Renal glucose production and utilization: New aspects in humans

Diabetologia

Volumn 40, Issue 7, 1997, Pages 749-757

  Stumvoll, M ^a   Meyer, C ^b   Mitrakou, A ^c   Nadkarni, V ^b   Gerich, J E ^b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF ROCHESTER   (United States)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Diabetes mellitus; Endogenous glucose production; Gluconeogenesis; Glycogenolysis; Liver

Indexed keywords

ADRENALIN; GLUCOSE; GLUTAMINE; GLYCEROL; INSULIN; LACTIC ACID;

CARBOHYDRATE METABOLISM; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE UTILIZATION; GLYCOGENOLYSIS; HORMONAL REGULATION; KIDNEY; METABOLIC ACIDOSIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; DIABETES MELLITUS, TYPE 1; EPINEPHRINE; GLUCAGON; GLUCONEOGENESIS; GLUCOSE; GLYCEROL; HUMANS; INSULIN; KIDNEY; LACTATES;

EID: 0030851974     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050745     Document Type: Review

References (89)

1. Mayes PA (1993) Gluconeogenesis and control of the blood glucose. In: Murray RK, Granner DK, Mayes PA, Rodwell VW (eds) Harper's biochemistry. Appleton and Lange, East Norwalk, Connecticut, pp 190-200
2. Gerich JE (1993) Control of glycaemia. Baillieres Clin Endocrinol Metab 7: 551-586
3. Landau BR, Wahren J, Chaandramouli V, Schumann WC, Ekberg K, Kalhan SC (1996) Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98: 378-385
4. Krebs HA (1963) Renal gluconeogenesis. Adv Enzyme Reg 1:385-400
5. Björkman O, Felig P, Wahren J (1980) The contrasting responses of splanchnic and renal glucose output to gluconeogenic substrates and to hypoglucagonemia in 60-h-fasted humans. Diabetes 29: 610-616
6. Björkman O, Felig P (1982) Role of the kidney in the metabolism of fructose in 60-hour fasted humans. Diabetes 31: 516-520
7. Brundin T, Wahren J (1994) Renal oxygen consumption, thermogenesis, and amino acid utilization during iv infusion of amino acids in man. Am J Physiol 267: E648-E655
8. Castellino P, DeFronzo RA (1990) Glucose metabolism and the kidney. Semin Nephrol 10: 458-463
9. Steinberg D (1991) Regulation of carbohydrate metabolism. In: Satterfield T (ed) Physiological basis of medical practice. Williams and Wilkins, Baltimore, pp 728-739
10. Felig P, Bergman M (1995) The endocrine pancreas: diabetes mellitus. In: Felig P, Baxter JD, Frohman LA (eds) Endocrinology and metabolism. McGraw-Hill, New York, pp 1107-1250
11. McGuinness OP, Fugiwara T, Murrell S et al. (1993) Impact of chronic stress hormone infusion on hepatic carbohydrate metabolism in the conscious dog. Am J Physiol 265: E314-E322
12. Cersosimo E, Judd RL, Miles JM (1994) Insulin regulation of renal glucose metabolism in conscious dogs. J Clin Invest 93: 2584-2589
13. Stumvoll M, Welle S, Chintalapudi U, Perriello G, Gutierrez O, Gerich J (1995) Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J Clin Invest 96: 2528-2533
14. Benoy MP, Elliot KAC (1937) The metabolism of lactic and pyruvic acids in normal and tumor tissue. V. Synthesis of carbohydrate. Biochem J 31: 1268-1275
15. Bergman H, Drury DR (1938) The relationship of kidney function to the glucose utilization of the extra abdominal tissues. Am J Physiol 124: 279-284
16. Reinecke RM (1943) The kidney as a source of glucose in the eviscerated rat. Am J Physiol 140: 276-280
