메뉴 건너뛰기




Volumn 14, Issue 7, 2012, Pages 601-607

Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus

Author keywords

SGLT 2 inhibitor; Type 1 diabetes

Indexed keywords

EMPAGLIFLOZIN; GLUCOSE; HEMOGLOBIN A1C; INSULIN GLARGINE; LINPLANT; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG;

EID: 84861886161     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2012.01569.x     Document Type: Article
Times cited : (74)

References (34)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: new perspectives on disease pathogenesis and treatment.
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221-229.
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 3
    • 79956157918 scopus 로고    scopus 로고
    • Use of continuous glucose monitoring in subjects with type 1 diabetes on multiple daily injections versus continuous subcutaneous insulin infusion therapy: a prospective 6-month study.
    • Garg SK, Voelmle MK, Beatson CR et al. Use of continuous glucose monitoring in subjects with type 1 diabetes on multiple daily injections versus continuous subcutaneous insulin infusion therapy: a prospective 6-month study. Diabetes Care 2011; 34: 574-579.
    • (2011) Diabetes Care , vol.34 , pp. 574-579
    • Garg, S.K.1    Voelmle, M.K.2    Beatson, C.R.3
  • 4
    • 33646359454 scopus 로고    scopus 로고
    • Spectrum and prevalence of atherogenic risk factors in 27 358 children, adolescents, and young adults with type 1 diabetes: cross-sectional data from the German diabetes documentation and quality management system (DPV).
    • Schwab KO, Doerfer J, Hecker W et al. Spectrum and prevalence of atherogenic risk factors in 27 358 children, adolescents, and young adults with type 1 diabetes: cross-sectional data from the German diabetes documentation and quality management system (DPV). Diabetes Care 2006; 29: 218-225.
    • (2006) Diabetes Care , vol.29 , pp. 218-225
    • Schwab, K.O.1    Doerfer, J.2    Hecker, W.3
  • 5
    • 33748037996 scopus 로고    scopus 로고
    • Multivariate models of health-related utility and the fear of hypoglycaemia in people with diabetes.
    • Currie CJ, Morgan CL, Poole CD, Sharplin P, Lammert M, McEwan P. Multivariate models of health-related utility and the fear of hypoglycaemia in people with diabetes. Curr Med Res Opin 2006; 22: 1523-1534.
    • (2006) Curr Med Res Opin , vol.22 , pp. 1523-1534
    • Currie, C.J.1    Morgan, C.L.2    Poole, C.D.3    Sharplin, P.4    Lammert, M.5    McEwan, P.6
  • 6
    • 0036020278 scopus 로고    scopus 로고
    • Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes.
    • Cryer PE. Hypoglycaemia: the limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 2002; 45: 937-948.
    • (2002) Diabetologia , vol.45 , pp. 937-948
    • Cryer, P.E.1
  • 8
    • 48649097595 scopus 로고    scopus 로고
    • Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire register of diabetes in children and young adults.
    • Feltbower RG, Bodansky HJ, Patterson CC et al. Acute complications and drug misuse are important causes of death for children and young adults with type 1 diabetes: results from the Yorkshire register of diabetes in children and young adults. Diabetes Care 2008; 31: 922-926.
    • (2008) Diabetes Care , vol.31 , pp. 922-926
    • Feltbower, R.G.1    Bodansky, H.J.2    Patterson, C.C.3
  • 9
    • 31844437817 scopus 로고    scopus 로고
    • Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway.
    • Skrivarhaug T, Bangstad H-J, Stene LC, Sandvik L, Hanssen KF, Joner G. Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway. Diabetologia 2006; 49: 298-305.
    • (2006) Diabetologia , vol.49 , pp. 298-305
    • Skrivarhaug, T.1    Bangstad, H.-J.2    Stene, L.C.3    Sandvik, L.4    Hanssen, K.F.5    Joner, G.6
  • 10
    • 25444470287 scopus 로고    scopus 로고
    • Weight gain and insulin treatment.
    • Larger E. Weight gain and insulin treatment. Diabetes Metab 2005; 31: 51-56.
    • (2005) Diabetes Metab , vol.31 , pp. 51-56
    • Larger, E.1
  • 11
    • 0033016601 scopus 로고    scopus 로고
    • Eating disorders in adolescent girls with insulin-dependent diabetes mellitus: a population-based case-control study.
