Chelerythrine and other benzophenanthridine alkaloids block the human P2X 7 receptor

British Journal of Pharmacology

Volumn 142, Issue 6, 2004, Pages 1015-1019

  Shemon, Anne N ^a   Sluyter, Ronald ^a   Conigrave, Arthur D ^a   Wiley, James S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cation flux; Chelerythrine; Extracellular ATP; Lymphocyte; Phospholipase D; Purinergic receptor

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2',3' O (4 BENZOYLBENZOYL)ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; BENZOPHENANTHRIDINE DERIVATIVE; BERBERINE; CHELERYTHRINE; PHORBOL 13 ACETATE 12 MYRISTATE; POTASSIUM; PURINE P2X7 RECEPTOR; RUBIDIUM 86; SANGUINARINE; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INHIBITION KINETICS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ADENOSINE TRIPHOSPHATE; ALKALOIDS; B-LYMPHOCYTES; BENZOPHENANTHRIDINES; BERBERINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; KINETICS; PHENANTHRIDINES; PHOSPHOLIPASE D; PROTEIN KINASE C; RECEPTORS, PURINERGIC P2; RUBIDIUM RADIOISOTOPES; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 3843066800     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705868     Document Type: Article

References (28)

1. 2 ATP-gated channels. J. Biol. Chem., 275, 10190-10195.
2. 7 receptor antagonists: probing multiple sites for linking and dimerization. Bioconjugale Chem., 13, 1100-1111.
3. + current by chelerythrine and bisindoylmaleimide I in atrial myocytes from mice. Eur. J. Pharmacol., 424, 73-178.
4. COHEN, H.G., SEIFEN, E.E., STRAUB, K.D., TIEFENBACK, C. & STERMITZ, F.R. (1978). Structural specificity of NaK-ATPase inhibition by sanguinarine, an isoquinoline benzophenanthridine alkaloid. Biochem. Pharmacol., 27, 2555-2558.
5. DUBYAK, G.R. (2001). Role of P2 receptors in the immune system. In: Purinergic and Pyrimidinergic Signalling II, ed. Abbracchio, M.P. & Williams, M. pp. 323-355. Berlin: Springer Verlag.
6. EXTON, J.H. (2002). Phospholipase D - structure, regulation and function. Rev. Physiol. Biochem. Pharmacol., 144, 1-94.
7. GARGETT, C.E., CORNISH, E.J. & WILEY, J.S. (1996). Phospholipase D activation by P2Z-purinoceptor agonists in human lymphocytes is dependent on bivalent cation influx. Biochem. J., 313, 529-535.
8. GARGETT, C.E. & WILEY, J.S. (1997). The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br. J. Pharmacol., 120, 1483-1490.
9. HERBERT, J.M., AUGEREAU, J.M., GLEYE, J. & MAFFRAND, J.P. (1990). Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun., 172, 993-999.
10. 7 nucleotide receptor. J. Biol. Chem., 275, 26792-26798.
11. 7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol., 168, 6436-6445.
12. LENFELD, J., KROUTIL, M., MARSALEK, E., SLAVIK, J., PREININGER, V. & SIMANEK, V. (1981). Anti-inflammatory activity of quaternary benzophenanthridine alkaloids from chelidonium majus. J. Med. Plant Res., 43, 161-165.
13. 3 subunit. J. Biol. Chem., 276, 21077-21082.
14. 7 agonists in rat submandibular gland acini. J. Lipid Res., 43, 1244-1255.
15. PERREGAUX, D.G. & GABEL, C.A. (1994). Interleukin-1β maturation and release in response to ATP and nigericin. J. Biol. Chem., 269, 15195-15203.
16. 7 receptors in submandibular ductal cells. Cell Signal., 15, 927-935.
17. SHI, L.J. & WANG, C.A. (1999). Inhibitory effect of the kinase inhibitor chelerythrine on acetylcholine-induced current in PC12 cells. Arch. Biochem. Biophys., 368, 40-44.
18. 7 receptor impairs ATP-induced IL-1β release from human monocytes. J. Immunol., 172, 3399-3405.
19. 7 receptors. J. Biol. Chem., 276, 125-132.
20. 4- promotes cation fluxes in the J774 mouse macrophage cell line. J. Biol. Chem., 262, 3118-3122.
21. 7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release. J. Immunol., 170, 5728-5738.
22. WALTEROVA, D., ULRICHOVA, J., PREININGER, V. & SIMANEK, V. (1981). Inhibition of liver alanine aminotransferase activity by some benzophenanthridine alkaloids. J. Med. Chem., 24, 1100-1103.
23. WANG, B.H., LU, Z.X. & POLYA, G.M. (1997). Inhibition of eukaryote protein kinases by isoquinoline and oxazine alkaloids. Planta Med., 63, 494-498.
24. 7 nucleotide receptor: Modulation of LPS-induced macrophage signalling and mediator production. Drug. Dev. Res., 53, 91-104.
25. 4- receptor-operated ion channel of human lymphocytes: inhibition of ion fluxes by amiloride analogs and by extracellular sodium ions. Arch. Biochem. Biophys., 292, 411-418.
26. 7 receptor. J. Biol. Chem., 278, 17108-17113.
27. WILEY, J.S., GU, B., ZHANG, W., WORTHINGTON, R., DAO-UNG, P., SHEMON, A.N., SLUYTER, R., LIANG, S. & BARDEN, J. (2001). Genetic polymorphisms of the human P2X7 receptor and relationship to function. Drug Dev. Res., 53, 72-76.
28. 7 receptor function. FEBS Lett., 512, 43-46.