Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5′-phosphosulfate reductase inhibitors

Journal of Medicinal Chemistry

Volumn 51, Issue 21, 2008, Pages 6627-6630

  Cosconati, Sandro ^a,c   Hong, Jiyoung A ^b   Novellino, Ettore ^c   Carroll, Kate S ^b   Goodsell, David S ^a   Olson, Arthur J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' PHOSPHOSULFATE REDUCTASE INHIBITOR; ANTIBIOTIC AGENT; CD45 ANTIGEN; NSC 133896; NSC 16211; NSC 228155; NSC 23180; NSC 327704; NSC 348401; NSC 55545; NSC 57476; NSC 60826; NSC 9746; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL SURVIVAL; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; MYCOBACTERIUM TUBERCULOSIS; PSEUDOMONAS AERUGINOSA; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 56249117015     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm800571m     Document Type: Article

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