Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients: An ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay

American Journal of Pathology

Volumn 160, Issue 4, 2002, Pages 1269-1278

  Hu, Yuan Yuan ^a   He, Shan Shu ^a   Wang, Xiaochuan ^a   Duan, Qiu Hong ^a   Grundke Iqbal, Inge ^b   Iqbal, Khalid ^b   Wang, Jianzhi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTERMETHOD COMPARISON; MALE; MULTIINFARCT DEMENTIA; NEUROLOGIC DISEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIVITY AND SPECIFICITY;

EID: 0036107977     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)62554-0     Document Type: Article

References (37)

1. Biomarkers of Alzheimer disease
2. Soluble interleukin-1 receptor type II levels are elevated in cerebral fluid in Alzheimer disease
3. Cerebrospinal fluid opens a window on Alzheimer disease
4. Increased CSF level of never growth factor in patients with Alzheimer disease
5. Tracking of Alzheimer disease progression with CSF tau protein phosphorylated at threonine 231
6. Evaluation of CSF-tau and CSF-Abeta42 as diagnostic markers for Alzheimer disease in clinical practice
7. Cerebrospinal fluid beta-amyloid (1-42) in Alzheimer disease: Differences between early and late-onset Alzheimer disease and stability during the course of disease
8. Tau in cerebrospinal fluid: A potential diagnostic marker in Alzheimer's disease
9. Increased cerebrospinal fluid tau in patients with Alzheimer disease
10. Tau in cerebrospinal fluid: Establishment of the sandwich ELISA with antibody specific to the repeat sequence in tau
11. Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer disease
12. (1-42) and tau levels in CSF
13. Combined assessment of tau and neuronal thread protein in Alzheimer's disease CSF
14. Microtubule-associated protein tau: A component of Alzheimer paired helical filaments
15. Abnormal phosphorylation of the microtubule associated protein τ (tau) in Alzheimer cytoskeletal pathology
16. Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules
17. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
18. Tau protein kinase I/GSK-3beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser396 and Ser400 sites phosphorylated in Alzheimer disease brain
19. Tau is phosphorylated by GSK-3 at several sites found in Alzheimer disease and its biological activity markedly inhibited only after it is prephosphorylated by A-kinase
20. Dephosphorylation of Alzheimer paired helical filaments with protein phosphatase 2A and 2B
21. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1
22. Phosphorylated tau in human cerebrospinal fluid is a diagnostic marker for Alzheimer's disease
23. Enzyme amplification for immunoassays. Detection limit of one hundredth of an attomole
24. Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-prolinedependent protein kinases and GSK-3
25. Microtubule associated protein tau: Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
26. Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments
27. Brain levels of microtubule associated protein tau are elevated in Alzheimer's disease brain: A radioimmunoslot-blot assay for nanograms of the protein
28. Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains
29. Proline-directed and non-proline-directed phosphorylation of PHF-tau
30. Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients
31. Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 1999 for the antemortem diagnosis of Alzheimer's disease
32. Both total and phosphorylated tau are increased in Alzheimer's disease
33. A method for quantitative determination of cellular immunoglobulins by enzyme-labeled antibodies
34. The avidin-biotin complex
35. Ultrasensitive enzymatic radioimmunoassay: Application to detection of cholera toxin and rotavirus
36. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments