Dysregulation between TH1 and TH2 T cell subpopulations in the elderly

Mechanisms of Ageing and Development

Volumn 87, Issue 3, 1996, Pages 197-209

  Cakman, Irem ^a   Rohwer, Jan ^a   Schütz, Rudolf M ^a   Kirchner, Holger ^a   Rink, Lothar ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Cytokines; Elderly; Lymphocyte subsets; Serum proteins; Zinc

Indexed keywords

ALBUMIN; ALPHA 2 MACROGLOBULIN; BINDING PROTEIN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; ZINC; CARRIER PROTEIN; CYTOKINE; PLASMA PROTEIN; ZINC BINDING PROTEIN; ZINC-BINDING PROTEIN;

AGED; AGING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; LYMPHOCYTE SUBPOPULATION; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ADULT; BIOSYNTHESIS; CELL CULTURE; FEMALE; FLOW CYTOMETRY; MALE; METABOLISM; PHYSIOLOGY; SOLUBILITY; TH1 CELL; TH2 CELL;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PROTEINS; CARRIER PROTEINS; CELLS, CULTURED; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; MALE; RECEPTORS, INTERLEUKIN-2; SOLUBILITY; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS; ZINC;

EID: 0029665576     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(96)01708-3     Document Type: Article

References (33)

