Treg Cell Resistance to Apoptosis in DNA Vaccination for Experimental Autoimmune Encephalomyelitis Treatment

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Kang, Youmin ^a   Sun, Yuhan ^a   Zhang, Jingyao ^a   Gao, Wenjuan ^a   Kang, Jingjing ^b   Wang, Yongqiang ^a   Wang, Bin ^c   Xia, Guoliang ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b AGRICULTURAL UNIVERSITY OF HEBEI   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; TACROLIMUS;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTIC INFILTRATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPINAL CORD; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; HISTOLOGICAL TECHNIQUES; IMMUNE TOLERANCE; MICE; MICE, INBRED C57BL; SPINAL CORD; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TACROLIMUS; VACCINES, DNA;

MUS;

EID: 84869146704     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049994     Document Type: Article

References (37)

1. Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG, (2000) Multiple Sclerosis. N Engl J Med 343: 938-952.
2. Kuerten S, Gruppe TL, Laurentius L-M, Kirch C, Tary-Lehmann M, et al. (2011) Differential patterns of spinal cord pathology induced by MP4, MOG peptide 35-55, and PLP peptide 178-191 in C57BL/6 mice. APMIS 119: 336-346.
3. Baker D, Gerritsen W, Rundle J, Amor S, (2011) Critical appraisal of animal models of multiple sclerosis. Multiple Sclerosis Journal 17: 647-657.
4. Kang Y, Zhao J, Liu Y, Chen A, Zheng G, et al. (2009) FK506 as an adjuvant of tolerogenic NA vaccination for the prevention of experimental autoimmune encephalomyelitis. The Journal of Gene Medicine 11: 1064-1070.
5. Kang Y, Zheng G, Chen A, Wang J, Hu Y, et al. (2012) Tolerogenic DNA Vaccine for Prevention of Autoimmune Ovarian Disease. Immunological Investigations 41: 249-260.
6. Mott KR, Gate D, Zandian M, Allen SJ, Rajasagi NK, et al. (2011) Macrophage IL-12p70 Signaling Prevents HSV-1-Induced CNS Autoimmunity Triggered by Autoaggressive CD4+ Tregs. Investigative Ophthalmology & Visual Science 52: 2321-2333.
7. Ellis RE, Yuan J, Horvitz HR, (1991) Mechanisms and Functions of Cell Death. Annual Review of Cell Biology 7: 663-698.
8. MacDonald HR, Lees RK, (1990) Programmed death of autoreactive thymocytes. Nature 343: 642-644.
9. Aranami T, Yamamura T, (2008) Th17 Cells and autoimmune encephalomyelitis (EAE/MS). Allergol Int 57: 115-120.
10. Allison AC, (2000) Immunosuppressive drugs: the first 50 years and a glance forward. Immunopharmacology 47: 63-83.
11. O'Keefe SJ, Tamura J, Kincaid RL, Tocci MJ, O'Neill EA, (1992) FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357: 692-694.
12. Migita K, Origuchi T, Kawabe Y, Tominaga M, Ida H, et al. (1999) FK506 markedly enhances apoptosis of antigen-stimulated peripheral T cells by down-regulation of Bcl-xL. Transplantation 68: 1018-1023.
13. Migita K, Eguchi K, Kawabe Y, Origuchi T, Tominaga M, et al. (1997) FK506 potentiates steroid-induced T-cell apoptosis. Transplantation 64: 1365-1369.
14. Migita K, Eguchi K, Kawabe Y, Tsukada T, Mizokami A, et al. (1995) FK506 augments activation-induced programmed cell death of T lymphocytes in vivo. J Clin Invest 96: 727-732.
15. Hashimoto Y, Matsuoka N, Kawakami A, Tsuboi M, Nakashima T, et al. (2001) Novel immunosuppressive effect of FK506 by augmentation of T cell apoptosis. Clinical & Experimental Immunology 125: 19-24.
16. Imai A, Sahara H, Tamura Y, Jimbow K, Saito T, et al. (2007) Inhibition of endogenous MHC class II-restricted antigen presentation by tacrolimus (FK506) via FKBP51. Eur J Immunol 37: 1730-1738.
17. Lee Y-R, Yang I-H, Lee Y-H, Im S-A, Song S, et al. (2005) Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells. Blood 105: 3951-3955.
18. Lobell A, Weissert R, Eltayeb S, de Graaf KL, Wefer J, et al. (2003) Suppressive DNA Vaccination in Myelin Oligodendrocyte Glycoprotein Peptide-Induced Experimental Autoimmune Encephalomyelitis Involves a T1-Biased Immune Response. J Immunol 170: 1806-1813.
19. Ferrera F, La Cava A, Rizzi M, Hahn BH, Indiveri F, et al. (2007) Gene vaccination for the induction of immune tolerance. Ann N Y Acad Sci 1110: 99-111.
20. Lobell A, Weissert R, Storch MK, Svanholm C, de Graaf KL, et al. (1998) Vaccination with DNA Encoding an Immunodominant Myelin Basic Protein Peptide Targeted to Fc of Immunoglobulin G Suppresses Experimental Autoimmune Encephalomyelitis. J Exp Med 187: 1543-1548.
21. Fissolo N, Costa C, Nurtdinov R, Bustamante M, Llombart V, et al. (2012) Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and upregulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis. Journal of Neuroinflammation 9: 139.
22. Shachar I, Karin N, (2012) The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications. Journal of Leukocyte Biology.
23. Almolda B, Costa M, Montoya M, Gonzalez B, Castellano B, (2011) Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat. PLoS One 6: e27473.
24. Fissolo N, Montalban X, Comabella M, (2012) DNA-based vaccines for multiple sclerosis: Current status and future directions. Clinical Immunology 142: 76-83.
25. Andersson Å, Isaksson M, Wefer J, Norling A, Flores-Morales A, et al. (2008) Impaired Autoimmune T Helper 17 Cell Responses Following DNA Vaccination against Rat Experimental Autoimmune Encephalomyelitis. PLoS ONE 3: e3682.
26. Schif-Zuck S, Wildbaum G, Karin N, (2006) Coadministration of Plasmid DNA Constructs Encoding an Encephalitogenic Determinant and IL-10 Elicits Regulatory T Cell-Mediated Protective Immunity in the Central Nervous System. The Journal of Immunology 177: 8241-8247.
27. Garren H, Ruiz PJ, Watkins TA, Fontoura P, Nguyen L-VT, et al. (2001) Combination of Gene Delivery and DNA Vaccination to Protect from and Reverse Th1 Autoimmune Disease via Deviation to the Th2 Pathway. Immunity 15: 15-22.
28. D'Adamio L, Awad KM, Reinherz EL, (1993) Thymic and peripheral apoptosis of antigen-specific T cells might cooperate in establishing self tolerance. European Journal of Immunology 23: 747-753.
29. Hayashi T, Faustman DL, (2003) Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases. Recent Prog Horm Res 58: 131-153.
30. Ju S-T, Panka DJ, Cui H, Ettinger R, Ei-Khatib M, et al. (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373: 444-448.
31. Lan Q, Fan H, Quesniaux V, Ryffel B, Liu Z, et al. (2012) Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? Journal of Molecular Cell Biology 4: 22-28.
32. Yolcu E, Ash S, Kaminitz A, Sagiv Y, Askenasy N, et al. (2008) Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression. Immunol Cell Biol 86: 650-658.
33. Banz A, Pontoux C, Papiernik M, (2002) Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells. The Journal of Immunology 169: 750-757.
34. Taylor SRJ, Alexander DR, Cooper JC, Higgins CF, Elliott JI, (2007) Regulatory T Cells Are Resistant to Apoptosis via TCR but Not P2X7. The Journal of Immunology 178: 3474-3482.
35. Nakano A, Watanabe M, Iida T, Kuroda S, Matsuzuka F, et al. (2007) Apoptosis-induced decrease of intrathyroidal CD4(+)CD25(+) regulatory T cells in autoimmune thyroid diseases. Thyroid 17: 25-31.
36. Lin X, Luo M, Cai X, (2011) Study of fas-mediated Foxp3+CD4+CD25+ Treg cell apoptosis in patients with systemic lupus erythematosus. Zhonghua Yi Xue Za Zhi 91: 586-590.
37. Kang Y, Jin H, Zheng G, Du X, Xiao C, et al. (2007) Co-inoculation of DNA and protein vaccines induces antigen-specific T cell suppression. Biochem Biophys Res Commun 353: 1034-1039.