메뉴 건너뛰기




Volumn 9, Issue 11, 2013, Pages 1419-1435

A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: Where to next

Author keywords

Chimeric mouse; Drug testing; Hepatitis infection model; Mouse with humanized liver

Indexed keywords

BIOTECHNOLOGY; CHIMERA; DISEASE MODEL; DRUG RESEARCH; DRUG SCREENING; IMMUNOCOMPETENT CELL; LIVER; LIVER CELL; MOUSE MODEL; NONHUMAN; PLURIPOTENT STEM CELL; REVIEW; VIRUS HEPATITIS;

EID: 84886032103     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.826649     Document Type: Review
Times cited : (19)

References (94)
  • 1
    • 84876914209 scopus 로고    scopus 로고
    • Development of liposomal anticancer drugs
    • Hyodo K, Yamamoto E, Suzuki T, et al. Development of liposomal anticancer drugs. Biol Pharm Bull 2013;36(5):703-7
    • (2013) Biol Pharm Bull , vol.36 , Issue.5 , pp. 703-707
    • Hyodo, K.1    Yamamoto, E.2    Suzuki, T.3
  • 2
    • 84862775836 scopus 로고    scopus 로고
    • Paradigm shift in toxicity testing and modeling
    • Sun H, Xia M, Austin CP, Huang R. Paradigm shift in toxicity testing and modeling. AAPS J 2012;14(3):473-80
    • (2012) AAPS J , vol.14 , Issue.3 , pp. 473-480
    • Sun, H.1    Xia, M.2    Austin, C.P.3    Huang, R.4
  • 3
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates Nat Rev Drug Discov 2004;3:711-15 (Pubitemid 39173511)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 5
    • 81855199725 scopus 로고    scopus 로고
    • Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice
    • Renaud HJ, Cui JY, Khan M, Klaassen CD. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci 2011;124:261-77
    • (2011) Toxicol Sci , vol.124 , pp. 261-277
    • Renaud, H.J.1    Cui, J.Y.2    Khan, M.3    Klaassen, C.D.4
  • 6
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Review
    • Wilkinson GR. Drug metabolism and variability among patients in drug response. N Engl J Med 2005;352:2211-21; Review
    • (2005) N Engl J Med , vol.352 , pp. 2211-2221
    • Wilkinson, G.R.1
  • 7
    • 79951893032 scopus 로고    scopus 로고
    • Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models
    • Jiang XL, Gonzalez FJ, Yu AM. Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metab Rev 2011;43:27-40
    • (2011) Drug Metab Rev , vol.43 , pp. 27-40
    • Jiang, X.L.1    Gonzalez, F.J.2    Yu, A.M.3
  • 8
    • 4344649384 scopus 로고    scopus 로고
    • Genetically modified mouse models for pharmacogenomic research
    • DOI 10.1038/nrg1429
    • Liggett SB. Genetically modified mouse models for pharmacogenomic research. Nat Rev Genet 2004;5:657-63; Review (Pubitemid 39150122)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.9 , pp. 657-663
    • Liggett, S.B.1
  • 9
    • 43949122957 scopus 로고    scopus 로고
    • Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism
    • DOI 10.1038/clpt.2008.50, PII CLPT200850
    • Muruganandan S, Sinal CJ. Mice as clinically relevant models for the study of cytochrome P450-dependent metabolism. Clin Pharmacol Ther 2008;83:818-28 (Pubitemid 351704925)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.6 , pp. 818-828
    • Muruganandan, S.1    Sinal, C.J.2
  • 10
    • 17744378552 scopus 로고    scopus 로고
    • Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
    • Dandri M, Burda MR, Torok E, et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 2001;33:981-8
    • (2001) Hepatology , vol.33 , pp. 981-988
    • Dandri, M.1    Burda, M.R.2    Torok, E.3
  • 13
    • 70449090414 scopus 로고    scopus 로고
    • In vivo modeling of human liver for pharmacological study using humanized mouse
    • Review
    • Yoshizato K, Tateno C. In vivo modeling of human liver for pharmacological study using humanized mouse. Expert Opin Drug Metab Toxicol 2009;5:1435-46; Review
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 1435-1446
    • Yoshizato, K.1    Tateno, C.2
  • 14
    • 77952504395 scopus 로고    scopus 로고
    • The mechanism of liver size control in mammals: A novel animal study
