-
1
-
-
0016261856
-
Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study
-
Vaughan DW, Peters A, (1974) Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study. J Neurocytol 3: 405-429.
-
(1974)
J Neurocytol
, vol.3
, pp. 405-429
-
-
Vaughan, D.W.1
Peters, A.2
-
2
-
-
0034652416
-
Brain-immune connection: immuno-regulatory properties of CNS-resident cells
-
Becher B, Prat A, Antel JP, (2000) Brain-immune connection: immuno-regulatory properties of CNS-resident cells. Glia 29: 293-304.
-
(2000)
Glia
, vol.29
, pp. 293-304
-
-
Becher, B.1
Prat, A.2
Antel, J.P.3
-
3
-
-
0035152836
-
Immune function of microglia
-
Aloisi F, (2001) Immune function of microglia. Glia 36: 165-179.
-
(2001)
Glia
, vol.36
, pp. 165-179
-
-
Aloisi, F.1
-
4
-
-
34247637676
-
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis
-
Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, et al. (2007) UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446: 1091-1095.
-
(2007)
Nature
, vol.446
, pp. 1091-1095
-
-
Koizumi, S.1
Shigemoto-Mogami, Y.2
Nasu-Tada, K.3
Shinozaki, Y.4
Ohsawa, K.5
-
5
-
-
84880185810
-
Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years
-
McGeer PL, Rogers J, McGeer EG, (2006) Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J Alzheimers Dis 9: 271-276.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 271-276
-
-
McGeer, P.L.1
Rogers, J.2
McGeer, E.G.3
-
6
-
-
33748447845
-
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
-
Kim YS, Joh TH, (2006) Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp Mol Med 38: 333-347.
-
(2006)
Exp Mol Med
, vol.38
, pp. 333-347
-
-
Kim, Y.S.1
Joh, T.H.2
-
7
-
-
0021077610
-
Senile dementia of the Alzheimer type
-
Terry RD, Katzman R, (1983) Senile dementia of the Alzheimer type. Ann Neurol 14: 497-506.
-
(1983)
Ann Neurol
, vol.14
, pp. 497-506
-
-
Terry, R.D.1
Katzman, R.2
-
8
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, et al. (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83: 4913-4917.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
-
9
-
-
33748471099
-
Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
-
Wyss-Coray T, (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12: 1005-1015.
-
(2006)
Nat Med
, vol.12
, pp. 1005-1015
-
-
Wyss-Coray, T.1
-
10
-
-
0028953529
-
Activation of microglial cells by beta-amyloid protein and interferon-gamma
-
Meda L, Cassatella MA, Szendrei GI, Otvos LJ, Baron P, et al. (1995) Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 374: 647-650.
-
(1995)
Nature
, vol.374
, pp. 647-650
-
-
Meda, L.1
Cassatella, M.A.2
Szendrei, G.I.3
Otvos, L.J.4
Baron, P.5
-
11
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E, (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82: 239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
12
-
-
0026512066
-
Identification of normal and pathological aging in prospectively studied nondemented elderly humans
-
Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, et al. (1992) Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 13: 179-189.
-
(1992)
Neurobiol Aging
, vol.13
, pp. 179-189
-
-
Dickson, D.W.1
Crystal, H.A.2
Mattiace, L.A.3
Masur, D.M.4
Blau, A.D.5
-
13
-
-
0036224457
-
Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study
-
Riley KP, Snowdon DA, Markesbery WR, (2002) Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 51: 567-577.
-
(2002)
Ann Neurol
, vol.51
, pp. 567-577
-
-
Riley, K.P.1
Snowdon, D.A.2
Markesbery, W.R.3
-
14
-
-
0033394155
-
Memory and mental status correlates of modified Braak staging
-
Grober E, Dickson D, Sliwinski MJ, Buschke H, Katz M, et al. (1999) Memory and mental status correlates of modified Braak staging. Neurobiol Aging 20: 573-579.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 573-579
-
-
Grober, E.1
Dickson, D.2
Sliwinski, M.J.3
Buschke, H.4
Katz, M.5
-
15
-
-
0027308924
-
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
-
Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, et al. (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10: 1089-1099.
