메뉴 건너뛰기




Volumn 58, Issue 1, 2014, Pages 145-152

Heat stress stimulates hepcidin mRNA expression and C/EBPα protein expression in aged rodent liver

Author keywords

Hypoferremia; IL 6; Inflammation; Iron; STAT3

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; HEPCIDIN; INTERLEUKIN 6; IRON; MESSENGER RNA; STAT3 PROTEIN;

EID: 84885959317     PISSN: 01674943     EISSN: 18726976     Source Type: Journal    
DOI: 10.1016/j.archger.2013.07.012     Document Type: Article
Times cited : (14)

References (61)
  • 1
    • 34548186999 scopus 로고    scopus 로고
    • Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon, France
    • Argaud L., Ferry T., Le Q., Marfisi A., Ciorba D., Achache P., et al. Short- and long-term outcomes of heatstroke following the 2003 heat wave in Lyon, France. Archives of Internal Medicine 2007, 167:2177-2183.
    • (2007) Archives of Internal Medicine , vol.167 , pp. 2177-2183
    • Argaud, L.1    Ferry, T.2    Le, Q.3    Marfisi, A.4    Ciorba, D.5    Achache, P.6
  • 5
    • 0031597367 scopus 로고    scopus 로고
    • C/ebpα is critical for the neonatal acute-phase response to inflammation
    • Burgess-Beusse B.L., Darlington G.J. C/ebpα is critical for the neonatal acute-phase response to inflammation. Molecular and Cellular Biology 1998, 18:7269-7277.
    • (1998) Molecular and Cellular Biology , vol.18 , pp. 7269-7277
    • Burgess-Beusse, B.L.1    Darlington, G.J.2
  • 6
    • 20644465187 scopus 로고    scopus 로고
    • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
    • Camargo C.A., Madden J.F., Gao W., Selvan R.S., Clavien P. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997, 26:1513-1520. 10.1002/hep.510260619.
    • (1997) Hepatology , vol.26 , pp. 1513-1520
    • Camargo, C.A.1    Madden, J.F.2    Gao, W.3    Selvan, R.S.4    Clavien, P.5
  • 9
    • 0032078775 scopus 로고    scopus 로고
    • Iron accumulation in aging: Modulation by dietary restriction
    • Cook C.I., Yu B.P. Iron accumulation in aging: Modulation by dietary restriction. Mechanisms of Ageing and Development 1998, 102:1-13.
    • (1998) Mechanisms of Ageing and Development , vol.102 , pp. 1-13
    • Cook, C.I.1    Yu, B.P.2
  • 10
    • 0017083210 scopus 로고
    • Evaluation of the iron status of a population
    • Cook J., Finch C., Smith N. Evaluation of the iron status of a population. Blood 1976, 48:449-455.
    • (1976) Blood , vol.48 , pp. 449-455
    • Cook, J.1    Finch, C.2    Smith, N.3
  • 12
    • 0037174609 scopus 로고    scopus 로고
    • C/ebpα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism
    • Courselaud B., Pigeon C., Inoue Y., Inoue J., Gonzalez F.J., Leroyer P., et al. C/ebpα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Journal of Biological Chemistry 2002, 277:41163-41170.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 41163-41170
    • Courselaud, B.1    Pigeon, C.2    Inoue, Y.3    Inoue, J.4    Gonzalez, F.J.5    Leroyer, P.6
  • 14
    • 33846111415 scopus 로고    scopus 로고
    • Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C., Capri M., Monti D., Giunta S., Olivieri F., Sevini F., et al. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mechanisms of Ageing and Development 2007, 128:92-105.
    • (2007) Mechanisms of Ageing and Development , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3    Giunta, S.4    Olivieri, F.5    Sevini, F.6
  • 15
    • 77951488966 scopus 로고    scopus 로고
    • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
    • Gao J., Chen J., De Domenico I., Koeller D.M., Harding C.O., Fleming R.E., et al. Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. Blood 2010, 115:3374-3381.
    • (2010) Blood , vol.115 , pp. 3374-3381
    • Gao, J.1    Chen, J.2    De Domenico, I.3    Koeller, D.M.4    Harding, C.O.5    Fleming, R.E.6
  • 16
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J., Chen J., Kramer M., Tsukamoto H., Zhang A.-S., Enns C.A. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metabolism 2009, 9:217-227.
    • (2009) Cell Metabolism , vol.9 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.-S.5    Enns, C.A.6
  • 17
    • 33749393565 scopus 로고    scopus 로고
    • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
    • Goswami T., Andrews N.C. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. Journal of Biological Chemistry 2006, 281:28494-28498.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 28494-28498
    • Goswami, T.1    Andrews, N.C.2
  • 20
    • 0037011992 scopus 로고    scopus 로고
    • Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of bcl-2 and bcl-x(l) proteins
