In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate

Retrovirology

Volumn 4, Issue , 2007, Pages

  Savarino, Andrea ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 (4 FLUOROBENZYL) 2 FURYL] 3 (1,2,4 TRIAZOL 3 YL) 1,3 PROPANEDIONE; 4 [1 (4 FLUOROBENZYL) 2 PYRROLYL] 2,4 DIOXOBUTYRIC ACID; 4,5 DIHYDROXYPYRIMIDINE CARBOXAMIDE DERIVATIVE; 5 HYDROXYPYRIMIDINONE CARBOXAMIDE DERIVATIVE; ADENOSINE PHOSPHATE; AMINO ACID; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHAETOCHROMIN B; CHLOROQUINE; CURCUMIN DIMETHYLETHER; DIKETO ACID B; ELVITEGRAVIR; EQUISETIN; GS 9137; INTEGRASE; INTEGRASE INHIBITOR; INTEGRIC ACID; JTK 303; KHD 161; L 870812; LEVOCHICORIC ACID; MEPACRINE; MK 0518; N (4 FLUOROBENZYL) 8 HYDROXY 5 (TETRAHYDRO 2H 1,2 THIAZIN 2 YL) 1,6 NAPHTHYRIDINE 7 CARBOXAMIDE S,S DIOXIDE; NAPHTHYRIDINE CARBOXAMINE; NUCLEIC ACID; OTEROMYCIN; PRIMAQUINE; QUERCETIN; RALTEGRAVIR; TRANSPOSASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS DNA; 1 (5 CHLOROINDOL 3 YL) 3 HYDROXY 3 (2H TETRAZOL 5 YL)PROPENONE; 1-(5-CHLOROINDOL-3-YL)-3-HYDROXY-3-(2H-TETRAZOL-5-YL)PROPENONE; INDOLE DERIVATIVE; RIBONUCLEASE H; TETRAZOLE DERIVATIVE; TN5 TRANSPOSASE;

ARTICLE; BINDING SITE; CLINICAL TRIAL; COMPUTER MODEL; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DNA BINDING; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME MECHANISM; FUSARIUM; GENETIC ALGORITHM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; SEQUENCE HOMOLOGY; SIMULATION; TRANSPOSON; VALIDATION PROCESS; VIRUS REPLICATION; ALGORITHM; BACILLUS; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PEPTIDE MAPPING; VIROLOGY;

FUSARIUM SP.; HUMAN IMMUNODEFICIENCY VIRUS 1; RUMEX;

ALGORITHMS; BACILLUS; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; DNA, VIRAL; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE MAPPING; RIBONUCLEASE H, CALF THYMUS; TETRAZOLES; TRANSPOSASES;

EID: 34147128555     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-4-21     Document Type: Article

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