17. Cohn C, Kolinsky M (1949) Effect of blood sugar levels and insulin lack on gluconeogenesis by the kidney of the dog. Am J Physiol 156: 345-348
18. Bollman JL, Grindlay JH (1952) Measurement of renal gluconeogenesis. Am J Physiol 170: 38-44
19. Drury DR, Wick AN, MacKay EM (1950) Formation of glucose by the kidney. Am J Physiol 163: 655-659
20. Saugman B (1951) Renal gluconeogenesis in eviscerated cats. Acta Physiol Scand 23: 187-189
21. Aber GM Morris LO, Housley E (1966) Gluconeogenesis by the human kidney. Nature 212: 1589-1590
22. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF Jr (1969) Liver and kidney metabolism during prolonged starvation. J Clin Invest 48: 574-583
23. Schoolwerth AC, Drewnowska K (1993) Renal metabolism. In: Schrier RW, Gottschalk CW (eds) Diseases of the kidney. Little Brown and Company, Boston, Toronto, London, pp 233-260
24. Nurjhan N, Kennedy F, Consoli A, Martin C, Miles J, Gerich J (1988) Quantification of the glycolytic origin of plasma glycerol: implications for the use of the rate of appearance of plasma glycerol as an index of lipolysis in vivo. Metabolism 37: 386-389
25. 14C] glutamine specific activity in plasma. J Liq Chromat 17: 1337-1348
26. Schoolwerth AC, Smith BC, Culpepper RM (1988) Renal gluconeogenesis. Miner Electrolyte Metab 14: 347-361
27. Wirthensohn G, Guder WG (1986) Renal substrate metabolism. Physiol Rev 66: 469-497
28. Guder WG, Ross BD (1984) Enzyme distribution along the nephron. Kidney Int 26: 101-111
29. Stumvoll M, Overkamp D, Gerich JE (1995) A primer on tracer methods for the study of glucose metabolism in man. Diab Nutr Metab 8: 298-314
30. Consoli A, Nurjhan N, Reilly JJ Jr, Bier DM, Gerich JE (1990) Contribution of liver and skeletal muscle to alanine and lactate metabolism in man. Am J Physiol 259: E677-E685
31. Stanley W, Gertz E, Wisneski J, Neese R, Morris D, Brooks G (1986) Lactate extraction during net lactate release in legs of humans during exercise. J Appl Physiol 60: 1116-1120
32. Kida K, Nakago S, Kamiya F, Toyama Y, Takashi N, Nakagawa H (1978) Renal net glucose release in vivo and its contribution to blood glucose in rats. J Clin Invest 62: 721-726
33. Biava C, Grossman A, West M (1966) Ultrastructural observations on renal glycogen in normal and pathologic human kidneys. Lab Invest 15: 330-356
34. Burch HB, Narins RG, Chu C et al. (1978) Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation. Am J Physiol 235: F246-F253
35. Lupianez JA, Dileepan KN, Wagle SR (1979) Interrelationship of somatostatin, insulin and calcium in the control of gluconeogenesis in kidney cortex slices. Biochem Biophys Res Commun 90: 1153-1158
36. Rizza R, Mandarino L, Gerich J (1986) Dose-response characteristics for the effects of insulin on production and utilization of glucose in man. Am J Physiol 240: E630-E639
37. Mitrakou A, Plantanisiotis D, Vlachos L et al. (1996) Increased renal glucose production in insulin dependent diabetes (IDDM): contribution to systemic glucose appearance and effect of insulin repletion. Diabetes 45 [Suppl2]: 33A (Abstract)
38. Bowman RH (1970) Gluconeogenesis in the isolated perfused rat kidney. J Biol Chem 245: 1604-1612
39. Stumvoll M, Meyer C, Chintalapudi U et al. (1996) Human renal glucose and glutamine metabolism. Effects of glucagon. Diabetes 45 [Suppl2]: 34A (Abstract)
40. Kurokawa K, Massry SG (1973) Evidence for stimulation of renal gluconeogenesis by catecholamines. J Clin Invest 52: 961-964
