Adjustment of the γ dihedral angle of an oligonucleotide P3′→N5′ phosphoramidate enhances its binding affinity towards complementary strands

Angewandte Chemie - International Edition

Volumn 44, Issue 13, 2005, Pages 1944-1947

  Obika, Satoshi ^a   Sekiguchi, Mitsuaki ^a   Somjing, Roongjang ^a   Imanishi, Takeshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Conformation analysis; Nucleic acids; Nucleosides; Oligonucleotides; Phosphoramidates

Indexed keywords

CHEMICAL ANALYSIS; HYDROLYSIS;

CHEMICAL EQUATIONS; DUPLEX-FORMING ABILITY; METHYLENE BRIDGE; OLIGONUCLEOTIDES;

OLIGOMERS;

AMIDE; DRUG DERIVATIVE; LIGAND; NUCLEIC ACID; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID; PHOSPHORIC ACID; THYMINE;

ARTICLE; BINDING SITE; CHEMICAL MODEL; CHEMISTRY; CONFORMATION; HYDROLYSIS; NUCLEOTIDE SEQUENCE; SYNTHESIS; TEMPERATURE; TIME;

AMIDES; BASE SEQUENCE; BINDING SITES; HYDROLYSIS; LIGANDS; MODELS, CHEMICAL; NUCLEIC ACID CONFORMATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PHOSPHORIC ACIDS; TEMPERATURE; THYMINE; TIME FACTORS;

EID: 16844365352     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200461942     Document Type: Article

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22. - was detected in all cases, except for oligonucleotide 12. See the Supporting Information.
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27. m, profiles of duplexes containing the oligonucleotides 11-13 can be found in the Supporting Information.