Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis

Experimental Neurology

Volumn 200, Issue 1, 2006, Pages 38-49

  Kelly, Melissa A ^a   Shuaib, Ashfaq ^a   Todd, Kathryn G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

BBB breakdown; Focal cerebral ischemia; MMP; tPA

Indexed keywords

FIBRONECTIN; GELATIN; GELATINASE A; GELATINASE B; LAMININ; MATRIX METALLOPROTEINASE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; ZYMOGRAPHY;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; ENZYME ACTIVATION; MALE; MATRIX METALLOPROTEINASES; RATS; RATS, SPRAGUE-DAWLEY; THROMBOLYTIC THERAPY; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33746080351     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.01.032     Document Type: Article

References (27)

1. Aoki S., Mori T., Wang X., and Lo E. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury. Stroke 33 (2002) 2711-2717
2. Asahi A., Jung J.C., del Zoppo G.J., Fini M.E., and Lo E. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J. Cereb. Blood Flow Metab. 20 (2000) 1681-1689
3. Bederson J.B., et al. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17 6 (1986) 1304-1308
4. Benchenane K., et al. Equivocal roles of tissue-type plasminogen activator in stroke-induced injury. Trends Neurosci. 27 3 (2004) 155-160
5. Calingasan B., Rex, Sheu, and Gibson. Blood-brain barrier abnormalities in vulnerable brain regions during thiamine deficiency. Exp. Neurol. 134 (1995) 64-72
6. Gasche Y., et al. Early appearance of activated matrix metalloproteinase-9 after focal cerebral ischemia in mice: a possible role in blood-brain barrier dysfunction. J. Cereb. Blood Flow Metab. 19 9 (1999) 1020-1028
7. Gasche C., Sugawara, Fujimura, and Chan. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood brain barrier disruption after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 21 (2001) 1393-1400
8. Gasche Y., et al. Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 21 12 (2001) 1393-1400
9. Gautier P., Gele P., Laprais M., Bastide M., Bauters A., Deplanque D., Jude B., Caron J., and Bordet R. Involvement of thrombolysis in recombinant tissue plasminogen activator-induced cerebral hemorrhages and effect on infarct volume and postischemic endothelial function. Stroke 34 (2003) 2975-2979
10. Graham G.D. Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data. Stroke 34 (2003) 2487-2850
11. Heo L., Abumiya T., Koziol J.A., Copeland B.R., and del Zoppo G.J. Matrix metalloproteinase increase very early during experimental focal cerebral ischemia. J. Cereb. Blood Flow Metab. 19 6 (1999) 624-633
12. Kahles T., et al. Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent. Vasc. Pharmacol. 43 4 (2005) 254-259
13. Krueger K., and Busch E. Protocol of a thromboembolic stroke model in the rat: review of the experimental procedure and comparison of models. Invest. Radiol. 37 11 (2002) 600-608
14. Lijnen H.R., et al. Characterization of the murine plasma fibrinolytic system. Eur. J. Biochem. 224 3 (1994) 863-871
15. Paxinos G., and Watson C. In: Paxinos G., and Watson C. (Eds). The Rat Brain in Stereotaxic Coordinates. 4th ed. (1998), Academic Press
16. Pfefferkorn T., and Rosenberg G.A. Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 34 8 (2003) 2025-2030
17. Romanic A.M., and Madri J.A. Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol. 4 2 (1994) 145-156
18. Sumii L. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal cerebral ischemia in rats. Stroke 33 (2002) 831-836
19. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., and Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 10 (1990) 290-293
20. Todd K.G., and Butterworth R.F. Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis. Glia 25 2 (1999) 190-198
21. Tsuji K., et al. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke 36 9 (2005) 1954-1959
22. Tureyen K., et al. Infarct volume quantification in mouse focal cerebral ischemia: a comparison of triphenyltetrazolium chloride and cresyl violet staining techniques. J. Neurosci. Methods 139 2 (2004) 203-207
23. Vivien D., and Buisson A. Serine protease inhibitors: novel therapeutic targets for stroke?. J. Cereb. Blood Flow Metab. 20 5 (2000) 755-764
24. Wang C.X., et al. A focal embolic model of cerebral ischemia in rats: introduction and evaluation. Brain Res. Brain Res. Protoc. 7 2 (2001) 115-120
25. Wang X., et al. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat. Med. 9 10 (2003) 1313-1317
26. Yepes S., Moore E.G., Bugge T.H., Strickland D.K., and Lawrence D.K. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest. 112 (2003) 1533-1540
27. Zhang R.L., et al. Early (1 h) administration of tissue plasminogen activator reduces infarct volume without increasing hemorrhagic transformation after focal cerebral embolization in rats. J. Neurol. Sci. 160 1 (1998) 1-8