41. Sacca L, Vigorito C, Cicala M, Corso G, Sherwin RS (1983) Role of gluconeogenesis in epinephrine-stimulated hepatic glucose production in humans. Am J Physiol 245: E294-E302
42. Mitrakou A, Ryan C, Veneman T et al. (1991) Hierarchy of thresholds for activation of counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260: E67-E74
43. Felig P, Wahren J, Hendler R, Brundin T (1974) Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest 53: 582-590
44. Vinay P, Mapes JP, Krebs HA (1978) Fate of glutamine carbon in renal metabolism. Am J Physiol 234: F123-F129
45. Roobol A, Alleyne GAO (1973) Regulation of renal gluconeogenesis by calcium ions, hormones and adenosine 3' : 5'-cyclic monophosphate. Biochem J 134: 157-165
46. Roxe DM, Schreiner GE, Preuss HG (1973) Regulation of renal gluconeogenesis and ammoniagenesis by physiologic fuels. Am J Physiol 225 (4): 908-911
47. Krebs HA, Bennett DAH, DeGasquet P, Gascoyne T, Yoshida T (1963) Renal gluconeogenesis the effect of diet on the gluconeogenic capacity of rat kidney cortex slices. Biochem J 86: 22-28
48. Nurjhan N, Bucci A, Perriello G et al. (1995) Glutamine: a major gluconeogenic precursor and vehicle for interorgan carbon transport in man. J Clin Invest 95: 272-277
49. Lochs H, Roth E, Gasic S, Hubl W, Morse EL, Adibi SA (1990) Splanchnic, renal and muscle clearance of alanylglutamine in man and organ fluxes of alanine and glutamine when infused in free dual peptide forms. Metabolism 39: 833-836
50. Felig P, Wahren J, Räf L (1973) Evidence of interorgan amino acid transport by blood cells in humans. Proc Natl Acad Sci USA 70: 1775-1779
51. Gelfand RA, Glickman MG, Jacob R, Sherwin RS, De Fronzo RA (1986) Removal of infused amino acids by splanchnic and leg tissues in man. Am J Physiol 250: E407-E413
52. Meyer C, Stumvoll M, Chintalapudi U et al. (1996) Alanine and glutamine: selective markers for hepatic and renal gluconeogenesis in humans. Diabetes 45 [Suppl 2]: 255A (Abstract)
53. Teng C (1954) Studies on carbohydrate metabolism in rat kidney slices. II effects of alloxan diabetes and insulin administration on glucose uptake and formation. Arch Biochem Biophys 48: 415-423
54. Landau BR (1960) Gluconeogenesis and pyruvate metabolism in rat kidney, in vitro. Endocrinology 67: 744-751
55. Lemieux G, Aranda MR, Fournel P, Lemieux C (1984) Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis. Can J Physiol Pharmacol 62: 70-75
56. Consoli A (1992) Role of liver in pathophysiology of NIDDM. Diabetes Care 15: 430-441
57. Lemieux G, Achkar M, Vinay P, Gougoux A (1982) Characteristics of ammoniagenesis and gluconeogenesis by the diabetic kidney. In vitro studies in the rat. Contrib Nephrol 31: 23-28
58. Wahren J, Felig P (1975) Renal substrate exchange in human diabetes mellitus. Diabetes 24: 730-734
59. Stumvoll M, Perriello G, Nurjhan N et al. (1996) Glutamine and alanine metabolism in NIDDM. Diabetes 45: 863-868
60. Owen R (1989) Hypoglycemia associated with renal failure. Endocrinol Metab Clin North Am 18: 103-121
61. Garber AJ, Bier DM, Cryer PE, Pagliari AS (1974) Hypoglycemia in compensated renal insufficiency. Diabetes 23: 982-986
62. Fischer KF, Lees JA, Newman JH (1986) Hypoglycemia in hospitalized patients. N Engl J Med 315: 1245-1250
63. Arem R (1989) Hypoglycemia associated with renal failure. Endocrinol Metab Clin North Am 18: 103-121
