Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice

Journal of Lipid Research

Volumn 41, Issue 10, 2000, Pages 1673-1679

  Maugeais, Cyrille ^a   Tietge, Uwe J F ^a   Tsukamoto, Kazuhisa ^a   Glick, Jane M ^a   Rader, Daniel J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Lipoproteins; Metabolism; Recombinant adenovirus

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN E; METHIONINE; SULFUR 35; TRIACYLGLYCEROL; TYLOXAPOL; VERY LOW DENSITY LIPOPROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; CATABOLISM; CONTROLLED STUDY; DYSLIPOPROTEINEMIA; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HYPERLIPOPROTEINEMIA TYPE 3; LIPID COMPOSITION; LIPOPROTEIN SYNTHESIS; LIQUID CHROMATOGRAPHY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; STEADY STATE;

ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS E; CHOLESTEROL; CHOLESTEROL ESTERS; FEMALE; HUMANS; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; TRIGLYCERIDES;

EID: 0033779756     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology
2. Apolipoprotein E: From atherosclerosis to Alzheimer's disease and beyond
3. Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E-deficient mouse hepatocytes
4. Altered lipid metabolism in apolipoprotein E-deficient mice does not affect cholesterol balance across the liver
5. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia
6. Markedly increased secretion of VLDL triglycerides induced by gene transfer of apolipoprotein E isoforms in apoE-deficient mice
7. Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation
8. Very low density lipoprotein overproduction in genetic forms of hypertriglyceridaemia
9. Influence of obesity on the metabolism of apolipoprotein B in humans
10. Effects of NIDDM on VLDL triglyceride and apolipoprotein B metabolism. Study before and after sulfonylurea therapy
11. Liver-directed gene transfer and prolonged expression of three major human apoE isoforms in apoE-deficient mice
12. Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B
13. Simultaneous quantification of apolipoprotein B-100, B-48, and E separated by SDS-PAGE
14. Post-secretory acquisition of apolipoprotein E by nascent rat hepatic very-low-density lipoproteins in the absence of cholesteryl ester transfer
15. Regulated turnover of a cell surface-associated pool of newly synthesized apolipoprotein E in HepG2 cells
16. The enhanced association of apolipoprotein E with apolipoprotein B-containing lipoproteins in serum-stimulated hepatocytes occurs intracellularly
17. Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections
18. Concentration of intracellular hepatic apolipoprotein E in Golgi apparatus saccular distensions and endosomes
19. Recycling of apolipoprotein E in mouse liver
20. Regulation of hepatic apolipoprotein-B-containing lipoprotein secretion
21. Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins
22. The role of factors that regulate the synthesis and secretion of very-low-density lipoprotein by hepatocytes
23. The assembly and secretion of apolipoprotein B-containing lipoproteins
24. Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells
25. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step
26. Understanding coronary heart disease as a consequence of defective regulation of apolipoprotein B metabolism
27. A two-site model for apoB degradation in HepG2 cells
28. Chinese hamster ovary cells require the coexpression of microsomal triglyceride transfer protein and cholesterol 7-α-hydroxylase for the assembly and secretion of apolipoprotein B-containing lipoproteins
29. Regulated cotranslational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein
30. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
31. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
32. The role of the LDL receptor in apolipoprotein B secretion
33. Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: Evidence for a very rapid turnover of VLDL and preferential removal of B-48 relative to B-100-containing lipoproteins
34. Mechanism of hypertriglyceridemia in human apolipoprotein (Apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles
35. Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
36. Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis