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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4690-4694

Synthesis and biophysical evaluation of 3′-Me-α-l-LNA - Substitution in the minor groove of α-l-LNA duplexes

(4) Seth, Punit P a Allerson, Charles A b Østergaard, Michael E a Swayze, Eric E a

a ISIS PHARMACEUTICALS (United States)

b REGULUS THERAPEUTICS (United States)

Author keywords

l LNA; 3 Me l LNA; Minor groove; Thermal stability

Indexed keywords

3' METHYL ALPHA LOCKED NUCLEIC ACID; ALPHA LOCKED NUCLEIC ACID; LOCKED NUCLEIC ACID; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; BIOPHYSICS; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG SYNTHESIS; MISMATCH REPAIR; OXIDATION REDUCTION REACTION; RING OPENING; SUBSTITUTION REACTION; THERMOSTABILITY;

MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGONUCLEOTIDES; STEREOISOMERISM; TEMPERATURE;

EID: 79960911525 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.104 Document Type: Article

Times cited : (8)

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