-
(1993)
Neuron
, vol.10
, pp. 1089-1099
-
-
Bramblett, G.T.1
Goedert, M.2
Jakes, R.3
Merrick, S.E.4
Trojanowski, J.Q.5
-
16
-
-
0029031214
-
Molecular dissection of the paired helical filament
-
Goedert M, Spillantini MG, Jakes R, Crowther RA, Vanmechelen E, et al. (1995) Molecular dissection of the paired helical filament. Neurobiol Aging 16: 325-334.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 325-334
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Crowther, R.A.4
Vanmechelen, E.5
-
17
-
-
33244456786
-
Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease
-
Maeda S, Sahara N, Saito Y, Murayama S, Ikai A, et al. (2006) Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci Res 54: 197-201.
-
(2006)
Neurosci Res
, vol.54
, pp. 197-201
-
-
Maeda, S.1
Sahara, N.2
Saito, Y.3
Murayama, S.4
Ikai, A.5
-
18
-
-
34147125835
-
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy
-
Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, et al. (2007) Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. J Neurosci 27: 3650-3662.
-
(2007)
J Neurosci
, vol.27
, pp. 3650-3662
-
-
Berger, Z.1
Roder, H.2
Hanna, A.3
Carlson, A.4
Rangachari, V.5
-
19
-
-
0024369521
-
Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease
-
Shin RW, Ogomori K, Kitamoto T, Tateishi J, (1989) Increased tau accumulation in senile plaques as a hallmark in Alzheimer's disease. Am J Pathol 134: 1365-1371.
-
(1989)
Am J Pathol
, vol.134
, pp. 1365-1371
-
-
Shin, R.W.1
Ogomori, K.2
Kitamoto, T.3
Tateishi, J.4
-
20
-
-
0036154419
-
Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease
-
Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, et al. (2002) Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Ann Neurol 51: 182-189.
-
(2002)
Ann Neurol
, vol.51
, pp. 182-189
-
-
Mitchell, T.W.1
Mufson, E.J.2
Schneider, J.A.3
Cochran, E.J.4
Nissanov, J.5
-
21
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
Kosik KS, Joachim CL, Selkoe DJ, (1986) Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A 83: 4044-4048.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
22
-
-
0035033619
-
Both total and phosphorylated tau are increased in Alzheimer's disease
-
Sjogren M, Davidsson P, Tullberg M, Minthon L, Wallin A, et al. (2001) Both total and phosphorylated tau are increased in Alzheimer's disease. J Neurol Neurosurg Psychiatry 70: 624-630.
-
(2001)
J Neurol Neurosurg Psychiatry
, vol.70
, pp. 624-630
-
-
Sjogren, M.1
Davidsson, P.2
Tullberg, M.3
Minthon, L.4
Wallin, A.5
-
23
-
-
25644456097
-
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
-
Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM, (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25: 8843-8853.
-
(2005)
J Neurosci
, vol.25
, pp. 8843-8853
-
-
Kitazawa, M.1
Oddo, S.2
Yamasaki, T.R.3
Green, K.N.4
LaFerla, F.M.5
-
24
-
-
77956592281
-
LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice
-
Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, et al. (2010) LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflammation 7: 56.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 56
-
-
Lee, D.C.1
Rizer, J.2
Selenica, M.L.3
Reid, P.4
Kraft, C.5
-
25
-
-
0022365608
-
The distribution of tau in the mammalian central nervous system
-
Binder LI, Frankfurter A, Rebhun LI, (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101: 1371-1378.
-
(1985)
J Cell Biol
, vol.101
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
26
-
-
0023505501
-
Phosphorylation determines two distinct species of Tau in the central nervous system
-
Papasozomenos SC, Binder LI, (1987) Phosphorylation determines two distinct species of Tau in the central nervous system. Cell Motil Cytoskeleton 8: 210-226.