1. R. K. Chandra. Nutritional regulation of immunity and risk of infection in old age. Immunology, 67, (1989) 141-147.
2. J. Sindermann, A. Kruse, H.-J. Frercks, R.M. Schütz and H. Kirchner, Investigations of the lymphokine system in elderly individuals. Mech. Ageing. Dev., 70 (1993) 149-159.
3. H. You-Peng, J.C. Pechere, M. Michel, L. Gauthey, M. Loreto, J.A. Curran and J.P. Michel, In vivo T Cell activation, in vitro defective IL-2 secretion, and response to influenza vaccination in elderly women. J. Gerontol., 148 (1992) 715-722.
4. + cells and cell subsets from young and old mice. Cell Immunol., 154 (1994) 264-272.
5. R. Dobber, M. Tielemanns and L. Nagelkerken, Enrichment for TH1 cells in the Mel-14 + CD4 + T Cell fraction in aged mice. Cell Immunol., 162 (1995) 321-325.
6. J.M. Didier, B. deWazieres, M. Becker-Schneider, E. Seilles, J.L. Dupond and D.A. Vuitton, Function of the oxidative metabolism of phagocytes in elderly people: relationship to nutritional and inflammatory status. Age Ageing, 24 (1995) 247-253.
7. S.C. Vir and A.H.G. Love, Zinc and copper status of the elderly. Am. J. Clin. Nutr., 32 (1979) 1472-1476.
8. D.-Y. Lee, A.S. Prasad, C. Hydrick-Adair, G. Brewer and P.E. Johnson, Homeostasis of zinc in marginal human zinc deficiency; role of absorption and endogenous excretion of zinc. J. Lab. Clin. Med., 122 (1993) 549-556.
9. P.J. Fraker, M.E. Gershwin, R.A. Good and A.S. Prasad, Interrelationship between zinc and immune function. Fed. Proc., 45 (1986) 1474-1479.
10. M. Dardenne, J.M. Pleau, B. Nabama, P. Lefancier, P. Denierr, M. Chosy and J.F. Bach, Contributions of zinc and other metal to the biological activity of serum thymic factor. Proc. Natl. Acad. Sci. USA, 79 (1982) 5370-5373.
11. D. Bulgarini, D. Habetswallner, G. Boccoli, E. Montesoro, A. Camagna, G. Mastroberardino, C. Rosania, U. Testa and C. Peschle, Zinc modulates the activation of human peripheral blood lymphocytes. Ann. Ist. Super Sanita, 25 (1989) 463-470.
12. N. Buokaiba, C. Flament, S. Acher, P. Chappuis, A. Piau, M. Fusselier, M. Dardenne and D. Lemonnier, A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am. J. Clin. Nutr., 57 (1993) 566-572.
13. G.M. Craig, S.J. Evans, B.J. Brayshaw and S.K. Raina, A study of serum zinc, alpha-2-macroglobulin and transferrin levels in acute and long stay elderly hospital patients. Postgrad. Med., 66 (1990) 205-209.
14. K. James, Interactions between cytokines and alpha-2-macroglobulin. Immunlogy Today, 11 (1990) 163-166.
15. A.W. Taylor and R.F. Mortensen, Effect of alpha-2-macroglobulin of cytokine-mediated human C-reactive protein production. Inflammation, 15 (1991) 61-70.
16. J. Westermann and R. Pabst, Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol. Today, 11 (1990) 406-410.
17. X. Xu, I. Beckermann, M. Ahern and J. Bradley, A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry. Immunol. Cell. Biol., 71 (1993) 549-557.
18. U. Fagiolo, A. Cossarizza, E. Scala, E. Fanales-Belasio, C. Orolani, E. Cozzi, D. Monti, C. Franceschi and R. Paganelli, Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol., 23 (1993) 2375-2378.
19. E.A. Burns, L.G. Lum, G. L'Hommedieu and J.S. Goodwin, Specific humoral immunity in the elderly in vivo and in vitro response to vaccination. J. Gerontol., 48 (1993) B231-B236.
20. G.J. Ligthart, J.X. Coberand, C. Fournier, P. Galanaud, W. Hijmans, B. Kennes, H.K. Müller-Hermelink and G.G. Steinmann, Admission criteria for immunogerontological studies in man: the senieur protocol. Mech. Ageing. Dev., 28 (1984) 47-55.
21. H. Kirchner, C. Kleinicke and W. Digel, A whole-blood technique for testing production of human interferon by leukocytes. J. Immunol. Methods, 48 (1982) 213-219.
22. J. Ringstad. S. Kildebo and Y. Thomassen, Serum selenium, copper, and zinc concentrations in Crohn's disease and ulcerative colitis. Scand. Gastroenterol., 28 (1993) 605-608.
23. M. Bonomini, V. Manfrini, P. Capelli and A. Albertazzi, Zinc and cell-mediated immunity in chronic uremia. Nephron, 65 (1993) 1-4.
24. M. Moseson, A. Zeleniuch-Jacqoutte, D.V. Belsito, R.E. Shore, M. Marmor and B. Pasternack, The potentional role of nutritional factors in the induction of immonologic abnormalities in HIV-positiv homosexual men. J. Acq. Immun. Def. Synd., 2 (1989) 235-247.
25. D. Moraglio, D. Testa and A. Arnelli, Zinc status in intensely transfused patients. Vox Sang., 64 (1993).
26. R. Mokni, A. Chakar, F. Bleiberg-Daniel, J.L. Mahu, P.A. Walravens, P. Chappius, J. Navarro and D. Lemmonier, Decreased serum levels of nutritional biochemical indices in healthy children with marginally delayed physical growth. Acta Paediatr., 82 (1993) 539-543.
27. T. Nakamura, S. Nishiyama, Y. Futagoishi-Suginohara, I. Matsuda and A. Higashi, Mild to moderate zinc deficiency in short children: effect of zinc supplementation on linear growth velocity. J. Paediatr., 127 (1993) 65-69.
28. C. Driessen, K. Hirv, L. Rink and H. Kirchner, Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes. Lymph. Cytok. Res., 13 (1994) 15-20.
29. H. Kirchner and H. Rühl, Stimulation of human peripheral lymphocytes by zinc in vitro. Exp. Cell Res., 61 (1970) 229-230.
30. S. Cunningham-Rundles, C. Cunningham-Rundles, B. Dupont and R.A. Good, Zinc induced activation of human B lymphocytes. Clin. Immunol. Immunopath., 16 (1980) 115-122.
31. D.M. Murasko, P. Weiner and D. Kaye, Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol., 70 (1987) 440-448.
32. 2. Clin. Immunol. Immunopathol., 64 (1992) 184-187.
33. M.E. Sanders, M.W. Makoba, S.O. Sharrow, D. Stephany, T.A. Springer, H.A. Young and S. Shaw, Human memory T lymphocytes express increased levels of three cell adhaesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL 1, Cdw29, and Pgp-1) and have enhanced IFN-gamma production. J. Immunol., 40 (1988) 1401-1407.