Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of alzheimer's disease

CNS Neuroscience and Therapeutics

Volumn 19, Issue 10, 2013, Pages 820-833

  Wang, Chun Yan ^a,b   Xie, Jing Wei ^a   Wang, Tao ^a   Xu, Ye ^b   Cai, Jian Hui ^b   Wang, Xu ^c   Zhao, Bao Lu ^d   An, Li ^a   Wang, Zhan You ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b JILIN MEDICAL COLLEGE   (China)

^c LIAONING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d INSTITUTE OF BIOPHYSICS   (China)

Author keywords

Alzheimer's disease; APP PS1 transgenic mouse; Calpain; Endoplasmic reticulum stress; Glycogen synthase kinase 3; Hypoxia; RNA interference

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALPAIN; CALPAIN 2; CASPASE; GLYCOGEN SYNTHASE KINASE 3BETA; PRESENILIN 1; SMALL INTERFERING RNA; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL LINE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEDIATOR; MEMORY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SPATIAL LEARNING; TRANSGENIC MOUSE;

ALZHEIMER'S DISEASE; APP/PS1 TRANSGENIC MOUSE; CALPAIN; ENDOPLASMIC RETICULUM STRESS; GLYCOGEN SYNTHASE KINASE 3; HYPOXIA; RNA INTERFERENCE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANOXIA; CALPAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HIPPOCAMPUS; HUMANS; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRESENILIN-1; RANDOM ALLOCATION;

EID: 84884818386     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12151     Document Type: Article

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