    • Yoshizato K, Tateno C, Utoh R. The mechanism of liver size control in mammals: a novel animal study. Int J Des Nature Ecodynamics 2009;4:123-42
    • (2009) Int J des Nature Ecodynamics , vol.4 , pp. 123-142
    • Yoshizato, K.1    Tateno, C.2    Utoh, R.3
  • 15
    • 72449189142 scopus 로고    scopus 로고
    • A human hepatocyte-bearing mouse: An animal model to predict drug metabolism and effectiveness in humans
    • Yoshizato K, Tateno C. A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans. PPAR Res 2009;2009:476217
    • (2009) PPAR Res , vol.2009 , pp. 476217
    • Yoshizato, K.1    Tateno, C.2
  • 16
    • 84858191432 scopus 로고    scopus 로고
    • Mice with liver composed of human hepatocytes as an animal model for drug testing
    • Yoshizato K, Tateno C, Utoh R. Mice with liver composed of human hepatocytes as an animal model for drug testing. Curr Drug Discov Technol 2012;9(1):63-76
    • (2012) Curr Drug Discov Technol , vol.9 , Issue.1 , pp. 63-76
    • Yoshizato, K.1    Tateno, C.2    Utoh, R.3
  • 17
    • 0028353410 scopus 로고
    • Replacement of diseased mouse liver by hepatic cell transplantation
    • Sandgren EP, Degen JL, Palmiter RD, et al. Replacement of diseased mouse liver by hepatic cell transplantation. Science 1994;263:1149-52 (Pubitemid 24105963)
    • (1994) Science , vol.263 , Issue.5150 , pp. 1149-1152
    • Rhim, J.A.1    Sandgren, E.P.2    Degen, J.L.3    Palmiter, R.D.4    Brinster, R.L.5
  • 18
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • DOI 10.1038/301527a0
    • Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature 1983;301:527-30 (Pubitemid 13160576)
    • (1983) Nature , vol.301 , Issue.5900 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 19
    • 7444236477 scopus 로고    scopus 로고
    • Antigen receptor genes and the evolution of a recombinase
    • DOI 10.1016/j.smim.2004.08.004, PII S1044532304000375, The Evolution of Rearranging Receptor Families
    • Schatz DG. Antigen receptor genes and the evolution of a recombinase. Semin Immunol 2004;16:245-56 (Pubitemid 39445623)
    • (2004) Seminars in Immunology , vol.16 , Issue.4 , pp. 245-256
    • Schatz, D.G.1
  • 23
    • 0026581936 scopus 로고
    • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D) J rearrangement
    • Shinkai Y, Rathbun G, Lam KP, et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992;68:855-67
    • (1992) Cell , Issue.68 , pp. 855-867
    • Shinkai, Y.1    Rathbun, G.2    Lam, K.P.3
  • 24
    • 1842558876 scopus 로고    scopus 로고
    • Molecular pathology of severe combined immunodeficiency in mice, horses, and dogs
    • DOI 10.1354/vp.41-2-95
    • Perryman LE. Molecular pathology of severe combined immunodeficiency in mice, horses, and dogs. Vet Pathol 2004;41:95-100 (Pubitemid 38453181)
    • (2004) Veterinary Pathology , vol.41 , Issue.2 , pp. 95-100
    • Perryman, L.E.1
  • 25
    • 0025811882 scopus 로고
    • The SCID mouse mutant: Definition, characterization, and potential uses
    • Review
    • Bosma MJ, Carroll AM. The SCID mouse mutant: definition, characterization, and potential uses. Annu Rev Immunol 1991;9:323-50; Review
    • (1991) Annu Rev Immunol , vol.9 , pp. 323-350
    • Bosma, M.J.1    Carroll, A.M.2
  • 26
    • 84954358569 scopus 로고    scopus 로고
    • Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice
    • Suemizu H, Hasegawa M, Kawai K, et al. Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem Biophys Res Commun 2008;377:248-52
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 248-252
    • Suemizu, H.1    Hasegawa, M.2    Kawai, K.3
  • 27
    • 0026646694 scopus 로고
    • The murine autoimmune diabetes model: NOD and related strains
    • Kikutani H, Makino S. The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 1992;51:285-322
    • (1992) Adv Immunol , vol.51 , pp. 285-322
    • Kikutani, H.1    Makino, S.2
  • 29
    • 0025144417 scopus 로고
    • Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
    • Heckel JL, Sandgren EP, Dege JL, et al. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 1990;62:447-56
