The sole gateway to endotoxin response: How LPS was identified as Tlr4, and its role in innate immunity

Drug Metabolism and Disposition

Volumn 29, Issue 4 II, 2001, Pages 474-478

  Beutler, B ^a   Poltorak, A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTOXIN; LEUCINE; TOLL LIKE RECEPTOR 4;

CONFERENCE PAPER; DROSOPHILA; GENE DELETION; GENE FUNCTION; GENE MAPPING; HUMAN; IMMUNITY; MONONUCLEAR CELL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; DROSOPHILA PROTEINS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; VARIATION (GENETICS);

BACTERIA (MICROORGANISMS); FUNGI; MAMMALIA; PROTOZOA;

EID: 0035064830     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (56)

1. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
2. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
3. A conserved signaling pathway: The Drosophila toll-dorsal pathway
4. Increased toxicity of endotoxin for tumor-bearing mice and mice responding to bacterial pathogens: Macrophage activation as a common denominator
5. Passive immunization against cachectin/tumor necrosis factor (TNF) protects mice from the lethal effect of endotoxin
6. Comparative study of lipopolysaccharide-, lipid IVa-, and lipid X-induced tumor necrosis factor production in murine macrophage-like cell lines
7. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
8. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
9. Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide
10. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice
11. A comparison of the effects of intact and deacylated lipopolysaccharide on human polymorphonuclear leukocytes
12. CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition
13. Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
14. Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin
15. Mechanisms of endotoxin shock and endotoxin hypersensitivity
16. Drosophila Toll and IL-1 receptor
17. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes
18. Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction
19. Cells that carry a null allele for toll-like receptor 2 are capable of responding to endotoxin
20. High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures
21. The immune system evolved to discriminate infectious nonself from noninfectious self
22. Unresponsiveness of MyD88-deficient mice to endotoxin
23. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
24. Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections
25. Partial purification of human lymphocyte activating factor (LAF) by ultrafiltration and electrophoretic techniques
26. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
27. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
28. Innate immune recognition and control of adaptive immune responses
29. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
30. MyD88 is an adaptor protein in the hToll/IL- 1 receptor family signaling pathways
31. The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin
32. Purification to apparent homogeneity of murine interleukin-1
33. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
34. Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene
35. Effects of BCG infection on the susceptibility of mouse macrophages to endotoxin
36. Genetic mapping of the Lps gene and construction of a physical map of the critical region at mid-chromosome 4
37. Defective LP8 signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
38. Physical contact between LPS and Tlr4 revealed by genetic complementation
39. Genetic and physical mapping of the Lps locus-identification of the toll-4 receptor as a candidate gene in the critical region
40. A high-resolution map in the chromosomal region surrounding the Lps locus
41. Endotoxin: Historical Perspectives
42. A family of human receptors structurally related to Drosophila Toll
43. Action of endotoxin on lymphoid cells
44. Genetic control of resistance to infection in mice
45. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
46. Endotoxin-induced insulin sensitivity in BCG infected mice
47. Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4)
48. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
49. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-Like receptor 2- and MyD88-dependent signaling pathway
50. Shock and tissue injury induced by recombinant human cachectin
51. The genetic mapping of a defective LPS response gene in C3H/HeJ mice
52. The response of recombinant inbred strains of mice to bacterial lipopolysaccharides
53. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
54. Cutting edge: Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2