-
(1987)
Cell Motil Cytoskeleton
, vol.8
, pp. 210-226
-
-
Papasozomenos, S.C.1
Binder, L.I.2
-
27
-
-
0028853922
-
Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes
-
LoPresti P, Szuchet S, Papasozomenos SC, Zinkowski RP, Binder LI, (1995) Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes. Proc Natl Acad Sci U S A 92: 10369-10373.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10369-10373
-
-
LoPresti, P.1
Szuchet, S.2
Papasozomenos, S.C.3
Zinkowski, R.P.4
Binder, L.I.5
-
28
-
-
0029055025
-
Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders
-
Odawara T, Iseki E, Kosaka K, Akiyama H, Ikeda K, et al. (1995) Investigation of tau-2 positive microglia-like cells in the subcortical nuclei of human neurodegenerative disorders. Neurosci Lett 192: 145-148.
-
(1995)
Neurosci Lett
, vol.192
, pp. 145-148
-
-
Odawara, T.1
Iseki, E.2
Kosaka, K.3
Akiyama, H.4
Ikeda, K.5
-
29
-
-
0035011587
-
Tau-66: evidence for a novel tau conformation in Alzheimer's disease
-
Ghoshal N, Garcia-Sierra F, Fu Y, Beckett LA, Mufson EJ, et al. (2001) Tau-66: evidence for a novel tau conformation in Alzheimer's disease. J Neurochem 77: 1372-1385.
-
(2001)
J Neurochem
, vol.77
, pp. 1372-1385
-
-
Ghoshal, N.1
Garcia-Sierra, F.2
Fu, Y.3
Beckett, L.A.4
Mufson, E.J.5
-
30
-
-
0034595537
-
Appearance of tau-2 immunoreactivity in glial cells in human brain with cerebral infarction
-
Uchihara T, Tsuchiya K, Nakamura A, Ikeda K, (2000) Appearance of tau-2 immunoreactivity in glial cells in human brain with cerebral infarction. Neurosci Lett 286: 99-102.
-
(2000)
Neurosci Lett
, vol.286
, pp. 99-102
-
-
Uchihara, T.1
Tsuchiya, K.2
Nakamura, A.3
Ikeda, K.4
-
31
-
-
33746507314
-
Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia
-
Iseki E, Yamamoto R, Murayama N, Minegishi M, Togo T, et al. (2006) Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia. Neurosci Lett 405: 29-33.
-
(2006)
Neurosci Lett
, vol.405
, pp. 29-33
-
-
Iseki, E.1
Yamamoto, R.2
Murayama, N.3
Minegishi, M.4
Togo, T.5
-
32
-
-
33748996792
-
Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies
-
Yoshida M, (2006) Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathology 26: 457-470.
-
(2006)
Neuropathology
, vol.26
, pp. 457-470
-
-
Yoshida, M.1
-
33
-
-
0032786370
-
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
-
Spittaels K, Van den Haute C, Van Dorpe J, Bruynseels K, Vandezande K, et al. (1999) Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 155: 2153-2165.
-
(1999)
Am J Pathol
, vol.155
, pp. 2153-2165
-
-
Spittaels, K.1
Van den Haute, C.2
Van Dorpe, J.3
Bruynseels, K.4
Vandezande, K.5
-
34
-
-
33847674888
-
Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration
-
Li HL, Wang HH, Liu SJ, Deng YQ, Zhang YJ, et al. (2007) Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin, a mechanism involved in Alzheimer's neurodegeneration. Proc Natl Acad Sci U S A 104: 3591-3596.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3591-3596
-
-
Li, H.L.1
Wang, H.H.2
Liu, S.J.3
Deng, Y.Q.4
Zhang, Y.J.5
-
35
-
-
34347218991
-
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
-
Liang CC, Park AY, Guan JL, (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2: 329-333.
-
(2007)
Nat Protoc
, vol.2
, pp. 329-333
-
-
Liang, C.C.1
Park, A.Y.2
Guan, J.L.3
-
36
-
-
0036734653
-
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200
-
Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, et al. (2002) Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Mol Biol Cell 13: 3178-3191.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 3178-3191
-
-
Abbi, S.1
Ueda, H.2
Zheng, C.3
Cooper, L.A.4
Zhao, J.5
-
37
-
-
0032806355
-
Increased microglial activation and protein nitration in white matter of the aging monkey
-
Sloane JA, Hollander W, Moss MB, Rosene DL, Abraham CR, (1999) Increased microglial activation and protein nitration in white matter of the aging monkey. Neurobiol Aging 20: 395-405.
-
(1999)
Neurobiol Aging
, vol.20
, pp. 395-405
-
-
Sloane, J.A.1
Hollander, W.2
Moss, M.B.3
Rosene, D.L.4
Abraham, C.R.5
-
38
-
-
70349807619
-
Immune activation in brain aging and neurodegeneration: too much or too little?
-
Lucin KM, Wyss-Coray T, (2009) Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64: 110-122.
-
(2009)
Neuron
, vol.64
, pp. 110-122
-
-
Lucin, K.M.1
Wyss-Coray, T.2
-
39
-
-
34147115541
-
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
-
El KJ, Toft M, Hickman SE, Means TK, Terada K, et al. (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13: 432-438.
-
(2007)
Nat Med
, vol.13
, pp. 432-438
-
-
El, K.J.1
Toft, M.2
Hickman, S.E.3
Means, T.K.4
Terada, K.5
-
40
-
-
0041319041
-
Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS
-
Babcock AA, Kuziel WA, Rivest S, Owens T, (2003) Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci 23: 7922-7930.
-
(2003)
J Neurosci
, vol.23
, pp. 7922-7930
-
-
Babcock, A.A.1
Kuziel, W.A.2
Rivest, S.3
Owens, T.4
-
41
-
-
19744380563
-
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
-
Nimmerjahn A, Kirchhoff F, Helmchen F, (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308: 1314-1318.
-
(2005)
Science
, vol.308
, pp. 1314-1318
-
-
Nimmerjahn, A.1
Kirchhoff, F.2
Helmchen, F.3
-
42
-
-
22244464662
-
ATP mediates rapid microglial response to local brain injury in vivo
-
Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, et al. (2005) ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8: 752-758.
-
(2005)
Nat Neurosci
, vol.8
, pp. 752-758
-
-
Davalos, D.1
Grutzendler, J.2
Yang, G.3
Kim, J.V.4
Zuo, Y.5
-
44
-
-
0035149829
-
Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods
-
Soltys Z, Ziaja M, Pawlinski R, Setkowicz Z, Janeczko K, (2001) Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods. J Neurosci Res 63: 90-97.
-
(2001)
J Neurosci Res
, vol.63
, pp. 90-97
-
-
Soltys, Z.1
Ziaja, M.2
Pawlinski, R.3
Setkowicz, Z.4
Janeczko, K.5
-
45
-
-
77957321869
-
Regulation of tau pathology by the microglial fractalkine receptor
-
Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, et al. (2010) Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68: 19-31.
-
(2010)
Neuron
, vol.68
, pp. 19-31
-
-
Bhaskar, K.1
Konerth, M.2
Kokiko-Cochran, O.N.3
Cardona, A.4
Ransohoff, R.M.5
-
46
-
-
0033889344
-
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
-
Tesseur I, Van Dorpe J, Spittaels K, Van den Haute C, Moechars D, et al. (2000) Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice. Am J Pathol 156: 951-964.
-
(2000)
Am J Pathol
, vol.156
, pp. 951-964
-
-
Tesseur, I.1
Van Dorpe, J.2
Spittaels, K.3
Van den Haute, C.4
Moechars, D.5
-
47
-
-
17944382037
-
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
-
Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, et al. (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293: 1487-1491.
-
(2001)
Science
, vol.293
, pp. 1487-1491
-
-
Lewis, J.1
Dickson, D.W.2
Lin, W.L.3
Chisholm, L.4
Corral, A.5
-
48
-
-
0034741554
-
Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values
-
Sjogren M, Vanderstichele H, Agren H, Zachrisson O, Edsbagge M, et al. (2001) Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values. Clin Chem 47: 1776-1781.
-
(2001)
Clin Chem
, vol.47
, pp. 1776-1781
-
-
Sjogren, M.1
Vanderstichele, H.2
Agren, H.3
Zachrisson, O.4
Edsbagge, M.5
-
49
-
-
0036107977
-
Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients: an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay
-
Hu YY, He SS, Wang X, Duan QH, Grundke-Iqbal I, et al. (2002) Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients: an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. Am J Pathol 160: 1269-1278.
-
(2002)
Am J Pathol
, vol.160
, pp. 1269-1278
-
-
Hu, Y.Y.1
He, S.S.2
Wang, X.3
Duan, Q.H.4
Grundke-Iqbal, I.5
-
50
-
-
0013831072
-
The initiation of cell division in a contact-inhibited mammalian cell line
-
Todaro GJ, Lazar GK, Green H, (1965) The initiation of cell division in a contact-inhibited mammalian cell line. J Cell Physiol 66: 325-333.
-
(1965)
J Cell Physiol
, vol.66
, pp. 325-333
-
-
Todaro, G.J.1
Lazar, G.K.2
Green, H.3
-
51
-
-
59349112140
-
Microglial clearance function in health and disease
-
Napoli I, Neumann H, (2009) Microglial clearance function in health and disease. Neuroscience 158: 1030-1038.
-
(2009)
Neuroscience
, vol.158
, pp. 1030-1038
-
-
Napoli, I.1
Neumann, H.2
-
52
-
-
60149098421
-
Debris clearance by microglia: an essential link between degeneration and regeneration
-
Neumann H, Kotter MR, Franklin RJ, (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132: 288-295.
-
(2009)
Brain
, vol.132
, pp. 288-295
-
-
Neumann, H.1
Kotter, M.R.2
Franklin, R.J.3
-
53
-
-
84155162481
-
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
-
Smith JA, Das A, Ray SK, Banik NL, (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 87: 10-20.
-
(2012)
Brain Res Bull
, vol.87
, pp. 10-20
-
-
Smith, J.A.1
Das, A.2
Ray, S.K.3
Banik, N.L.4
-
54
-
-
84655176335
-
Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
-
Simon D, Garcia-Garcia E, Royo F, Falcon-Perez JM, Avila J, (2012) Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles. FEBS Lett 586: 47-54.
-
(2012)
FEBS Lett
, vol.586
, pp. 47-54
-
-
Simon, D.1
Garcia-Garcia, E.2
Royo, F.3
Falcon-Perez, J.M.4
Avila, J.5
-
55
-
-
84863011855
-
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model
-
Lee S, Kim W, Li Z, Hall GF, (2012) Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. Int J Alzheimers Dis 2012: 172837.
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 172837
-
-
Lee, S.1
Kim, W.2
Li, Z.3
Hall, G.F.4
-
56
-
-
84856707794
-
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
-
Saman S, Kim W, Raya M, Visnick Y, Miro S, et al. (2012) Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem 287: 3842-3849.
-
(2012)
J Biol Chem
, vol.287
, pp. 3842-3849
-
-
Saman, S.1
Kim, W.2
Raya, M.3
Visnick, Y.4
Miro, S.5
-
57
-
-
0030028366
-
Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons
-
Hirokawa N, Funakoshi T, Sato-Harada R, Kanai Y, (1996) Selective stabilization of tau in axons and microtubule-associated protein 2C in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons. J Cell Biol 132: 667-679.
