메뉴 건너뛰기




Volumn 115, Issue 16, 2010, Pages 3374-3381

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; HEMOCHROMATOSIS PROTEIN; HEPCIDIN; IRON; MESSENGER RNA; PROTEIN; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 77951488966     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-09-245209     Document Type: Article
Times cited : (66)

References (50)
  • 1
    • 33750095012 scopus 로고    scopus 로고
    • Hereditary hemochromatosis
    • Pietrangelo A. Hereditary hemochromatosis. Annu Rev Nutr. 2006;26:251-270.
    • (2006) Annu Rev Nutr. , vol.26 , pp. 251-270
    • Pietrangelo, A.1
  • 2
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13(4):399-408.
    • (1996) Nat Genet. , vol.13 , Issue.4 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 3
    • 9144252017 scopus 로고    scopus 로고
    • Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    • Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36(1):77-82.
    • (2004) Nat Genet. , vol.36 , Issue.1 , pp. 77-82
    • Papanikolaou, G.1    Samuels, M.E.2    Ludwig, E.H.3
  • 4
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33(1):21-22.
    • (2003) Nat Genet. , vol.33 , Issue.1 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3
  • 7
    • 0036800649 scopus 로고    scopus 로고
    • Hereditary hemochromatosis
    • Ajioka RS, Kushner JP. Hereditary hemochromatosis. Semin Hematol. 2002;39(4):235-241.
    • (2002) Semin Hematol. , vol.39 , Issue.4 , pp. 235-241
    • Ajioka, R.S.1    Kushner, J.P.2
  • 8
    • 0032478524 scopus 로고    scopus 로고
    • Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
    • Lebrón JA, Bennett MJ, Vaughn DE, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell. 1998;93(1):111-123.
    • (1998) Cell , vol.93 , Issue.1 , pp. 111-123
    • Lebrón, J.A.1    Bennett, M.J.2    Vaughn, D.E.3
  • 9
    • 17644434333 scopus 로고    scopus 로고
    • The hemochromatosis founder mutation in HLA-H disrupts b2-microglobulin interaction and cell surface expression
    • Feder JN, Tsuchihashi Z, Irrinki A, et al. The hemochromatosis founder mutation in HLA-H disrupts b2-microglobulin interaction and cell surface expression. J Biol Chem. 1997;272(22):14025-14028.
    • (1997) J Biol Chem. , vol.272 , Issue.22 , pp. 14025-14028
    • Feder, J.N.1    Tsuchihashi, Z.2    Irrinki, A.3
  • 10
    • 0033168767 scopus 로고    scopus 로고
    • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
    • Levy JE, Montross LK, Cohen DE, Fleming MD, Andrews NC. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood. 1999;94(1):9-11.
    • (1999) Blood , vol.94 , Issue.1 , pp. 9-11
    • Levy, J.E.1    Montross, L.K.2    Cohen, D.E.3    Fleming, M.D.4    Andrews, N.C.5
  • 11
    • 0001376313 scopus 로고    scopus 로고
    • HFE gene knockout produces mouse model of hereditary hemochromatosis
    • Zhou XY, Tomatsu S, Fleming RE, et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A. 1998;95(5):2492-2497.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.5 , pp. 2492-2497
    • Zhou, X.Y.1    Tomatsu, S.2    Fleming, R.E.3
  • 12
    • 0036678091 scopus 로고    scopus 로고
    • Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    • Fleming RE, Ahmann JR, Migas MC, et al. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A. 2002;99(16):10653-10658.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.16 , pp. 10653-10658
    • Fleming, R.E.1    Ahmann, J.R.2    Migas, M.C.3
  • 14
    • 0034007995 scopus 로고    scopus 로고
    • Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
    • Fleming RE, Migas MC, Holden CC, et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2000;97(5):2214-2219.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.5 , pp. 2214-2219
    • Fleming, R.E.1    Migas, M.C.2    Holden, C.C.3
  • 15
    • 0034595856 scopus 로고    scopus 로고
    • Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo
    • DOI 10.1074/jbc.M908846199
    • Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem. 2000;275(22):16618-16625. (Pubitemid 30398888)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 16618-16625
    • Kawabata, H.1    Germain, R.S.2    Vuong, P.T.3    Nakamaki, T.4    Said, J.W.5    Koeffler, H.P.6
  • 16
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • DOI 10.1074/jbc.C000664200
    • West AP, Jr., Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000;275(49):38135-38138. (Pubitemid 32009130)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.49 , pp. 38135-38138
    • West Jr., A.P.1    Bennett, M.J.2    Sellers, V.M.3    Andrews, N.C.4    Enns, C.A.5    Bjorkman, P.J.6
  • 17
    • 0020579367 scopus 로고
    • Characterization of transferrin binding and specificity of the placental transferrin receptor
    • Tsunoo H, Sussman HH. Characterization of transferrin binding and specificity of the placental transferrin receptor. Arch Biochem Biophys. 1983;225(1):42-54. (Pubitemid 13044847)
    • (1983) Archives of Biochemistry and Biophysics , vol.225 , Issue.1 , pp. 42-54
    • Tsunoo, H.1    Sussman, H.H.2
  • 18
    • 0031567095 scopus 로고    scopus 로고
    • The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
    • DOI 10.1016/S0304-4157(96)00014-7, PII S0304415796000147
    • Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997;1331(1):1-40. (Pubitemid 27168147)
    • (1997) Biochimica et Biophysica Acta - Reviews on Biomembranes , vol.1331 , Issue.1 , pp. 1-40
    • Richardson, D.R.1    Ponka, P.2
  • 20
    • 0024276911 scopus 로고
    • A stem-loop in the 3′ untranslated region mediates iron dependent regulation of transferrin receptor mRNA stability in the cytoplasm
    • Müllner EW, Kuhn LC. A stem-loop in the 3′ untranslated region mediates iron dependent regulation of transferrin receptor mRNA stability in the cytoplasm. Cell. 1988;53(5):815-825.
    • (1988) Cell , vol.53 , Issue.5 , pp. 815-825
    • Müllner, E.W.1    Kuhn, L.C.2
  • 22
    • 10244265904 scopus 로고    scopus 로고
    • Diferric transferrin regulates transferrin receptor 2 protein stability
    • DOI 10.1182/blood-2004-06-2477
    • Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood. 2004;104(13):4287-4293. (Pubitemid 39620184)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4287-4293
    • Johnson, M.B.1    Enns, C.A.2
  • 23
    • 10244255021 scopus 로고    scopus 로고
    • Regulation of transferrin receptor 2 protein levels by transferrin
    • DOI 10.1182/blood-2004-06-2481
    • Robb A, Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood. 2004;104(13):4294-4299. (Pubitemid 39620185)
    • (2004) Blood , vol.104 , Issue.13 , pp. 4294-4299
    • Robb, A.1    Wessling-Resnick, M.2
  • 24
    • 8644221378 scopus 로고    scopus 로고
    • Transferrin Receptor-2 Mediates a Biphasic Pattern of Transferrin Uptake Associated with Ligand Delivery to Multivesicular Bodies
    • Robb AD, Ericsson M, Wessling-Resnick M. Transferrin Receptor-2 Mediates a Biphasic Pattern of Transferrin Uptake Associated with Ligand Delivery to Multivesicular Bodies. Am J Physiol Cell Physiol. 2004;287(6):C1769-C1775.
    • (2004) Am J Physiol Cell Physiol. , vol.287 , Issue.6
    • Robb, A.D.1    Ericsson, M.2    Wessling-Resnick, M.3
  • 25
    • 0038312385 scopus 로고    scopus 로고
    • Decreased liver hepcidin expression in the hfe knockout mouse
    • Ahmad KA,Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the hfe knockout mouse. Blood Cells Mol Dis. 2002;29(3):361-366.
    • (2002) Blood Cells Mol Dis. , vol.29 , Issue.3 , pp. 361-366
    • Ahmad, K.A.1    Ahmann, J.R.2    Migas, M.C.3
  • 26
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 2003;361(9358):669-673.
    • (2003) Lancet , vol.361 , Issue.9358 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 27
  • 28
    • 21044434748 scopus 로고    scopus 로고
    • First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
    • DOI 10.1136/gut.2004.062018
    • Wallace DF, Summerville L, Lusby PE, Subramaniam VN. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut. 2005;54(7):980-986. (Pubitemid 40873913)
    • (2005) Gut , vol.54 , Issue.7 , pp. 980-986
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3    Subramaniam, V.N.4
  • 30
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • DOI 10.1126/science.1104742
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306(5704):2090-2093. (Pubitemid 40007660)
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.D.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 31
    • 0035896581 scopus 로고    scopus 로고
    • A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
    • DOI 10.1074/jbc.M008923200
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276(11):7811-7819. (Pubitemid 37385574)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.11 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 32
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100(10):3776-3781.
    • (2002) Blood , vol.100 , Issue.10 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 33
    • 0842263988 scopus 로고    scopus 로고
    • Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes
    • DOI 10.1182/blood-2003-07-2378
    • Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 2004;103(4):1509-1514. (Pubitemid 38168670)
    • (2004) Blood , vol.103 , Issue.4 , pp. 1509-1514
    • Zhang, A.-S.1    Xiong, S.2    Tsukamoto, H.3    Enns, C.A.4
  • 34
    • 38649128515 scopus 로고    scopus 로고
    • Hfe acts in hepatocytes to prevent hemochromatosis
    • Vujić Spasić M, Kiss J, Herrmann T, et al. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab. 2008;7(2):173-178.
    • (2008) Cell Metab. , vol.7 , Issue.2 , pp. 173-178
    • Vujić Spasić, M.1    Kiss, J.2    Herrmann, T.3
  • 35
    • 37549055467 scopus 로고    scopus 로고
    • HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions
    • Chen J, Chloupkova M, Gao J, Chapman-Arvedson TL, Enns CA. HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions. J Biol Chem. 2007;282(51):36862- 36870.
    • (2007) J Biol Chem. , vol.282 , Issue.51 , pp. 36862-36870
    • Chen, J.1    Chloupkova, M.2    Gao, J.3    Chapman-Arvedson, T.L.4    Enns, C.A.5
  • 36
    • 33749393565 scopus 로고    scopus 로고
    • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
    • Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem. 2006;281(39(:28494-28498.
    • (2006) . J Biol Chem. , vol.281 , Issue.39 , pp. 28494-28498
    • Goswami, T.1    Andrews, N.C.2
  • 37
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009;9(3):217-227.
    • (2009) Cell Metab. , vol.9 , Issue.3 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3    Tsukamoto, H.4    Zhang, A.S.5    Enns, C.A.6
  • 38
    • 27744533046 scopus 로고    scopus 로고
    • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II
    • Franco LM, Sun B, Yang X, et al. Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. Mol Ther. 2005;12(5):876-884.
    • (2005) Mol Ther. , vol.12 , Issue.5 , pp. 876-884
    • Franco, L.M.1    Sun, B.2    Yang, X.3
  • 39
    • 35348926853 scopus 로고    scopus 로고
    • Enhanced response to enzyme replacement therapy in pompe disease after the induction of immune tolerance
    • DOI 10.1086/522236
    • Sun B, Bird A, Young SP, Kishnani PS, Chen YT, Koeberl DD. Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance. Am J Hum Genet. 2007;81(5):1042-1049. (Pubitemid 47580255)
    • (2007) American Journal of Human Genetics , vol.81 , Issue.5 , pp. 1042-1049
    • Sun, B.1    Bird, A.2    Young, S.P.3    Kishnani, P.S.4    Chen, Y.-T.5    Koeber, D.D.6
  • 40
    • 52049125740 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells
    • Gao J, Zhao N, Knutson MD, Enns CA. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008;283(31):21462-21468.
