Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 8, 2009, Pages 1463-1474

  Armstead, William M ^a   Ganguly, Kumkum ^b   Kiessling, John W ^a   Chen, Xiao Han ^a   Smith, Douglas H ^a   Higazi, Abd A R ^a,c   Cines, Douglas B ^a   Bdeir, Khalil ^a   Zaitsev, Sergei ^a,d   Muzykantov, Vladimir R ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cerebral circulation; Newborn; Stroke; TPA

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CIRCULATION; BRAIN HYPOXIA; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG INHIBITION; ERYTHROCYTE; HIPPOCAMPUS; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; BIOTINYLATION; BRAIN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; FIBRINOLYTIC AGENTS; HYPERCAPNIA; HYPOTENSION; HYPOXIA-ISCHEMIA, BRAIN; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; SWINE; TISSUE PLASMINOGEN ACTIVATOR; VASODILATION;

EID: 68249122804     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.61     Document Type: Article

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