-
(1996)
J Cell Biol
, vol.132
, pp. 667-679
-
-
Hirokawa, N.1
Funakoshi, T.2
Sato-Harada, R.3
Kanai, Y.4
-
58
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, et al. (2010) Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142: 387-397.
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
-
59
-
-
17544393297
-
Tau dephosphorylation at tau-1 site correlates with its association to cell membrane
-
Arrasate M, Perez M, Avila J, (2000) Tau dephosphorylation at tau-1 site correlates with its association to cell membrane. Neurochem Res 25: 43-50.
-
(2000)
Neurochem Res
, vol.25
, pp. 43-50
-
-
Arrasate, M.1
Perez, M.2
Avila, J.3
-
60
-
-
0028785525
-
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
-
Brandt R, Leger J, Lee G, (1995) Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol 131: 1327-1340.
-
(1995)
J Cell Biol
, vol.131
, pp. 1327-1340
-
-
Brandt, R.1
Leger, J.2
Lee, G.3
-
61
-
-
0040141570
-
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
-
Maas T, Eidenmuller J, Brandt R, (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275: 15733-15740.
-
(2000)
J Biol Chem
, vol.275
, pp. 15733-15740
-
-
Maas, T.1
Eidenmuller, J.2
Brandt, R.3
-
62
-
-
33846245120
-
Kainate induces AKT, ERK and cdk5/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus
-
Crespo-Biel N, Canudas AM, Camins A, Pallas M, (2007) Kainate induces AKT, ERK and cdk5/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus. Neurochem Int 50: 435-442.
-
(2007)
Neurochem Int
, vol.50
, pp. 435-442
-
-
Crespo-Biel, N.1
Canudas, A.M.2
Camins, A.3
Pallas, M.4
-
63
-
-
2642518949
-
Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction
-
Song X, Tanaka S, Cox D, Lee SC, (2004) Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. J Leukoc Biol 75: 1147-1155.
-
(2004)
J Leukoc Biol
, vol.75
, pp. 1147-1155
-
-
Song, X.1
Tanaka, S.2
Cox, D.3
Lee, S.C.4
-
65
-
-
0346434153
-
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory
-
Liu SJ, Zhang AH, Li HL, Wang Q, Deng HM, et al. (2003) Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 87: 1333-1344.
-
(2003)
J Neurochem
, vol.87
, pp. 1333-1344
-
-
Liu, S.J.1
Zhang, A.H.2
Li, H.L.3
Wang, Q.4
Deng, H.M.5
-
66
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin M, Rehani K, Jope RS, Michalek SM, (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784.
-
(2005)
Nat Immunol
, vol.6
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
67
-
-
0034746919
-
NF-kappaB: a key role in inflammatory diseases
-
Tak PP, Firestein GS, (2001) NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107: 7-11.
-
(2001)
J Clin Invest
, vol.107
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
68
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX, (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22: 1942-1950.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
69
-
-
0346848898
-
Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts
-
Zhao WQ, Feng C, Alkon DL, (2003) Impairment of phosphatase 2A contributes to the prolonged MAP kinase phosphorylation in Alzheimer's disease fibroblasts. Neurobiol Dis 14: 458-469.
-
(2003)
Neurobiol Dis
, vol.14
, pp. 458-469
-
-
Zhao, W.Q.1
Feng, C.2
Alkon, D.L.3
-
70
-
-
0035075793
-
PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus
-
Vogelsberg-Ragaglia V, Schuck T, Trojanowski JQ, Lee VM, (2001) PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Exp Neurol 168: 402-412.
-
(2001)
Exp Neurol
, vol.168
, pp. 402-412
-
-
Vogelsberg-Ragaglia, V.1
Schuck, T.2
Trojanowski, J.Q.3
Lee, V.M.4
-
71
-
-
35548986304
-
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
-
Hanisch UK, Kettenmann H, (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
-
(2007)
Nat Neurosci
, vol.10
, pp. 1387-1394
-
-
Hanisch, U.K.1
Kettenmann, H.2
-
72
-
-
0027299745
-
On the crawling of animal cells
-
Stossel TP, (1993) On the crawling of animal cells. Science 260: 1086-1094.