    • (2008) . J Biol Chem. , vol.283 , Issue.31 , pp. 21462-21468
    • Gao, J.1    Zhao, N.2    Knutson, M.D.3    Enns, C.A.4
  • 41
    • 0014267781 scopus 로고
    • A simple technique for measuring storage iron concentrations in formalinised liver samples
    • Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci. 1968;33(1):9-11.
    • (1968) S Afr J Med Sci. , vol.33 , Issue.1 , pp. 9-11
    • Torrance, J.D.1    Bothwell, T.H.2
  • 42
    • 48149090865 scopus 로고    scopus 로고
    • The hepcidin-binding site on ferroportin is evolutionarily conserved
    • De Domenico I, Nemeth E, Nelson JM, et al. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab. 2008;8(2):146-156.
    • (2008) Cell Metab. , vol.8 , Issue.2 , pp. 146-156
    • De Domenico, I.1    Nemeth, E.2    Nelson, J.M.3
  • 43
    • 19444365150 scopus 로고    scopus 로고
    • Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models
    • Davidoff AM, Gray JT, Ng CY, et al. Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models. Mol Ther. 2005;11(6):875-888.
    • (2005) Mol Ther. , vol.11 , Issue.6 , pp. 875-888
    • Davidoff, A.M.1    Gray, J.T.2    Ng, C.Y.3
  • 44
    • 41149109650 scopus 로고    scopus 로고
    • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia
    • Koeberl DD, Pinto C, Sun B, et al. AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. Mol Ther. 2008;16(4):665-672.
    • (2008) Mol Ther. , vol.16 , Issue.4 , pp. 665-672
    • Koeberl, D.D.1    Pinto, C.2    Sun, B.3
  • 45
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110(7):1037-1044.
    • (2002) J Clin Invest. , vol.110 , Issue.7 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 46
    • 33846225653 scopus 로고    scopus 로고
    • Targeted Disruption of the Hepatic Transferrin Receptor 2 Gene in Mice Leads to Iron Overload
    • DOI 10.1053/j.gastro.2006.11.028, PII S0016508506024838
    • Wallace DF, Summerville L, Subramaniam VN. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology. 2007;132(1):301-310. (Pubitemid 46108757)
    • (2007) Gastroenterology , vol.132 , Issue.1 , pp. 301-310
    • Wallace, D.F.1    Summerville, L.2    Subramaniam, V.N.3
  • 47
    • 72649093389 scopus 로고    scopus 로고
    • Stoichiometries of transferrin receptors 1 and 2 in human liver
    • Chloupková M, Zhang AS, Enns CA. Stoichiometries of transferrin receptors 1 and 2 in human liver. Blood Cells Mol Dis. 2010;44(1):28-33.
    • (2010) Blood Cells Mol Dis. , vol.44 , Issue.1 , pp. 28-33
    • Chloupková, M.1    Zhang, A.S.2    Enns, C.A.3
  • 48
    • 0034610781 scopus 로고    scopus 로고
    • Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor
    • Bennett MJ, Lebron JA, Bjorkman PJ. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Nature. 2000;403(6765):46-53.
    • (2000) Nature , vol.403 , Issue.6765 , pp. 46-53
    • Bennett, M.J.1    Lebron, J.A.2    Bjorkman, P.J.3
  • 49
    • 2442657217 scopus 로고    scopus 로고
    • Mechanism for multiple ligand recognition by the human transferrin receptor
    • Giannetti AM, Snow PM, Zak O, Bjorkman PJ. Mechanism for multiple ligand recognition by the human transferrin receptor. PLoS Biol. 2003;1(3):e51.
    • (2003) PLoS Biol. , vol.1 , Issue.3
    • Giannetti, A.M.1    Snow, P.M.2    Zak, O.3    Bjorkman, P.J.4
  • 50
    • 39649115776 scopus 로고    scopus 로고
    • The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression
    • Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008;7(3):205-214.
    • (2008) Cell Metab. , vol.7 , Issue.3 , pp. 205-214
    • Schmidt, P.J.1    Toran, P.T.2    Giannetti, A.M.3    Bjorkman, P.J.4    Andrews, N.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.