Potential impact of probiotic consumption on the bioactivity of dietary phytochemicals

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 40, 2013, Pages 9551-9558

  Rossi, Maddalena ^a   Amaretti, Alberto ^a   Leonardi, Alan ^a   Raimondi, Stefano ^a   Simone, Marta ^a   Quartieri, Andrea ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Bifidobacterium; isoflavones; Lactobacillus; lignans; microbiota; phytochemicals; probiotics

Indexed keywords

BIFIDOBACTERIUM; ISOFLAVONES; LACTOBACILLUS; LIGNANS; MICROBIOTAS; PHYTOCHEMICALS; PROBIOTICS;

BACTERIA; FLAVONOIDS;

HYDROLASES;

BETA GLUCOSIDASE; ISOFLAVONE DERIVATIVE; LIGNAN; PLANT MEDICINAL PRODUCT; PROBIOTIC AGENT;

ANIMAL; BIFIDOBACTERIUM; BLOOD; GASTROINTESTINAL TRACT; HUMAN; LACTOBACILLUS; METABOLISM; MICROBIOLOGY; MICROFLORA; REVIEW; URINE;

ANIMALS; BETA-GLUCOSIDASE; BIFIDOBACTERIUM; GASTROINTESTINAL TRACT; HUMANS; ISOFLAVONES; LACTOBACILLUS; LIGNANS; MICROBIOTA; PHYTOCHEMICALS; PROBIOTICS;

EID: 84885460423     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf402722m     Document Type: Review

References (104)

1. Kris-Etherton, P. M.; Hecker, K. D.; Bonanome, A.; Coval, S. M.; Binkoski, A. E.; Hilpert, K. F.; Griel, A. E.; Etherton, T. D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer Am. J. Med. 2002, 113, 71S-88S (Pubitemid 36151834)
2. Cederroth, C. R.; Nef, S. Soy, phytoestrogens and metabolism: a review Mol. Cell. Endocrinol. 2009, 304, 30-42
3. Crozier, A.; Jaganath, I. B.; Clifford, M. N. Dietary phenolics: chemistry, bioavailability and effects on health Nat. Prod. Rep. 2009, 26, 1001-1043
4. Scalbert, A.; Williamson, G. Dietary intake and bioavailability of polyphenols J. Nutr. 2000, 130, 2073S-2085S (Pubitemid 30619386)
5. Manach, C.; Scalbert, A.; Morand, C.; Rémésy, C.; Jiménez, L. Polyphenols: food sources and bioavailability Am. J. Clin. Nutr. 2004, 79, 727-747 (Pubitemid 41103873)
6. Aura, A. M. Microbial metabolism of dietary phenolic compounds in the colon Phytochem. Rev. 2008, 7, 407-429
7. Selma, M. V.; Espín, J. C.; Tomás-Barberán, F. A. Interaction between phenolics and gut microbiota: role in human health J. Agric. Food Chem. 2009, 57, 6485-6501
8. Clavel, T.; Borrmann, D.; Braune, A.; Doré, J.; Blaut, M. Occurrence and activity of human intestinal bacteria involved in the conversion of dietary lignans Anaerobe 2006, 12, 140-147 (Pubitemid 43831679)
9. Clavel, T.; Henderson, G.; Engst, W.; Doré, J.; Blaut, M. Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside FEMS Microbiol. Ecol. 2006, 55, 471-478
10. Tsangalis, D.; Wilcox, G.; Shah, N. P.; McGill, A. E.; Stojanovska, L. Urinary excretion of equol by postmenopausal women consuming soymilk fermented by probiotic bifidobacteria Eur. J. Clin. Nutr. 2007, 61, 438-441 (Pubitemid 46358787)
11. Wang, X. L.; Kim, H. J.; Kang, S. I.; Kim, S. I.; Hur, H. G. Production of phytestrogen S -equol from daidzein in mixed colture of two anaerobic bacteria Arch. Microbiol. 2007, 187, 155-160