-
(1993)
Science
, vol.260
, pp. 1086-1094
-
-
Stossel, T.P.1
-
73
-
-
0030049170
-
Actin-based cell motility and cell locomotion
-
Mitchison TJ, Cramer LP, (1996) Actin-based cell motility and cell locomotion. Cell 84: 371-379.
-
(1996)
Cell
, vol.84
, pp. 371-379
-
-
Mitchison, T.J.1
Cramer, L.P.2
-
74
-
-
0346750747
-
Actin and microtubules in neurite initiation: are MAPs the missing link?
-
Dehmelt L, Halpain S, (2004) Actin and microtubules in neurite initiation: are MAPs the missing link? J Neurobiol 58: 18-33.
-
(2004)
J Neurobiol
, vol.58
, pp. 18-33
-
-
Dehmelt, L.1
Halpain, S.2
-
75
-
-
0025095717
-
Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease
-
Perlmutter LS, Barron E, Chui HC, (1990) Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 119: 32-36.
-
(1990)
Neurosci Lett
, vol.119
, pp. 32-36
-
-
Perlmutter, L.S.1
Barron, E.2
Chui, H.C.3
-
76
-
-
33847613885
-
Inflammatory processes in Alzheimer's disease
-
Heneka MT, O'Banion MK, (2007) Inflammatory processes in Alzheimer's disease. J Neuroimmunol 184: 69-91.
-
(2007)
J Neuroimmunol
, vol.184
, pp. 69-91
-
-
Heneka, M.T.1
O'Banion, M.K.2
-
77
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, et al. (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53: 337-351.
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
-
78
-
-
32344440522
-
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
-
Simard AR, Soulet D, Gowing G, Julien JP, Rivest S, (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49: 489-502.
-
(2006)
Neuron
, vol.49
, pp. 489-502
-
-
Simard, A.R.1
Soulet, D.2
Gowing, G.3
Julien, J.P.4
Rivest, S.5
-
79
-
-
34249899174
-
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
-
Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, et al. (2007) Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117: 1595-1604.
-
(2007)
J Clin Invest
, vol.117
, pp. 1595-1604
-
-
Shaftel, S.S.1
Kyrkanides, S.2
Olschowka, J.A.3
Miller, J.N.4
Johnson, R.E.5
-
80
-
-
0036850422
-
Immune response gene expression increases in the aging murine hippocampus
-
Terao A, Apte-Deshpande A, Dousman L, Morairty S, Eynon BP, et al. (2002) Immune response gene expression increases in the aging murine hippocampus. J Neuroimmunol 132: 99-112.
-
(2002)
J Neuroimmunol
, vol.132
, pp. 99-112
-
-
Terao, A.1
Apte-Deshpande, A.2
Dousman, L.3
Morairty, S.4
Eynon, B.P.5
-
81
-
-
0036132452
-
Gene expression profiling of aging using DNA microarrays
-
Weindruch R, Kayo T, Lee CK, Prolla TA, (2002) Gene expression profiling of aging using DNA microarrays. Mech Ageing Dev 123: 177-193.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 177-193
-
-
Weindruch, R.1
Kayo, T.2
Lee, C.K.3
Prolla, T.A.4
-
82
-
-
0029665576
-
Dysregulation between TH1 and TH2 T cell subpopulations in the elderly
-
Cakman I, Rohwer J, Schutz RM, Kirchner H, Rink L, (1996) Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev 87: 197-209.
-
(1996)
Mech Ageing Dev
, vol.87
, pp. 197-209
-
-
Cakman, I.1
Rohwer, J.2
Schutz, R.M.3
Kirchner, H.4
Rink, L.5
-
83
-
-
0033557187
-
Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death
-
Pearson VL, Rothwell NJ, Toulmond S, (1999) Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 25: 311-323.