64. Service F (1995) Hypoglycemic disorders. N Engl J Med 332: 1144-1152
65. Puhakainen I, Koivisto VA, Yki-Järvinen H (1991) No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes 40: 1319-1327
66. Jones VD, Spalding CT, Jenkins ML (1971) Ethanol induced hypoglycemia and renal gluconeogenesis. Res Comm Chem Pathol Pharmacol 2: 67-77
67. Adrogue HJ (1992) Glucose homeostasis and the kidney. Kidney Int 42: 1266-1282
68. Kalhan SC, Ricanati ES, Tserng K-Y, Savin SM (1983) Glucose turnover in chronic uremia: increased recycling with diminished oxidation of glucose. Metabolism 32: 1155-1162
69. DeFronzo RA, Alvestrand A, Smith D, Hendler R, Hendler E, Wahren J (1981) Insulin resistance in uremia. J Clin Invest 67: 563-568
70. Rubenfeld S, Garber AJ (1978) Abnormal carbohydrate metabolism in chronic renal failure. J Clin Invest 62: 20-28
71. Kelley D, Mitrakou A, Marsh H et al. (1988) Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest 81: 1563-1571
72. Dinneen S, Gerich J, Rizza R (1992) Carbohydrate metabolism in non-insulin-dependent diabetes mellitus. N Engl J Med 327: 707-713
73. Mari A, Wahren J, DeFronzo RA, Ferrannini E (1994) Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods. Metabolism 43: 1419-1425
74. DeFronzo R, Ferrannini E, Hendler R, Felig R, Wahren J (1983) Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32: 35-45
75. Gregg CM, Cohen JJ, Black AJ, Espeland MA, Feldstein ML (1978) Effects of glucose and insulin on metabolism and function of perfused rat kidney. Am J Physiol 235: F52-F61
76. DeFronzo R, Abnestrand A, Smith D, Hendler R, Wahren J (1981) Insulin resistance in uremia. J Clin Invest 67: 563-568
77. Rabkin R, Ryan MP, Duckworth WC (1984) The renal metabolism of insulin. Diabetologia 27: 351-357
78. Duckworth WC (1988) Insulin degradation: mechanisms, products, and significance. Endocr Rev 9: 319-345
79. DeFronzo RA, Simonson D, Ferrannini E (1983) Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia 23: 313-318
80. 13C nuclear magnetic resonance study. J Clin Invest 90: 1323-1327
81. Consoli A, Nurjhan N, Capani F, Gerich J (1989) Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-561
82. Prager R, Wallace P, Olefsky J (1987) Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36: 607-611
83. Giacca A, Fisher S, Gupta R, Shi Z, Lickley L, Vranic M (1992) Importance of peripheral mechanisms of insulin action for the regulation of hepatic glucose production in depancreatectomized dogs. J Clin Invest 90: 1769-1777
84. Ader M, Bergman R (1990) Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 245: E1020-E1032
85. Owen OE, Robinson RR (1963) Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride. J Clin Invest 42: 263-276
86. Nieth H, Schollmeyer P (1966) Substrate-utilization of the human kidney. Nature 209: 1244-1245
87. Tizianello A, DeFerrari G, Garibotto G, Gurreiri G (1978) Effects of chronic renal insufficiency and metabolic acidosis on glutamine metabolism in man. Clin Sci 55: 391-397
88. Owen OE, Reichle FA, Mozzoli MA et al. (1981) Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis. J Clin Invest 68: 240-252
89. Ahlborg G, Weitzberg E, Sollevi A, Lundberg JM (1992) Splanchnic and renal vasoconstrictor and metabolic responses to neuropeptide Y in resting and exercising man. Acta Physiol Scand 145: 139-149