12. Zhang, L.; Zuo, Z.; Lin, G. Intestinal and hepatic glucuronidation of flavonoids Mol. Pharmaceutics 2007, 4, 833-845
13. Xu, X.; Harris, K. S.; Wang, H. J.; Murphy, P. A.; Hendrich, S. Bioavalability of soybean isoflavones depends upon gut microflora in women J. Nutr. 1995, 125, 2307-2315
14. Zhang, Y.; Wang, G.; Song, T. T.; Murphy, P. A.; Hendrich, S. Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone J. Nutr. 1999, 129, 957-962
15. Hur, H. G.; Beger, R. D.; Heinze, T. M.; Lay, J. O., Jr.; Freeman, J. P.; Dore, J.; Rafii, F. Isolation of an anaerobic intestinal bacterium capable of cleaving the C-ring of the isoflavonoid daidzein Arch. Microbiol. 2002, 178, 8-12 (Pubitemid 34639509)
16. Tomas-Barberan, F.; García-Villaba, R.; Quartieri, A.; Raimondi, S.; Amaretti, A.; Leonardi, A.; Rossi, M. In vitro transformation of chlorogenic acid by human gut microbiota. Mol. Nutr. Food Res. 2013.
17. Eckburg, P. B.; Bik, E. M.; Bernstein, C. N.; Purdom, E.; Dethlefsen, L.; Sargent, M.; Gill, S. R.; Nelson, K. E.; Relman, D. A. Diversity of the human intestinal microbial flora Science 2005, 308, 1635-1638 (Pubitemid 40807514)
18. O'Keefe, S. J. Nutrition and colonic health: the critical role of the microbiota Curr. Opin. Gastroenterol. 2008, 24, 51-58 (Pubitemid 350190898)
19. Hamer, H. M.; De Preter, V.; Windey, K.; Verbeke, K. Functional analysis of colonic bacterial metabolism: relevant to health? Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 302, G1-G9
20. Leser, T. D.; Mølbak, L. Better living through microbial action: the benefits of the mammalian gastrointestinal microbiota on the host Environ. Microbiol. 2009, 11, 2194-2206
21. O'Keefe, S. J.; Ou, J.; Aufreiter, S.; O'Connor, D.; Sharma, S.; Sepulveda, J.; Fukuwatari, T.; Shibata, K.; Mawhinney, T. Products of the colonic microbiota mediate the effects of diet on colon cancer risk J. Nutr. 2009, 139, 2044-2048
22. FAO/WHO working group. Evaluation of Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria; report of a joint FAO/WHO expert consultation; Rome, Italy, 2001; pp 1-34.
23. Schrezenmeir, J.; de Vrese, M. Probiotics, prebiotics, and synbiotics: approaching a definition Am. J. Clin. Nutr. 2001, 73, 361S-364S (Pubitemid 32113256)
24. De Vrese, M.; Schrezenmeir, J. Probiotics, prebiotics, and synbiotics Adv. Biochem. Eng. Biotechnol. 2008, 111, 1-66
25. Biavati, B.; Mattarelli, P. The family Bifidobacteriaceae. In The Prokaryotes, 3 rd ed.; Dworkin, M.; Falkow, S.; Rosenberg, E.; Schleifer, K. H.; Stackebrandt, E., Eds.; Springer: New York, 2006; Vol. 3, Chapter 3, pp 322-382.
26. Rossi, M.; Amaretti, A. Probiotic properties of bifidobacteria. In Bifidobacteria: Genomics and Molecular Aspects; van Synderen, D.; Mayo, B., Eds.; Horizon Scientific Press: Rowan House, UK, 2010; pp 97-123.
27. Collado, M. C.; Jalonen, L.; Meriluoto, J.; Salminen, S. Protection mechanism of probiotic combination against human pathogens: in vitro adhesion to human intestinal mucus Asia Pac. J. Clin. Nutr. 2006, 15, 570-575 (Pubitemid 44905139)
28. Howarth, G. S.; Wang, H. Role of endogenous microbiota, probiotics and their biological products in human health Nutrients 2013, 10, 58-81
29. Round, J. L.; Mazmanian, S. K. The gut microbiota shapes intestinal immune responses during health and disease Nat. Rev. Immunol. 2009, 9, 313-323
30. Pompei, A.; Cordisco, L.; Amaretti, A.; Zanoni, S.; Raimondi, S.; Matteuzzi, D.; Rossi, M. Administration of folate-producing bifidobacteria enhances folate status in Wistar rats J. Nutr. 2007, 137, 2742-2746 (Pubitemid 350255307)
31. Makarova, K. S.; Koonin, E. V. Evolutionary genomics of lactic acid bacteria J. Bacteriol. 2007, 189, 1199-1208 (Pubitemid 46239741)
32. Kinová Sepová, H.; Bilková, A.; Bukovský, M. Lactobacilli and their probiotic properties Ceska Slov. Farm. 2008, 57, 95-98 (Pubitemid 351651883)
33. Turpin, W.; Humblot, C.; Thomas, M.; Guyot, J. P. Lactobacilli as multifaceted probiotics with poorly disclosed molecular mechanisms Int. J. Food Microbiol. 2010, 143, 87-102
34. Williams, N. T. Probiotics Am. J. Health Syst. Pharm. 2010, 67, 449-458
35. Sanders, M. E.; Guarner, F.; Guerrant, R.; Holt, P. R.; Quigley, E. M.; Sartor, R. B.; Sherman, P. M.; Mayer, E. A. An update on the use and investigation of probiotics in health and disease Gut 2013, 62, 787-796
36. Mach, T. Clinical usefulness of probiotics in inflammatory bowel diseases J. Physiol. Pharmacol. 2006, 57, S23-S33
37. Vanderhoof, J. A. Probiotics in allergy management J. Pediatr. Gastroenterol. Nutr. 2008, 47, S38-S40
38. Amaretti, A.; di Nunzio, M.; Pompei, A.; Raimondi, S.; Rossi, M.; Bordoni, A. Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities Appl. Microbiol. Biotechnol. 2013, 97, 809-817
39. Jones, M. L.; Tomaro-Duchesneau, C.; Martoni, C. J.; Prakash, S. Cholesterol lowering with bile salt hydrolase-active probiotic bacteria, mechanism of action, clinical evidence, and future direction for heart health applications Expert Opin. Biol. Ther. 2013, 13, 631-642
40. Setchell, K. D. R.; Brown, N. B.; Zimmer-Nechemias, L.; Brashear, W. T.; Wolfe, B.; Kirscher, A. S.; Heubi, J. E. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability Am. J. Clin. Nutr. 2002, 76, 447-453 (Pubitemid 34804071)
41. Tsangalis, D.; Wilcox, G.; Shah, N. P.; Stojanovska, L. Bioavailability of isoflavone phytoestrogens in postmenopausal women consuming soya milk fermented with probiotic bifidobacteria Br. J. Nutr. 2005, 93, 867-877 (Pubitemid 43899565)
42. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Rémésy, C. Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies Am. J. Clin. Nutr. 2005, 81, 230S-242S
43. Wiseman, H. The bioavailability of non-nutrient plant factors: dietary flavonoids and phyto-oestrogens Proc. Nutr. Soc. 1999, 58, 139-146 (Pubitemid 29225558)
44. Murota, K.; Shimizu, S.; Miyamoto, S.; Izumi, T.; Obata, A.; Kikuchi, M.; Terao, J. Unique uptake and transport of isoflavone aglycones by human intestinal Caco-2 cells: comparison of isoflavonoids and flavonoids J. Nutr. 2002, 132, 1956-1961 (Pubitemid 34742884)
45. Izumi, T.; Piskula, M.; Osawa, S.; Obata, A.; Tobe, K.; Saito, M. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans J. Nutr. 2000, 130, 1695-1699 (Pubitemid 30451055)
46. Walle, T.; Browning, A. M.; Steed, L. L.; Reed, S. G.; Walle, U. K. Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans J. Nutr. 2005, 135, 48-52 (Pubitemid 40094319)
47. Hollman, P. C. H.; Devries, J. H. M.; Vanleeuwen, S. D.; Menglers, M. J. B.; Katan, M. B. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers Am. J. Clin. Nutr. 1995, 62, 1276-1282
48. Rossi, M.; Amaretti, A.; Roncaglia, L.; Leonardi, A.; Raimondi, S. Dietary isoflavones and intestinal microbiota: metabolism and transformation into bioactive compounds. In Isoflavones: Biosynthesis, Occurrence and Health Effects; Thomson, M. J., Ed.; Nova Science Publishers: Hauppauge, NY, 2010; pp 137-161.
