The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes

Journal of Biological Chemistry

Volumn 278, Issue 50, 2003, Pages 50250-50258

  Makarova, Alexandra ^a,b   Mikhailenko, Irina ^a   Bugge, Thomas H ^c   List, Karin ^c   Lawrencet, Daniel A ^a,b   Strickland, Dudley K ^a,b  

^a HOLLAND LABORATORY   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; BRAIN; CELLS; ENZYME INHIBITION; NEUROLOGY; PROTEINS; TISSUE;

CELLULAR INTERNALIZATION;

BIOCHEMISTRY;

LOW DENSITY LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NEUROSERPIN; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FIBROBLAST; GLIA CELL; INTERNALIZATION; LONG TERM POTENTIATION; MOUSE; MULTIGENE FAMILY; NERVE CELL CULTURE; NERVE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; SYNAPTIC TRANSMISSION; TARGET CELL;

ANIMALS; BRAIN; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; FIBROBLASTS; IMMUNOBLOTTING; LDL-RECEPTOR RELATED PROTEIN 1; LIGANDS; MICE; MICROSCOPY, FLUORESCENCE; NEURONS; NEUROPEPTIDES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SERPINS; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR;

ANIMALIA;

EID: 0346749512     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309150200     Document Type: Article

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