    • Hong F., Kim W., Tian Z., Jaruga B., Ishac E., Shen X., et al. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of bcl-2 and bcl-x(l) proteins. Oncogene 2002, 21:32-43.
    • (2002) Oncogene , vol.21 , pp. 32-43
    • Hong, F.1    Kim, W.2    Tian, Z.3    Jaruga, B.4    Ishac, E.5    Shen, X.6
  • 22
    • 19944427107 scopus 로고    scopus 로고
    • Expression of hepcidin is down-regulated in TFR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    • Kawabata H., Fleming R.E., Gui D., Moon S.Y., Saitoh T., O'Kelly J., et al. Expression of hepcidin is down-regulated in TFR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005, 105:376-381.
    • (2005) Blood , vol.105 , pp. 376-381
    • Kawabata, H.1    Fleming, R.E.2    Gui, D.3    Moon, S.Y.4    Saitoh, T.5    O'Kelly, J.6
  • 23
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E., Pickkers P., Nemeth E., van der Hoeven H., Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005, 106:1864-1866.
    • (2005) Blood , vol.106 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    van der Hoeven, H.4    Swinkels, D.5
  • 27
    • 33745526068 scopus 로고    scopus 로고
    • Tumour necrosis factor α causes hypoferraemia and reduced intestinal iron absorption in mice
    • Laftah A.H., Sharma N., Brookes M.J., McKie A.T., Simpson R.J., Iqbal T.H., et al. Tumour necrosis factor α causes hypoferraemia and reduced intestinal iron absorption in mice. Biochemical Journal 2006, 397:61-67. 10.1042/bj20060215.
    • (2006) Biochemical Journal , vol.397 , pp. 61-67
    • Laftah, A.H.1    Sharma, N.2    Brookes, M.J.3    McKie, A.T.4    Simpson, R.J.5    Iqbal, T.H.6
  • 28
    • 84861626192 scopus 로고    scopus 로고
    • Toll-like receptor signal adaptor protein myd88 is required for sustained endotoxin-induced acute hypoferremic response in mice
    • Layoun A., Huang H., Calvé A., Santos M.M. Toll-like receptor signal adaptor protein myd88 is required for sustained endotoxin-induced acute hypoferremic response in mice. American Journal of Pathology 2012, 180:2340-2350.
    • (2012) American Journal of Pathology , vol.180 , pp. 2340-2350
    • Layoun, A.1    Huang, H.2    Calvé, A.3    Santos, M.M.4
  • 29
  • 30
    • 33646346116 scopus 로고    scopus 로고
    • Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery
    • Leon L.R., Blaha M.D., DuBose D.A. Time course of cytokine, corticosterone, and tissue injury responses in mice during heat strain recovery. Journal of Applied Physiology 2006, 100:1400-1409.
    • (2006) Journal of Applied Physiology , vol.100 , pp. 1400-1409
    • Leon, L.R.1    Blaha, M.D.2    DuBose, D.A.3
  • 32
    • 1942501694 scopus 로고    scopus 로고
    • CCAAT enhancer-binding protein α is required for interleukin-6 receptor α signaling in newborn hepatocytes
    • Mackey S.L., Darlington G.J. CCAAT enhancer-binding protein α is required for interleukin-6 receptor α signaling in newborn hepatocytes. Journal of Biological Chemistry 2004, 279:16206-16213.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 16206-16213
    • Mackey, S.L.1    Darlington, G.J.2
  • 34
    • 0031006421 scopus 로고    scopus 로고
    • Cytokines and the hepatic acute phase response
    • Moshage H. Cytokines and the hepatic acute phase response. Journal of Pathology 1997, 181:257-266.
    • (1997) Journal of Pathology , vol.181 , pp. 257-266
    • Moshage, H.1
  • 35
    • 0344269351 scopus 로고    scopus 로고
    • Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status
    • Myśliwska J., Bryl E., Foerster J., Myśliwski A. Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status. Mechanisms of Ageing and Development 1998, 100:313-328.
    • (1998) Mechanisms of Ageing and Development , vol.100 , pp. 313-328
    • Myśliwska, J.1    Bryl, E.2    Foerster, J.3    Myśliwski, A.4
  • 36
    • 2342510407 scopus 로고    scopus 로고
    • Il-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E., Rivera S., Gabayan V., Keller C., Taudorf S., Pedersen B.K., et al. Il-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. Journal of Clinical Investigation 2004, 113:1271-1276.
    • (2004) Journal of Clinical Investigation , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6
  • 37
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 38
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101:2461-2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 39
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. Journal of Clinical Investigation 2002, 110:1037-1044.
    • (2002) Journal of Clinical Investigation , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 40
    • 43949092438 scopus 로고    scopus 로고
    • Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress
    • Oberley T.D., Swanlund J.M., Zhang H.J., Kregel K.C. Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress. Journal of Histochemistry & Cytochemistry 2008, 56:615-627.
    • (2008) Journal of Histochemistry & Cytochemistry , vol.56 , pp. 615-627
    • Oberley, T.D.1    Swanlund, J.M.2    Zhang, H.J.3    Kregel, K.C.4
  • 41
    • 68949162173 scopus 로고    scopus 로고
    • ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPα activity
    • Oliveira S.J., Pinto J.P., Picarote G., Costa V.M., Carvalho F., Rangel M., et al. ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPα activity. PLoS ONE 2009, 4:e6618.
    • (2009) PLoS ONE , vol.4
    • Oliveira, S.J.1    Pinto, J.P.2    Picarote, G.3    Costa, V.M.4    Carvalho, F.5    Rangel, M.6
  • 44
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. Journal of Biological Chemistry 2001, 276:7811-7819.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6
  • 45
    • 13544252463 scopus 로고    scopus 로고
    • Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    • Rivera S., Liu L., Nemeth E., Gabayan V., Sorensen O.E., Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 2005, 105:1797-1802.
    • (2005) Blood , vol.105 , pp. 1797-1802
    • Rivera, S.1    Liu, L.2    Nemeth, E.3    Gabayan, V.4    Sorensen, O.E.5    Ganz, T.6
  • 46
    • 24744458603 scopus 로고    scopus 로고
    • Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
    • Rivera S., Nemeth E., Gabayan V., Lopez M.A., Farshidi D., Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 2005, 106:2196-2199.
    • (2005) Blood , vol.106 , pp. 2196-2199
    • Rivera, S.1    Nemeth, E.2    Gabayan, V.3    Lopez, M.A.4    Farshidi, D.5    Ganz, T.6
  • 49
    • 0032819392 scopus 로고    scopus 로고
    • Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of c57bl/6 mice
    • Sohal R.S., Wennberg-Kirch E., Jaiswal K., Kwong L.K., Forster M.J. Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of c57bl/6 mice. Free Radical Biology & Medicine 1999, 27:287-293.
    • (1999) Free Radical Biology & Medicine , vol.27 , pp. 287-293
    • Sohal, R.S.1    Wennberg-Kirch, E.2    Jaiswal, K.3    Kwong, L.K.4    Forster, M.J.5
  • 50
    • 0032125606 scopus 로고    scopus 로고
    • Regenerating livers of old rats contain high levels of c/ebpα that correlate with altered expression of cell cycle associated proteins
    • Timchenko N.A., Wilde M., Kosai K.-I., Heydari A., Bilyeu T.A., Finegold M.J., et al. Regenerating livers of old rats contain high levels of c/ebpα that correlate with altered expression of cell cycle associated proteins. Nucleic Acids Research 1998, 26:3293-3299.
    • (1998) Nucleic Acids Research , vol.26 , pp. 3293-3299
    • Timchenko, N.A.1    Wilde, M.2    Kosai, K.-I.3    Heydari, A.4    Bilyeu, T.A.5    Finegold, M.J.6
  • 51
    • 0002413872 scopus 로고
    • Tissue iron stores
    • Churchill Livingstone, New York, J.D. Cook (Ed.)
    • Torrance J.D., Bothwell T.H. Tissue iron stores. Iron. Methods in hematology 1980, 90-115. Churchill Livingstone, New York. J.D. Cook (Ed.).
    • (1980) Iron. Methods in hematology , pp. 90-115
    • Torrance, J.D.1    Bothwell, T.H.2
  • 55
    • 33846225653 scopus 로고    scopus 로고
    • Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
    • Wallace D.F., Summerville L., Subramaniam V.N. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology 2007, 132:301-310.
    • (2007) Gastroenterology , vol.132 , pp. 301-310
    • Wallace, D.F.1    Summerville, L.2    Subramaniam, V.N.3
  • 56
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease. Blood 2002, 100:3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 58
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting D.M., Andrews N.C. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006, 108:3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 60
    • 9444222523 scopus 로고    scopus 로고
    • Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress
    • Zhang H.J., Doctrow S.R., Xu L., Oberley L.W., Beecher B., Morrison J., et al. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. FASEB Journal 2004, 18:1547-1549.
    • (2004) FASEB Journal , vol.18 , pp. 1547-1549
    • Zhang, H.J.1    Doctrow, S.R.2    Xu, L.3    Oberley, L.W.4    Beecher, B.5    Morrison, J.6
  • 61
    • 0642364454 scopus 로고    scopus 로고
    • Heat-induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation
    • Zhang H.J., Xu L., Drake V.J., Oberley L.W., Kregel K.C. Heat-induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation. FASEB Journal 2003, 17:2293-2295.
    • (2003) FASEB Journal , vol.17 , pp. 2293-2295
    • Zhang, H.J.1    Xu, L.2    Drake, V.J.3    Oberley, L.W.4    Kregel, K.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.