Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats

Journal of Cerebral Blood Flow and Metabolism

Volumn 19, Issue 12, 1999, Pages 1316-1321

  Meng, Wei ^a   Wang, Xiaoying ^a   Asahi, Minoru ^a   Kano, Tsuneo ^a,b   Asahi, Kazuko ^a   Ackerman, Robert H ^a   Lo, Eng H ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Cerebral ischemia; Excitotoxicity; Hemorrhage; Neuroprotection; Reperfusion injury; Thrombolysis

Indexed keywords

ALTEPLASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; BRAIN EMBOLISM; BRAIN ISCHEMIA; BRAIN PERFUSION; CONTROLLED STUDY; DRUG EFFECT; FIBRINOLYTIC THERAPY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STROKE;

EID: 0033375290     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199912000-00004     Document Type: Article

References (11)

1. Busch E, Kruger K, Allegrini PR, Kerskens CM, Gyngell ML, HoehnBerlage M, Hossmann K-A (1998) Reperfusion after thrombolytic therapy of embolie stroke in rats: magnetic resonance and biochemical imaging. J Cereb Blood Flow Metab 18:407-418
2. Chen ZL, Strickland S (1997) Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin. Cell 91:917-925
3. Choi DW, Rothman SM (1990) The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu Rev Neurosci 13:171-182
4. del Zoppo GJ (1994) Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev 6:47-96
5. Hamberg LM, Hunter GJ, Kierstad D, Lo EH, Gonzalez RG, Wolf GL (1996) Measurement of quantitative cerebral blood volume with subtraction 3D functional CT. AJNR 17:1861-1869
6. Hamman GF, Okada Y, del Zoppo GJ (1996) Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J Cereb Blood Flow Metab 16:1373-1378
7. Heo JH, Lucero J, Abumiya T, Koizol JA, Copeland BR, del Zoppo GJ (1999) Matrix metalloproteinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab 19:624-633
8. Jiang Q, Zhang RL, Zhang ZG, Ewing JR, Divine GW, Chopp M (1998) Diffusion, T2, and perfusion weighted MRI of middle cerebral artery embolie stroke and recombinant tissue plasminogen activator intervention in the rat. J Cereb Blood Flow Metab 18:758-767
9. Korninger C, Collen D (1981) Studies on specific fibrinolytic effect of human extrinsic plasminogen activator in human blood and in various animal species in vitro. Thromb Haemost 46:561-565
10. Kudo M, Aoyama A, Ichimori S, Fukunaga N (1982) An animal model of cerebral infarction: homologous blood clot emboli in rats. Stroke 13:505-510
11. Lin TN, Yong YH, Wa G, Khan M, Hsu CY (1993) Effect of brain edema on infarct volume in a focal ischemia model in rats. Stroke 24:117-121