    • (1990) Cell , vol.62 , pp. 447-456
    • Heckel, J.L.1    Sandgren, E.P.2    Dege, J.L.3
  • 31
    • 38049164210 scopus 로고    scopus 로고
    • Repopulation of adult and neonatal mice with human hepatocytes: A chimeric animal model
    • Bissig KD, Le TT, Woods NB, Verma IM. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci USA 2007;104:20507-11
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20507-20511
    • Bissig, K.D.1    Le Woods, T.T.N.B.2    Verma, I.M.3
  • 33
    • 58149191925 scopus 로고    scopus 로고
    • Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes
    • Brezillon NM, DaSilva L, L'Hôte D, et al. Rescue of fertility in homozygous mice for the urokinase plasminogen activator transgene by the transplantation of mouse hepatocytes. Cell Transplant 2008;17:803-12
    • (2008) Cell Transplant , vol.17 , pp. 803-812
    • Brezillon, N.M.1    Dasilva, L.2    L'Hôte, D.3
  • 34
    • 0025781894 scopus 로고
    • Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
    • Sandgren EP, Palmiter RD, Heckel JL, et al. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell 1991;66:245-56 (Pubitemid 121001363)
    • (1991) Cell , vol.66 , Issue.2 , pp. 245-256
    • Sandgren, E.P.1    Palmiter, R.D.2    Heckel, J.L.3    Daughterly, C.C.4    Brinster, R.L.5    Degen, J.L.6
  • 36
    • 84871789410 scopus 로고    scopus 로고
    • Morphological and microarray analyses of human hepatocytes from xenogeneic host livers
    • Tateno C, Miya F, Wake K, et al. Morphological and microarray analyses of human hepatocytes from xenogeneic host livers. Lab Invest 2013;93(1):54-71
    • (2013) Lab Invest , vol.93 , Issue.1 , pp. 54-71
    • Tateno, C.1    Miya, F.2    Wake, K.3
  • 37
    • 70349690193 scopus 로고    scopus 로고
    • UPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: Methandienone as a case study
    • Lootens L, Meuleman P, Pozo OJ, et al. uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study. Clin Chem 2009;55:1783-93
    • (2009) Clin Chem , vol.55 , pp. 1783-1793
    • Lootens, L.1    Meuleman, P.2    Pozo, O.J.3
  • 39
    • 70349687121 scopus 로고    scopus 로고
    • Humanized animal models to study drug metabolism: No longer a chimera
    • Botrè F. Humanized animal models to study drug metabolism: no longer a "chimera" Clin Chem 2009;55(10):1763-4
    • (2009) Clin Chem , vol.55 , Issue.10 , pp. 1763-1764
    • Botrè, F.1
  • 40
    • 71049178282 scopus 로고    scopus 로고
    • The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione
    • Lootens L, Van Eenoo P, Meuleman P, et al. The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione. Drug Metab Dispos 2009;37:2367-74
    • (2009) Drug Metab Dispos , vol.37 , pp. 2367-2374
    • Lootens, L.1    Van Eenoo, P.2    Meuleman, P.3
  • 41
    • 84873722475 scopus 로고    scopus 로고
    • Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-g
    • Mehta JL. Epub ahead of print
    • Dai Y, Su W, Ding Z, et al. Mehta JL. Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-g. Biochem Biophys Res Commun 2013; [Epub ahead of print]
    • (2013) Biochem Biophys Res Commun
    • Dai, Y.1    Su, W.2    Ding, Z.3
  • 42
    • 84860564694 scopus 로고    scopus 로고
    • Evaluation of the pharmacokinetics biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers
    • Schulz-Utermoehl T, Sarda S, Foster JR, et al. Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers. Xenobiotica 2012;42(6):503-17
    • (2012) Xenobiotica , vol.42 , Issue.6 , pp. 503-517
    • Schulz-Utermoehl, T.1    Sarda, S.2    Foster, J.R.3
  • 43
    • 84869128749 scopus 로고    scopus 로고
    • Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes
    • Sanoh S, Horiguchi A, Sugihara K, et al. Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes. Drug Metab Dispos 2012;40(12):2267-72
    • (2012) Drug Metab Dispos , vol.40 , Issue.12 , pp. 2267-2272
    • Sanoh, S.1    Horiguchi, A.2    Sugihara, K.3
  • 44
    • 84855997102 scopus 로고    scopus 로고
    • Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver
    • Sanoh S, Horiguchi A, Sugihara K, et al. Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver. Drug Metab Dispos 2012;40(2):322-8
    • (2012) Drug Metab Dispos , vol.40 , Issue.2 , pp. 322-328
    • Sanoh, S.1    Horiguchi, A.2    Sugihara, K.3
  • 45
    • 0037954564 scopus 로고    scopus 로고
    • Mammalian molybdo-flavoenzymes, an expanding family of proteins: Structure, genetics, regulation, function and pathophysiology
    • DOI 10.1042/BJ20030121
    • Garattini E, Mendel R, Romão MJ, et al. Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology. Biochem J 2003;372(Pt 1):15-32; Review (Pubitemid 36609603)
    • (2003) Biochemical Journal , vol.372 , Issue.1 , pp. 15-32
    • Garattini, E.1    Mendel, R.2    Romao, M.J.3    Wright, R.4    Terao, M.5
  • 46
    • 84455171514 scopus 로고    scopus 로고
    • Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes
    • Sanoh S, Nozaki K, Murai H, et al. Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes. Drug Metab Dispos 2012;40(1):76-82
    • (2012) Drug Metab Dispos , vol.40 , Issue.1 , pp. 76-82
    • Sanoh, S.1    Nozaki, K.2    Murai, H.3
  • 47
    • 78650379608 scopus 로고    scopus 로고
    • Aldehyde oxidase: An enzyme of emerging importance in drug discovery
    • Pryde DC, Dalvie D, Hu Q, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem 2010;53:8441-60
    • (2010) J Med Chem , vol.53 , pp. 8441-8460
    • Pryde, D.C.1    Dalvie, D.2    Hu, Q.3
  • 48
    • 79960719085 scopus 로고    scopus 로고
    • Increasing recognition of the importance of aldehyde oxidase in drug development and discovery
    • Garattini E, Terao M. Increasing recognition of the importance of aldehyde oxidase in drug development and discovery. Drug Metab Rev 2011;43:374-86
    • (2011) Drug Metab Rev , vol.43 , pp. 374-386
    • Garattini, E.1    Terao, M.2
  • 49
    • 79954525297 scopus 로고    scopus 로고
    • Case report of extensive metabolism by aldehyde oxidase in humans: Pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans
    • Akabane T, Tanaka K, Irie M, et al. Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans. Xenobiotica 2011;41:372-84
    • (2011) Xenobiotica , vol.41 , pp. 372-384
    • Akabane, T.1    Tanaka, K.2    Irie, M.3
  • 50
    • 21644444503 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is involved in innate and adaptive immunity
    • Brunner C, Muller B, Wirth T. Bruton's tyrosine kinase is involved in innate and adaptive immunity. Histol Histopathol 2005;20:945-55 (Pubitemid 40932612)
    • (2005) Histology and Histopathology , vol.20 , Issue.3 , pp. 945-955
    • Brunner, C.1    Muller, B.2    Wirth, T.3
  • 51
    • 58849148654 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase as a drug discovery target
    • Pan Z. Bruton's tyrosine kinase as a drug discovery target. Drug News Perspect 2008;21:357-62
    • (2008) Drug News Perspect , vol.21 , pp. 357-362
    • Pan, Z.1
  • 52
    • 79959522607 scopus 로고    scopus 로고
    • Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism based pharmacokinetic/ pharmacodynamic modeling: Relationships between inhibition of BTK phosphorylation and efficacy
    • Liu L, Di Paolo J, Barbosa J, et al. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. J Pharmacol Exp Ther 2011;338:154-63
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 154-163
    • Liu, L.1    Di Paolo, J.2    Barbosa, J.3
  • 53
    • 80053137262 scopus 로고    scopus 로고
    • Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor
    • Liu L, Halladay JS, Shin Y, et al. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor. Drug Metab Dispos 2011;39(10):1840-9
    • (2011) Drug Metab Dispos , vol.39 , Issue.10 , pp. 1840-1849
    • Liu, L.1    Halladay, J.S.2    Shin, Y.3
  • 54
    • 70449084685 scopus 로고    scopus 로고
    • Towards a small animal model for hepatitis C
    • Ploss A, Rice CM. Towards a small animal model for hepatitis C. EMBO Rep 2009;10:1220-7
    • (2009) EMBO Rep , vol.10 , pp. 1220-1227
    • Ploss, A.1    Rice, C.M.2
  • 55
