Isozyme-Specific Ligands for O-acetylserine sulfhydrylase, a Novel Antibiotic Target

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Spyrakis, Francesca ^a,g   Singh, Ratna ^a   Cozzini, Pietro ^a,b   Campanini, Barbara ^a   Salsi, Enea ^a,h   Felici, Paolo ^a   Raboni, Samanta ^a   Benedetti, Paolo ^c   Cruciani, Gabriele ^d   Kellogg, Glen E ^e   Cook, Paul F ^f   Mozzarelli, Andrea ^a,b  

^a UNIVERSITY OF PARMA   (Italy)

^b NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

^c Molecular Discovery Limited   (United Kingdom)

^d UNIVERSITY OF PERUGIA   (Italy)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f UNIVERSITY OF OKLAHOMA   (United States)

^g UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^h UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE SYNTHASE; ISOENZYME; S SULFOCYSTEINE SYNTHASE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CYSTEINE; ENZYME INHIBITOR;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; ENZYME SYNTHESIS; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN TARGETING; SALMONELLA TYPHIMURIUM; ANIMAL; ANTAGONISTS AND INHIBITORS; BACTERIA; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; CYSTEINE; CYSTEINE SYNTHASE; ENZYME INHIBITORS; HUMANS; ISOENZYMES;

EID: 84886040250     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077558     Document Type: Article

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