Platelet-derived growth factor C deficiency in C57BL/6 mice leads to abnormal cerebral vascularization, loss of neuroependymal integrity, and ventricular abnormalities

American Journal of Pathology

Volumn 180, Issue 3, 2012, Pages 1136-1144

  Fredriksson, Linda ^a,b   Nilsson, Ingrid ^b   Su, Enming J ^a   Andrae, Johanna ^b   Ding, Hao ^c   Betsholtz, Christer ^b   Eriksson, Ulf ^b   Lawrence, Daniel A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PLATELET DERIVED GROWTH FACTOR C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MALFORMATION; BRAIN VENTRICLE; CEREBROVASCULAR MALFORMATION; EPENDYMA; LOSS OF NEUROEPENDYMAL INTEGRITY; MOUSE; NONHUMAN; PHENOTYPE; PLATELET DERIVED GROWTH FACTOR C DEFICIENCY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SEPTUM PELLUCIDUM; SMOOTH MUSCLE FIBER;

ANIMALS; CEREBRAL VENTRICLES; EPENDYMA; INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; LYMPHOKINES; MICE; MICE, INBRED C57BL; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA;

EID: 84857208625     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.12.006     Document Type: Article

References (36)

1. J. Andrae, R. Gallini, C. Betsholtz Role of platelet-derived growth factors in physiology and medicine Genes Dev 22 2008 1276 1312
2. X. Li, A. Pontn, K. Aase, L. Karlsson, A. Abramsson, M. Uutela, G. Bckstrm, M. Hellstrm, H. Bostrm, H. Li, P. Soriano, C. Betsholtz, C.H. Heldin, K. Alitalo, A. stman, U. Eriksson PDGF-C is a new protease-activated ligand for the PDGF α-receptor Nat Cell Biol 2 2000 302 309
3. L. Fredriksson, H. Li, C. Fieber, X. Li, U. Eriksson Tissue plasminogen activator is a potent activator of PDGF-CC EMBO J 23 2004 3793 3802
4. E.J. Su, L. Fredriksson, M. Geyer, E. Folestad, J. Cale, J. Andrae, Y. Gao, K. Pietras, K. Mann, M. Yepes, D.K. Strickland, C. Betsholtz, U. Eriksson, D.A. Lawrence Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke Nat Med 14 2008 731 737
5. P. Soriano The PDGF α receptor is required for neural crest cell development and for normal patterning of the somites Development 124 1997 2691 2700
6. H. Ding, X. Wu, H. Bostrm, I. Kim, N. Wong, B. Tsoi, M. O'Rourke, G.Y. Koh, P. Soriano, C. Betsholtz, T.C. Hart, M.L. Marazita, L.L. Field, P.P. Tam, A. Nagy A specific requirement for PDGF-C in palate formation and PDGFR-α signaling Nat Genet 36 2004 1111 1116
7. C. Betsholtz Insight into the physiological functions of PDGF through genetic studies in mice Cytokine Growth Factor Rev 15 2004 215 228
8. L.A. Lowery, H. Sive Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a 1 gene products Development 132 2005 2057 2067
9. T.G. Hamilton, R.A. Klinghoffer, P.D. Corrin, P. Soriano Evolutionary divergence of platelet-derived growth factor α receptor signaling mechanisms Mol Cell Biol 23 2003 4013 4025
10. H. Li, L. Fredriksson, X. Li, U. Eriksson PDGF-D is a potent transforming and angiogenic growth factor Oncogene 22 2003 1501 1510
11. E. di Tomaso, N. London, D. Fuja, J. Logie, J.A. Tyrrell, W. Kamoun, L.L. Munn, R.K. Jain PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment PLoS One 4 2009 e5123
12. K. Aase, A. Abramsson, L. Karlsson, C. Betsholtz, U. Eriksson Expression analysis of PDGF-C in adult and developing mouse tissues Mech Dev 110 2002 187 191
13. J.E. Bruni Ependymal development, proliferation, and functions: a review Microsc Res Tech 41 1998 2 13
14. C. Silva-Alvarez, M. Carrasco, C. Balmaceda-Aguilera, P. Pastor, L. Garcia Mde, K. Reinicke, L. Aguayo, B. Molina, M. Cifuentes, R. Medina, F. Nualart Ependymal cell differentiation and GLUT1 expression is a synchronous process in the ventricular wall Neurochem Res 30 2005 1227 1236
15. F. Doetsch, I. Caille, D.A. Lim, J.M. Garcia-Verdugo, A. Alvarez-Buylla Subventricular zone astrocytes are neural stem cells in the adult mammalian brain Cell 97 1999 703 716
16. E.L. Jackson, J.M. Garcia-Verdugo, S. Gil-Perotin, M. Roy, A. Quinones-Hinojosa, S. VandenBerg, A. Alvarez-Buylla PDGFR α-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling Neuron 51 2006 187 199
17. Z. Tang, P. Arjunan, C. Lee, Y. Li, A. Kumar, X. Hou, B. Wang, P. Wardega, F. Zhang, L. Dong, Y. Zhang, S.Z. Zhang, H. Ding, R.N. Fariss, K.G. Becker, J. Lennartsson, N. Nagai, Y. Cao, X. Li Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3β phosphorylation J Exp Med 207 2010 867 880
18. N.P. Pringle, H.S. Mudhar, E.J. Collarini, W.D. Richardson PDGF receptors in the rat CNS: during late neurogenesis, PDGF α-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage Development 115 1992 535 551
19. M. Fruttiger, L. Karlsson, A.C. Hall, A. Abramsson, A.R. Calver, H. Bostrom, K. Willetts, C.H. Bertold, J.K. Heath, C. Betsholtz, W.D. Richardson Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice Development 126 1999 457 467
20. L. Vignais, B. Nait Oumesmar, A.B. Baron-Van Evercooren PDGF-α receptor is expressed by mature neurones of the central nervous system Neuroreport 6 1995 1993 1996
21. A. Raine, L. Lee, Y. Yang, P. Colletti Neurodevelopmental marker for limbic maldevelopment in antisocial personality disorder and psychopathy Br J Psychiatry 197 2010 186 192
22. J.B. Bodensteiner, G.B. Schaefer Wide cavum septum pellucidum: a marker of disturbed brain development Pediatr Neurol 6 1990 391 394
23. M.J. Kim, I.K. Lyoo, S.R. Dager, S.D. Friedman, J. Chey, J. Hwang, Y.J. Lee, D.L. Dunner, P.F. Renshaw The occurrence of cavum septi pellucidi enlargement is increased in bipolar disorder patients Bipolar Disord 9 2007 274 280
24. P. Nopoulos, A. Krie, N.C. Andreasen Enlarged cavum septi pellucidi in patients with schizophrenia: clinical and cognitive correlates J Neuropsychiatry Clin Neurosci 12 2000 344 349
25. P. Nopoulos, S. Berg, D. VanDemark, L. Richman, J. Canady, N.C. Andreasen Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the lip and/or palate J Neuroimaging 11 2001 418 424
26. A. Jugessur, M. Shi, H.K. Gjessing, R.T. Lie, A.J. Wilcox, C.R. Weinberg, K. Christensen, A.L. Boyles, S. Daack-Hirsch, T.N. Trung, C. Bille, A.C. Lidral, J.C. Murray Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia PLoS One 4 2009 e5385
27. S.J. Choi, M.L. Marazita, P.S. Hart, P.P. Sulima, L.L. Field, T.G. McHenry, M. Govil, M.E. Cooper, A. Letra, R. Menezes, S. Narayanan, M.A. Mansilla, J.M. Granjeiro, A.R. Vieira, A.C. Lidral, J.C. Murray, T.C. Hart The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P Eur J Hum Genet 17 2009 774 784
28. M.R. Del Bigio The ependyma: a protective barrier between brain and cerebrospinal fluid Glia 14 1995 1 13
29. N. Spassky, F.T. Merkle, N. Flames, A.D. Tramontin, J.M. Garcia-Verdugo, A. Alvarez-Buylla Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis J Neurosci 25 2005 10 18
30. F.T. Merkle, A.D. Tramontin, J.M. Garcia-Verdugo, A. Alvarez-Buylla Radial glia give rise to adult neural stem cells in the subventricular zone Proc Natl Acad Sci U S A 101 2004 17528 17532
31. J. Andrae, I. Hansson, G.B. Afink, M. Nister Platelet-derived growth factor receptor-α in ventricular zone cells and in developing neurons Mol Cell Neurosci 17 2001 1001 1013
32. M.R. Del Bigio Ependymal cells: biology and pathology Acta Neuropathol 119 2010 55 73
33. R.J. Ferland, L.F. Batiz, J. Neal, G. Lian, E. Bundock, J. Lu, Y.-C. Hsiao, R. Diamond, D. Mei, A.H. Banham, P.J. Brown, C.R. Vanderburg, J. Joseph, J.L. Hecht, R. Folkerth, R. Guerrini, C.A. Walsh, E.M. Rodriguez, V.L. Sheen Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia Hum Mol Genet 18 2009 497 516
34. J. Lu, V. Sheen Periventricular heterotopia Epilepsy Behav 7 2005 143 149
35. A.M. Lavezzi, M.F. Corna, L. Matturri Ependymal alterations in sudden intrauterine unexplained death and sudden infant death syndrome: possible primary consequence of prenatal exposure to cigarette smoking Neural Dev 5 2010 17
36. Q. Ma, B. Huang, N. Khatibi, W. Rolland II, H. Suzuki, J. Zhang, J. Tang PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage Ann Neurol 70 2011 920 931