (2 THIENYLMETHYL)THIENO[2,3 E][1,2,3]TRIAZOLO[1,5 A]PYRIMIDIN 5 AMINE; 3 (PHENYLSULFONYL)THIENO[2,3 E][1,2,3]TRIAZOLO[1,5 A]PYRIMIDINE; 3 [(3 CHLOROPHENYL)SULFONYL] N (TETRAHYDROFURAN 2 YLMETHYL)THIENO[2,3 E][1,2,3]TRIAZOLO[1,5 A]PYRIMIDIN 5 AMINE; RADIOLIGAND; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

CELL LINE; HUMANS; PYRIMIDINES; RECEPTORS, SEROTONIN; SEROTONIN RECEPTOR AGONISTS; TRIAZOLES;

HUMAN ECHOVIRUS 1;

EID: 77955326279     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.05.051     Document Type: Article

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