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Volumn 34, Issue SUPPL. 2, 2011, Pages

Incretin effects on β-cell function, replication, and mass: The human perspective

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; ARGININE; C PEPTIDE; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; INCRETIN; INSULIN; LIRAGLUTIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; PLACEBO; PROINSULIN; ROSIGLITAZONE; SULFONYLUREA; DRUG DERIVATIVE; GLUCAGON LIKE PEPTIDE RECEPTOR; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE RECEPTOR; PEPTIDE; VENOM;

EID: 79959803070     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc11-s230     Document Type: Review
Times cited : (89)

References (57)
  • 1
    • 0034884627 scopus 로고    scopus 로고
    • The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus
    • DOI 10.1007/s001250100580
    • Pratley RE, Weyer C. The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia 2001;44:929-945 (Pubitemid 32778125)
    • (2001) Diabetologia , vol.44 , Issue.8 , pp. 929-945
    • Pratley, R.E.1    Weyer, C.2
  • 2
    • 0035132672 scopus 로고    scopus 로고
    • Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development
    • Weyer C, Tataranni PA, Bogardus C, Pratley RE. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 2001;24:89-94
    • (2001) Diabetes Care , vol.24 , pp. 89-94
    • Weyer, C.1    Tataranni, P.A.2    Bogardus, C.3    Pratley, R.E.4
  • 3
    • 0028817815 scopus 로고
    • U.K. Prospective Diabetes Study 16: Overview of 6 years' therapy of type II diabetes: A progressive disease
    • U.K. Prospective Diabetes Study Group
    • U.K. Prospective Diabetes Study Group. U.K. Prospective Diabetes Study 16: overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995;44:1249-1258
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 5
    • 36448968168 scopus 로고    scopus 로고
    • Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus
    • Hermansen K, Mortensen LS. Bodyweight changes associated with antihyperglycaemic agents in type 2 diabetes mellitus. Drug Saf 2007;30:1127-1142 (Pubitemid 350172854)
    • (2007) Drug Safety , vol.30 , Issue.12 , pp. 1127-1142
    • Hermansen, K.1    Mortensen, L.S.2
  • 6
    • 0023916553 scopus 로고
    • Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus
    • Polonsky KS, Given BD, Hirsch LJ, et al. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 1988;318:1231-1239
    • (1988) N Engl J Med , vol.318 , pp. 1231-1239
    • Polonsky, K.S.1    Given, B.D.2    Hirsch, L.J.3
  • 7
    • 0021751981 scopus 로고
    • Diminished B cell secretory capacity in patients with noninsulin dependent diabetes mellitus
    • Ward WK, Bolgiano DC, McKnight B, Halter JB, Porte D Jr. Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1984;74:1318-1328 (Pubitemid 15206828)
    • (1984) Journal of Clinical Investigation , vol.74 , Issue.4 , pp. 1318-1328
    • Ward, W.K.1    Bolgiano, D.C.2    McKnight, B.3
  • 8
    • 0021023231 scopus 로고
    • Evidence that basal beta cell activity may play a role in determining insulin sensitivity in healthy man
    • Bonora E, Capretti L, Coscelli C, Butturini U. Evidence that basal beta cell activity may play a role in determining insulin sensitivity in healthy man. Ann Nutr Metab 1983;27:501-504
    • (1983) Ann Nutr Metab , vol.27 , pp. 501-504
    • Bonora, E.1    Capretti, L.2    Coscelli, C.3    Butturini, U.4
  • 9
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • DOI 10.2337/diabetes.52.1.102
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110 (Pubitemid 36042113)
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 10
    • 0036097472 scopus 로고    scopus 로고
    • Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    • Biarnés M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002;51:66-72 (Pubitemid 34517981)
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 66-72
    • Biarnes, M.1    Montolio, M.2    Nacher, V.3    Raurell, M.4    Soler, J.5    Montanya, E.6
  • 11
    • 1442352339 scopus 로고    scopus 로고
    • Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
    • DOI 10.1210/jc.2003-030723
    • Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 2004;89:463-478 (Pubitemid 38269844)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.2 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    DeFronzo, R.A.3
  • 12
    • 0035461929 scopus 로고    scopus 로고
    • Decrease in beta-Cell Mass Leads to Impaired Pulsatile Insulin Secretion, Reduced Postprandial Hepatic Insulin Clearance, and Relative Hyperglucagonemia in the Minipig
    • Kjems LL, Kirby BM, Welsh EM, et al. Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. Diabetes 2001;50:2001-2012 (Pubitemid 33643666)
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2001-2012
    • Kjems, L.L.1    Kirby, B.M.2    Welsh, E.M.3    Veldhuis, J.D.4    Straume, M.5    McIntyre, S.S.6    Yang, D.7    Lefebvre, P.8    Butler, P.C.9
  • 13
    • 67349236690 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: Targeting both hyperglycaemia and disease processes in diabetes
    • Holst JJ, Seino Y. GLP-1 receptor agonists: targeting both hyperglycaemia and disease processes in diabetes. Diabetes Res Clin Pract 2009;85:1-3
    • (2009) Diabetes Res Clin Pract , vol.85 , pp. 1-3
    • Holst, J.J.1    Seino, Y.2
  • 16
    • 41149088656 scopus 로고    scopus 로고
    • Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes
    • Højberg PV, Zander M, Vilsbøll T, et al. Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia 2008;51:632-640
    • (2008) Diabetologia , vol.51 , pp. 632-640
    • Højberg, P.V.1    Zander, M.2    Vilsbøll, T.3
  • 17
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by gip in obese type ii diabetic patients
    • DOI 10.1007/s00125-002-0878-6
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients.Diabetologia 2002;45:1111-1119 (Pubitemid 34985287)
    • (2002) Diabetologia , vol.45 , Issue.8 , pp. 1111-1119
    • Vilsboll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.4
  • 18
    • 0345257136 scopus 로고    scopus 로고
    • Glucagon-Like Peptide-1 and the Islet beta-Cell: Augmentation of Cell Proliferation and Inhibition of Apoptosis
    • DOI 10.1210/en.2003-1147
    • Drucker DJ. Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 2003;144:5145-5148 (Pubitemid 37476039)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5145-5148
    • Drucker, D.J.1
  • 20
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999;48:2270-2276 (Pubitemid 30395416)
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 21
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • DOI 10.1210/en.141.12.4600
    • Perfetti R, Zhou J, Doyle ME, Egan JM. Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000;141:4600-4605 (Pubitemid 32055138)
    • (2000) Endocrinology , vol.141 , Issue.12 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.I.E.2    Doyle, M.E.3    Egan, J.M.4
  • 23
    • 2942568445 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
    • DOI 10.1007/s00125-004-1379-6
    • Buteau J, El-Assaad W, Rhodes CJ, Rosenberg L, Joly E, Prentki M. Glucagon-like peptide-1 prevents beta cell glucolipotoxicity. Diabetologia 2004;47:806-815 (Pubitemid 38756992)
    • (2004) Diabetologia , vol.47 , Issue.5 , pp. 806-815
    • Buteau, J.1    El-Assaad, W.2    Rhodes, C.J.3    Mosenberg, L.4    Joly, E.5    Prentki, M.6
  • 25
    • 36749050813 scopus 로고    scopus 로고
    • Exenatide and rimonabant: New treatments that may be useful in the management of diabetes and obesity
    • Green JB, Feinglos MN. Exenatide and rimonabant: new treatments that may be useful in the management of diabetes and obesity. Curr Diab Rep 2007;7:369-375
    • (2007) Curr Diab Rep , vol.7 , pp. 369-375
    • Green, J.B.1    Feinglos, M.N.2
  • 26
    • 12244268666 scopus 로고    scopus 로고
    • On the physiology of GIP and GLP-1
    • DOI 10.1055/s-2004-826158
    • Holst JJ. On the physiology of GIP and GLP-1. Horm Metab Res 2004;36:747-754 (Pubitemid 40115894)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 747-754
    • Holst, J.J.1
  • 28
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006;368:1696-1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 30
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • DOI 10.1007/s00125-001-0719-z
    • Agersø H, Jensen LB, Elbrønd B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002;45:195-202 (Pubitemid 34208381)
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 31
    • 0038353630 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    • Chang AM, Jakobsen G, Sturis J, et al. The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 2003;52:1786-1791 (Pubitemid 36792471)
    • (2003) Diabetes , vol.52 , Issue.7 , pp. 1786-1791
    • Chang, A.M.1    Jakobsen, G.2    Sturis, J.3    Smith, M.J.4    Bloem, C.J.5    An, B.6    Galecki, A.7    Halter, J.B.8
  • 32
    • 0036784675 scopus 로고    scopus 로고
    • The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice
    • Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002;283:E745-E752
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Rolin, B.1    Larsen, M.O.2    Gotfredsen, C.F.3
  • 34
    • 33745196669 scopus 로고    scopus 로고
    • Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin- interacting protein
    • Chen J, Couto FM, Minn AH, Shalev A. Exenatide inhibits beta-cell apoptosis by decreasing thioredoxin-interacting protein. Biochem Biophys Res Commun 2006;346:1067-1074
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 1067-1074
    • Chen, J.1    Couto, F.M.2    Minn, A.H.3    Shalev, A.4
  • 35
    • 74849108033 scopus 로고    scopus 로고
    • Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats
    • Kwon DY, Kim YS, Ahn IS, et al. Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats. J Pharmacol Sci 2009;111:361-371
    • (2009) J Pharmacol Sci , vol.111 , pp. 361-371
    • Kwon, D.Y.1    Kim, Y.S.2    Ahn, I.S.3
  • 36
    • 70349320177 scopus 로고    scopus 로고
    • Low- And high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells
    • Rütti S, Ehses JA, Sibler RA, et al. Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells. Endocrinology 2009;150:4521-4530
    • (2009) Endocrinology , vol.150 , pp. 4521-4530
    • Rütti, S.1    Ehses, J.A.2    Sibler, R.A.3
  • 37
    • 33646492251 scopus 로고    scopus 로고
    • GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts
    • DOI 10.1016/j.diabres.2005.11.007, PII S0168822705004341
    • Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract 2006;73:107-110 (Pubitemid 43765553)
    • (2006) Diabetes Research and Clinical Practice , vol.73 , Issue.1 , pp. 107-110
    • Xu, G.1    Kaneto, H.2    Lopez-Avalos, M.D.3    Weir, G.C.4    Bonner-Weir, S.5
  • 38
    • 2342599057 scopus 로고    scopus 로고
    • One Week's Treatment with the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and alpha- and beta-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes
    • DOI 10.2337/diabetes.53.5.1187
    • Degn KB, Juhl CB, Sturis J, et al. One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004;53:1187-1194 (Pubitemid 38569002)
    • (2004) Diabetes , vol.53 , Issue.5 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3    Jakobsen, G.4    Brock, B.5    Chandramouli, V.6    Rungby, J.7    Landau, B.R.8    Schmitz, O.9
  • 39
    • 0030662718 scopus 로고    scopus 로고
    • Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
    • Kahn SE, Halban PA. Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 1997;46:1725-1732 (Pubitemid 27456403)
    • (1997) Diabetes , vol.46 , Issue.11 , pp. 1725-1732
    • Kahn, S.E.1    Halban, P.A.2
  • 40
    • 2542451393 scopus 로고    scopus 로고
    • Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
    • DOI 10.2337/diacare.27.6.1335
    • Madsbad S, Schmitz O, Ranstam J, Jakobsen G, Matthews DR; NN2211-1310 International Study Group. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004;27:1335-1342 (Pubitemid 38679980)
    • (2004) Diabetes Care , vol.27 , Issue.6 , pp. 1335-1342
    • Madsbad, S.1    Schmitz, O.2    Ranstam, J.3    Jakobsen, G.4    Matthews, D.R.5
  • 41
    • 39749143348 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
    • DOI 10.1111/j.1464-5491.2007.02333.x
    • Vilsbøll T, Brock B, Perrild H, et al. Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus. Diabet Med 2008;25:152-156 (Pubitemid 351293400)
    • (2008) Diabetic Medicine , vol.25 , Issue.2 , pp. 152-156
    • Vilsboll, T.1    Brock, B.2    Perrild, H.3    Levin, K.4    Lervang, H.-H.5    Kolendorf, K.6    Krarup, T.7    Schmitz, O.8    Zdravkovic, M.9    Le-Thi, T.10    Madsbad, S.11
  • 42
    • 34547684649 scopus 로고    scopus 로고
    • Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions
    • DOI 10.2337/dc07-0310
    • Mari A, Degn K, Brock B, Rungby J, Ferrannini E, Schmitz O. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. Diabetes Care 2007;30:2032-2033 (Pubitemid 47219415)
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 2032-2033
    • Mari, A.1    Degn, K.2    Brock, B.3    Rungby, J.4    Ferrannini, E.L.E.5    Schmitz, O.6
  • 43
    • 33845968872 scopus 로고    scopus 로고
    • Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea
    • DOI 10.1055/s-2006-956505
    • Mari A, Nielsen LL, Nanayakkara N, DeFronzo RA, Ferrannini E, Halseth A. Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. Horm Metab Res 2006;38:838-844 (Pubitemid 46051506)
    • (2006) Hormone and Metabolic Research , vol.38 , Issue.12 , pp. 838-844
    • Mari, A.1    Nielsen, L.L.2    Nanayakkara, N.3    DeFronzo, R.A.4    Ferrannini, E.5    Halseth, A.6
  • 44
    • 0036965113 scopus 로고    scopus 로고
    • The insulinotropic effect of acute exendin-4 administered to humans: Comparison of nondiabetic state to type 2 diabetes
    • DOI 10.1210/jc.87.3.1282
    • Egan JM, Clocquet AR, Elahi D. The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. J Clin Endocrinol Metab 2002;87:1282-1290 (Pubitemid 36121100)
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , Issue.3 , pp. 1282-1290
    • Egan, J.M.1    Clocquet, A.R.2    Elahi, D.3
  • 46
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • DOI 10.2337/diacare.27.11.2628
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD; Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004;27:2628-2635 (Pubitemid 39441462)
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 47
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2
    • DOI 10.2337/diacare.28.5.1092
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005;28:1092-1100 (Pubitemid 40616618)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 48
    • 77249090274 scopus 로고    scopus 로고
    • Exenatide versus glibenclamide in patients with diabetes
    • Derosa G, Maffioli P, Salvadeo SA, et al. Exenatide versus glibenclamide in patients with diabetes. Diabetes Technol Ther 2010;12:233-240
    • (2010) Diabetes Technol Ther , vol.12 , pp. 233-240
    • Derosa, G.1    Maffioli, P.2    Salvadeo, S.A.3
  • 50
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brändle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-278
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brändle, M.3
  • 51
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • Nauck MA, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care 2009;32:84-90
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.A.1    Frid, A.2    Hermansen, K.3
  • 52
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373:473-481
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 53
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse J, et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009;32:1224-1230
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.3
  • 54
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs. insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009;52:2046-2055
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 55
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 56
    • 73349102524 scopus 로고    scopus 로고
    • The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: An overview of the LEAD 1-5 studies
    • Blonde L, Russell-Jones D. The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies. Diabetes Obes Metab 2009;11(Suppl. 3):26-34
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 3 , pp. 26-34
    • Blonde, L.1    Russell-Jones, D.2
  • 57
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • DOI 10.2337/diacare.28.5.1083
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005;28:1083-1091 (Pubitemid 40616617)
    • (2005) Diabetes Care , vol.28 , Issue.5 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.