49. Smeds, A. I.; Eklund, P. C.; Sjöholm, R. E.; Willför, S. M.; Nishibe, S.; Deyama, T.; Holmbom, B. R. Quantification of a broad spectrum of lignans in cereals, oilseeds, and nuts J. Agric. Food Chem. 2007, 55, 1337-1346
50. Ford, J. D.; Huang, K. S.; Wang, H. B.; Davin, L. B.; Lewis, N. G. Biosynthetic pathway to the cancer chemopreventive secoisolariciresinoldiglucoside-hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed J. Nat. Prod. 2001, 64, 1388-1397 (Pubitemid 33116678)
51. Yuan, J. P.; Li, X.; Xu, S. P.; Wang, J. H.; Liu, X. Hydrolysis kinetics of secoisolariciresinol diglucoside oligomers from flaxseed J. Agric. Food Chem. 2008, 56, 10041-10047
52. Rowland, I.; Faughnan, M.; Honey, L.; Wähälä, K.; Williamson, G.; Cassidy, A. Bioavailability of phyto-oestrogens Br. J. Nutr. 2003, 89, S45-S58
53. Adlercreutz, H. Lignans and human health Crit. Rev. Clin. Lab. 2007, 44, 483-525 (Pubitemid 47619399)
54. El-Seedi, H. R.; El-Said, A. M.; Khalifa, S. A.; Göransson, U.; Bohlin, L.; Borg-Karlson, A. K.; Verpoorte, R. Biosynthesis, natural sources, dietary intake, pharmacokinetic properties, and biological activities of hydroxycinnamic acids J. Agric. Food Chem. 2012, 60, 10877-10895
55. Setchell, K.; Brown, N.; Desai, P.; Zimmer-Nechemias, L.; Wolfe, B.; Brashear, W. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements J. Nutr. 2001, 131, 1362S-1375S (Pubitemid 32268489)
56. Steer, T.; Johnson, I.; Gee, J.; Gibson, G. Metabolism of the soyabean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebiotics Br. J. Nutr. 2003, 90, 635-642 (Pubitemid 37168363)
57. Larkin, T. A.; Price, W. E.; Astheimer, L. B. Increased probiotic yogurt or resistant starch intake does not affect isoflavone bioavailability in subjects consuming a high soy diet Nutrition 2007, 23, 709-718 (Pubitemid 47409961)
58. Tsangalis, D.; Ashton, J. F.; McGill, A. E. J.; Shah, N. P. Enzymatic transformation of isoflavone phytoestrogens in soymilk by β-glucosidase- producing bifidobacteria J. Food Sci. 2002, 67, 3104-3113 (Pubitemid 35376196)
59. Marotti, I.; Bonetti, A.; Biavati, B.; Catizone, P.; Dinelli, G. Biotransformation of common bean (Phaseolus vulgaris L.) flavonoid glycosides by Bifidobacterium species from human intestinal origin J. Agric. Food Chem. 2007, 55, 3913-3919 (Pubitemid 46867396)
60. Dabek, M.; McCrae, S. I.; Stevens, V. J.; Duncan, S. H.; Louis, P. Distribution of β-glucosidase and β-glucuronidase activity and of β-glucuronidase gene gus in human colonic bacteria FEMS Microbiol. Ecol. 2008, 66, 487-495
61. Raimondi, S.; Roncaglia, L.; De Lucia, M.; Amaretti, A.; Leonardi, A.; Pagnoni, U. M.; Rossi, M. Bioconversion of soy isoflavones daidzin and daidzein by Bifidobacterium strains Appl. Microbiol. Biotechnol. 2009, 81, 943-950
62. Roncaglia, L.; Amaretti, A.; Raimondi, S.; Leonardi, A.; Rossi, M. Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside Appl. Microbiol. Biotechnol. 2011, 92, 159-168
