Toll-Like Receptor 4 Deficiency Accelerates the Development of Insulin-Deficient Diabetes in Non-Obese Diabetic Mice

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Gülden, Elke ^a,c   Ihira, Masaru ^a   Ohashi, Atsushi ^a   Reinbeck, Anna Lena ^a   Freudenberg, Marina A ^b   Kolb, Hubert ^a,d   Burkart, Volker ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d West German Centre of Diabetes and Health   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; NITRIC OXIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; OLIGONUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL ISOLATION; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HISTOLOGY; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEFICIENT DIABETES; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; ONSET AGE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PATHOGENESIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; WILD TYPE; ANIMAL; C57BL MOUSE; CROSS BREEDING; DEFICIENCY; GENETICS; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; PANCREAS; PATHOLOGY; POLYMERASE CHAIN REACTION;

AGE OF ONSET; ANIMALS; CROSSES, GENETIC; DIABETES MELLITUS, TYPE 1; FEMALE; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; OLIGONUCLEOTIDES; PANCREAS; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTOR 4;

EID: 84884505361     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075385     Document Type: Article

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