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Volumn , Issue , 2012, Pages 127-156

Plasminogen Activators in Ischemic Stroke

Author keywords

blood brain barrier and PDGFcc; cerebral blood flow; excitotoxicity; ischemic penumbra; ischemic stroke; plasminogen activator; thrombolysis

Indexed keywords


EID: 84885692412     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527649327.ch6     Document Type: Chapter
Times cited : (3)

References (180)
  • 1
    • 0019822988 scopus 로고
    • Thresholds in cerebral ischemia - the ischemic penumbra
    • Astrup, J., Siesjo, B.K., and Symon, L. (1981) Thresholds in cerebral ischemia - the ischemic penumbra. Stroke, 12 (6), 723-725.
    • (1981) Stroke , vol.12 , Issue.6 , pp. 723-725
    • Astrup, J.1    Siesjo, B.K.2    Symon, L.3
  • 2
    • 0021990364 scopus 로고
    • CBF and time thresholds for the formation of ischemic cerebral edema, and effect of reperfusion in baboons
    • Bell, B.A., Symon, L., and Branston, N.M. (1985) CBF and time thresholds for the formation of ischemic cerebral edema, and effect of reperfusion in baboons. J. Neurosurg., 62 (1), 31-41.
    • (1985) J. Neurosurg. , vol.62 , Issue.1 , pp. 31-41
    • Bell, B.A.1    Symon, L.2    Branston, N.M.3
  • 3
    • 0020596567 scopus 로고
    • The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography of changes in blood flow. potassium ion activity, and EEG.
    • Strong, A.J., Venables, G.S., and Gibson, G. (1983) The cortical ischaemic penumbra associated with occlusion of the middle cerebral artery in the cat: 1. Topography of changes in blood flow, potassium ion activity, and EEG. J. Cereb. Blood Flow Metab., 3 (1), 86-96.
    • (1983) J. Cereb. Blood Flow Metab. , vol.3 , Issue.1 , pp. 86-96
    • Strong, A.J.1    Venables, G.S.2    Gibson, G.3
  • 4
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • Benveniste, H., Drejer, J., Schousboe, A., and Diemer, N.H. (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem., 43 (5), 1369-1374.
    • (1984) J. Neurochem. , vol.43 , Issue.5 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 6
    • 0030039690 scopus 로고    scopus 로고
    • Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: effect on infarct morphology
    • Back, T., Ginsberg, M.D., Dietrich, W.D., and Watson, B.D. (1996) Induction of spreading depression in the ischemic hemisphere following experimental middle cerebral artery occlusion: effect on infarct morphology. J. Cereb. Blood Flow Metab., 16 (2), 202-213.
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , Issue.2 , pp. 202-213
    • Back, T.1    Ginsberg, M.D.2    Dietrich, W.D.3    Watson, B.D.4
  • 7
    • 0029689972 scopus 로고    scopus 로고
    • Alterations in cerebral endothelial cell function in ischemia
    • discussion.311-313
    • Betz, A.L. (1996) Alterations in cerebral endothelial cell function in ischemia. Adv. Neurol., 71, 301-311; discussion 311-313.
    • (1996) Adv. Neurol. , vol.71 , pp. 301-311
    • Betz, A.L.1
  • 8
    • 0033512004 scopus 로고    scopus 로고
    • Inflammatory mediators and stroke: new opportunities for novel therapeutics
    • Barone, F.C. and Feuerstein, G.Z. (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J. Cereb. Blood Flow Metab., 19 (8), 819-834.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , Issue.8 , pp. 819-834
    • Barone, F.C.1    Feuerstein, G.Z.2
  • 9
    • 0028145984 scopus 로고
    • The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke
    • Ginsberg, M.D. and Pulsinelli, W.A. (1994) The ischemic penumbra, injury thresholds, and the therapeutic window for acute stroke. Ann. Neurol., 36 (4), 553-554.
    • (1994) Ann. Neurol. , vol.36 , Issue.4 , pp. 553-554
    • Ginsberg, M.D.1    Pulsinelli, W.A.2
  • 11
    • 0028351886 scopus 로고
    • Effect of delayed thrombolysis with rt-PA in a rat embolic stroke model
    • Overgaard, K., Sereghy, T., Pedersen, H., and Boysen, G. (1994) Effect of delayed thrombolysis with rt-PA in a rat embolic stroke model. J. Cereb. Blood Flow Metab., 14 (3), 472-477.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , Issue.3 , pp. 472-477
    • Overgaard, K.1    Sereghy, T.2    Pedersen, H.3    Boysen, G.4
  • 12
    • 0025913062 scopus 로고
    • Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia
    • Kaplan, B., Brint, S., Tanabe, J., Jacewicz, M., Wang, X.J., and Pulsinelli, W. (1991) Temporal thresholds for neocortical infarction in rats subjected to reversible focal cerebral ischemia. Stroke, 22 (8), 1032-1039.
    • (1991) Stroke , vol.22 , Issue.8 , pp. 1032-1039
    • Kaplan, B.1    Brint, S.2    Tanabe, J.3    Jacewicz, M.4    Wang, X.J.5    Pulsinelli, W.6
  • 13
    • 0026598564 scopus 로고
    • Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats
    • Memezawa, H., Smith, M.L., and Siesjo, B.K. (1992) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke, 23 (4), 552-559.
    • (1992) Stroke , vol.23 , Issue.4 , pp. 552-559
    • Memezawa, H.1    Smith, M.L.2    Siesjo, B.K.3
  • 14
    • 0017254089 scopus 로고
    • Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke
    • Hanaway, J., Torack, R., Fletcher, A.P., and Landau, W.M. (1976) Intracranial bleeding associated with urokinase therapy for acute ischemic hemispheral stroke. Stroke, 7 (2), 143-146.
    • (1976) Stroke , vol.7 , Issue.2 , pp. 143-146
    • Hanaway, J.1    Torack, R.2    Fletcher, A.P.3    Landau, W.M.4
  • 15
    • 0025609948 scopus 로고
    • Incidence of cerebral hemorrhage after treatment with tissue plasminogen activator or streptokinase following embolic stroke in rabbits [corrected]
    • Lyden, P.D., Madden, K.P., Clark, W.M., Sasse, K.C., and Zivin, J.A. (1990) Incidence of cerebral hemorrhage after treatment with tissue plasminogen activator or streptokinase following embolic stroke in rabbits [corrected]. Stroke, 21 (11), 1589-1593.
    • (1990) Stroke , vol.21 , Issue.11 , pp. 1589-1593
    • Lyden, P.D.1    Madden, K.P.2    Clark, W.M.3    Sasse, K.C.4    Zivin, J.A.5
  • 16
    • 0022405261 scopus 로고
    • Tissue plasminogen activator reduces neurological damage after cerebral embolism
    • Zivin, J.A., Fisher, M., DeGirolami, U., Hemenway, C.C., and Stashak, J.A. (1985) Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science, 230, 1289-1292.
    • (1985) Science , vol.23 , pp. 1289-1292
    • Zivin, J.A.1    Fisher, M.2    DeGirolami, U.3    Hemenway, C.C.4    Stashak, J.A.5
  • 17
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke. The national institute of neurological disorders and stroke rt-PA stroke study group
    • NINDA and Stroke rtPA Study Group.
    • NINDA and Stroke rtPA Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. The national institute of neurological disorders and stroke rt-PA stroke study group. N. Engl. J. Med., 333 (24), 1581-1587.
    • (1995) N. Engl. J. Med. , vol.333 , Issue.24 , pp. 1581-1587
  • 18
    • 0343118114 scopus 로고    scopus 로고
    • Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke
    • NINDA and Stroke rtPA Study Group.
    • NINDA and Stroke rtPA Study Group (1997) Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. Stroke, 28 (11), 2109-2118.
    • (1997) Stroke , vol.28 , Issue.11 , pp. 2109-2118
  • 19
    • 0029050323 scopus 로고
    • Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European cooperative acute stroke study (ECASS).
    • Hacke, W., Kaste, M., Fieschi, C., Toni, D., Lesaffre, E., von Kummer, R., Boysen, G., Bluhmki, E., Hoxter, G., Mahagne, M.H. et al. (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European cooperative acute stroke study (ECASS). JAMA, 274 (13), 1017-1025.
