Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature

Journal of Medicinal Chemistry

Volumn 53, Issue 1, 2010, Pages 345-356

  Salsi, Enea ^a   Bayden, Alexander S ^b   Spyrakis, Francesca ^a,e   Amadasi, Alessio ^a   Campanini, Barbara ^a   Bettati, Stefano ^a,e   Dodatko, Tetyana ^d   Cozzini, Pietro ^a,e   Kellogg, Glen E ^b   Cook, Paul F ^c   Roderick, Steven L ^d   Mozzarelli, Andrea ^a,e  

^a UNIVERSITY OF PARMA   (Italy)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE SYNTHASE; ENZYME INHIBITOR; PENTAPEPTIDE; PEPTIDOMIMETIC AGENT;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; X RAY ANALYSIS;

CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYSTEINE SYNTHASE; DRUG DESIGN; ENZYME INHIBITORS; HAEMOPHILUS INFLUENZAE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 74849085165     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm901325e     Document Type: Article

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