    • 33750804220 scopus 로고    scopus 로고
    • Replication of a hepatitis C virus replicon clone in mouse cells
    • Uprichard SL, Chung J, Chisari FV, Wakita T. Replication of a hepatitis C virus replicon clone in mouse cells. Virol J 2006;3:89
    • (2006) Virol J , vol.3 , pp. 89
    • Uprichard, S.L.1    Chung, J.2    Chisari, F.V.3    Wakita, T.4
  • 57
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • Bissig KD, Wieland SF, Tran P, et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest 2010;120:924-30
    • (2010) J Clin Invest , vol.120 , pp. 924-930
    • Bissig, K.D.1    Wieland, S.F.2    Tran, P.3
  • 59
    • 52649153452 scopus 로고    scopus 로고
    • Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice
    • Kimura T, Imamura M, Hiraga N, et al. Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice. J Gen Virol 2008;89(Pt 9):2108-13
    • (2008) J Gen Virol , vol.89 , Issue.PART. 9 , pp. 2108-2113
    • Kimura, T.1    Imamura, M.2    Hiraga, N.3
  • 60
    • 77954155771 scopus 로고    scopus 로고
    • Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor
    • Kamiya N, Iwao E, Hiraga N, et al. Practical evaluation of a mouse with chimeric human liver model for hepatitis C virus infection using an NS3-4A protease inhibitor. J Gen Virol 2010;91(Pt 7):1668-77
    • (2010) J Gen Virol , vol.91 , Issue.PART. 7 , pp. 1668-1677
    • Kamiya, N.1    Iwao, E.2    Hiraga, N.3
  • 61
    • 79954911259 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
    • Ohara E, Hiraga N, Imamura M, et al. Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice. J Hepatol 2011;54(5):872-8
    • (2011) J Hepatol , vol.54 , Issue.5 , pp. 872-878
    • Ohara, E.1    Hiraga, N.2    Imamura, M.3
  • 62
    • 79958840246 scopus 로고    scopus 로고
    • ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo
    • Abe H, Imamura M, Hiraga N, et al. ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo. J Hepatol 2011;55(1):11-18
    • (2011) J Hepatol , vol.55 , Issue.1 , pp. 11-18
    • Abe, H.1    Imamura, M.2    Hiraga, N.3
  • 64
    • 80052035379 scopus 로고    scopus 로고
    • Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo
    • Hiraga N, Imamura M, Abe H, et al. Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo. Hepatology 2011;54(3):781-8
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 781-788
    • Hiraga, N.1    Imamura, M.2    Abe, H.3
  • 65
    • 73649131938 scopus 로고    scopus 로고
    • A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation
    • Song X, Guo Y, Duo S, et al. A mouse model of inducible liver injury caused by tet-on regulated urokinase for studies of hepatocyte transplantation. Am J Pathol 2009;175:1975-83
    • (2009) Am J Pathol , vol.175 , pp. 1975-1983
    • Song, X.1    Guo, Y.2    Duo, S.3
  • 66
    • 0024448460 scopus 로고
    • T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene
    • Held WA, Mullins JJ, Kuhn NJ, et al. T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene. EMBO J 1989;8:183-91 (Pubitemid 19273961)
    • (1989) EMBO Journal , vol.8 , Issue.1 , pp. 183-191
    • Held, W.A.1    Mullins, J.J.2    Kuhn, N.J.3    Gallagher, J.F.4    Gu, G.D.5    Gross, K.W.6
  • 67
    • 0033636738 scopus 로고    scopus 로고
    • Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes
    • Weglarz TC, Degen JL, Sandgren EP. Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes. Am J Pathol 2000;157:1963-74
    • (2000) Am J Pathol , vol.157 , pp. 1963-1974
    • Weglarz, T.C.1    Degen, J.L.2    Sandgren, E.P.3
  • 68
    • 77956556521 scopus 로고    scopus 로고
    • Liver xeno-repopulation with human hepatocytes in Fah-/-Rag2-/-mice after pharmacological immunosuppression
    • He Z, Zhang H, Zhang X, et al. Liver xeno-repopulation with human hepatocytes in Fah-/-Rag2-/-mice after pharmacological immunosuppression. Am J Pathol 2010;177:1311-19
    • (2010) Am J Pathol , vol.177 , pp. 1311-1319
    • He, Z.1    Zhang, H.2    Zhang, X.3
  • 70
    • 67651102866 scopus 로고    scopus 로고