    • (1995) JAMA , vol.274 , Issue.13 , pp. 1017-1025
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3    Toni, D.4    Lesaffre, E.5    von Kummer, R.6    Boysen, G.7    Bluhmki E.Hoxter, G.8    Mahagne, M.H.9
  • 20
    • 0032541845 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian acute stroke study investigators.
    • Hacke, W., Kaste, M., Fieschi, C., von Kummer, R., Davalos, A., Meier, D., Larrue, V., Bluhmki, E., Davis, S., Donnan, G., Schneider, D., Diez-Tejedor, E., and Trouillas, P. (1998) Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian acute stroke study investigators. Lancet, 352 (9136), 1245-1251.
    • (1998) Lancet , vol.352 , Issue.9136 , pp. 1245-1251
    • Hacke, W.1    Kaste, M.2    Fieschi, C.3    von Kummer, R.4    Davalos, A.5    Meier, D.6    Larrue, V.7    Bluhmki, E.8    Davis, S.9    Donnan, G.10    Schneider, D.11    Diez-Tejedor, E.12    Trouillas, P.13
  • 21
    • 0033485522 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase thrombolysis for acute noninterventional therapy in ischemic stroke.
    • Clark, W.M., Wissman, S., Albers, G.W., Jhamandas, J.H., Madden, K.P., and Hamilton, S. (1999) Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase thrombolysis for acute noninterventional therapy in ischemic stroke. J. Am. Med. Assoc., 282 (21), 2019-2026.
    • (1999) J. Am. Med. Assoc. , vol.282 , Issue.21 , pp. 2019-2026
    • Clark, W.M.1    Wissman, S.2    Albers, G.W.3    Jhamandas, J.H.4    Madden, K.P.5    Hamilton, S.6
  • 23
    • 74149095001 scopus 로고    scopus 로고
    • Intravenous tissue plasminogen activator for stroke: a review of the ECASS III results in relation to prior clinical trials
    • Cronin, C.A. (2010) Intravenous tissue plasminogen activator for stroke: a review of the ECASS III results in relation to prior clinical trials. J. Emerg. Med., 38 (1), 99-105.
    • (2010) J. Emerg. Med. , vol.38 , Issue.1 , pp. 99-105
    • Cronin, C.A.1
  • 25
    • 67650084702 scopus 로고    scopus 로고
    • Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window: joint outcome table analysis of the ECASS 3 trial
    • Saver, J.L., Gornbein, J., Grotta, J., Liebeskind, D., Lutsep, H., Schwamm, L., Scott, P., and Starkman, S. (2009) Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window: joint outcome table analysis of the ECASS 3 trial. Stroke, 40 (7), 2433-2437.
    • (2009) Stroke , vol.40 , Issue.7 , pp. 2433-2437
    • Saver, J.L.1    Gornbein, J.2    Grotta, J.3    Liebeskind, D.4    Lutsep, H.5    Schwamm, L.6    Scott, P.7    Starkman, S.8
  • 26
    • 68749100878 scopus 로고    scopus 로고
    • Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American heart association/American stroke association
    • Del Zoppo, G.J., Saver, J.L., Jauch, E.C., and Adams, H.P. Jr. (2009) Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American heart association/American stroke association. Stroke, 40 (8), 2945-2948.
    • (2009) Stroke , vol.40 , Issue.8 , pp. 2945-2948
    • Del Zoppo, G.J.1    Saver, J.L.2    Jauch, E.C.3    Adams Jr, H.P.4
  • 27
    • 60049091968 scopus 로고    scopus 로고
    • Penumbral selection of patients for trials of acute stroke therapy
    • Donnan, G.A., Baron, J.C., Ma, H., and Davis, S.M. (2009) Penumbral selection of patients for trials of acute stroke therapy. Lancet Neurol., 8 (3), 261-269.
    • (2009) Lancet Neurol. , vol.8 , Issue.3 , pp. 261-269
    • Donnan, G.A.1    Baron, J.C.2    Ma, H.3    Davis, S.M.4
  • 28
    • 0033021740 scopus 로고    scopus 로고
    • Mapping the ischaemic penumbra with PET: implications for acute stroke treatment
    • Baron, J.C. (1999) Mapping the ischaemic penumbra with PET: implications for acute stroke treatment. Cerebrovasc. Dis., 9 (4), 193-201.
    • (1999) Cerebrovasc. Dis. , vol.9 , Issue.4 , pp. 193-201
    • Baron, J.C.1
  • 29
    • 0035186833 scopus 로고    scopus 로고
    • Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia
    • Heiss, W.D., Kracht, L.W., Thiel, A., Grond, M., and Pawlik, G. (2001) Penumbral probability thresholds of cortical flumazenil binding and blood flow predicting tissue outcome in patients with cerebral ischaemia. Brain, 124 (Pt 1), 20-29.
    • (2001) Brain , vol.124 , Issue.PART. 1 , pp. 20-29
    • Heiss, W.D.1    Kracht, L.W.2    Thiel, A.3    Grond, M.4    Pawlik, G.5
  • 30
    • 3242781057 scopus 로고    scopus 로고
    • Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke
    • Heiss, W.D., Sobesky, J., Smekal, U., Kracht, L.W., Lehnhardt, F.G., Thiel, A., Jacobs, A.H., and Lackner, K. (2004) Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early ischemic stroke. Stroke, 35 (8), 1892-1898.
    • (2004) Stroke , vol.35 , Issue.8 , pp. 1892-1898
    • Heiss, W.D.1    Sobesky, J.2    Smekal, U.3    Kracht, L.W.4    Lehnhardt, F.G.5    Thiel, A.6    Jacobs, A.H.7    Lackner, K.8
  • 36
    • 0037321482 scopus 로고    scopus 로고
    • Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration
    • Liberatore, G.T., Samson, A., Bladin, C., Schleuning, W.D., and Medcalf, R.L. (2003) Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke, 34 (2), 537-543.
    • (2003) Stroke , vol.34 , Issue.2 , pp. 537-543
    • Liberatore, G.T.1    Samson, A.2    Bladin, C.3    Schleuning, W.D.4    Medcalf, R.L.5
  • 37
    • 33646705400 scopus 로고    scopus 로고
    • Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset
    • Furlan, A.J., Eyding, D., Albers, G.W., Al-Rawi, Y., Lees, K.R., Rowley, H.A., Sachara, C., Soehngen, M., Warach, S., and Hacke, W. (2006) Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke, 37 (5), 1227-1231.
    • (2006) Stroke , vol.37 , Issue.5 , pp. 1227-1231
    • Furlan, A.J.1    Eyding, D.2    Albers, G.W.3    Al-Rawi, Y.4    Lees, K.R.5    Rowley, H.A.6    Sachara, C.7    Soehngen, M.8    Warach, S.9    Hacke, W.10
  • 38
  • 40
    • 79952116549 scopus 로고    scopus 로고
    • Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches
    • Molina, C.A. (2010) Reperfusion therapies for acute ischemic stroke: current pharmacological and mechanical approaches. Stroke, 42 (Suppl. 1), S16-S19.
    • (2010) Stroke , vol.42 , Issue.SUPPL. 1
    • Molina, C.A.1
  • 42
    • 34848883164 scopus 로고    scopus 로고
    • Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan
    • Ogawa, A., Mori, E., Minematsu, K., Taki, W., Takahashi, A., Nemoto, S., Miyamoto, S., Sasaki, M., and Inoue, T. (2007) Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke, 38 (10), 2633-2639.
    • (2007) Stroke , vol.38 , Issue.10 , pp. 2633-2639
    • Ogawa, A.1    Mori, E.2    Minematsu, K.3    Taki, W.4    Takahashi, A.5    Nemoto, S.6    Miyamoto, S.7    Sasaki, M.8    Inoue, T.9
  • 43
    • 0022530448 scopus 로고
    • The beneficial effect of intracarotid urokinase on acute stroke in a baboon model
    • Del Zoppo, G.J., Copeland, B.R., Waltz, T.A., Zyroff, J., Plow, E.F., and Harker, L.A. (1986) The beneficial effect of intracarotid urokinase on acute stroke in a baboon model. Stroke, 17 (4), 638-643.
