Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat

British Journal of Pharmacology

Volumn 148, Issue 2, 2006, Pages 154-161

  Wibberley, Alexandra ^a,b   McCafferty, Gerald P ^a   Evans, Christopher ^a   Edwards, Richard M ^a   Hieble, J Paul ^a  

^a GLAXOSMITHKLINE   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

Author keywords

Cat; Cyclooxygenase; Irritation; Micturition; Urinary bladder

Indexed keywords

ACETIC ACID; CHLORALOSE; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; DRUG VEHICLE; FR 122047; INDOMETACIN; KETOPROFEN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER CAPACITY; BLADDER CATHETERIZATION; BLADDER CONTRACTION; BLADDER IRRITATION; BLADDER PRESSURE; BLOOD ANALYSIS; BLOOD LEVEL; CAT; CONTROLLED STUDY; CYSTOMETRY; DRUG EFFECT; DRUG SELECTIVITY; EVALUATION; FEMALE; GENDER; IN VITRO STUDY; INFUSION; INHIBITION KINETICS; MICTURITION; MICTURITION REFLEX; NONHUMAN; PARAMETERS OF MEASUREMENT AND ANALYSIS; PRIORITY JOURNAL;

ACETIC ACID; ANESTHESIA; ANIMALS; CATS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INDOMETHACIN; KETOPROFEN; MALE; NITROBENZENES; PIPERAZINES; REFLEX, ABNORMAL; SODIUM CHLORIDE; SULFONAMIDES; THIAZOLES; URINARY BLADDER DISEASES;

EID: 33745038063     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706715     Document Type: Article

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