63. Turner, N.; Thomson, B.; Shaw, I. Bioactive isoflavones in functional foods: the importance of gut microflora on bioavailability Nutr. Rev. 2003, 61, 204-213 (Pubitemid 37259938)
64. Chien, H. L.; Huang, H. Y.; Chou, C. C. Transformation of isoflavone phytoestrogens during the fermentation of soymilk with lactic acid bacteria and bifidobacteria Food Microbiol. 2006, 23, 772-778
65. Otieno, D. O.; Shah, N. P. A comparison of changes in the transformation of isoflavones in soymilk using varying concentrations of exogenous and probiotic-derived endogenous β-glucosidases J. Appl. Microbiol. 2007, 103, 601-612 (Pubitemid 47256323)
66. Otieno, D. O.; Shah, N. P. Endogenous beta-glucosidase and beta-galactosidase activities from selected probiotic micro-organisms and their role in isoflavone biotransformation in soymilk J. Appl. Microbiol. 2007, 103, 910-917 (Pubitemid 47493271)
67. Pham, T. T.; Shah, N. P. Biotransformation of isoflavone glycosides by Bifidobacterium animalis in soymilk supplemented with skim milk powder J. Food Sci. 2007, 72, 316-324
68. Wei, Q. K.; Chen, T. R.; Chen, J. T. Using of Lactobacillus and Bifidobacterium to product the isoflavone aglycones in fermented soymilk Int. J. Food Microbiol. 2007, 117, 120-124
69. Iqbal, M. F.; Zhu, W. Y. Characterization of newly isolated Lactobacillus delbrueckii -like strain MF-07 isolated from chicken and its role in isoflavone biotransformation FEMS Microbiol. Lett. 2009, 291, 180-187
70. Otieno, D. O.; Ashton, J. F.; Shah, N. P. Isoflavone phytoestrogen degradation in fermented soymilk with selected β-glucosidase producing L. acidophilus strains during storage at different temperatures Int. J. Food Microbiol. 2007, 115, 79-88 (Pubitemid 46350888)
71. Chun, J.; Kim, G. M.; Lee, K. W.; Choi, I. D.; Kwon, G. H.; Park, J. Y.; Jeong, S. J.; Kim, J. S.; Kim, J. H. Conversion of isoflavone glucosides to aglycones in soymilk by fermentation with lactic acid bacteria J. Food Sci. 2007, 72, 39-44
72. Beekwilder, J.; Marcozzi, D.; Vecchi, S.; de Vos, R.; Janssen, P.; Francke, C.; van Hylckama Vlieg, J.; Hall, R. D. Characterization of rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus Appl. Environ. Microbiol. 2009, 75, 3447-3454
73. Avila, M.; Jaquet, M.; Moine, D.; Requena, T.; Peláez, C.; Arigoni, F.; Jankovic, I. Physiological and biochemical characterization of the two α- l -rhamnosidases of Lactobacillus plantarum NCC245 Microbiology 2009, 155, 2739-2749
74. Bae, E. A.; Han, M. J.; Choo, M. K.; Park, S. Y.; Kim, D. H. Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities Biol. Pharm. Bull. 2002, 25, 58-63
75. Bae, E. A.; Han, M. J.; Kim, E. J.; Kim, D. H. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants Arch. Pharm. Res. 2004, 27, 61-67
76. Bae, E. A.; Park, S. Y.; Kim, D. H. Constitutive β-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria Biol. Pharm. Bull. 2000, 23, 1481-1485
