Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2′-fluoro RNA

Journal of Organic Chemistry

Volumn 77, Issue 11, 2012, Pages 5074-5085

  Seth, Punit P ^a   Yu, Jinghua ^a   Jazayeri, Ali ^a   Pallan, Pradeep S ^b   Allerson, Charles R ^c   Østergaard, Michael E ^a   Liu, Fengwu ^d   Herdewijn, Piet ^d   Egli, Martin ^b   Swayze, Eric E ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c REGULUS THERAPEUTICS   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENTS; ANTISENSE; BIOLOGICAL EVALUATION; FERRIER REARRANGEMENT; FLUORINE ATOMS; FURANOSE; HEPTAMERS; HEXITOL NUCLEIC ACIDS; MITSUNOBU CONDITION; MODIFIED DNA; MODIFIED NUCLEOTIDES; MODIFIED OLIGONUCLEOTIDES; MULTI-GRAM QUANTITIES; NUCLEOBASES; NUCLEOSIDE PHOSPHORAMIDITES; PALLADIUM-CATALYZED; PHOSPHODIESTERASES; PHOSPHORAMIDITES; PROTECTING GROUP; PSEUDO-HYDROGEN; RING SYSTEMS; SNAKE VENOMS;

AROMATIC COMPOUNDS; BIOMOLECULES; CONFORMATIONS; DNA; FLUORINE; HYDROGEN BONDS; OLIGONUCLEOTIDES; X RAY CRYSTALLOGRAPHY;

RNA;

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE A1; ANTISENSE OLIGONUCLEOTIDE A2; FLUORIDE; FLUORINE; FLUORO CYCLOHEXENYL NUCLEIC ACID; MANNOSE; MESSENGER RNA; NUCLEIC ACID BASE; PALLADIUM; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHODIESTERASE; PHOSPHORAMIDIC ACID; PHOSPHORAMIDOUS ACID DERIVATIVE; PYRANOSIDE; PYRIMIDINE DERIVATIVE; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOPHYSICS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG DESIGN; DRUG SYNTHESIS; FLUORINATION; MITSUNOBU REACTION; MOUSE; NONHUMAN; SINGLE DRUG DOSE; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXENES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; NUCLEIC ACIDS; OLIGONUCLEOTIDES; RNA; SUGAR ALCOHOLS;

EID: 84861832860     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo300594b     Document Type: Article

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