A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

Nucleic Acids Research

Volumn 41, Issue 4, 2013, Pages 2769-2778

  Chen, Shijia ^a   Oikonomou, Grigorios ^a   Chiu, Cindy N ^a   Niles, Brett J ^a   Liu, Justin ^a   Lee, Daniel A ^a   Antoshechkin, Igor ^a   Prober, David A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEASE; TAL EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CPG ISLAND; EMBRYO; EXPERIMENTAL MODEL; GENE SEQUENCE; GERM LINE; IN VIVO STUDY; INDEL MUTATION; MUTAGENICITY; MUTATIONAL ANALYSIS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN METHYLATION; SOMATIC CELL; SOMATIC MUTATION; ZEBRA FISH;

ANIMALS; CPG ISLANDS; DEOXYRIBONUCLEASES; GERM-LINE MUTATION; INDEL MUTATION; MUTAGENESIS; MUTATION; ZEBRAFISH; ZINC FINGERS;

ANIMALIA; DANIO RERIO;

EID: 84875298381     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1356     Document Type: Article

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