-
1
-
-
0035147120
-
Structure-based HIV-1 integrase inhibitor design: A future perspective
-
Neamati, N. Structure-based HIV-1 integrase inhibitor design: A future perspective. Expert Opin. Investig. Drugs 2001, 10, 281-296.
-
(2001)
Expert Opin. Investig. Drugs
, vol.10
, pp. 281-296
-
-
Neamati, N.1
-
2
-
-
0035986699
-
Structurebased inhibitor design targeting HIV-1 integrase
-
Chen, I. J.; Neamati, N.; MacKerell, A. D., Jr. Structurebased inhibitor design targeting HIV-1 integrase. Curr. Drug Targets Infect. Disord. 2002, 2, 217-234.
-
(2002)
Curr. Drug Targets Infect. Disord.
, vol.2
, pp. 217-234
-
-
Chen, I.J.1
Neamati, N.2
MacKerell Jr., A.D.3
-
3
-
-
14944374558
-
Integrase inhibitors to treat HIV/AIDS
-
Pommier, Y.; Johnson, A. A.; Marchand, C. Integrase inhibitors to treat HIV/AIDS. Nat. Rev. Drug Discov. 2005, 4, 236-248.
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 236-248
-
-
Pommier, Y.1
Johnson, A.A.2
Marchand, C.3
-
4
-
-
33645891478
-
HIV-1 reverse transcriptase: A therapeutical target in the spotlight
-
Castro, H. C.; Loureiro, N. I.; Pujol-Luz, M.; Souza, A. M.; Albuquerque, M. G.; Santos, D. O.; Cabral, L. M.; Frugulhetti, I. C.; Rodrigues, C. R. HIV-1 reverse transcriptase: A therapeutical target in the spotlight. Curr. Med. Chem. 2006, 13, 313-324.
-
(2006)
Curr. Med. Chem.
, vol.13
, pp. 313-324
-
-
Castro, H.C.1
Loureiro, N.I.2
Pujol-Luz, M.3
Souza, A.M.4
Albuquerque, M.G.5
Santos, D.O.6
Cabral, L.M.7
Frugulhetti, I.C.8
Rodrigues, C.R.9
-
5
-
-
34250336893
-
HIV-1 protease: Structure, dynamics, and inhibition
-
Louis, J. M.; Ishima, R.; Torchia, D. A.; Weber, I. T. HIV-1 protease: Structure, dynamics, and inhibition. Adv. Pharmacol. 2007, 55, 261-298.
-
(2007)
Adv. Pharmacol.
, vol.55
, pp. 261-298
-
-
Louis, J.M.1
Ishima, R.2
Torchia, D.A.3
Weber, I.T.4
-
6
-
-
77949365510
-
Retroviral intasome assembly and inhibition of DNA strand transfer
-
Hare, S.; Gupta, S. S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature. 2010, 464, 232-236.
-
(2010)
Nature
, vol.464
, pp. 232-236
-
-
Hare, S.1
Gupta, S.S.2
Valkov, E.3
Engelman, A.4
Cherepanov, P.5
-
7
-
-
0030986376
-
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
-
Cai, M.; Zheng, R.; Caffrey, M.; Craigie, R.; Clore, G. M.; Gronenborn, A. M. Solution structure of the N-terminal zinc binding domain of HIV-1 integrase. Nat. Struct. Biol. 1997, 4, 567-577.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 567-577
-
-
Cai, M.1
Zheng, R.2
Caffrey, M.3
Craigie, R.4
Clore, G.M.5
Gronenborn, A.M.6
-
8
-
-
0037126629
-
Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein
-
Wang, J. Y.; Ling, H.; Yang, W.; Craigie, R. Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein. EMBO J. 2001, 20, 7333-7343.
-
(2001)
EMBO J
, vol.20
, pp. 7333-7343
-
-
Wang, J.Y.1
Ling, H.2
Yang, W.3
Craigie, R.4
-
9
-
-
0034682511
-
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
-
USA
-
Chen, J. C.; Krucinski, J.; Miercke, L. J.; Finer-Moore, J. S.; Tang, A. H.; Leavitt, A. D.; Stroud, R. M. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding. Proc. Natl. Acad. Sci. USA 2000, 97, 8233-8238.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 8233-8238
-
-
Chen, J.C.1
Krucinski, J.2
Miercke, L.J.3
Finer-Moore, J.S.4
Tang, A.H.5
Leavitt, A.D.6
Stroud, R.M.7
-
10
-
-
0034681278
-
X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)-An initial glance of the viral DNA binding platform
-
Chen, Z.; Yan, Y.; Munshi, S.; Li, Y.; Zugay-Murphy, J.; Xu, B.; Witmer, M.; Felock, P.; Wolfe, A.; Sardana, V.; Emini, E. A.; Hazuda, D.; Kuo, L. C. X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)-An initial glance of the viral DNA binding platform. J. Mol. Biol. 2000, 296, 521-533.
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 521-533
-
-
Chen, Z.1
Yan, Y.2
Munshi, S.3
Li, Y.4
Zugay-Murphy, J.5
Xu, B.6
Witmer, M.7
Felock, P.8
Wolfe, A.9
Sardana, V.10
Emini, E.A.11
Hazuda, D.12
Kuo, L.C.13
-
11
-
-
0034681303
-
Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase
-
Yang, Z. N.; Mueser, T. C.; Bushman, F. D.; Hyde, C. C. Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase. J. Mol. Biol. 2000, 296, 535-548.
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 535-548
-
-
Yang, Z.N.1
Mueser, T.C.2
Bushman, F.D.3
Hyde, C.C.4
-
12
-
-
0032483022
-
Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium
-
USA
-
Goldgur, Y.; Dyda, F.; Hickman, A. B.; Jenkins, T. M.; Craigie, R.; Davies, D. R. Three new structures of the core domain of HIV-1 integrase: An active site that binds magnesium. Proc. Natl. Acad. Sci. USA 1998, 95, 9150-9154.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 9150-9154
-
-
Goldgur, Y.1
Dyda, F.2
Hickman, A.B.3
Jenkins, T.M.4
Craigie, R.5
Davies, D.R.6
-
13
-
-
0030566832
-
The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the F185H mutant
-
Bujacz, G.; Alexandratos, J.; Qing, Z. L.; Clement-Mella, C.; Wlodawer, A. The catalytic domain of human immunodeficiency virus integrase: Ordered active site in the F185H mutant. FEBS Lett. 1996, 398, 175-178.
-
(1996)
FEBS Lett
, vol.398
, pp. 175-178
-
-
Bujacz, G.1
Alexandratos, J.2
Qing, Z.L.3
Clement-Mella, C.4
Wlodawer, A.5
-
14
-
-
0028584269
-
Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases
-
Dyda, F.; Hickman, A. B.; Jenkins, T. M.; Engelman, A.; Craigie, R.; Davies, D. R. Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases. Science 1994, 266, 1981-1986.
-
(1994)
Science
, vol.266
, pp. 1981-1986
-
-
Dyda, F.1
Hickman, A.B.2
Jenkins, T.M.3
Engelman, A.4
Craigie, R.5
Davies, D.R.6
-
15
-
-
0032544311
-
Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: High level of similarity of the active site with other viral integrases
-
Maignan, S.; Guilloteau, J. P.; Zhou-Liu, Q.; Clement-Mella, C.; Mikol, V. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: High level of similarity of the active site with other viral integrases. J. Mol. Biol. 1998, 282, 359-368.
-
(1998)
J. Mol. Biol.
, vol.282
, pp. 359-368
-
-
Maignan, S.1
Guilloteau, J.P.2
Zhou-Liu, Q.3
Clement-Mella, C.4
Mikol, V.5
-
16
-
-
13044295993
-
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
-
USA
-
Goldgur, Y.; Craigie, R.; Cohen, G. H.; Fujiwara, T.; Yoshinaga, T.; Fujishita, T.; Sugimoto, H.; Endo, T.; Murai, H.; Davies, D. R. Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design. Proc. Natl. Acad. Sci. USA 1999, 96, 13040-13043.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 13040-13043
-
-
Goldgur, Y.1
Craigie, R.2
Cohen, G.H.3
Fujiwara, T.4
Yoshinaga, T.5
Fujishita, T.6
Sugimoto, H.7
Endo, T.8
Murai, H.9
Davies, D.R.10
-
17
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda, D. J.; Felock, P.; Witmer, M.; Wolfe, A.; Stillmock, K.; Grobler, J. A.; Espeseth, A.; Gabryelski, L.; Schleif, W.; Blau, C.; Miller, M. D. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000, 287, 646-650.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
18
-
-
0034622428
-
Determinants of Mg2{thorn} -dependent activities of recombinant human immunodeficiency virus type 1 integrase
-
Leh, H.; Brodin, P.; Bischerour, J.; Deprez, E.; Tauc, P.; Brochon, J. C.; LeCam, E.; Coulaud, D.; Auclair, C.; Mouscadet, J. F. Determinants of Mg2{thorn} -dependent activities of recombinant human immunodeficiency virus type 1 integrase. Biochemistry 2000, 39, 9285-9294.
-
(2000)
Biochemistry
, vol.39
, pp. 9285-9294
-
-
Leh, H.1
Brodin, P.2
Bischerour, J.3
Deprez, E.4
Tauc, P.5
Brochon, J.C.6
LeCam, E.7
Coulaud, D.8
Auclair, C.9
Mouscadet, J.F.10
-
19
-
-
0037137602
-
Metal-dependent inhibition of HIV-1 integrase
-
Neamati, N.; Lin, Z.; Karki, R. G.; Orr, A.; Cowansage, K.; Strumberg, D.; Pais, G. C.; Voigt, J. H.; Nicklaus, M. C.; Winslow, H. E.; Zhao, H.; Turpin, J. A.; Yi, J.; Skalka, A. M.; Burke, T. R., Jr.; Pommier, Y. Metal-dependent inhibition of HIV-1 integrase. J. Med. Chem. 2002, 45, 5661-5670.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 5661-5670
-
-
Neamati, N.1
Lin, Z.2
Karki, R.G.3
Orr, A.4
Cowansage, K.5
Strumberg, D.6
Pais, G.C.7
Voigt, J.H.8
Nicklaus, M.C.9
Winslow, H.E.10
Zhao, H.11
Turpin, J.A.12
Yi, J.13
Skalka, A.M.14
Burke Jr., T.R.15
Pommier, Y.16
-
20
-
-
0041353616
-
Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S)
-
Marchand, C.; Johnson, A. A.; Karki, R. G.; Pais, G. C.; Zhang, X.; Cowansage, K.; Patel, T. A.; Nicklaus, M. C.; Burke, T. R., Jr.; Pommier, Y. Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S). Mol. Pharmacol. 2003, 64, 600-609.
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 600-609
-
-
Marchand, C.1
Johnson, A.A.2
Karki, R.G.3
Pais, G.C.4
Zhang, X.5
Cowansage, K.6
Patel, T.A.7
Nicklaus, M.C.8
Burke Jr., T.R.9
Pommier, Y.10
-
21
-
-
0034616993
-
Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
-
Davies, D. R.; Goryshin, I. Y.; Reznikoff, W. S.; Rayment, I. Three-dimensional structure of the Tn5 synaptic complex transposition intermediate. Science 2000, 289, 77-85.
-
(2000)
Science
, vol.289
, pp. 77-85
-
-
Davies, D.R.1
Goryshin, I.Y.2
Reznikoff, W.S.3
Rayment, I.4
-
22
-
-
0036924813
-
A Hoogsteen base pair embedded in undistorted B-DNA
-
Aishima, J.; Gitti, R. K.; Noah, J. E.; Gan, H. H.; Schlick, T.; Wolberger, C. A Hoogsteen base pair embedded in undistorted B-DNA. Nucleic Acids Res. 2002, 30, 5244-5252.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 5244-5252
-
-
Aishima, J.1
Gitti, R.K.2
Noah, J.E.3
Gan, H.H.4
Schlick, T.5
Wolberger, C.6
-
23
-
-
0035900960
-
Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein
-
Norman, D. P.; Bruner, S. D.; Verdine, G. L. Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J. Am. Chem. Soc. 2001, 123, 359-360.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 359-360
-
-
Norman, D.P.1
Bruner, S.D.2
Verdine, G.L.3
-
24
-
-
33645216987
-
Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends
-
Chen, A.;Weber, I. T.; Harrison, R.W.; Leis, J. Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat ends. J. Biol. Chem. 2006, 281, 4173-4182.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4173-4182
-
-
Chen, A.1
Weber, I.T.2
Harrison, R.W.3
Leis, J.4
-
25
-
-
0033063512
-
Molecular dynamics studies on the HIV-1 integrase catalytic domain
-
Lins, R. D.; Briggs, J. M.; Straatsma, T. P.; Carlson, H. A.; Greenwald, J.; Choe, S.; McCammon, J. A. Molecular dynamics studies on the HIV-1 integrase catalytic domain. Biophys. J. 1999, 76, 2999-3011.
-
(1999)
Biophys. J.
, vol.76
, pp. 2999-3011
-
-
Lins, R.D.1
Briggs, J.M.2
Straatsma, T.P.3
Carlson, H.A.4
Greenwald, J.5
Choe, S.6
McCammon, J.A.7
-
26
-
-
0034104449
-
Investigations on human immunodeficiency virus type 1 integrase/DNA binding interactions via molecular dynamics and electrostatics calculations
-
Lins, R. D.; Adesokan, A.; Soares, T. A.; Briggs, J. M. Investigations on human immunodeficiency virus type 1 integrase/DNA binding interactions via molecular dynamics and electrostatics calculations. Pharmacol. Ther. 2000, 85, 123-131.
-
(2000)
Pharmacol. Ther.