    • (1986) Stroke , vol.17 , Issue.4 , pp. 638-643
    • Del Zoppo, G.J.1    Copel, B.R.2    Waltz, T.A.3    Zyroff, J.4    Plow, E.F.5    Harker, L.A.6
  • 46
    • 0036871178 scopus 로고    scopus 로고
    • Aggressive mechanical clot disruption and low-dose intra-arterial third-generation thrombolytic agent for ischemic stroke: a prospective study
    • discussion.1327-1329
    • Qureshi, A.I., Siddiqui, A.M., Suri, M.F., Kim, S.H., Ali, Z., Yahia, A.M., Lopes, D.K., Boulos, A.S., Ringer, A.J., Saad, M., Guterman, L.R., and Hopkins, L.N. (2002) Aggressive mechanical clot disruption and low-dose intra-arterial third-generation thrombolytic agent for ischemic stroke: a prospective study. Neurosurgery, 51 (5), 1319-1327; discussion 1327-1329.
    • (2002) Neurosurgery , vol.51 , Issue.5 , pp. 1319-1327
    • Qureshi, A.I.1    Siddiqui, A.M.2    Suri, M.F.3    Kim, S.H.4    Ali, Z.5    Yahia, A.M.6    Lopes, D.K.7    Boulos, A.S.8    Ringer, A.J.9    Saad, M.10    Guterman, L.R.11    Hopkins, L.N.12
  • 47
    • 0034905963 scopus 로고    scopus 로고
    • Tenecteplase: a review
    • discussion.
    • Davydov, L. and Cheng, J.W. (2001) Tenecteplase: a review. Clin. Ther., 23 (7), 982-997; discussion 981.
    • (2001) Clin. Ther. , vol.23 , Issue.7
    • Davydov, L.1    Cheng, J.W.2
  • 49
    • 64049096017 scopus 로고    scopus 로고
    • Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window
    • Parsons, M.W., Miteff, F., Bateman, G.A., Spratt, N., Loiselle, A., Attia, J., and Levi, C.R. (2009) Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window. Neurology, 72 (10), 915-921.
    • (2009) Neurology , vol.72 , Issue.10 , pp. 915-921
    • Parsons, M.W.1    Miteff, F.2    Bateman, G.A.3    Spratt, N.4    Loiselle, A.5    Attia, J.6    Levi, C.R.7
  • 51
    • 77955514388 scopus 로고    scopus 로고
    • Current endovascular treatment of acute stroke and future aspects
    • Killer, M., Ladurner, G., Kunz, A.B., and Kraus, J. (2010) Current endovascular treatment of acute stroke and future aspects. Drug Discov. Today, 15 (15-16), 640-647.
    • (2010) Drug Discov. Today , vol.15 , Issue.15-16 , pp. 640-647
    • Killer, M.1    Ladurner, G.2    Kunz, A.B.3    Kraus, J.4
  • 53
    • 0036712353 scopus 로고    scopus 로고
    • Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits
    • Lapchak, P.A., Araujo, D.M., Pakola, S., Song, D., Wei, J., and Zivin, J.A. (2002) Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits. Stroke, 33 (9), 2279-2284.
    • (2002) Stroke , vol.33 , Issue.9 , pp. 2279-2284
    • Lapchak, P.A.1    Araujo, D.M.2    Pakola, S.3    Song, D.4    Wei, J.5    Zivin, J.A.6
  • 55
    • 0031941584 scopus 로고    scopus 로고
    • Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent
    • Collen, D. (1998) Staphylokinase: a potent, uniquely fibrin-selective thrombolytic agent. Nat. Med., 4 (3), 279-284.
    • (1998) Nat. Med. , vol.4 , Issue.3 , pp. 279-284
    • Collen, D.1
  • 56
    • 68249122804 scopus 로고    scopus 로고
    • Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation
    • Armstead, W.M., Ganguly, K., Kiessling, J.W., Chen, X.H., Smith, D.H., Higazi, A.A., Cines, D.B., Bdeir, K., Zaitsev, S., and Muzykantov, V.R. (2009) Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation. J. Cereb. Blood Flow Metab., 29 (8), 1463-1474.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , Issue.8 , pp. 1463-1474
    • Armstead, W.M.1    Ganguly, K.2    Kiessling, J.W.3    Chen, X.H.4    Smith, D.H.5    Higazi, A.A.6    Cines, D.B.7    Bdeir, K.8    Zaitsev, S.9    Muzykantov, V.R.10
  • 58
    • 78650179303 scopus 로고    scopus 로고
    • Coupling of anti-thrombotic agents to red blood cells offers safer and more effective management of thrombosis
    • Murciano, J.C. and Muzykantov, V.R. (2003) Coupling of anti-thrombotic agents to red blood cells offers safer and more effective management of thrombosis. Discov. Med., 3 (18), 28-29.
    • (2003) Discov. Med. , vol.3 , Issue.18 , pp. 28-29
    • Murciano, J.C.1    Muzykantov, V.R.2
  • 63
    • 0028908173 scopus 로고
    • Localization of tissue plasminogen activator mRNA in adult rat brain
    • Ware, J.H., Dibenedetto, A.J., and Pittman, R.N. (1995) Localization of tissue plasminogen activator mRNA in adult rat brain. Brain Res. Bull., 37 (3), 275-281.
    • (1995) Brain Res. Bull. , vol.37 , Issue.3 , pp. 275-281
    • Ware, J.H.1    Dibenedetto, A.J.2    Pittman, R.N.3
  • 64
    • 0029087997 scopus 로고
    • Localization of tissue plasminogen activator mRNA in the developing rat cerebellum and effects of inhibiting tissue plasminogen activator on granule cell migration
    • Ware, J.H., DiBenedetto, A.J., and Pittman, R.N. (1995) Localization of tissue plasminogen activator mRNA in the developing rat cerebellum and effects of inhibiting tissue plasminogen activator on granule cell migration. J. Neurobiol., 28 (1), 9-22.
    • (1995) J. Neurobiol. , vol.28 , Issue.1 , pp. 9-22
    • Ware, J.H.1    DiBenedetto, A.J.2    Pittman, R.N.3
  • 66
    • 4444379260 scopus 로고    scopus 로고
    • Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system
    • Teesalu, T., Kulla, A., Simisker, A., Siren, V., Lawrence, D.A., Asser, T., and Vaheri, A. (2004) Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb. Haemost., 92 (2), 358-368.
    • (2004) Thromb. Haemost. , vol.92 , Issue.2 , pp. 358-368
    • Teesalu, T.1    Kulla, A.2    Simisker, A.3    Siren, V.4    Lawrence, D.A.5    Asser, T.6    Vaheri, A.7
  • 68
    • 0030690117 scopus 로고    scopus 로고
    • Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse
    • Krueger, S.R., Ghisu, G.P., Cinelli, P., Gschwend, T.P., Osterwalder, T., Wolfer, D.P., and Sonderegger, P. (1997) Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J. Neurosci., 17 (23), 8984-8996.
    • (1997) J. Neurosci. , vol.17 , Issue.23 , pp. 8984-8996
    • Krueger, S.R.1    Ghisu, G.P.2    Cinelli, P.3    Gschwend, T.P.4    Osterwalder, T.5    Wolfer, D.P.6    Sonderegger, P.7
  • 70
    • 79953177895 scopus 로고    scopus 로고
    • Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice
    • Noel, M., Norris, E.H., and Strickland, S. (2011) Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. Proc. Natl. Acad. Sci. U.S.A., 108 (12), 5069-5074.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , Issue.12 , pp. 5069-5074
    • Noel, M.1    Norris, E.H.2    Strickland, S.3
  • 71
    • 0027976526 scopus 로고
    • Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain
    • Reinhard, E., Suidan, H.S., Pavlik, A., and Monard, D. (1994) Glia-derived nexin/protease nexin-1 is expressed by a subset of neurons in the rat brain. J. Neurosci. Res., 37 (2), 256-270.
    • (1994) J. Neurosci. Res. , vol.37 , Issue.2 , pp. 256-270
    • Reinhard, E.1    Suidan, H.S.2    Pavlik, A.3    Monard, D.4
  • 72
    • 0035083864 scopus 로고    scopus 로고
    • Plasminogen expression in the neonatal and adult mouse brain
    • Basham, M.E. and Seeds, N.W. (2001) Plasminogen expression in the neonatal and adult mouse brain. J. Neurochem., 77 (1), 318-325.
