Regulation of MSR-1 and CD36 in macrophages by LOX-1 mediated through PPAR-γ

Biochemical and Biophysical Research Communications

Volumn 431, Issue 3, 2013, Pages 496-500

  Dai, Yao ^a,b   Su, Wei ^a,b   Ding, Zufeng ^a,b   Wang, Xianwei ^a,b   Mercanti, Federico ^a,b   Chen, Mingwei ^a,b   Raina, Sameer ^a,b   Mehta, Jawahar L ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Macrophage MSR1 CD36 PPAR LOX 1; CD36; LOX 1; Macrophage; MSR1; PPAR

Indexed keywords

CD36 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROPHAGE SCAVENGER RECEPTOR 1; MESSENGER RNA; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SCAVENGER RECEPTOR; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; WILD TYPE;

ANIMALS; ANTIGENS, CD36; CELLS, CULTURED; CHROMANS; GENE EXPRESSION REGULATION; LIPOPROTEINS, LDL; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; NF-KAPPA B; PPAR GAMMA; SCAVENGER RECEPTORS, CLASS A; SCAVENGER RECEPTORS, CLASS E; THIAZOLIDINEDIONES;

MUS;

EID: 84873722475     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.01.029     Document Type: Article

References (22)

1. Mitra S., Goyal T., Mehta J.L. Oxidized LDL, LOX-1 and atherosclerosis. Cardiovasc. Drugs Ther. 2011, 25:419-429.
2. Lu J., Mitra S., Wang X., et al. Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis. Antioxid. Redox Signal. 2011, 15:2301-2333.
3. Matsumoto A., Naito M., Itakura H., et al. Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc. Natl. Acad. Sci. USA 1990, 87:9133-9137.
4. Piechota M., Banaszewska A., Dudziak J., et al. Highly upregulated expression of CD36 and MSR1 in circulating monocytes of patients with acute coronary syndromes. Protein J. 2012, 31:511-518.
5. Husemann J., Loike J.D., Anankov R., et al. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 2002, 40:195-205.
6. Ito S., Naito M., Kobayashi Y., et al. Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages. Arch. Histol. Cytol. 1999, 62:83-95.
7. Kunjathoor V.V., Febbraio M., Podrez E.A., et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J. Biol. Chem. 2002, 277:49982-49988.
8. Draude G., Lorenz R.L. TGF-beta1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages. Am. J. Physiol. Heart Circ. Physiol. 2000, 278:H1042-1048.
9. Sharma A.M., Staels B. Peroxisome proliferator-activated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. J. Clin. Endocrinol. Metab. 2007, 92:386-395.
10. Feng J., Han J., Pearce S.F., et al. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-gamma. J. Lipid Res. 2000, 41:688-696.
11. Tontonoz P., Nagy L., Alvarez J.G., et al. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998, 93:241-252.
12. Ricote M., Glass C.K. New roles for PPARs in cholesterol homeostasis. Trends Pharmacol. Sci. 2001, 22:441-443.
13. Moore K.J., Rosen E.D., Fitzgerald M.L., et al. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat. Med. 2001, 7:41-47.
14. Mehta J.L., Sanada N., Hu C.P., et al. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ. Res. 2007, 100:1634-1642.
15. Lu J., Wang X., Wang W., et al. LOX-1 abrogation reduces cardiac hypertrophy and collagen accumulation following chronic ischemia in the mouse. Gene Ther. 2012, 19:522-531.
16. Hu C., Dandapat A., Sun L., et al. Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion. Hypertension 2008, 52:556-562.
17. Wang X., Khaidakov M., Ding Z., et al. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and cardiac fibroblast growth. Hypertension 2012, 60:1437-1442.
18. Mehta J.L., Hu B., Chen J., et al. Pioglitazone inhibits LOX-1 expression in human coronary artery endothelial cells by reducing intracellular superoxide radical generation. Arterioscler. Thromb. Vasc. Biol. 2003, 23:2203-2208.
19. Berkel T.J.Van., Eck M.Van., Herijgers N., et al. Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL. Ann. NY. Acad. Sci. 2000, 902:113-126.
20. Moore K.J., Kunjathoor V.V., Koehn S.L., et al. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J. Clin. Invest. 2005, 115:2192-2201.
21. Manning-Tobin J.J., Moore K.J., Seimon T.A., et al. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler. Thromb. Vasc. Biol. 2009, 29:19-26.
22. Khaidakov M., Mitra S., Wang X., et al. Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. PLoS One 2012, 7:e47421.