77. Shin, H. Y.; Lee, J. H.; Lee, J. Y.; Han, Y. O.; Han, M. J.; Kim, D. H. Purification and characterization of ginsenoside Ra-hydrolyzing β- d -xylosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium Biol. Pharm. Bull. 2003, 26, 1170-1173 (Pubitemid 40012584)
78. Dupas, C.; Marsset Baglieri, A.; Ordonaud, C.; Tomé, D.; Maillard, M. N. Chlorogenic acid is poorly absorbed, independently of the food matrix: a Caco-2 cells and rat chronic absorption study Mol. Nutr. Food Res. 2006, 50, 1053-1060 (Pubitemid 44861501)
79. Lafay, S.; Morand, C.; Manach, C.; Besson, C.; Scalbert, A. Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats Br. J. Nutr. 2006, 96, 39-46 (Pubitemid 44160894)
80. Erk, T.; Williamson, G.; Renouf, M.; Marmet, C. Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists Mol. Nutr. Food Res. 2012, 56, 1488-1500
81. Williamson, G.; Dionisi, F.; Renouf, M. Flavanols from green tea and phenolic acids from coffee: critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages Mol. Nutr. Food Res. 2011, 55, 864-873
82. Bel-Rhlid, R.; Thapa, D.; Kraehenbuehl, K.; Hansen, C. E.; Fischer, L. Biotransformation of caffeoyl-quinic acids from green coffee extracts by Lactobacillus johnsonii NCC 533 AMB Express. 2013, 21, 28
83. Couteau, D.; McCartney, A. L.; Gibson, G. R.; Williamson, G.; Faulds, C. B. Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid J. Appl. Microbiol. 2001, 90, 873-881 (Pubitemid 32500234)
84. Barnes, S.; Kim, H. Cautions and research needs identified at the equol, soy, and menopause research leadership conference J. Nutr. 2010, 140, 1390S-1394S
85. McCue, P.; Shetty, K. Health benefits of soy isoflavonoids and strategies for enhancement: a review Crit. Rev. Food Sci. Nutr. 2004, 44, 361-367 (Pubitemid 39357993)
86. Lichtenstein, A. H. Soy protein, isoflavones and cardiovascular disease risk J. Nutr. 1998, 128, 1589-1592 (Pubitemid 28452838)
87. Ioku, K.; Pongpiriyadacha, Y.; Konishi, Y.; Takei, Y.; Nakatani, N.; Terao, J. β-Glucosidase activity in the rat small intestine toward quercetin monoglucosides Biosci., Biotechnol., Biochem. 1998, 62, 1428-1431 (Pubitemid 128473391)
88. McMahon, L. G.; Nakano, H.; Levy, M. D.; Gregory, J. F., 3rd. Cytosolic pyridoxine β- d -glucoside hydrolase from porcine jejunal mucosa. Purification, properties and comparison with broad specificity β-glucosidase J. Biol. Chem. 1997, 272, 32025-32033 (Pubitemid 28011870)
89. Yuan, J. P.; Wang, J. H.; Liu, X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora-implications for health Mol. Nutr. Food Res. 2007, 51, 765-781 (Pubitemid 47173687)
90. Jin, J. S.; Nishihata, T.; Kakiuchi, N.; Hattori, M. Biotransformation of C -glucosylisoflavone puerarin to estrogenic (3 S)-equol in co-culture of two human intestinal bacteria Biol. Pharm. Bull. 2008, 31, 1621-1625
91. Yokoyama, S. I.; Suzuki, T. Isolation and characterization of novel equol-producing bacterium from human feces Biosci., Biotechnol., Biochem. 2008, 72, 2660-2666