, vol.85
, pp. 123-131
-
-
Lins, R.D.1
Adesokan, A.2
Soares, T.A.3
Briggs, J.M.4
-
27
-
-
0035855917
-
Ordered water and ligand mobility in the HIV-1 integrase-5CITEP complex: A molecular dynamics study
-
Ni, H.; Sotriffer, C. A.; McCammon, J. A. Ordered water and ligand mobility in the HIV-1 integrase-5CITEP complex: A molecular dynamics study. J. Med. Chem. 2001, 44, 3043-3047.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3043-3047
-
-
Ni, H.1
Sotriffer, C.A.2
McCammon, J.A.3
-
28
-
-
0037339235
-
Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: Mechanism for inhibition and drug resistance
-
Barreca, M. L.; Lee, K. W.; Chimirri, A.; Briggs, J. M. Molecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: Mechanism for inhibition and drug resistance. Biophys. J. 2003, 84, 1450-1463.
-
(2003)
Biophys. J.
, vol.84
, pp. 1450-1463
-
-
Barreca, M.L.1
Lee, K.W.2
Chimirri, A.3
Briggs, J.M.4
-
29
-
-
17844395966
-
Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/ M154I catalytic domain
-
Brigo, A.; Lee, K.W.; Iurcu Mustata, G.; Briggs, J. M. Comparison of multiple molecular dynamics trajectories calculated for the drug-resistant HIV-1 integrase T66I/ M154I catalytic domain. Biophys. J. 2005, 88, 3072-3082.
-
(2005)
Biophys. J.
, vol.88
, pp. 3072-3082
-
-
Brigo, A.1
Lee, K.W.2
Iurcu Mustata, G.3
Briggs, J.M.4
-
30
-
-
18844369136
-
Comparative molecular dynamics simulations of HIV-1 integrase and the T66I/M154I mutant: Binding modes and drug resistance to a diketo acid inhibitor
-
Brigo, A.; Lee, K. W.; Fogolari, F.; Mustata, G. I.; Briggs, J. M. Comparative molecular dynamics simulations of HIV-1 integrase and the T66I/M154I mutant: Binding modes and drug resistance to a diketo acid inhibitor. Proteins 2005, 59, 723-741.
-
(2005)
Proteins
, vol.59
, pp. 723-741
-
-
Brigo, A.1
Lee, K.W.2
Fogolari, F.3
Mustata, G.I.4
Briggs, J.M.5
-
31
-
-
17844406393
-
Large-scale conformational dynamics of the HIV-1 integrase core domainand its catalytic loop mutants
-
Lee, M. C.; Deng, J.; Briggs, J. M.; Duan, Y. Large-scale conformational dynamics of the HIV-1 integrase core domainand its catalytic loop mutants. Biophys. J. 2005, 88, 3133-3146.
-
(2005)
Biophys. J.
, vol.88
, pp. 3133-3146
-
-
Lee, M.C.1
Deng, J.2
Briggs, J.M.3
Duan, Y.4
-
32
-
-
0034725381
-
HIV-1 integrase inhibitor interactions at the active site: Prediction of binding modes unaffected by crystal packing
-
Sotriffer, C. A.; Ni, H.; McCammon, J. A. HIV-1 integrase inhibitor interactions at the active site: Prediction of binding modes unaffected by crystal packing. J. Am. Chem. Soc. 2000, 122, 6136-6137.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 6136-6137
-
-
Sotriffer, C.A.1
Ni, H.2
McCammon, J.A.3
-
33
-
-
0034597625
-
Active site binding modes of HIV-1 integrase inhibitors
-
Sotriffer, C. A.; Ni, H.; McCammon, J. A. Active site binding modes of HIV-1 integrase inhibitors. J. Med. Chem. 2000, 43, 4109-4117.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 4109-4117
-
-
Sotriffer, C.A.1
Ni, H.2
McCammon, J.A.3
-
34
-
-
0035915338
-
Fully flexible low-mode docking: Application to induced fit in HIVintegrase
-
Keseru, G. M.; Kolossvary, I. Fully flexible low-mode docking: Application to induced fit in HIVintegrase. J. Am. Chem. Soc. 2001, 123, 12708-12709.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 12708-12709
-
-
Keseru, G.M.1
Kolossvary, I.2
-
35
-
-
8844247763
-
Active site binding modes of the beta-diketoacids: A multi-active site approach in HIV-1 integrase inhibitor design
-
Dayam, R.; Neamati, N. Active site binding modes of the beta-diketoacids: A multi-active site approach in HIV-1 integrase inhibitor design. Bioorg. Med. Chem. 2004, 12, 6371-6381.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 6371-6381
-
-
Dayam, R.1
Neamati, N.2
-
36
-
-
33845944851
-
Novel HIV integrase inhibitors with anti-HIV activity: Insights into integrase inhibition from docking studies
-
Cox, A. G.; Nair, V. Novel HIV integrase inhibitors with anti-HIV activity: Insights into integrase inhibition from docking studies. Antivir. Chem. Chemother. 2006, 17, 343-353.
-
(2006)
Antivir. Chem. Chemother.
, vol.17
, pp. 343-353
-
-
Cox, A.G.1
Nair, V.2
-
37
-
-
0037137609
-
AutoDocking dinucleotides to the HIV-1 integrase core domain: Exploring possible binding sites for viral and genomic DNA
-
Perryman, A. L.; McCammon, J. A. AutoDocking dinucleotides to the HIV-1 integrase core domain: Exploring possible binding sites for viral and genomic DNA. J. Med. Chem. 2002, 45, 5624-5627.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 5624-5627
-
-
Perryman, A.L.1
McCammon, J.A.2
-
38
-
-
0842304431
-
Prediction of HIV-1 integrase/viral DNA interactions in the catalytic domain by fast molecular docking
-
Adesokan, A. A.; Roberts, V. A.; Lee, K. W.; Lins, R. D.; Briggs, J. M. Prediction of HIV-1 integrase/viral DNA interactions in the catalytic domain by fast molecular docking. J. Med. Chem. 2004, 47, 821-828.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 821-828
-
-
Adesokan, A.A.1
Roberts, V.A.2
Lee, K.W.3
Lins, R.D.4
Briggs, J.M.5
-
39
-
-
2942553781
-
Structure and function of HIV-1 integrase
-
Chiu, T. K.; Davies, D. R. Structure and function of HIV-1 integrase. Curr. Top. Med. Chem. 2004, 4, 965-977.
-
(2004)
Curr. Top. Med. Chem.
, vol.4
, pp. 965-977
-
-
Chiu, T.K.1
Davies, D.R.2
-
40
-
-
33744963969
-
Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA
-
Agapkina, J.; Smolov, M.; Barbe, S.; Zubin, E.; Zatsepin, T.; Deprez, E.; Le Bret, M.; Mouscadet, J. F.; Gottikh, M. Probing of HIV-1 integrase/DNA interactions using novel analogs of viral DNA. J. Biol. Chem. 2006, 281, 11530-11540.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 11530-11540
-
-
Agapkina, J.1
Smolov, M.2
Barbe, S.3
Zubin, E.4
Zatsepin, T.5
Deprez, E.6
Le Bret, M.7
Mouscadet, J.F.8
Gottikh, M.9
-
41
-
-
34147128555
-
In-silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
-
Savarino, A. In-silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate. Retrovirology 2007, 4, 21-34.