    • Engström I, Kroon M, Arvidsson C-G, Segnestam K, Snellman K, Åman J. Eating disorders in adolescent girls with insulin-dependent diabetes mellitus: a population-based case-control study. Acta Paediatr 1999; 88: 175-180.
    • (1999) Acta Paediatr , vol.88 , pp. 175-180
    • Engström, I.1    Kroon, M.2    Arvidsson, C.-G.3    Segnestam, K.4    Snellman, K.5    Åman, J.6
  • 12
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition-a novel strategy for diabetes treatment.
    • Chao EC, Henry RR. SGLT2 inhibition-a novel strategy for diabetes treatment. Nat Rev Drug Discov 2010; 9: 551-559.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 13
    • 0032850016 scopus 로고    scopus 로고
    • T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
    • Oku A, Ueta K, Arakawa K et al. T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes 1999; 48: 1794-1800.
    • (1999) Diabetes , vol.48 , pp. 1794-1800
    • Oku, A.1    Ueta, K.2    Arakawa, K.3
  • 14
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats.
    • Han S, Hagan DL, Taylor JR et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 2008; 57: 1723-1729.
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 15
    • 41649087328 scopus 로고    scopus 로고
    • Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose costrasporter (SGLT2) inhibitor for the treatment of type 2 diabetes.
    • Meng W, Ellsworth BA, Nirschl AA et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose costrasporter (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem 2008; 51: 1145-1149.
    • (2008) J Med Chem , vol.51 , pp. 1145-1149
    • Meng, W.1    Ellsworth, B.A.2    Nirschl, A.A.3
  • 16
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozinetabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models.
    • Fujimori Y, Katsuno K, Nakashima I, Ishikawa-Takemura Y, Fujikura H, Isaji M. Remogliflozinetabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther 2008; 327: 268-276.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3    Ishikawa-Takemura, Y.4    Fujikura, H.5    Isaji, M.6
  • 17
    • 64549093267 scopus 로고    scopus 로고
    • Sergliflozinetabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats.
    • Fujimori Y, Katsuno K, Ojima K et al. Sergliflozinetabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats. Eur J Pharmacol 2009; 609: 148-154.
    • (2009) Eur J Pharmacol , vol.609 , pp. 148-154
    • Fujimori, Y.1    Katsuno, K.2    Ojima, K.3
  • 18
    • 68949186346 scopus 로고    scopus 로고
    • Long-term treatment with sergliflozinetabonate improves disturbed glucose metabolism in KK-A(y) mice.
    • Katsuno K, Fujimori Y, Ishikawa-Takemura Y, Isaji M. Long-term treatment with sergliflozinetabonate improves disturbed glucose metabolism in KK-A(y) mice. Eur J Pharmacol 2009; 618: 98-104.
    • (2009) Eur J Pharmacol , vol.618 , pp. 98-104
    • Katsuno, K.1    Fujimori, Y.2    Ishikawa-Takemura, Y.3    Isaji, M.4
  • 19
    • 79961228970 scopus 로고    scopus 로고
    • TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity.
    • Yamamoto K, Uchida S, Kitano K et al. TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activity. Br J Pharmacol 2011; 164: 181-191.
    • (2011) Br J Pharmacol , vol.164 , pp. 181-191
    • Yamamoto, K.1    Uchida, S.2    Kitano, K.3
  • 20
    • 79951810378 scopus 로고    scopus 로고
    • EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats.
    • Zhang W, Welihinda A, Mechanic J et al. EGT1442, a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. Pharmacol Res 2011; 63: 284-293.
    • (2011) Pharmacol Res , vol.63 , pp. 284-293
    • Zhang, W.1    Welihinda, A.2    Mechanic, J.3
  • 21
    • 83655167071 scopus 로고    scopus 로고
    • Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.
    • Thomas L, Grempler R, Eckhardt M et al. Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. Diabetes Obes Metab 2012; 14: 94-96.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 94-96
    • Thomas, L.1    Grempler, R.2    Eckhardt, M.3
  • 22
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.
    • Grempler R, Thomas L, Eckhardt M et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 2012; 14: 83-90.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3
  • 23
    • 77957573037 scopus 로고    scopus 로고
    • BI 10773, a sodium-glucose co-transporter inhibitor (SGLT-2), is safe and efficacious following 4-week treatment in patients with type 2 diabetes.
    • Heise T, Seewaldt-Becker E, Macha S et al. BI 10773, a sodium-glucose co-transporter inhibitor (SGLT-2), is safe and efficacious following 4-week treatment in patients with type 2 diabetes. Diabetes 2010; 59: 629.
    • (2010) Diabetes , vol.59 , pp. 629
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3
  • 24
    • 0015122757 scopus 로고
    • Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects.
    • Mogensen CE. Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest 1971; 28: 101-109.
    • (1971) Scand J Clin Lab Invest , vol.28 , pp. 101-109
    • Mogensen, C.E.1
  • 25
    • 79952209559 scopus 로고    scopus 로고
    • Glucose handling by the kidney.
    • Mather A, Pollock C. Glucose handling by the kidney. Kidney Int 2011; 79: S1-6.
    • (2011) Kidney Int , vol.79
    • Mather, A.1    Pollock, C.2
  • 26
    • 10644248270 scopus 로고    scopus 로고
    • Blood glucose profiles in diabetic rodents using different insulin preparations.
    • Schneider S, Weber R, Luippold G. Blood glucose profiles in diabetic rodents using different insulin preparations. Arzneimittelforschung 2004; 54: 842-846.
    • (2004) Arzneimittelforschung , vol.54 , pp. 842-846
    • Schneider, S.1    Weber, R.2    Luippold, G.3
  • 27
    • 0034997336 scopus 로고    scopus 로고
    • +-glucose cotransporters.
    • +-glucose cotransporters. Am J Physiol 2001; 280: F10-F18.
    • (2001) Am J Physiol , vol.280
    • Wright, E.M.1
  • 28
    • 78651406659 scopus 로고    scopus 로고
    • SGLT2 mediates glucose reabsorption in the early proximal tubule.
    • Vallon V, Platt KA, Cunard R et al. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 2011; 22: 104-112.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 104-112
    • Vallon, V.1    Platt, K.A.2    Cunard, R.3
  • 29
    • 27944488002 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents.
    • Handlon AL. Sodium glucose co-transporter 2 (SGLT2) inhibitors as potential antidiabetic agents. Expert Opin Ther Pat 2005; 15: 1531-1540.
    • (2005) Expert Opin Ther Pat , vol.15 , pp. 1531-1540
    • Handlon, A.L.1
  • 30
    • 79952366290 scopus 로고    scopus 로고
    • Learning from glycosuria.
    • Ferrannini E. Learning from glycosuria. Diabetes 2011; 60: 695-696.
    • (2011) Diabetes , vol.60 , pp. 695-696
    • Ferrannini, E.1
  • 32
    • 74949093195 scopus 로고    scopus 로고
    • Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents.
    • Washburn WN. Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents. Expert Opin Ther Pat 2009; 19: 1485-1499.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1485-1499
    • Washburn, W.N.1
  • 33
    • 77957567883 scopus 로고    scopus 로고
    • Weight loss induced by potent and selective SGLT2 inhibitor, BI 10773, is due to body fat reduction. Studies in dietary-induced obese rats.
    • Grempler R, Thomas L, Klein T et al. Weight loss induced by potent and selective SGLT2 inhibitor, BI 10773, is due to body fat reduction. Studies in dietary-induced obese rats. Diabetes 2010; 59: 1793.
    • (2010) Diabetes , vol.59 , pp. 1793
    • Grempler, R.1    Thomas, L.2    Klein, T.3
  • 34
    • 80155124676 scopus 로고    scopus 로고
    • Long term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with T2DM inadequately controlled with metformin: 2-year results.
    • Nauck M, Del PS, Rohwedder K, Theuerkauf A, Langkilde AM, Parikh SJ. Long term efficacy and safety of add-on dapagliflozin vs add-on glipizide in patients with T2DM inadequately controlled with metformin: 2-year results. Diabetes Care 2011; 34: 2015.
    • (2011) Diabetes Care , vol.34 , pp. 2015
    • Nauck, M.1    Del, P.S.2    Rohwedder, K.3    Theuerkauf, A.4    Langkilde, A.M.5    Parikh, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.