-
(1999)
Glia
, vol.25
, pp. 311-323
-
-
Pearson, V.L.1
Rothwell, N.J.2
Toulmond, S.3
-
84
-
-
0032814562
-
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function
-
Raivich G, Bohatschek M, Kloss CU, Werner A, Jones LL, et al. (1999) Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res Brain Res Rev 30: 77-105.
-
(1999)
Brain Res Brain Res Rev
, vol.30
, pp. 77-105
-
-
Raivich, G.1
Bohatschek, M.2
Kloss, C.U.3
Werner, A.4
Jones, L.L.5
-
85
-
-
0028178798
-
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
-
Cheng B, Christakos S, Mattson MP, (1994) Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12: 139-153.
-
(1994)
Neuron
, vol.12
, pp. 139-153
-
-
Cheng, B.1
Christakos, S.2
Mattson, M.P.3
-
86
-
-
0033215124
-
Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways
-
Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, et al. (1999) Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol 163: 3963-3968.
-
(1999)
J Immunol
, vol.163
, pp. 3963-3968
-
-
Carlson, N.G.1
Wieggel, W.A.2
Chen, J.3
Bacchi, A.4
Rogers, S.W.5
-
87
-
-
84876179150
-
A Novel Synthetic Compound 4-Acetyl-3-methyl-6-(2-bromophenyl)pyrano[3,4-c]pyran-1,8-dione Inhibits the Production of Nitric Oxide and Proinflammatory Cytokines Via the NF-kappaB Pathway in Lipopolysaccharide-Activated Microglia Cells
-
Chung HS, Kim SN, Jeong JH, Bae H (2013) A Novel Synthetic Compound 4-Acetyl-3-methyl-6-(2-bromophenyl)pyrano[3,4-c]pyran-1,8-dione Inhibits the Production of Nitric Oxide and Proinflammatory Cytokines Via the NF-kappaB Pathway in Lipopolysaccharide-Activated Microglia Cells. Neurochem Res.
-
(2013)
Neurochem Res
-
-
Chung, H.S.1
Kim, S.N.2
Jeong, J.H.3
Bae, H.4
-
88
-
-
84856012960
-
Effect of psychosine on inducible nitric-oxide synthase expression under different culture conditions: implications for Krabbe disease
-
Bashir A, Haq E, (2011) Effect of psychosine on inducible nitric-oxide synthase expression under different culture conditions: implications for Krabbe disease. Eur Rev Med Pharmacol Sci 15: 1282-1287.
-
(2011)
Eur Rev Med Pharmacol Sci
, vol.15
, pp. 1282-1287
-
-
Bashir, A.1
Haq, E.2
-
89
-
-
67649273927
-
Propagation of tau misfolding from the outside to the inside of a cell
-
Frost B, Jacks RL, Diamond MI, (2009) Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem 284: 12845-12852.
-
(2009)
J Biol Chem
, vol.284
, pp. 12845-12852
-
-
Frost, B.1
Jacks, R.L.2
Diamond, M.I.3
-
90
-
-
33750589818
-
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
-
Buerger K, Ewers M, Pirttila T, Zinkowski R, Alafuzoff I, et al. (2006) CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 129: 3035-3041.
-
(2006)
Brain
, vol.129
, pp. 3035-3041
-
-
Buerger, K.1
Ewers, M.2
Pirttila, T.3
Zinkowski, R.4
Alafuzoff, I.5
-
91
-
-
0031583947
-
The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease
-
Tapiola T, Overmyer M, Lehtovirta M, Helisalmi S, Ramberg J, et al. (1997) The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease. Neuroreport 8: 3961-3963.
-
(1997)
Neuroreport
, vol.8
, pp. 3961-3963
-
-
Tapiola, T.1
Overmyer, M.2
Lehtovirta, M.3
Helisalmi, S.4
Ramberg, J.5
|