    • Humanized mice for modeling human infectious disease: Challenges, progress, and outlook
    • Review
    • Legrand N, Ploss A, Balling R, et al. Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe 2009;6:5-9; Review
    • (2009) Cell Host Microbe , vol.6 , pp. 5-9
    • Legrand, N.1    Ploss, A.2    Balling, R.3
  • 71
    • 23944467250 scopus 로고    scopus 로고
    • Adaptive immune responses in acute and chronic hepatitis C virus infection
    • DOI 10.1038/nature04079
    • Bowen DG, Walker CM. Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature 2005;436:946-52; Review (Pubitemid 41191670)
    • (2005) Nature , vol.436 , Issue.7053 , pp. 946-952
    • Bowen, D.G.1    Walker, C.M.2
  • 72
    • 79953196869 scopus 로고    scopus 로고
    • A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease
    • Washburn ML, Bility MT, Zhang L, et al. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 2011;140:1334-44
    • (2011) Gastroenterology , vol.140 , pp. 1334-1344
    • Washburn, M.L.1    Bility, M.T.2    Zhang, L.3
  • 73
    • 80455162464 scopus 로고    scopus 로고
    • Inducible apoptosis as a safety switch for adoptive cell therapy
    • Di Stasi A, Tey SK, Dotti G, et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med 2011;365(18):1673-83
    • (2011) N Engl J Med , vol.365 , Issue.18 , pp. 1673-1683
    • Di Stasi, A.1    Tey, S.K.2    Dotti, G.3
  • 75
    • 84860389893 scopus 로고    scopus 로고
    • A first step towards a mouse model for hepatitis C virus infection containing a human immune system
    • Robinet E, Baumert TF. A first step towards a mouse model for hepatitis C virus infection containing a human immune system. J Hepatol 2011;55:718-20
    • (2011) J Hepatol , vol.55 , pp. 718-720
    • Robinet, E.1    Baumert, T.F.2
  • 76
    • 0842300376 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells
    • DOI 10.1053/j.gastro.2003.11.018
    • Bataller R, Paik YH, Lindquist JN, et al. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 2004;126:529-40 (Pubitemid 38182310)
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 529-540
    • Bataller, R.1    Paik, Y.-H.2    Lindquist, J.N.3    Lemasters, J.J.4    Brenner, D.A.5
  • 77
    • 77957288391 scopus 로고    scopus 로고
    • Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice
    • Utoh R, Tateno C, Kataoka M, et al. Hepatic hyperplasia associated with discordant xenogeneic parenchymal-nonparenchymal interactions in human hepatocyte-repopulated mice. Am J Pathol 2010;177:654-65
    • (2010) Am J Pathol , vol.177 , pp. 654-665
    • Utoh, R.1    Tateno, C.2    Kataoka, M.3
  • 78
    • 80052010610 scopus 로고    scopus 로고
    • Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse
    • Tsuge M, Fujimoto Y, Hiraga N, et al. Hepatitis C virus infection suppresses the interferon response in the liver of the human hepatocyte chimeric mouse. PLoS ONE 2011;6(8):e23856
    • (2011) PLoS ONE , vol.6 , Issue.8
    • Tsuge, M.1    Fujimoto, Y.2    Hiraga, N.3
  • 79
    • 84864369008 scopus 로고    scopus 로고
    • Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse
    • Okazaki A, Hiraga N, Imamura M, et al. Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse. Hepatology 2012;56:555-66
    • (2012) Hepatology , vol.56 , pp. 555-566
    • Okazaki, A.1    Hiraga, N.2    Imamura, M.3
  • 80
    • 9644284438 scopus 로고    scopus 로고
    • Human hepatocytes in mice receiving]g pre-immune injection with human cord blood cells
    • Turrini P, Monego G, Gonzalez J, et al. Human hepatocytes in mice receiving]g pre-immune injection with human cord blood cells. Biochem Biophys Res Commun 2005;326(1):66-73
    • (2005) Biochem Biophys Res Commun , vol.326 , Issue.1 , pp. 66-73
    • Turrini, P.1    Monego, G.2    Gonzalez, J.3
  • 81
    • 0027429851 scopus 로고
    • The immune system victorious: Selective preservation of self
    • Cruse JM, Lewis RE Jr. The immune system victorious: selective preservation of self. Immunol Res 1993;12(2):101-14; Review (Pubitemid 23285735)
    • (1993) Immunologic Research , vol.12 , Issue.2 , pp. 101-114
