메뉴 건너뛰기




Volumn 9, Issue 1, 2000, Pages 55-66

Enhancing the efficiency of introducing precise mutations into the mouse genome by hit and run gene targeting

Author keywords

Cystic fibrosis; ES cells; Gene inactivation; Gene targeting; Hit and run

Indexed keywords

ANIMAL MODEL; CLONE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE; CYTOTOXICITY; EXON; EXPRESSION VECTOR; GANCICLOVIR; GENE MUTATION; GENE TARGETING; GENETIC MARKER; GENETIC RECOMBINATION; GENETIC SCREENING; GERM LINE; MOUSE; PROMOTER REGION; THYMIDINE KINASE; TRANSGENE;

EID: 0034072796     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008915026660     Document Type: Article
Times cited : (15)

References (21)
  • 1
    • 0027316203 scopus 로고
    • Site-directed point mutations in embryonic stem cells: A gene-targeting, tag-and-exchange strategy
    • 1. Askew GR, Doetschman T and Lingrel JB (1993) Site-directed point mutations in embryonic stem cells: a gene-targeting, tag-and-exchange strategy. Mol Cell Biol 13: 4115-4124.
    • (1993) Mol Cell Biol , vol.13 , pp. 4115-4124
    • Askew, G.R.1    Doetschman, T.2    Lingrel, J.B.3
  • 4
    • 0027532257 scopus 로고
    • Location of crossovers during gene targeting with insertion and replacement vectors
    • 4. Deng C, Thomas KR and Capecchi MR (1993) Location of crossovers during gene targeting with insertion and replacement vectors. Mol Cell Biol 13: 2134-2139.
    • (1993) Mol Cell Biol , vol.13 , pp. 2134-2139
    • Deng, C.1    Thomas, K.R.2    Capecchi, M.R.3
  • 7
    • 0029091902 scopus 로고
    • Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
    • 7. Fiering S, Epner E, Robinson K, Zhuang Y, Telling A, Hu M, Martin DI, Enver T, Ley TJ and Groudine M (1995) Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev 9: 2203-2213.
    • (1995) Genes Dev , vol.9 , pp. 2203-2213
    • Fiering, S.1    Epner, E.2    Robinson, K.3    Zhuang, Y.4    Telling, A.5    Hu, M.6    Martin, D.I.7    Enver, T.8    Ley, T.J.9    Groudine, M.10
  • 8
    • 0031830673 scopus 로고    scopus 로고
    • Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: A comparison of homologous recombination methods
    • 8. Gschwind M and Huber G (1998) Introduction of hereditary disease-associated mutations into the beta-amyloid precursor protein gene of mouse embryonic stem cells: a comparison of homologous recombination methods. Mol Cell Biol 18: 4651-4658.
    • (1998) Mol Cell Biol , vol.18 , pp. 4651-4658
    • Gschwind, M.1    Huber, G.2
  • 9
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
    • 9. Hasty P, Ramirez-Solis R, Krumlauf R and Bradley A (1991) Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350: 243-246.
    • (1991) Nature , vol.350 , pp. 243-246
    • Hasty, P.1    Ramirez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 10
    • 0027361810 scopus 로고
    • Inactive chromatin spreads from a focus of methylation
    • 10. Kass SU, Goddard JP and Adams RLP (1993) Inactive chromatin spreads from a focus of methylation. Mol Cell Biol 13: 7372-7379.
    • (1993) Mol Cell Biol , vol.13 , pp. 7372-7379
    • Kass, S.U.1    Goddard, J.P.2    Adams, R.L.P.3
  • 11
    • 0025853454 scopus 로고
    • Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene
    • 11. Lupton SD, Brunton LL, Kalberg VA and Overell RW (1991) Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol 11: 3374-3378.
    • (1991) Mol Cell Biol , vol.11 , pp. 3374-3378
    • Lupton, S.D.1    Brunton, L.L.2    Kalberg, V.A.3    Overell, R.W.4
  • 12
    • 0030987540 scopus 로고    scopus 로고
    • Stability of HPRT marker gene expression at different gene-targeted loci: Observing and overcoming a position effect
    • 12. Melton DW, Ketchen AM and Selfridge J (1997) Stability of HPRT marker gene expression at different gene-targeted loci: observing and overcoming a position effect. Nucleic Acids Res 25: 3937-3943.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3937-3943
    • Melton, D.W.1    Ketchen, A.M.2    Selfridge, J.3
  • 13
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    • 13. Meyers EN, Lewandoski M and Martin GR (1998) An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet 18: 136-141.
    • (1998) Nat Genet , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 14
    • 0029092955 scopus 로고
    • Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations
    • 14. Moore RC, Redhead NJ, Selfridge J, Hope J, Manson JC and Melton DW (1995) Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations. Bio/Technology 13: 999-1004.
    • (1995) Bio/Technology , vol.13 , pp. 999-1004
    • Moore, R.C.1    Redhead, N.J.2    Selfridge, J.3    Hope, J.4    Manson, J.C.5    Melton, D.W.6
  • 15
    • 0027189536 scopus 로고
    • Hox-4b (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments
    • 15. Ramirez-Solis R, Zeng H, Whiting J, Krumlauf R and Bradley A (1993) Hox-4b (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell 73: 279-294.
    • (1993) Cell , vol.73 , pp. 279-294
    • Ramirez-Solis, R.1    Zeng, H.2    Whiting, J.3    Krumlauf, R.4    Bradley, A.5
  • 16
    • 0028158627 scopus 로고
    • Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
    • 16. Stacey A, Schnieke A, McWhir J, Cooper J, Colman A and Melton DW (1994) Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol Cell Biol 14: 1009-1016.
    • (1994) Mol Cell Biol , vol.14 , pp. 1009-1016
    • Stacey, A.1    Schnieke, A.2    McWhir, J.3    Cooper, J.4    Colman, A.5    Melton, D.W.6
  • 17
    • 0023646810 scopus 로고
    • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
    • 17. Thomas KR and Capecchi MR (1987) Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51: 503-512.
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 18
    • 0025773393 scopus 로고
    • Double-strand gap repair in a mammalian gene targeting reaction
    • 18. Valancius V and Smithies O (1991a) Double-strand gap repair in a mammalian gene targeting reaction. Mol Cell Biol 11: 4389-4397.
    • (1991) Mol Cell Biol , vol.11 , pp. 4389-4397
    • Valancius, V.1    Smithies, O.2
  • 19
    • 0026100231 scopus 로고
    • Testing an 'In-Out' targeting procedure for making subtle genomic modifications in mouse embryonic stem cells
    • 19. Valancius V and Smithies O (1991b) Testing an 'In-Out' targeting procedure for making subtle genomic modifications in mouse embryonic stem cells. Mol Cell Biol 11: 1402-1408.
    • (1991) Mol Cell Biol , vol.11 , pp. 1402-1408
    • Valancius, V.1    Smithies, O.2
  • 21
    • 0028333746 scopus 로고
    • Double replacement: Strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells
    • 21. Wu H, Liu X and Jaenisch R (1994) Double replacement: strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci USA 91: 2819-2823.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2819-2823
    • Wu, H.1    Liu, X.2    Jaenisch, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.