    • (2001) J. Neurochem. , vol.77 , Issue.1 , pp. 318-325
    • Basham, M.E.1    Seeds, N.W.2
  • 74
    • 0031021357 scopus 로고    scopus 로고
    • An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus
    • Tsirka, S.E., Rogove, A.D., Bugge, T.H., Degen, J.L., and Strickland, S. (1997) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J. Neurosci., 17 (2), 543-552.
    • (1997) J. Neurosci. , vol.17 , Issue.2 , pp. 543-552
    • Tsirka, S.E.1    Rogove, A.D.2    Bugge, T.H.3    Degen, J.L.4    Strickland, S.5
  • 75
    • 0032192461 scopus 로고    scopus 로고
    • Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway
    • Baranes, D., Lederfein, D., Huang, Y.Y., Chen, M., Bailey, C.H., and Kandel, E.R. (1998) Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway. Neuron, 21 (4), 813-825.
    • (1998) Neuron , vol.21 , Issue.4 , pp. 813-825
    • Baranes, D.1    Lederfein, D.2    Huang, Y.Y.3    Chen, M.4    Bailey, C.H.5    Kandel, E.R.6
  • 76
    • 0029556177 scopus 로고
    • Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning
    • Seeds, N.W., Williams, B.L., and Bickford, P.C. (1995) Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning. Science, 270 (5244), 1992-1994.
    • (1995) Science , vol.270 , Issue.5244 , pp. 1992-1994
    • Seeds, N.W.1    Williams, B.L.2    Bickford, P.C.3
  • 77
    • 29144526450 scopus 로고    scopus 로고
    • Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus
    • Pawlak, R., Rao, B.S., Melchor, J.P., Chattarji, S., McEwen, B., and Strickland, S. (2005) Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampus. Proc. Natl. Acad. Sci. U.S.A., 102 (50), 18201-18206.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.50 , pp. 18201-18206
    • Pawlak, R.1    Rao, B.S.2    Melchor, J.P.3    Chattarji, S.4    McEwen, B.5    Strickland, S.6
  • 78
    • 9244261036 scopus 로고    scopus 로고
    • Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior
    • Matys, T., Pawlak, R., Matys, E., Pavlides, C., McEwen, B.S., and Strickland, S. (2004) Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior. Proc. Natl. Acad. Sci. U.S.A., 101 (46), 16345-16350.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , Issue.46 , pp. 16345-16350
    • Matys, T.1    Pawlak, R.2    Matys, E.3    Pavlides, C.4    McEwen, B.S.5    Strickland, S.6
  • 79
    • 0037314824 scopus 로고    scopus 로고
    • Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
    • Pawlak, R., Magarinos, A.M., Melchor, J., McEwen, B., and Strickland, S. (2003) Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior. Nat. Neurosci., 6 (2), 168-174.
    • (2003) Nat. Neurosci. , vol.6 , Issue.2 , pp. 168-174
    • Pawlak, R.1    Magarinos, A.M.2    Melchor, J.3    McEwen, B.4    Strickland, S.5
  • 81
    • 0037088905 scopus 로고    scopus 로고
    • Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus
    • Salles, F.J. and Strickland, S. (2002) Localization and regulation of the tissue plasminogen activator-plasmin system in the hippocampus. J. Neurosci., 22 (6), 2125-2134.
    • (2002) J. Neurosci. , vol.22 , Issue.6 , pp. 2125-2134
    • Salles, F.J.1    Strickland, S.2
  • 82
    • 0034661923 scopus 로고    scopus 로고
    • Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis
    • Yepes, M., Sandkvist, M., Wong, M.K., Coleman, T.A., Smith, E., Cohan, S.L., and Lawrence, D.A. (2000) Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis. Blood, 96 (2), 569-576.
    • (2000) Blood , vol.96 , Issue.2 , pp. 569-576
    • Yepes, M.1    Sandkvist, M.2    Wong, M.K.3    Coleman, T.A.4    Smith, E.5    Cohan, S.L.6    Lawrence, D.A.7
  • 83
    • 0034992131 scopus 로고    scopus 로고
    • Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion
    • Hosomi, N., Lucero, J., Heo, J.H., Koziol, J.A., Copeland, B.R., and Del Zoppo, G.J. (2001) Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion. Stroke, 32 (6), 1341-1348.
    • (2001) Stroke , vol.32 , Issue.6 , pp. 1341-1348
    • Hosomi, N.1    Lucero, J.2    Heo, J.H.3    Koziol, J.A.4    Copeland, B.R.5    Del Zoppo, G.J.6
  • 84
    • 0027535364 scopus 로고
    • Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation
    • Qian, Z., Gilbert, M.E., Colicos, M.A., Kandel, E.R., and Kuhl, D. (1993) Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature, 361 (6411), 453-457.
    • (1993) Nature , vol.361 , Issue.6411 , pp. 453-457
    • Qian, Z.1    Gilbert, M.E.2    Colicos, M.A.3    Kandel, E.R.4    Kuhl, D.5
  • 85
    • 0024426481 scopus 로고
    • Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos
    • Sappino, A.P., Huarte, J., Belin, D., and Vassalli, J.D. (1989) Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos. J. Cell Biol., 109 (5), 2471-2479.
    • (1989) J. Cell Biol. , vol.109 , Issue.5 , pp. 2471-2479
    • Sappino, A.P.1    Huarte, J.2    Belin, D.3    Vassalli, J.D.4
  • 87
    • 0034912401 scopus 로고    scopus 로고
    • Tissue plasminogen activator in nervous system function and dysfunction
    • Strickland, S. (2001) Tissue plasminogen activator in nervous system function and dysfunction. Thromb. Haemost., 86 (1), 138-143.
    • (2001) Thromb. Haemost. , vol.86 , Issue.1 , pp. 138-143
    • Strickland, S.1
  • 88
    • 0036081376 scopus 로고    scopus 로고
    • Tissue plasminogen activator and seizures: a clot-buster's secret life
    • Pawlak, R. and Strickland, S. (2002) Tissue plasminogen activator and seizures: a clot-buster's secret life. J. Clin. Invest., 109 (12), 1529-1531.
    • (2002) J. Clin. Invest. , vol.109 , Issue.12 , pp. 1529-1531
    • Pawlak, R.1    Strickland, S.2
  • 89
    • 0021961417 scopus 로고
    • Glutamate neurotoxicity in cortical cell culture is calcium dependent
    • Choi, D.W. (1985) Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci. Lett., 58 (3), 293-297.
    • (1985) Neurosci. Lett. , vol.58 , Issue.3 , pp. 293-297
    • Choi, D.W.1
  • 90
    • 0029088484 scopus 로고
    • Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator
    • Tsirka, S.E., Gualandris, A., Amaral, D.G., and Strickland, S. (1995) Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature, 377 (6547), 340-344.
    • (1995) Nature , vol.377 , Issue.6547 , pp. 340-344
    • Tsirka, S.E.1    Gualandris, A.2    Amaral, D.G.3    Strickland, S.4
  • 91
    • 0029857469 scopus 로고    scopus 로고
    • Neuronal cell death and tPA
    • Tsirka, S.E., Rogove, A.D., and Strickland, S. (1996) Neuronal cell death and tPA. Nature, 384 (6605), 123-124.
    • (1996) Nature , vol.384 , Issue.6605 , pp. 123-124
    • Tsirka, S.E.1    Rogove, A.D.2    Strickland, S.3
  • 92
    • 0030984481 scopus 로고    scopus 로고
    • Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin
    • Tsirka, S.E., Bugge, T.H., Degen, J.L., and Strickland, S. (1997) Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin. Proc. Natl. Acad. Sci. U.S.A., 94 (18), 9779-9781.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.18 , pp. 9779-9781
    • Tsirka, S.E.1    Bugge, T.H.2    Degen, J.L.3    Strickland, S.4
  • 93
    • 28344454373 scopus 로고    scopus 로고
    • The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo
    • Lebeurrier, N., Liot, G., Lopez-Atalaya, J.P., Orset, C., Fernandez-Monreal, M., Sonderegger, P., Ali, C., and Vivien, D. (2005) The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo. Mol. Cell. Neurosci., 30 (4), 552-558.
    • (2005) Mol. Cell. Neurosci. , vol.30 , Issue.4 , pp. 552-558
    • Lebeurrier, N.1    Liot, G.2    Lopez-Atalaya, J.P.3    Orset, C.4    Fernandez-Monreal, M.5    Sonderegger, P.6    Ali, C.7    Vivien, D.8
  • 94
    • 34250731169 scopus 로고    scopus 로고
    • Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies
    • Hazell, A.S. (2007) Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem. Int., 50 (7-8), 941-953.