-
(2007)
Retrovirology
, vol.4
, pp. 21-34
-
-
Savarino, A.1
-
42
-
-
48149101517
-
Computational studies of HIV-1 integrase and its inhibitors
-
Nunthaboot, N.; Pianwanit, S.; Parasuk,V.;Kokpol, S.; Briggs, J. M. Computational studies of HIV-1 integrase and its inhibitors. Curr. Comput-Aided Drug Des. 2007, 3, 160-190.
-
(2007)
Curr. Comput-Aided Drug Des.
, vol.3
, pp. 160-190
-
-
Nunthaboot, N.1
Pianwanit, S.2
Parasuk, V.3
Kokpol, S.4
Briggs, J.M.5
-
43
-
-
44949212848
-
Modeling analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors
-
Chen, X.; Tsiang, M.; Yu, F.; Hung, M.; Jones, G. S.; Zeynalzadegan, A.; Qi, X.; Jin, H.; Kim, C. U.; Swaminathan, S.; Chen, J. M. Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors. J. Mol. Biol. 2008, 380, 504-519.
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 504-519
-
-
Chen, X.1
Tsiang, M.2
Yu, F.3
Hung, M.4
Jones, G.S.5
Zeynalzadegan, A.6
Qi, X.7
Jin, H.8
Kim, C.U.9
Swaminathan, S.10
Chen, J.M.11
-
44
-
-
69849093567
-
Inducedfit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors
-
Barreca, M. L.; Iraci, N.; De Luca, L.; Chimirri, A. Inducedfit docking approach provides insight into the binding mode and mechanism of action of HIV-1 integrase inhibitors. ChemMedChem 2009, 4, 1446-1456.
-
(2009)
ChemMedChem
, vol.4
, pp. 1446-1456
-
-
Barreca, M.L.1
Iraci, N.2
De Luca, L.3
Chimirri, A.4
-
45
-
-
77954682878
-
Computer tools in the discovery of HIV-1 integrase inhibitors
-
Liao, C.; Nicklaus, M. C. Computer tools in the discovery of HIV-1 integrase inhibitors. Future Med Chem, 2010, 2, 1123-1140.
-
(2010)
Future Med Chem
, vol.2
, pp. 1123-1140
-
-
Liao, C.1
Nicklaus, M.C.2
-
46
-
-
48549103167
-
HIV-1 integrase-DNA interactions investigated by molecular modelling
-
Fenollar-Ferrer, C.; Carnevale, V.; Raugei, S.; Carloni, P. HIV-1 integrase-DNA interactions investigated by molecular modelling. Comput. Math Methods Med. 2008, 9, 231-243.
-
(2008)
Comput. Math Methods Med.
, vol.9
, pp. 231-243
-
-
Fenollar-Ferrer, C.1
Carnevale, V.2
Raugei, S.3
Carloni, P.4
-
47
-
-
0032510707
-
Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex
-
Heuer, T. S.; Brown, P. O. Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex. Biochemistry 1998, 37, 6667-6678.
-
(1998)
Biochemistry
, vol.37
, pp. 6667-6678
-
-
Heuer, T.S.1
Brown, P.O.2
-
48
-
-
0030875813
-
Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photocross-linking
-
Heuer, T. S.; Brown, P. O. Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photocross-linking. Biochemistry 1997, 36, 10655-10665.
-
(1997)
Biochemistry
, vol.36
, pp. 10655-10665
-
-
Heuer, T.S.1
Brown, P.O.2
-
49
-
-
0031718377
-
The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA
-
Gao, Y. G.; Su, S. Y.; Robinson, H.; Padmanabhan, S.; Lim, L.; McCrary, B. S.; Edmondson, S. P.; Shriver, J. W.; Wang, A. H. The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA. Nat. Struct. Biol. 1998, 5, 782-786.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 782-786
-
-
Gao, Y.G.1
Su, S.Y.2
Robinson, H.3
Padmanabhan, S.4
Lim, L.5
McCrary, B.S.6
Edmondson, S.P.7
Shriver, J.W.8
Wang, A.H.9
-
50
-
-
0032510217
-
The hyperthermophile chromosomal protein Sac7d sharply kinks DNA
-
Robinson, H.; Gao, Y. G.; McCrary, B. S.; Edmondson, S. P.; Shriver, J. W.; Wang, A. H. The hyperthermophile chromosomal protein Sac7d sharply kinks DNA. Nature 1998, 392, 202-205.
-
(1998)
Nature
, vol.392
, pp. 202-205
-
-
Robinson, H.1
Gao, Y.G.2
McCrary, B.S.3
Edmondson, S.P.4
Shriver, J.W.5
Wang, A.H.6
-
51
-
-
0033543174
-
The solution structure of the Sac7d/DNA complex: A small-angle X-ray scattering study
-
Krueger, J. K.; McCrary, B. S.; Wang, A. H.; Shriver, J. W.; Trewhella, J.; Edmondson, S. P. The solution structure of the Sac7d/DNA complex: A small-angle X-ray scattering study. Biochemistry 1999, 38, 10247-10255.
-
(1999)
Biochemistry
, vol.38
, pp. 10247-10255
-
-
Krueger, J.K.1
McCrary, B.S.2
Wang, A.H.3
Shriver, J.W.4
Trewhella, J.5
Edmondson, S.P.6
-
52
-
-
0002181955
-
The MIDAS display system
-
Ferrin, T. E.; Huang, C. C.; Jarvis, L. E.; Langridge, R. The MIDAS display system. J. Mol. Graphics 1988, 6, 13-27.
-
(1988)
J. Mol. Graphics
, vol.6
, pp. 13-27
-
-
Ferrin, T.E.1
Huang, C.C.2
Jarvis, L.E.3
Langridge, R.4
-
53
-
-
0035796559
-
Human immunodeficiency virus type 1 integrase: Arrangement of protein domains in active cDNA complexes
-
Gao, K.; Butler, S. L.; Bushman, F. Human immunodeficiency virus type 1 integrase: Arrangement of protein domains in active cDNA complexes. EMBO J. 2001, 20, 3565-3576.
-
(2001)
EMBO J
, vol.20
, pp. 3565-3576
-
-
Gao, K.1
Butler, S.L.2
Bushman, F.3
-
54
-
-
0037234457
-
Modeling HIV-1 integrase complexes based on their hydrodynamic properties
-
Podtelezhnikov, A. A.; Gao, K.; Bushman, F. D.; McCammon, J. A. Modeling HIV-1 integrase complexes based on their hydrodynamic properties. Biopolymers 2003, 68, 110-120.
-
(2003)
Biopolymers
, vol.68
, pp. 110-120
-
-
Podtelezhnikov, A.A.1
Gao, K.2
Bushman, F.D.3
McCammon, J.A.4
-
55
-
-
0034622521
-
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy
-
Deprez, E.; Tauc, P.; Leh, H.; Mouscadet, J. F.; Auclair, C.; Brochon, J. C. Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy. Biochemistry 2000, 39, 9275-9284.
