Cysteine synthase (CysM) of Mycobacterium tuberculosis is an O-phosphoserine sulfhydrylase: Evidence for an alternative cysteine biosynthesis pathway in Mycobacteria

Journal of Biological Chemistry

Volumn 283, Issue 46, 2008, Pages 31567-31574

  Ågren, Daniel ^a   Schnell, Robert ^a   Oehlmann, Wulf ^b   Singh, Mahavir ^b,c   Schneider, Gunter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LIONEX DIAGNOSTICS AND THERAPEUTICS GMBH   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTAL STRUCTURE; HYDROGEN; HYDROGEN BONDS; ORGANIC ACIDS; SULFUR; SULFUR COMPOUNDS;

BIOSYNTHETIC PATHWAYS; BUILDING BLOCKS; CYSTEINE BIOSYNTHESIS; DEFENSE MECHANISMS; DESIGN STRATEGIES; DORMANT STATES; HYDROGEN BONDING INTERACTIONS; KEY FEATURES; M. TUBERCULOSES; METABOLIC PATHWAYS; METABOLIC ROUTES; MYCOBACTERIUM TUBERCULOSIS; NOVO PROTEINS; PHOSPHATE GROUPS; PHOSPHOSERINE; SIDE CHAINS; SUBSTRATE SELECTIVITIES; SULFATE REDUCTIONS; SULFUR DONORS; SYNTHASE;

ENZYMES;

ARGININE; CYSTEINE SYNTHASE; LYASE; PHOSPHOSERINE; SULFUR;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; REDUCTION;

BINDING SITES; BIOCATALYSIS; CARBON-OXYGEN LYASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; CYSTEINE SYNTHASE; KINETICS; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; PYRIDOXAL PHOSPHATE; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 57649136751     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804877200     Document Type: Article

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