    • (2007) Neurochem. Int. , vol.50 , Issue.7-8 , pp. 941-953
    • Hazell, A.S.1
  • 95
    • 84982003493 scopus 로고
    • New models of focal cerebral ischaemia
    • Mhairi Macrae, I. (1992) New models of focal cerebral ischaemia. Br. J. Clin. Pharmacol., 34 (4), 302-308.
    • (1992) Br. J. Clin. Pharmacol. , vol.34 , Issue.4 , pp. 302-308
    • Mhairi Macrae, I.1
  • 96
    • 0034091586 scopus 로고    scopus 로고
    • Viewpoint: are studies in genetically altered mice out of control? Arterioscler
    • Sigmund, C.D. (2000) Viewpoint: are studies in genetically altered mice out of control? Arterioscler. Thromb. Vasc. Biol., 20 (6), 1425-1429.
    • (2000) Thromb. Vasc. Biol. , vol.20 , Issue.6 , pp. 1425-1429
    • Sigmund, C.D.1
  • 97
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
    • Wang, Y.F., Tsirka, S.E., Strickland, S., Stieg, P.E., Soriano, S.G., and Lipton, S.A. (1998) Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat. Med., 4 (2), 228-231.
    • (1998) Nat. Med. , vol.4 , Issue.2 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3    Stieg, P.E.4    Soriano, S.G.5    Lipton, S.A.6
  • 98
    • 0031883406 scopus 로고    scopus 로고
    • tPA: a neuron buster, too?
    • Del Zoppo, G.J. (1998) tPA: a neuron buster, too? Nat. Med., 4 (2), 148-150.
    • (1998) Nat. Med. , vol.4 , Issue.2 , pp. 148-150
    • Del Zoppo, G.J.1
  • 99
    • 0032743293 scopus 로고    scopus 로고
    • On ischemic brain injury in genetically altered mice
    • Ginsberg, M.D. (1999) On ischemic brain injury in genetically altered mice. Arterioscler. Thromb. Vasc. Biol., 19 (11), 2581-2583.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , Issue.11 , pp. 2581-2583
    • Ginsberg, M.D.1
  • 100
    • 0032741931 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background
    • Tabrizi, P., Wang, L., Seeds, N., McComb, J.G., Yamada, S., Griffin, J.H., Carmeliet, P., Weiss, M.H., and Zlokovic, B.V. (1999) Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler. Thromb. Vasc. Biol., 19 (11), 2801-2806.
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , Issue.11 , pp. 2801-2806
    • Tabrizi, P.1    Wang, L.2    Seeds, N.3    McComb, J.G.4    Yamada, S.5    Griffin, J.H.6    Carmeliet, P.7    Weiss, M.H.8    Zlokovic, B.V.9
  • 101
    • 0033941427 scopus 로고    scopus 로고
    • Monoclonal antibody designated T2G1 reacts with human fibrin beta-chain but not with the corresponding chain from mouse fibrin
    • Kudryk, B.J. and Bini, A. (2000) Monoclonal antibody designated T2G1 reacts with human fibrin beta-chain but not with the corresponding chain from mouse fibrin. Arterioscler. Thromb. Vasc. Biol., 20 (7), 1848-1849.
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , Issue.7 , pp. 1848-1849
    • Kudryk, B.J.1    Bini, A.2
  • 102
    • 0033545965 scopus 로고    scopus 로고
    • Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice
    • Nagai, N., De Mol, M., Lijnen, H.R., Carmeliet, P., and Collen, D. (1999) Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation, 99 (18), 2440-2444.
    • (1999) Circulation , vol.99 , Issue.18 , pp. 2440-2444
    • Nagai, N.1    De Mol, M.2    Lijnen, H.R.3    Carmeliet, P.4    Collen, D.5
  • 103
    • 25144460038 scopus 로고    scopus 로고
    • Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice
    • Nagai, N., Suzuki, Y., Van Hoef, B., Lijnen, H.R., and Collen, D. (2005) Effects of plasminogen activator inhibitor-1 on ischemic brain injury in permanent and thrombotic middle cerebral artery occlusion models in mice. J. Thromb. Haemost., 3 (7), 1379-1384.
    • (2005) J. Thromb. Haemost. , vol.3 , Issue.7 , pp. 1379-1384
    • Nagai, N.1    Suzuki, Y.2    Van Hoef, B.3    Lijnen, H.R.4    Collen, D.5
  • 105
    • 0033580092 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice
    • Kilic, E., Hermann, D.M., and Hossmann, K.A. (1999) Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice. Neuroreport, 10 (1), 107-111.
    • (1999) Neuroreport , vol.10 , Issue.1 , pp. 107-111
    • Kilic, E.1    Hermann, D.M.2    Hossmann, K.A.3
  • 106
    • 0032544586 scopus 로고    scopus 로고
    • Early (1 h) administration of tissue plasminogen activator reduces infarct volume without increasing hemorrhagic transformation after focal cerebral embolization in rats
    • Zhang, R.L., Chopp, M., Zhang, Z.G., and Divine, G. (1998) Early (1 h) administration of tissue plasminogen activator reduces infarct volume without increasing hemorrhagic transformation after focal cerebral embolization in rats. J. Neurol. Sci., 160 (1), 1-8.
    • (1998) J. Neurol. Sci. , vol.160 , Issue.1 , pp. 1-8
    • Zhang, R.L.1    Chopp, M.2    Zhang, Z.G.3    Divine, G.4
  • 107
    • 0028511585 scopus 로고
    • Thrombolytic therapy in experimental embolic stroke
    • Overgaard, K. (1994) Thrombolytic therapy in experimental embolic stroke. Cerebrovasc. Brain Metab. Rev., 6 (3), 257-286.
    • (1994) Cerebrovasc. Brain Metab. Rev. , vol.6 , Issue.3 , pp. 257-286
    • Overgaard, K.1
  • 108
    • 0035164372 scopus 로고    scopus 로고
    • Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice: role of hemodynamic alterations
    • Kilic, E., Bahr, M., and Hermann, D.M. (2001) Effects of recombinant tissue plasminogen activator after intraluminal thread occlusion in mice: role of hemodynamic alterations. Stroke, 32 (11), 2641-2647.
    • (2001) Stroke , vol.32 , Issue.11 , pp. 2641-2647
    • Kilic, E.1    Bahr, M.2    Hermann, D.M.3
  • 109
    • 0033375290 scopus 로고    scopus 로고
    • Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats
    • Meng, W., Wang, X., Asahi, M., Kano, T., Asahi, K., Ackerman, R.H., and Lo, E.H. (1999) Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab., 19 (12), 1316-1321.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , Issue.12 , pp. 1316-1321
    • Meng, W.1    Wang, X.2    Asahi, M.3    Kano, T.4    Asahi, K.5    Ackerman, R.H.6    Lo, E.H.7
  • 111
    • 36749086638 scopus 로고    scopus 로고
    • Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia
    • Lee, S.R., Lok, J., Rosell, A., Kim, H.Y., Murata, Y., Atochin, D., Huang, P.L., Wang, X., Ayata, C., Moskowitz, M.A., and Lo, E.H. (2007) Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience, 150 (1), 50-57.
    • (2007) Neuroscience , vol.150 , Issue.1 , pp. 50-57
    • Lee, S.R.1    Lok, J.2    Rosell, A.3    Kim, H.Y.4    Murata, Y.5    Atochin, D.6    Huang, P.L.7    Wang, X.8    Ayata, C.9    Moskowitz, M.A.10    Lo, E.H.11
  • 112
    • 77953182892 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus
    • Echeverry, R., Wu, J., Haile, W.B., Guzman, J., and Yepes, M. (2010) Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus. J. Clin. Invest., 120 (6), 2194-2205.
    • (2010) J. Clin. Invest. , vol.120 , Issue.6 , pp. 2194-2205
    • Echeverry, R.1    Wu, J.2    Haile, W.B.3    Guzman, J.4    Yepes, M.5
  • 113
    • 77955570062 scopus 로고    scopus 로고
    • Glutamate receptors, neurotoxicity and neurodegeneration
    • Lau, A. and Tymianski, M. (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch., 460 (2), 525-542.
    • (2010) Pflugers Arch. , vol.460 , Issue.2 , pp. 525-542
    • Lau, A.1    Tymianski, M.2
  • 114
    • 34249085665 scopus 로고    scopus 로고
    • NMDA and AMPA receptors: old channels, new tricks
    • Rao, V.R. and Finkbeiner, S. (2007) NMDA and AMPA receptors: old channels, new tricks. Trends Neurosci., 30 (6), 284-291.
    • (2007) Trends Neurosci. , vol.30 , Issue.6 , pp. 284-291
    • Rao, V.R.1    Finkbeiner, S.2
  • 115
    • 33748921093 scopus 로고    scopus 로고
    • NMDA receptor function: subunit composition versus spatial distribution
    • Kohr, G. (2006) NMDA receptor function: subunit composition versus spatial distribution. Cell Tissue Res., 326 (2), 439-446.
    • (2006) Cell Tissue Res. , vol.326 , Issue.2 , pp. 439-446
    • Kohr, G.1
  • 116
    • 33846920665 scopus 로고    scopus 로고
    • NMDA receptor subunits: function and pharmacology
    • Paoletti, P. and Neyton, J. (2007) NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol., 7 (1), 39-47.
    • (2007) Curr. Opin. Pharmacol. , vol.7 , Issue.1 , pp. 39-47
    • Paoletti, P.1    Neyton, J.2
  • 117
    • 0034746189 scopus 로고    scopus 로고
    • The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
    • Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie, E.T., Vivien, D., and Buisson, A. (2001) The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat. Med., 7 (1), 59-64.
    • (2001) Nat. Med. , vol.7 , Issue.1 , pp. 59-64
    • Nicole, O.1    Docagne, F.2    Ali, C.3    Margaill, I.4    Carmeliet, P.5    MacKenzie, E.T.6    Vivien, D.7    Buisson, A.8
  • 118
    • 77950860159 scopus 로고    scopus 로고
    • NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity
    • Baron, A., Montagne, A., Casse, F., Launay, S., Maubert, E., Ali, C., and Vivien, D. (2010) NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ., 17 (5), 860-871.
    • (2010) Cell Death Differ. , vol.17 , Issue.5 , pp. 860-871
    • Baron, A.1    Montagne, A.2    Casse, F.3    Launay, S.4    Maubert, E.5    Ali, C.6    Vivien, D.7
  • 122
    • 78650416546 scopus 로고    scopus 로고
    • Functional occurrence of the interaction of tissue plasminogen activator with the NR1 subunit of N-Methyl-D-Aspartate receptors during stroke
    • Macrez, R., Bezin, L., Le Mauff, B., Ali, C., and Vivien, D. (2010) Functional occurrence of the interaction of tissue plasminogen activator with the NR1 subunit of N-Methyl-D-Aspartate receptors during stroke. Stroke, 41 (12), 2950-2955.
    • (2010) Stroke , vol.41 , Issue.12 , pp. 2950-2955
    • Macrez, R.1    Bezin, L.2    Le Mauff, B.3    Ali, C.4    Vivien, D.5
  • 123
    • 0037391807 scopus 로고    scopus 로고
    • Tissue plasminogen activator and NMDA receptor cleavage
    • author reply 372-373.
    • Matys, T. and Strickland, S. (2003) Tissue plasminogen activator and NMDA receptor cleavage. Nat. Med., 9 (4), 371-372; author reply 372-373.
    • (2003) Nat. Med. , vol.9 , Issue.4 , pp. 371-372
    • Matys, T.1    Strickland, S.2
  • 124
    • 34548075540 scopus 로고    scopus 로고
    • Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system
    • Norris, E.H. and Strickland, S. (2007) Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system. Proc. Natl. Acad. Sci. U.S.A., 104 (33), 13473-13478.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.33 , pp. 13473-13478
    • Norris, E.H.1    Strickland, S.2
  • 125
    • 12244255365 scopus 로고    scopus 로고
    • Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors
    • Pawlak, R., Melchor, J.P., Matys, T., Skrzypiec, A.E., and Strickland, S. (2005) Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proc. Natl. Acad. Sci. U.S.A., 102 (2), 443-448.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , Issue.2 , pp. 443-448
    • Pawlak, R.1    Melchor, J.P.2    Matys, T.3    Skrzypiec, A.E.4    Strickland, S.5
  • 126
    • 33746080943 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity
    • Samson, A.L. and Medcalf, R.L. (2006) Tissue-type plasminogen activator: a multifaceted modulator of neurotransmission and synaptic plasticity. Neuron, 50 (5), 673-678.
    • (2006) Neuron , vol.50 , Issue.5 , pp. 673-678
    • Samson, A.L.1    Medcalf, R.L.2
  • 127
    • 67649752347 scopus 로고    scopus 로고
    • The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors
    • Yuan, H., Vance, K.M., Junge, C.E., Geballe, M.T., Snyder, J.P., Hepler, J.R., Yepes, M., Low, C.M., and Traynelis, S.F. (2009) The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J. Biol. Chem., 284 (19), 12862-12873.
    • (2009) J. Biol. Chem. , vol.284 , Issue.19 , pp. 12862-12873
    • Yuan, H.1    Vance, K.M.2    Junge, C.E.3    Geballe, M.T.4    Snyder, J.P.5    Hepler, J.R.6    Yepes, M.7    Low, C.M.8    Traynelis, S.F.9
  • 132
    • 0034633703 scopus 로고    scopus 로고
    • The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors
    • Bacskai, B.J., Xia, M.Q., Strickland, D.K., Rebeck, G.W., and Hyman, B.T. (2000) The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. U.S.A., 97 (21), 11551-11556.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , Issue.21 , pp. 11551-11556
    • Bacskai, B.J.1    Xia, M.Q.2    Strickland, D.K.3    Rebeck, G.W.4    Hyman, B.T.5
  • 133
    • 33847649975 scopus 로고    scopus 로고
    • HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    • Eugenin, E.A., King, J.E., Nath, A., Calderon, T.M., Zukin, R.S., Bennett, M.V., and Berman, J.W. (2007) HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes. Proc. Natl. Acad. Sci. U.S.A., 104 (9), 3438-3443.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , Issue.9 , pp. 3438-3443
    • Eugenin, E.A.1    King, J.E.2    Nath, A.3    Calderon, T.M.4    Zukin, R.S.5    Bennett, M.V.6    Berman, J.W.7
  • 134
    • 45549088806 scopus 로고    scopus 로고
    • The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors
    • Martin, A.M., Kuhlmann, C., Trossbach, S., Jaeger, S., Waldron, E., Roebroek, A., Luhmann, H.J., Laatsch, A., Weggen, S., Lessmann, V., and Pietrzik, C.U. (2008) The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. J. Biol. Chem., 283 (18), 12004-12013.
    • (2008) J. Biol. Chem. , vol.283 , Issue.18 , pp. 12004-12013
    • Martin, A.M.1    Kuhlmann, C.2    Trossbach, S.3    Jaeger, S.4    Waldron, E.5    Roebroek, A.6    Luhmann, H.J.7    Laatsch, A.8    Weggen, S.9    Lessmann, V.10    Pietrzik, C.U.11
  • 135
    • 0037177803 scopus 로고    scopus 로고
    • alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons
    • Qiu, Z., Strickland, D.K., Hyman, B.T., and Rebeck, G.W. (2002) alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J. Biol. Chem., 277 (17), 14458-14466.
    • (2002) J. Biol. Chem. , vol.277 , Issue.17 , pp. 14458-14466
    • Qiu, Z.1    Strickland, D.K.2    Hyman, B.T.3    Rebeck, G.W.4
  • 136
    • 78649983743 scopus 로고    scopus 로고
    • Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95
    • Zhou, L., Li, F., Xu, H.B., Luo, C.X., Wu, H.Y., Zhu, M.M., Lu, W., Ji, X., Zhou, Q.G., and Zhu, D.Y. (2010) Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat. Med., 16 (12), 1439-1443.
    • (2010) Nat. Med. , vol.16 , Issue.12 , pp. 1439-1443
    • Zhou, L.1    Li, F.2    Xu, H.B.3    Luo, C.X.4    Wu, H.Y.5    Zhu, M.M.6    Lu, W.7    Ji, X.8    Zhou, Q.G.9    Zhu, D.Y.10
  • 139
    • 0027007972 scopus 로고
    • An overview of the multiple functions of the blood-brain barrier
    • Betz, A.L. (1992) An overview of the multiple functions of the blood-brain barrier. NIDA Res. Monogr., 120, 54-72.
    • (1992) NIDA Res. Monogr. , vol.120 , pp. 54-72
    • Betz, A.L.1
  • 140
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • Sandoval, K.E. and Witt, K.A. (2008) Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol. Dis., 32 (2), 200-219.
    • (2008) Neurobiol. Dis. , vol.32 , Issue.2 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 141
    • 78149238637 scopus 로고    scopus 로고
    • Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment? Ann
    • Morancho, A., Rosell, A., Garcia-Bonilla, L., and Montaner, J. (2010) Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment? Ann. N.Y. Acad. Sci., 1207, 123-133.
    • (2010) N.Y. Acad. Sci. , vol.1207 , pp. 123-133
    • Morancho, A.1    Rosell, A.2    Garcia-Bonilla, L.3    Montaner, J.4
  • 142
    • 77952547253 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator
    • Jin, R., Yang, G., and Li, G. (2010) Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol. Dis., 38 (3), 376-385.
    • (2010) Neurobiol. Dis. , vol.38 , Issue.3 , pp. 376-385
    • Jin, R.1    Yang, G.2    Li, G.3
  • 143
    • 38749096624 scopus 로고    scopus 로고
    • Multiphasic roles for matrix metalloproteinases after stroke
    • Rosell, A. and Lo, E.H. (2008) Multiphasic roles for matrix metalloproteinases after stroke. Curr. Opin. Pharmacol., 8 (1), 82-89.
    • (2008) Curr. Opin. Pharmacol. , vol.8 , Issue.1 , pp. 82-89
    • Rosell, A.1    Lo, E.H.2
  • 144
  • 145
    • 77954989091 scopus 로고    scopus 로고
    • Role of tissue-type plasminogen activator in ischemic stroke
    • Suzuki, Y. (2010) Role of tissue-type plasminogen activator in ischemic stroke. J. Pharmacol. Sci., 113 (3), 203-207.
    • (2010) J. Pharmacol. Sci. , vol.113 , Issue.3 , pp. 203-207
    • Suzuki, Y.1
  • 146
    • 0142137232 scopus 로고    scopus 로고
    • Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    • Wang, X., Lee, S.R., Arai, K., Tsuji, K., Rebeck, G.W., and Lo, E.H. (2003) Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat. Med., 9 (10), 1313-1317.
    • (2003) Nat. Med. , vol.9 , Issue.10 , pp. 1313-1317
    • Wang, X.1    Lee, S.R.2    Arai, K.3    Tsuji, K.4    Rebeck, G.W.5    Lo, E.H.6
  • 147
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    • Yepes, M., Sandkvist, M., Moore, E.G., Bugge, T.H., Strickland, D.K., and Lawrence, D.A. (2003) Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest., 112 (10), 1533-1540.
    • (2003) J. Clin. Invest. , vol.112 , Issue.10 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 148
    • 34047230161 scopus 로고    scopus 로고
    • Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators
    • Lee, S.R., Guo, S.Z., Scannevin, R.H., Magliaro, B.C., Rhodes, K.J., Wang, X., and Lo, E.H. (2007) Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci. Lett., 417 (1), 1-5.
    • (2007) Neurosci. Lett. , vol.417 , Issue.1 , pp. 1-5
    • Lee, S.R.1    Guo, S.Z.2    Scannevin, R.H.3    Magliaro, B.C.4    Rhodes, K.J.5    Wang, X.6    Lo, E.H.7
  • 149
    • 24644519846 scopus 로고    scopus 로고
    • Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    • Tsuji, K., Aoki, T., Tejima, E., Arai, K., Lee, S.R., Atochin, D.N., Huang, P.L., Wang, X., Montaner, J., and Lo, E.H. (2005) Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke, 36 (9), 1954-1959.
    • (2005) Stroke , vol.36 , Issue.9 , pp. 1954-1959
    • Tsuji, K.1    Aoki, T.2    Tejima, E.3    Arai, K.4    Lee, S.R.5    Atochin, D.N.6    Huang, P.L.7    Wang, X.8    Montaner, J.9    Lo, E.H.10
  • 150
    • 0036843258 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats
    • Aoki, T., Sumii, T., Mori, T., Wang, X., and Lo, E.H. (2002) Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke, 33 (11), 2711-2717.
    • (2002) Stroke , vol.33 , Issue.11 , pp. 2711-2717
    • Aoki, T.1    Sumii, T.2    Mori, T.3    Wang, X.4    Lo, E.H.5
  • 151
    • 33746080351 scopus 로고    scopus 로고
    • Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis
    • Kelly, M.A., Shuaib, A., and Todd, K.G. (2006) Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis. Exp. Neurol., 200 (1), 38-49.
    • (2006) Exp. Neurol. , vol.200 , Issue.1 , pp. 38-49
    • Kelly, M.A.1    Shuaib, A.2    Todd, K.G.3
  • 152
    • 78149245608 scopus 로고    scopus 로고
    • The neurovascular unit, matrix proteases, and innate inflammation
    • Del Zoppo, G.J. (2010) The neurovascular unit, matrix proteases, and innate inflammation. Ann. N.Y. Acad. Sci., 1207, 46-49.
    • (2010) Ann. N.Y. Acad. Sci. , vol.1207 , pp. 46-49
    • Del Zoppo, G.J.1
  • 153
    • 80053566544 scopus 로고    scopus 로고
    • Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse
    • Copin, J.C., Bengualid, D.J., Da Silva, R.F., Kargiotis, O., Schaller, K., and Gasche, Y. (2011) Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse. Eur. J. Neurosci., 34 (7), 1085-1092.
    • (2011) Eur. J. Neurosci. , vol.34 , Issue.7 , pp. 1085-1092
    • Copin, J.C.1    Bengualid, D.J.2    Da Silva, R.F.3    Kargiotis, O.4    Schaller, K.5    Gasche, Y.6
  • 154
    • 23744437416 scopus 로고    scopus 로고
    • Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia
    • Gidday, J.M., Gasche, Y.G., Copin, J.C., Shah, A.R., Perez, R.S., Shapiro, S.D., Chan, P.H., and Park, T.S. (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am. J. Physiol. Heart Circ. Physiol., 289 (2), H558-H568.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289 , Issue.2
    • Gidday, J.M.1    Gasche, Y.G.2    Copin, J.C.3    Shah, A.R.4    Perez, R.S.5    Shapiro, S.D.6    Chan, P.H.7    Park, T.S.8
  • 155
    • 0348141856 scopus 로고    scopus 로고
    • Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats
    • Justicia, C., Panes, J., Sole, S., Cervera, A., Deulofeu, R., Chamorro, A., and Planas, A.M. (2003) Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats. J. Cereb. Blood Flow Metab., 23 (12), 1430-1440.
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , Issue.12 , pp. 1430-1440
    • Justicia, C.1    Panes, J.2    Sole, S.3    Cervera, A.4    Deulofeu, R.5    Chamorro, A.6    Planas, A.M.7
  • 156
    • 26444501098 scopus 로고    scopus 로고
    • Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke
    • Harris, A.K., Ergul, A., Kozak, A., Machado, L.S., Johnson, M.H., and Fagan, S.C. (2005) Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke. BMC Neurosci., 6, 49.
    • (2005) BMC Neurosci. , vol.6 , pp. 49
    • Harris, A.K.1    Ergul, A.2    Kozak, A.3    Machado, L.S.4    Johnson, M.H.5    Fagan, S.C.6
  • 159
    • 0034836428 scopus 로고    scopus 로고
    • LRP: a multifunctional scavenger and signaling receptor
    • Herz, J. and Strickland, D.K. (2001) LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest., 108 (6), 779-784.
    • (2001) J. Clin. Invest. , vol.108 , Issue.6 , pp. 779-784
    • Herz, J.1    Strickland, D.K.2
  • 160
    • 50349092250 scopus 로고    scopus 로고
    • LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
    • Lillis, A.P., Van Duyn, L.B., Murphy-Ullrich, J.E., and Strickland, D.K. (2008) LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol. Rev., 88 (3), 887-918.
