Structural requirements for hybridization at the 5′-position are different in α-l-LNA as compared to β-d-LNA

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 296-299

  Seth, Punit P ^a   Allerson, Charles R ^b   Østergaard, Michael E ^a   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

l LNA; 5 Me l LNA; Duplex thermal stability; LNA

Indexed keywords

ACETONYLACETONE; ALPHA LEVO LOCKED NUCLEIC ACID; BETA DEXTRO LOCKED NUCLEIC ACID; BROMINE DERIVATIVE; DEOXYRIBONUCLEOTIDE; GLUCOSE; NUCLEOTIDE DERIVATIVE; OLIGO 2' DEOXYRIBONUCLEOTIDE DERIVATIVE; PHOSPHORAMIDOUS ACID DERIVATIVE; RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DENATURATION; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYBRIDIZATION; ISOMER; MITSUNOBU REACTION; THERMAL STIMULATION; THERMOSTABILITY;

ANIMALS; BIOCHEMISTRY; BIOPHYSICS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GLUCOSE; MICE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; NUCLEIC ACID HYBRIDIZATION; NUCLEOSIDES; OLIGONUCLEOTIDES; ORGANOPHOSPHORUS COMPOUNDS; STEREOISOMERISM; TEMPERATURE;

EID: 84655169891     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.012     Document Type: Article

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