-
(2000)
Biochemistry
, vol.39
, pp. 9275-9284
-
-
Deprez, E.1
Tauc, P.2
Leh, H.3
Mouscadet, J.F.4
Auclair, C.5
Brochon, J.C.6
-
56
-
-
0035343895
-
Comparative architecture of transposase and integrase complexes
-
Rice, P. A.; Baker, T. A. Comparative architecture of transposase and integrase complexes. Nat. Struct. Biol. 2001, 8, 302-307.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 302-307
-
-
Rice, P.A.1
Baker, T.A.2
-
57
-
-
33645405333
-
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, biological activities, and mechanism of action
-
Di Santo, R.; Costi, R.; Roux, A.; Artico, M.; Lavecchia, A.; Marinelli, L.; Novellino, E.; Palmisano, L.; Andreotti, M.; Amici, R.; Galluzzo, C. M.; Nencioni, L.; Palamara, A. T.; Pommier, Y.; Marchand, C. Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: Design, synthesis, biological activities, and mechanism of action. J. Med. Chem. 2006, 49, 1939-1945.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1939-1945
-
-
Di Santo, R.1
Costi, R.2
Roux, A.3
Artico, M.4
Lavecchia, A.5
Marinelli, L.6
Novellino, E.7
Palmisano, L.8
Andreotti, M.9
Amici, R.10
Galluzzo, C.M.11
Nencioni, L.12
Palamara, A.T.13
Pommier, Y.14
Marchand, C.15
-
58
-
-
0141927229
-
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking
-
De Luca, L.; Pedretti, A.; Vistoli, G.; Barreca, M. L.; Villa, L.; Monforte, P.; Chimirri, A. Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking. Biochem. Biophys. Res. Commun. 2003, 310, 1083-1088.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, pp. 1083-1088
-
-
De Luca, L.1
Pedretti, A.2
Vistoli, G.3
Barreca, M.L.4
Villa, L.5
Monforte, P.6
Chimirri, A.7
-
59
-
-
0030855390
-
Escher: A new docking procedure applied to the reconstruction of protein tertiary structure
-
Ausiello, G.; Cesareni, G.; Helmer-Citterich, M. ESCHER: A new docking procedure applied to the reconstruction of protein tertiary structure. Proteins 1997, 28, 556-567.
-
(1997)
Proteins
, vol.28
, pp. 556-567
-
-
Ausiello, G.1
Cesareni, G.2
Helmer-Citterich, M.3
-
60
-
-
25644450220
-
Molecular dynamics studies of the full-length integrase-DNA complex
-
De Luca, L.; Vistoli, G.; Pedretti, A.; Barreca, M. L.; Chimirri, A. Molecular dynamics studies of the full-length integrase-DNA complex. Biochem. Biophys. Res. Commun. 2005, 336, 1010-1016.61
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.336
, pp. 10101016
-
-
De Luca, L.1
Vistoli, G.2
Pedretti, A.3
Barreca, M.L.4
Chimirri, A.5
-
61
-
-
22144463200
-
Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design
-
Karki, R. G.; Tang, Y.; Burke, T. R., Jr.; Nicklaus, M. C. Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design. J. Comput. Aided Mol. Des. 2004, 18, 739-760.
-
(2004)
J. Comput. Aided Mol. Des.
, vol.18
, pp. 739-760
-
-
Karki, R.G.1
Tang, Y.2
Burke Jr, T.R.3
Nicklaus, M.C.4
-
62
-
-
0037463757
-
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors
-
Zhang, X.; Pais, G. C.; Svarovskaia, E. S.; Marchand, C.; Johnson, A. A.; Karki, R. G.; Nicklaus, M. C.; Pathak, V. K.; Pommier, Y.; Burke, T. R. Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors. Bioorg. Med. Chem. Lett. 2003, 13, 1215-1219.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1215-1219
-
-
Zhang, X.1
Pais, G.C.2
Svarovskaia, E.S.3
Marchand, C.4
Johnson, A.A.5
Karki, R.G.6
Nicklaus, M.C.7
Pathak, V.K.8
Pommier, Y.9
Burke, T.R.10
-
63
-
-
34548609774
-
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA
-
Liao, C.; Karki, R. G.; Marchand, C.; Pommier, Y.; Nicklaus, M. C. Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA. Bioorg. Med. Chem. Lett. 2007, 17, 5361-5365.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 5361-5365
-
-
Liao, C.1
Karki, R.G.2
Marchand, C.3
Pommier, Y.4
Nicklaus, M.C.5
-
64
-
-
26644456674
-
A threedimensional model of the human immunodeficiency virus type 1 integration complex
-
Wielens, J.; Crosby, I. T.; Chalmers, D. K. A threedimensional model of the human immunodeficiency virus type 1 integration complex. J. Comput. Aided Mol. Des. 2005, 19, 301-317.
-
(2005)
J. Comput. Aided Mol. Des.
, vol.19
, pp. 301-317
-
-
Wielens, J.1
Crosby, I.T.2
Chalmers, D.K.3
-
65
-
-
0030828521
-
Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking
-
Jenkins, T. M.; Esposito, D.; Engelman, A.; Craigie, R. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 1997, 16, 6849-6859.
-
(1997)
EMBO J
, vol.16
, pp. 6849-6859
-
-
Jenkins, T.M.1
Esposito, D.2
Engelman, A.3
Craigie, R.4
-
66
-
-
0032189652
-
Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction
-
Esposito, D.; Craigie, R. Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. EMBO J. 1998, 17, 5832-5843.
-
(1998)
EMBO J
, vol.17
, pp. 5832-5843
-
-
Esposito, D.1
Craigie, R.2
-
67
-
-
0026696624
-
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection
-
Pryciak, P. M.; Varmus, H. E. Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection. Cell 1992, 69, 769-780.
-
(1992)
Cell
, vol.69
, pp. 769-780
-
-
Pryciak, P.M.1
Varmus, H.E.2
-
68
-
-
0030219760
-
Targetsequence preferences of HIV-1 integration complexes in vitro
-
Bor, Y. C.; Miller,M. D.; Bushman, F. D.; Orgel, L. E. Targetsequence preferences of HIV-1 integration complexes in vitro. Virology 1996, 222, 283-288.
-
(1996)
Virology
, vol.222
, pp. 283-288
-
-
Bor, Y.C.1
Miller, M.D.2
Bushman, F.D.3
Orgel, L.E.4
-
69
-
-
0035823488
-
Role of DNA end distortion in catalysis by avian sarcoma virus integrase
-
Katz, R. A.; DiCandeloro, P.; Kukolj, G.; Skalka, A. M. Role of DNA end distortion in catalysis by avian sarcoma virus integrase. J. Biol. Chem. 2001, 276, 34213-34220.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 34213-34220
-
-
Katz, R.A.1
DiCandeloro, P.2
Kukolj, G.3
Skalka, A.M.4
-
70
-
-
0028264042
-
Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core
-
Pruss, D.; Bushman, F. D.; Wolffe, A. P. Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core. Proc. Natl. Acad. Sci. USA 1994, 91, 5913-5917.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5913-5917
-
-
Pruss, D.1
Bushman, F.D.2
Wolffe, A.P.3
-
71
-
-
0028125005
-
The influence of DNA and nucleosome structure on integration events directed by HIV integrase
-
Pruss, D.; Reeves, R.; Bushman, F. D.; Wolffe, A. P. The influence of DNA and nucleosome structure on integration events directed by HIV integrase. J. Biol. Chem. 1994, 269, 25031-25041.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 25031-25041
-
-
Pruss, D.1
Reeves, R.2
Bushman, F.D.3
Wolffe, A.P.4
-
72
-
-
84886122992
-
-
HIV Sequence Compendium, Published by Theoretical Biology and Biophysics, Group T-10, Mail Stop K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (LA-UR-06-0680)
-
Leitner, T.; Foley, B.; Hahn, B.; Marx, P.; McCutchan, F.; Mellors, J.; Wolinsky, S.; Korber, B. HIV Sequence Compendium, Published by Theoretical Biology and Biophysics, Group T-10, Mail Stop K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (LA-UR-06-0680). 2005.
-
(2005)
-
-
Leitner, T.1
Foley, B.2
Hahn, B.3
Marx, P.4
McCutchan, F.5
Mellors, J.6
Wolinsky, S.7
Korber, B.8
-
73
-
-
84886206729
-
-
HIV Sequence Compendium, Published by Theoretical Biology and Biophysics, Group T-10, Mail Stop K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (LA-UR-06-0680)
-
Leitner, T.; Foley, B.; Hahn, B.; Marx, P.; McCutchan, F.; Mellors, J.; Wolinsky, S.; Korber, B. HIV Sequence Compendium, Published by Theoretical Biology and Biophysics, Group T-10, Mail Stop K710, Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (LA-UR-06-0680). 2005.
-
(2005)
-
-
Leitner, T.1
Foley, B.2
Hahn, B.3
Marx, P.4
McCutchan, F.5
Mellors, J.6
Wolinsky, S.7
Korber, B.8
-
74
-
-
25844474350
-
Constructing HIV-1 integrase tetramer and exploring influences of metal ions on forming integrase-DNA complex
-
Wang, L. D.; Liu, C. L.; Chen, W. Z.; Wang, C. X. Constructing HIV-1 integrase tetramer and exploring influences of metal ions on forming integrase-DNA complex. Biochem. Biophys. Res. Commun. 2005, 337, 313-319.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.337
, pp. 313-319
-
-
Wang, L.D.1
Liu, C.L.2
Chen, W.Z.3
Wang, C.X.4
-
75
-
-
33646540704
-
Structural and dynamical properties of a full-length HIV-1 integrase: Molecular dynamics simulations
-
Wijitkosoom, A.; Tonmunphean, S.; Truong, T. N.; Hannongbua, S. Structural and dynamical properties of a full-length HIV-1 integrase: Molecular dynamics simulations. J. Biomol. Struct. Dyn. 2006, 23, 613-624.
-
(2006)
J. Biomol. Struct. Dyn.
, vol.23
, pp. 613-624
-
-
Wijitkosoom, A.1
Tonmunphean, S.2
Truong, T.N.3
Hannongbua, S.4
-
76
-
-
33846272678
-
Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA
-
Ren, G.; Gao, K.; Bushman, F. D.; Yeager, M. Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA. J. Mol. Biol. 2007, 366, 286-294.
-
(2007)
J. Mol. Biol.
, vol.366
, pp. 286-294
-
-
Ren, G.1
Gao, K.2
Bushman, F.D.3
Yeager, M.4
-
77
-
-
38949110763
-
Raltegravir (MK-0518): A novel integrase inhibitor for the treatment of HIV infection
-
Anker, M.; Corales, R. B. Raltegravir (MK-0518): A novel integrase inhibitor for the treatment of HIV infection. Expert Opin. Investig. Drugs 2008, 17, 97-103.
-
(2008)
Expert Opin. Investig. Drugs
, vol.17
, pp. 97-103
-
-
Anker, M.1
Corales, R.B.2
-
78
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato, M.; Motomura, T.; Aramaki, H.; Matsuda, T.; Yamashita, M.; Ito, Y.; Kawakami, H.; Matsuzaki, Y.; Watanabe, W.; Yamataka, K.; Ikeda, S.; Kodama, E.; Matsuoka, M.; Shinkai, H. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J. Med. Chem. 2006, 49, 1506-1508.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
Matsuda, T.4
Yamashita, M.5
Ito, Y.6
Kawakami, H.7
Matsuzaki, Y.8
Watanabe, W.9
Yamataka, K.10
Ikeda, S.11
Kodama, E.12
Matsuoka, M.13
Shinkai, H.14
-
79
-
-
33745656139
-
L.; De Luca, L.; Iraci, N.; Chimirri
-
Barreca, M. L.; De Luca, L.; Iraci, N.; Chimirri, A. Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase. J. Med. Chem. 2006, 49, 3994-3997.
-
(2006)
A. Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase. J. Med. Chem.
, vol.49
, pp. 3994-3997
-
-
Barreca, M.1
-
80
-
-
18244375843
-
Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors
-
Ason, B.; Knauss, D. J.; Balke, A. M.; Merkel, G.; Skalka, A. M.; Reznikoff, W. S. Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors. Antimicrob. Agents Chemother. 2005, 49, 2035-2043.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 2035-2043
-
-
Ason, B.1
Knauss, D.J.2
Balke, A.M.3
Merkel, G.4
Skalka, A.M.5
Reznikoff, W.S.6
-
81
-
-
33745172864
-
Design, synthesis, and SAR studies of novel and highly active tricyclic HIV integrase inhibitors
-
Jin, H.; Cai, R. Z.; Schacherer, L.; Jabri, S.; Tsiang, M.; Fardis, M.; Chen, X.; Chen, J. M.; Kim, C. U. Design, synthesis, and SAR studies of novel and highly active tricyclic HIV integrase inhibitors. Bioorg. Med. Chem. Lett. 2006, 16, 3989-3992.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 3989-3992
-
-
Jin, H.1
Cai, R.Z.2
Schacherer, L.3
Jabri, S.4
Tsiang, M.5
Fardis, M.6
Chen, X.7
Chen, J.M.8
Kim, C.U.9
-
82
-
-
33750532296
-
A platform for designing HIV integrase inhibitors Part 2 A two-metal binding model as a potential mechanism of HIV integrase inhibitors
-
Kawasuji, T.; Fuji, M.; Yoshinaga, T.; Sato, A.; Fujiwara, T.; Kiyama, R. A platform for designing HIV integrase inhibitors. Part 2: A two-metal binding model as a potential mechanism of HIV integrase inhibitors. Bioorg. Med. Chem. 2006, 14, 8420-8429.
-
(2006)
Bioorg. Med. Chem.
