The uPA(+/+)-SCID mouse with humanized liver as a model for in vivo metabolism of 4-androstene-3,17-dione

Drug Metabolism and Disposition

Volumn 37, Issue 12, 2009, Pages 2367-2374

  Lootens, Leen ^a   Van Eenoo, Peter ^a   Meuleman, Philip ^b   Leroux Roels, Geert ^b   Delbeke, Frans T ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; ETIOCHOLANOLONE; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER; LIVER CELL; LIVER CELL CULTURE; MASS FRAGMENTOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; URINALYSIS; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANDROGENS; ANDROSTENEDIONE; ANDROSTERONE; ANIMALS; BIOTRANSFORMATION; ETIOCHOLANOLONE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEPATOCYTES; HUMANS; HYDROXYLATION; LIVER; MICE; MICE, SCID; MICE, TRANSGENIC; SPECIES SPECIFICITY; TRANSPLANTATION, HETEROLOGOUS; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

MUS;

EID: 71049178282     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028183     Document Type: Article

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