    • Cruse, J.M.1    Lewis Jr., R.E.2
  • 82
    • 23444441147 scopus 로고    scopus 로고
    • Gene targeting using zinc finger nucleases
    • DOI 10.1038/nbt1125
    • Porteus MH, Carroll D. Gene targeting using zinc finger nucleases. Nat Biotechnol 2005;23(8):967-73 (Pubitemid 41114030)
    • (2005) Nature Biotechnology , vol.23 , Issue.8 , pp. 967-973
    • Porteus, M.H.1    Carroll, D.2
  • 83
    • 67749106611 scopus 로고    scopus 로고
    • Knockout rats via embryo microinjection of zinc-finger nucleases
    • Geurts AM, Cost GJ, Freyvert Y, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science 2009;325(5939):433
    • (2009) Science , vol.325 , Issue.5939 , pp. 433
    • Geurts, A.M.1    Cost, G.J.2    Freyvert, Y.3
  • 84
    • 84866924344 scopus 로고    scopus 로고
    • Generation and characterization of severe combined immunodeficiency rats
    • Mashimo T, Takizawa A, Kobayashi J, et al. Generation and characterization of severe combined immunodeficiency rats. Cell Rep 2012;2(3):685-94
    • (2012) Cell Rep , vol.2 , Issue.3 , pp. 685-694
    • Mashimo, T.1    Takizawa, A.2    Kobayashi, J.3
  • 86
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126(4):663-76 (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 87
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318(5858):1917-20
    • (2007) Science , vol.318 , Issue.5858 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 88
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • Si-Tayeb K, Noto FK, Nagaoka M, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 2010;51(1):297-305
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 297-305
    • Si-Tayeb, K.1    Noto, F.K.2    Nagaoka, M.3
  • 89
    • 84865152827 scopus 로고    scopus 로고
    • Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1alpha transduction
    • Takayama K, Inamura M, Kawabata K, et al. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1alpha transduction. J Hepatol 2012;57(3):628-36
    • (2012) J Hepatol , vol.57 , Issue.3 , pp. 628-636
    • Takayama, K.1    Inamura, M.2    Kawabata, K.3
  • 90
    • 84857125662 scopus 로고    scopus 로고
    • Modeling hepatitis C virus infection using human induced pluripotent stem cells
    • Schwartz RE, Trehan K, Andrus L, et al. Modeling hepatitis C virus infection using human induced pluripotent stem cells. Proc Natl Acad Sci USA 2012;109(7):2544-8
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.7 , pp. 2544-2548
    • Schwartz, R.E.1    Trehan, K.2    Andrus, L.3
  • 91
    • 84861206498 scopus 로고    scopus 로고
    • Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation
    • Wu X, Robotham JM, Lee E, et al. Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog 2012;8(4):e1002617
    • (2012) PLoS Pathog , vol.8 , Issue.4
    • Wu, X.1    Robotham, J.M.2    Lee, E.3
  • 92
    • 82455188188 scopus 로고    scopus 로고
    • Hepatitis C virus induces interferon-l and interferon-stimulated genes in primary liver cultures
    • Marukian S, Andrus L, Sheahan TP, et al. Hepatitis C virus induces interferon-l and interferon-stimulated genes in primary liver cultures. Hepatology 2011;54(6):1913-23
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 1913-1923
    • Marukian, S.1    Andrus, L.2    Sheahan, T.P.3
  • 93
    • 77956354626 scopus 로고    scopus 로고
    • Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
    • Espejel S, Roll GR, McLaughlin KJ, et al. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest 2010;120(9):3120-6
    • (2010) J Clin Invest , vol.120 , Issue.9 , pp. 3120-3126
    • Espejel, S.1    Roll, G.R.2    McLaughlin, K.J.3
  • 94
    • 0029082193 scopus 로고
    • Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type i
    • Grompe M, Lindstedt S, al-Dhalimy M, et al. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat Genet 1995;10(4):453-60
    • (1995) Nat Genet , vol.10 , Issue.4 , pp. 453-460
    • Grompe, M.1    Lindstedt, S.2    Al-Dhalimy, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.