92. Matthies, A.; Blaut, M.; Braune, A. Isolation of a human intestinal bacterium capable of daidzein and genistein conversion Appl. Environ. Microbiol. 2009, 75, 1740-1744
93. Minamida, K.; Tanaka, M.; Abe, A.; Sone, T.; Tomita, F.; Hara, H.; Asano, K. Production of equol from daidzein by Gram-positive rod-shaped bacterium isolated from rat intestine J. Biosci. Bioeng. 2006, 102, 247-250 (Pubitemid 44537867)
94. Minamida, K.; Ota, K.; Nishimukai, M.; Tanaka, M.; Abe, A.; Sone, T.; Tomita, F.; Hara, H.; Asano, K. Asaccharobacter celatus gen. nov., sp. nov., isolated from rat caecum Int. J. Syst. Evol. Microbiol. 2008, 58, 1238-1240
95. Maruo, T.; Sakamoto, M.; Ito, C.; Toda, T.; Benno, Y. Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the the genus Eggerthella Int. J. Syst. Evol. Microbiol. 2008, 58, 1221-1227
96. Matthies, A.; Clavel, T.; Gütschow, M.; Engst, W.; Haller, D.; Blaut, M.; Braune, A. Conversion of daidzein and genistein by a newly isolated anaerobic bacterium from mouse intestine Appl. Environ. Microbiol. 2008, 74, 4847-4852
97. Clavel, T.; Lippman, R.; Gavini, F.; Doré, J.; Blaut, M. Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside Syst. Appl. Microbiol. 2007, 30, 16-26 (Pubitemid 44969475)
98. Woting, A.; Clavel, T.; Loh, G.; Blaut, M. Bacterial transformation of dietary lignans in gnotobiotic rats FEMS Microbiol. Ecol. 2010, 72, 507-514
99. Marteau, P.; Pochart, P.; Flourie, B.; Pellier, P.; Santos, L.; Desjeux, J. F.; Rambaud, J. C. Effect of chronic ingestion of a fermented dairy product containing Lactobacillus acidophilus and Bifidobacterium bifidum on metabolic activities of the colonic flora in humans Am. J. Clin. Nutr. 1990, 52, 685-688
100. Nettleton, J. A.; Greany, K. A.; Thomas, W.; Wangen, K. E.; Adlercreutz, H.; Kurzer, M. S. The effect of soy consumption on the urinary 2:16-hydroxyestrone ratio in postmenopausal women depends on equol production status but is not influenced by probiotic consumption J. Nutr. 2005, 135, 603-608 (Pubitemid 40365225)
101. Cohen, L. A.; Crespin, J. S.; Wolper, C.; Zang, E. A.; Pittman, B.; Zhao, Z.; Holt, P. R. Soy isoflavone intake and estrogen excretion patterns in young women: effect of probiotic administration In Vivo 2007, 21, 507-512 (Pubitemid 46901410)
102. Kekkonen, R. A.; Holma, R.; Hatakka, K.; Suomalainen, T.; Poussa, T.; Adlercreutz, H.; Korpela, R. A probiotic mixture including galactooligosaccharides decreases fecal β-glucosidase activity but does not affect serum enterolactone concentration in men during a two-week intervention J. Nutr. 2011, 141, 870-876
103. Lahtinen, S.; Saarinen, N. M.; Ammala, J.; Makela, S. I.; Salminen, S.; Ouwehand, A. C. Interactions between lignans and probiotics Microb. Ecol. Health Dis. 2002, 14, 106-109 (Pubitemid 34832424)
104. Rowland, I. R.; Mallett, A. K.; Wise, A. The effect of diet on the mammalian gut flora and its metabolic activities Crit. Rev. Toxicol. 1985, 16, 31-103