    • (2008) Physiol. Rev. , vol.88 , Issue.3 , pp. 887-918
    • Lillis, A.P.1    Van Duyn, L.B.2    Murphy-Ullrich, J.E.3    Strickland, D.K.4
  • 162
    • 28344453429 scopus 로고    scopus 로고
    • Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability
    • Lillis, A.P., Mikhailenko, I., and Strickland, D.K. (2005) Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. J. Thromb. Haemost., 3 (8), 1884-1893.
    • (2005) J. Thromb. Haemost. , vol.3 , Issue.8 , pp. 1884-1893
    • Lillis, A.P.1    Mikhailenko, I.2    Strickland, D.K.3
  • 163
    • 0026756089 scopus 로고
    • Low density lipoprotein receptor-related protein/ alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator
    • Bu, G., Williams, S., Strickland, D.K., and Schwartz, A.L. (1992) Low density lipoprotein receptor-related protein/ alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc. Natl. Acad. Sci. U.S.A., 89 (16), 7427-7431.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , Issue.16 , pp. 7427-7431
    • Bu, G.1    Williams, S.2    Strickland, D.K.3    Schwartz, A.L.4
  • 164
    • 0346749512 scopus 로고    scopus 로고
    • The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes
    • Makarova, A., Mikhailenko, I., Bugge, T.H., List, K., Lawrence, D.A., and Strickland, D.K. (2003) The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes. J. Biol. Chem., 278 (50), 50250-50258.
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 50250-50258
    • Makarova, A.1    Mikhailenko, I.2    Bugge, T.H.3    List, K.4    Lawrence, D.A.5    Strickland, D.K.6
  • 165
    • 0037166319 scopus 로고    scopus 로고
    • Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain
    • May, P., Reddy, Y.K., and Herz, J. (2002) Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem., 277 (21), 18736-18743.
    • (2002) J. Biol. Chem. , vol.277 , Issue.21 , pp. 18736-18743
    • May, P.1    Reddy, Y.K.2    Herz, J.3
  • 167
    • 34147143557 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit
    • Polavarapu, R., Gongora, M.C., Yi, H., Ranganthan, S., Lawrence, D.A., Strickland, D., and Yepes, M. (2007) Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood, 109 (8), 3270-3278.
    • (2007) Blood , vol.109 , Issue.8 , pp. 3270-3278
    • Polavarapu, R.1    Gongora, M.C.2    Yi, H.3    Ranganthan, S.4    Lawrence, D.A.5    Strickland, D.6    Yepes, M.7
  • 168
    • 35348892539 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-?B pathway activation
    • Zhang, X., Polavarapu, R., She, H., Mao, Z., and Yepes, M. (2007) Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-?B pathway activation. Am. J. Pathol., 171 (4), 1281-1290.
    • (2007) Am. J. Pathol. , vol.171 , Issue.4 , pp. 1281-1290
    • Zhang, X.1    Polavarapu, R.2    She, H.3    Mao, Z.4    Yepes, M.5
  • 169
    • 2942676788 scopus 로고    scopus 로고
    • The PDGF family: four gene products form five dimeric isoforms
    • Fredriksson, L., Li, H., and Eriksson, U. (2004) The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev., 15 (4), 197-204.
    • (2004) Cytokine Growth Factor Rev. , vol.15 , Issue.4 , pp. 197-204
    • Fredriksson, L.1    Li, H.2    Eriksson, U.3
  • 170
    • 6344236867 scopus 로고    scopus 로고
    • Tissue plasminogen activator is a potent activator of PDGF-CC
    • Fredriksson, L., Li, H., Fieber, C., Li, X., and Eriksson, U. (2004) Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J., 23 (19), 3793-3802.
    • (2004) EMBO J. , vol.23 , Issue.19 , pp. 3793-3802
    • Fredriksson, L.1    Li, H.2    Fieber, C.3    Li, X.4    Eriksson, U.5
  • 171
    • 67849090567 scopus 로고    scopus 로고
    • Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke
    • Su, E.J., Fredriksson, L., Schielke, G.P., Eriksson, U., and Lawrence, D.A. (2009) Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke. J. Thromb. Haemost., 7 (Suppl. 1), 155-158.
    • (2009) J. Thromb. Haemost. , vol.7 , Issue.SUPPL. 1 , pp. 155-158
    • Su, E.J.1    Fredriksson, L.2    Schielke, G.P.3    Eriksson, U.4    Lawrence, D.A.5
  • 173
    • 84857208625 scopus 로고    scopus 로고
    • Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities
    • Fredriksson, L., Nilsson, I., Su, E.J., Andrea, J., Ding, H., Betsholtz, C., Eriksson, U., and Lawrence, D.A. (2012) Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities. Am. J. Pathol, http://dx.doi.org/10.1016/j.ajpath.2011.12.006
    • (2012) Am. J. Pathol
    • Fredriksson, L.1    Nilsson, I.2    Su, E.J.3    Andrea, J.4    Ding, H.5    Betsholtz, C.6    Eriksson, U.7    Lawrence, D.A.8
  • 174
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae, J., Gallini, R., and Betsholtz, C. (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev., 22 (10), 1276-1312.
    • (2008) Genes Dev. , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 175
    • 70349462812 scopus 로고    scopus 로고
    • A developmental study on the expression of PDGFalphaR immunoreactive cells in the brain of postnatal rats
    • He, Y., Cai, W., Wang, L., and Chen, P. (2009) A developmental study on the expression of PDGFalphaR immunoreactive cells in the brain of postnatal rats. Neurosci. Res., 65 (3), 272-279.
    • (2009) Neurosci. Res. , vol.65 , Issue.3 , pp. 272-279
    • He, Y.1    Cai, W.2    Wang, L.3    Chen, P.4
  • 176
    • 33745880884 scopus 로고    scopus 로고
    • PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling
    • Jackson, E.L., Garcia-Verdugo, J.M., Gil-Perotin, S., Roy, M., Quinones- Hinojosa, A., VandenBerg, S., and Alvarez-Buylla, A. (2006) PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron, 51 (2), 187-199.
    • (2006) Neuron , vol.51 , Issue.2 , pp. 187-199
    • Jackson, E.L.1    Garcia-Verdugo, J.M.2    Gil-Perotin, S.3    Roy, M.4    Quinones-Hinojosa, A.5    VandenBerg, S.6    Alvarez Buylla, A.7
  • 177
    • 0026689059 scopus 로고
    • PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage
    • Pringle, N.P., Mudhar, H.S., Collarini, E.J., and Richardson, W.D. (1992) PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development, 115 (2), 535-551.
    • (1992) Development , vol.115 , Issue.2 , pp. 535-551
    • Pringle, N.P.1    Mudhar, H.S.2    Collarini, E.J.3    Richardson, W.D.4
  • 178
    • 0030752920 scopus 로고    scopus 로고
    • Serum opens tight junctions and reduces ZO-1 protein in retinal epithelial cells
    • Chang, C., Wang, X., and Caldwell, R.B. (1997) Serum opens tight junctions and reduces ZO-1 protein in retinal epithelial cells. J. Neurochem., 69 (2), 859-867.
    • (1997) J. Neurochem. , vol.69 , Issue.2 , pp. 859-867
    • Chang, C.1    Wang, X.2    Caldwell, R.B.3
  • 179
    • 77951252847 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown as a novel mechanism underlying cerebral hyperperfusion syndrome
    • Ivens, S., Gabriel, S., Greenberg, G., Friedman, A., and Shelef, I. (2010) Blood-brain barrier breakdown as a novel mechanism underlying cerebral hyperperfusion syndrome. J. Neurol., 257 (4), 615-620.
    • (2010) J. Neurol. , vol.257 , Issue.4 , pp. 615-620
    • Ivens, S.1    Gabriel, S.2    Greenberg, G.3    Friedman, A.4    Shelef, I.5
  • 180
    • 84255196110 scopus 로고    scopus 로고
    • PDGFR-a inhibition preserves blood-brain barrier after intracerebral hemorrhage
    • Ma, Q., Huang, B., Khatibi, N., Rolland, W.II., Suzuki, H., Zhang, J.H., and Tang, J. (2011) PDGFR-a inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann. Neurol, 70, 920-931.
    • (2011) Ann. Neurol , vol.70 , pp. 920-931
    • Ma, Q.1    Huang, B.2    Khatibi, N.3    Rolland, W.4    Suzuki, H.5    Zhang, J.H.6    Tang, J.7


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