, vol.14
, pp. 8420-8429
-
-
Kawasuji, T.1
Fuji, M.2
Yoshinaga, T.3
Sato, A.4
Fujiwara, T.5
Kiyama, R.6
-
83
-
-
38449089374
-
Anti-Hiv agents. New drugs-Hope and a degree of caution
-
Anti-HIV agents. New drugs-Hope and a degree of caution. TreatmentUpdate 2007, 19, 9-10.
-
(2007)
TreatmentUpdate
, vol.19
, pp. 9-10
-
-
-
84
-
-
38449112846
-
Anti-Hiv agents. Raltegravir (Isentress)-Results after one year
-
Anti-HIV agents. Raltegravir (Isentress)-Results after one year. TreatmentUpdate 2007, 19, 8-9.
-
(2007)
TreatmentUpdate
, vol.19
, pp. 8-9
-
-
-
85
-
-
38349194563
-
Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects
-
Iwamoto, M.; Wenning, L. A.; Petry, A. S.; Laethem, M.; De Smet, M.; Kost, J. T.; Merschman, S. A.; Strohmaier, K. M.; Ramael, S.; Lasseter, K. C.; Stone, J. A.; Gottesdiener, K. M.; Wagner, J. A. Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects. Clin. Pharmacol. Ther. 2008, 83, 293-299.
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 293-299
-
-
Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
Laethem, M.4
De Smet, M.5
Kost, J.T.6
Merschman, S.A.7
Strohmaier, K.M.8
Ramael, S.9
Lasseter, K.C.10
Stone, J.A.11
Gottesdiener, K.M.12
Wagner, J.A.13
-
86
-
-
0029116747
-
Solution structure of the DNA binding domain of HIV-1 integrase
-
Lodi, P. J.; Ernst, J. A.; Kuszewski, J.; Hickman, A. B.; Engelman, A.; Craigie, R.; Clore, G. M.; Gronenborn, A. M. Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry 1995, 34, 9826-9833.
-
(1995)
Biochemistry
, vol.34
, pp. 9826-9833
-
-
Lodi, P.J.1
Ernst, J.A.2
Kuszewski, J.3
Hickman, A.B.4
Engelman, A.5
Craigie, R.6
Clore, G.M.7
Gronenborn, A.M.8
-
87
-
-
0028865574
-
High-resolution structure of the catalytic domain of avian sarcoma virus integrase
-
Bujacz, G.; Jaskolski, M.; Alexandratos, J.; Wlodawer, A.; Merkel, G.; Katz, R. A.; Skalka, A. M. High-resolution structure of the catalytic domain of avian sarcoma virus integrase. J. Mol. Biol. 1995, 253, 333-346.
-
(1995)
J. Mol. Biol.
, vol.253
, pp. 333-346
-
-
Bujacz, G.1
Jaskolski, M.2
Alexandratos, J.3
Wlodawer, A.4
Merkel, G.5
Katz, R.A.6
Skalka, A.M.7
-
88
-
-
0030746054
-
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity
-
Bujacz, G.; Alexandratos, J.; Wlodawer, A.; Merkel, G.; Andrake, M.; Katz, R. A.; Skalka, A. M. Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity. J. Biol. Chem. 1997, 272, 18161-18168.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18161-18168
-
-
Bujacz, G.1
Alexandratos, J.2
Wlodawer, A.3
Merkel, G.4
Andrake, M.5
Katz, R.A.6
Skalka, A.M.7
-
89
-
-
0034824775
-
Mapping DNA-binding sites of HIV-1 integrase by protein footprinting
-
Dirac, A. M.; Kjems, J. Mapping DNA-binding sites of HIV-1 integrase by protein footprinting. Eur. J. Biochem. 2001, 268, 743-751.
-
(2001)
Eur. J. Biochem.
, vol.268
, pp. 743751
-
-
Dirac, A.M.1
Kjems, J.2
-
90
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
Grobler, J. A.; Stillmock, K.; Hu, B.; Witmer, M.; Felock, P.; Espeseth, A. S.; Wolfe, A.; Egbertson, M.; Bourgeois, M.; Melamed, J.; Wai, J. S.; Young, S.; Vacca, J.; Hazuda, D. J. Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes. Proc. Natl. Acad. Sci. USA 2002, 99, 6661-6666.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
Witmer, M.4
Felock, P.5
Espeseth, A.S.6
Wolfe, A.7
Egbertson, M.8
Bourgeois, M.9
Melamed, J.10
Wai, J.S.11
Young, S.12
Vacca, J.13
Hazuda, D.J.14
-
91
-
-
0025908083
-
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
-
Davies, J. F., 2nd; Hostomska, Z.; Hostomsky, Z.; Jordan, S. R.; Matthews, D. A. Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science 1991, 252, 88-95.
-
(1991)
Science
, vol.252
, pp. 88-95
-
-
Davies II, J.F.1
Hostomska, Z.2
Hostomsky, Z.3
Jordan, S.R.4
Matthews, D.A.5
-
92
-
-
0027184481
-
A general two-metal-ion mechanism for catalytic RNA
-
Steitz, T. A.; Steitz, J. A. A general two-metal-ion mechanism for catalytic RNA. Proc. Natl. Acad. Sci. USA 1993, 90, 6498-6502.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6498-6502
-
-
Steitz, T.A.1
Steitz, J.A.2
-
93
-
-
0032005866
-
Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes
-
Brautigam, C. A.; Steitz, T. A. Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes. Curr. Opin. Struct. Biol. 1998, 8, 54-63.
-
(1998)
Curr. Opin. Struct. Biol.
, vol.8
, pp. 54-63
-
-
Brautigam, C.A.1
Steitz, T.A.2
-
94
-
-
0032791840
-
Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase
-
Eijkelenboom, A. P.; Sprangers, R.; Hard, K.; Puras Lutzke, R. A.; Plasterk, R. H.; Boelens, R.; Kaptein, R. Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase. Proteins 1999, 36, 556-564.
-
(1999)
Proteins
, vol.36
, pp. 556-564
-
-
Eijkelenboom, A.P.1
Sprangers, R.2
Hard, K.3
Puras Lutzke, R.A.4
Plasterk, R.H.5
Boelens, R.6
Kaptein, R.7
-
95
-
-
0031949592
-
Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzymesubstrate interactions
-
Gerton, J. L.; Ohgi, S.; Olsen, M.; DeRisi, J.; Brown, P. O. Effects of mutations in residues near the active site of human immunodeficiency virus type 1 integrase on specific enzymesubstrate interactions. J. Virol. 1998, 72, 5046-5055.
-
(1998)
J. Virol.
, vol.72
, pp. 5046-5055
-
-
Gerton, J.L.1
Ohgi, S.2
Olsen, M.3
DeRisi, J.4
Brown, P.O.5
-
96
-
-
0025133394
-
Retroviral DNA integration directed by HIV integration protein in vitro
-
Bushman, F. D.; Fujiwara, T.; Craigie, R. Retroviral DNA integration directed by HIV integration protein in vitro. Science 1990, 249, 1555-1558.
-
(1990)
Science
, vol.249
, pp. 1555-1558
-
-
Bushman, F.D.1
Fujiwara, T.2
Craigie, R.3
-
97
-
-
0030478950
-
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity
-
Zheng, R.; Jenkins, T. M.; Craigie, R. Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc. Natl. Acad. Sci. USA 1996, 93, 13659-13664.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13659-13664
-
-
Zheng, R.1
Jenkins, T.M.2
Craigie, R.3
-
98
-
-
0029980485
-
A soluble active mutant of HIV-1 integrase: Involvement of both the core and carboxyl-terminal domains in multimerization
-
Jenkins, T. M.; Engelman, A.; Ghirlando, R.; Craigie, R. A soluble active mutant of HIV-1 integrase: Involvement of both the core and carboxyl-terminal domains in multimerization. J. Biol. Chem. 1996, 271, 7712-7718.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 7712-7718
-
-
Jenkins, T.M.1
Engelman, A.2
Ghirlando, R.3
Craigie, R.4
-
99
-
-
0028863151
-
Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase
-
Andrake, M. D.; Skalka, A. M., Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase. J. Biol. Chem. 1995, 270, 29299-29306.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29299-29306
-
-
Andrake, M.D.1
Skalka, A.M.2
-
100
-
-
0032601403
-
HIV-1 integrase: Structural organization, conformational changes, and catalysis
-
Asante-Appiah, E.; Skalka, A. M. HIV-1 integrase: Structural organization, conformational changes, and catalysis. Adv. Virus Res. 1999, 52, 351-369.
-
(1999)
Adv. Virus Res.
, vol.52
, pp. 351-369
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
101
-
-
0030922072
-
A metal-induced conformational change and activation of HIV-1 integrase
-
Asante-Appiah, E.; Skalka, A. M. A metal-induced conformational change and activation of HIV-1 integrase. J. Biol. Chem. 1997, 272, 16196-16205.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16196-16205
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
102
-
-
0028125329
-
Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA
-
Vink, C.; Lutzke, R. A.; Plasterk, R. H. Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA. Nucleic Acids Res. 1994, 22, 4103-4110.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4103-4110
-
-
Vink, C.1
Lutzke, R.A.2
Plasterk, R.H.3
-
103
-
-
0028034050
-
Characterization of the minimal DNA-binding domain of the HIV integrase protein
-
Lutzke, R. A.; Vink, C.; Plasterk, R. H. Characterization of the minimal DNA-binding domain of the HIV integrase protein. Nucleic Acids Res. 1994, 22, 4125-4131.
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4125-4131
-
-
Lutzke, R.A.1
Vink, C.2
Plasterk, R.H.3
-
104
-
-
0034739559
-
Characterization of mutant HIV-1 integrase carrying amino acid changes in the catalytic domain
-
Sayasith, K.; Sauve, G.; Yelle, J. Characterization of mutant HIV-1 integrase carrying amino acid changes in the catalytic domain. Mol. Cells 2000, 10, 525-532.
-
(2000)
Mol. Cells
, vol.10
, pp. 525-532
-
-
Sayasith, K.1
Sauve, G.2
Yelle, J.3
-
105
-
-
13444269378
-
Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase
-
Lu, R.; Limon, A.; Ghory, H. Z.; Engelman, A. Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase. J. Virol. 2005, 79, 2493-2505.
-
(2005)
J. Virol.
, vol.79
, pp. 2493-2505
-
-
Lu, R.1
Limon, A.2
Ghory, H.Z.3
Engelman, A.4
-
106
-
-
0001166515
-
Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding
-
Lutzke, R. A.; Plasterk, R. H. Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: Critical residues for protein oligomerization and DNA binding. J. Virol. 1998, 72, 4841-4848.
-
(1998)
J. Virol.
, vol.72
, pp. 4841-4848
-
-
Lutzke, R.A.1
Plasterk, R.H.2
-
107
-
-
0026668776
-
Mutational analysis of the integrase protein of human immunodeficiency virus type 2
-
USA
-
van Gent, D. C.; Groeneger, A. A.; Plasterk, R. H. Mutational analysis of the integrase protein of human immunodeficiency virus type 2. Proc. Natl. Acad. Sci. USA 1992, 89, 9598-9602.
-
(1992)
Proc. Natl. Acad. Sci.
, vol.89
, pp. 9598-9602
-
-
van Gent, D.C.1
Groeneger, A.A.2
Plasterk, R.H.3
-
108
-
-
0030988998
-
Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase
-
Engelman, A.; Liu, Y.; Chen, H.; Farzan, M.; Dyda, F. Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. J. Virol. 1997, 71, 3507-3514.
-
(1997)
J. Virol.
, vol.71
, pp. 3507-3514
-
-
Engelman, A.1
Liu, Y.2
Chen, H.3
Farzan, M.4
Dyda, F.5
-
109
-
-
0034908087
-
Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection
-
Harper, A. L.; Skinner, L. M.; Sudol, M.; Katzman, M. Use of patient-derived human immunodeficiency virus type 1 integrases to identify a protein residue that affects target site selection. J. Virol. 2001, 75, 7756-7762.
-
(2001)
J. Virol.
, vol.75
, pp. 7756-7762
-
-
Harper, A.L.1
Skinner, L.M.2
Sudol, M.3
Katzman, M.4
-
110
-
-
0027179694
-
Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex
-
Engelman, A.; Bushman, F. D.; Craigie, R. Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J. 1993, 12, 3269-3275.
-
(1993)
EMBO J
, vol.12
, pp. 3269-3275
-
-
Engelman, A.1
Bushman, F.D.2
Craigie, R.3
-
111
-
-
0033952347
-
Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions
-
Morgan, A. L.; Katzman, M. Subterminal viral DNA nucleotides as specific recognition signals for human immunodeficiency virus type 1 and visna virus integrases under magnesium-dependent conditions. J. Gen. Virol. 2000, 81, 839-849.
-
(2000)
J. Gen. Virol.
, vol.81
, pp. 839-849
-
-
Morgan, A.L.1
Katzman, M.2
-
112
-
-
0032508613
-
A preferred target DNA structure for retroviral integrase in vitro
-
Katz, R. A.; Gravuer, K.; Skalka, A. M. A preferred target DNA structure for retroviral integrase in vitro. J. Biol. Chem. 1998, 273, 24190-24195.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24190-24195
-
-
Katz, R.A.1
Gravuer, K.2
Skalka, A.M.3
-
113
-
-
4444221565
-
UCSF Chimera-A visualization system for exploratory research and analysis
-
Pettersen, E. F.; Goddard, T. D.; Huang, C. C.; Couch, G. S.; Greenblatt, D. M.; Meng, E. C.; Ferrin, T. E. UCSF Chimera-A visualization system for exploratory research and analysis. J. Comput. Chem. 2004, 25, 1605-1612.
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
114
-
-
84886137967
-
-
Maestro version 8.0. Schrödinger New York
-
Maestro, version 8.0. Schrödinger, New York, 2007.
-
(2007)
-
-
|