The human PDZome: A gateway to PSD95-disc large-zonula occludens (PDZ)-mediated functions

Molecular and Cellular Proteomics

Volumn 12, Issue 9, 2013, Pages 2587-2603

  Belotti, Edwige ^a,b,c   Polanowska, Jolanta ^a,b,c,h   Daulat, Avais M ^a,b,c   Audebert, Stéphane ^a,b,c   Thomé, Virginie ^c,d   Lissitzky, Jean Claude ^a,b,c   Lembo, Frédérique ^a,b,c   Blibek, Karim ^a,b,c,i   Omi, Shizue ^a,b,c,h   Lenfant, Nicolas ^a,b,c   Gangar, Akanksha ^a,b,c,j   Montcouquiol, Mireille ^d   Santoni, Marie Josée ^a,b,c   Sebbagh, Michael ^a,b,c   Aurrand Lions, Michel ^a,b,c   Angers, Stéphane ^e,f   Kodjabachian, Laurent ^c,g   Reboul, Jérome ^a,b,c,h   Borg, Jean Paul ^a,b,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d CNRS   (France)

^e INSTITUT FRANÇOIS MAGENDIE   (France)

^f UNIVERSITY OF TORONTO   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

^h NEW YORK UNIVERSITY   (United States)

ⁱ UNIVERSITY OF LIÈGE   (Belgium)

^j GLAXOSMITHKLINE   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ACVR2B; PROTEIN BRSK2; PROTEIN E6; PROTEIN HER4; PROTEIN KINASE; PROTEIN PCTK1; PROTEIN SCRIB; PROTEIN SNX27; PROTEIN VANGL2; PROTEOME; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; XENOPUS; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CELL MOVEMENT; EMBRYO, NONMAMMALIAN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; ONCOGENE PROTEINS, VIRAL; PDZ DOMAINS; PROTEIN INTERACTION MAPPING; PROTEIN KINASES; PROTEOME; REPRODUCIBILITY OF RESULTS; SORTING NEXINS; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES; XENOPUS;

EID: 84884398431     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.O112.021022     Document Type: Article

References (86)

1. Pawson, T., Gish, G. D., and Nash, P. (2001) SH2 domains, interaction modules and cellular wiring. Trends Cell Biol. 11, 504-511 (Pubitemid 33079144)
2. Scott, J. D., and Pawson, T. (2009) Cell signaling in space and time: where proteins come together and when they're apart. Science 326, 1220-1224
3. Pawson, T. (2007) Dynamic control of signaling by modular adaptor proteins. Curr. Opin. Cell Biol. 19, 112-116 (Pubitemid 46386409)
4. Nourry, C., Grant, S. G., and Borg, J. P. (2003) PDZ domain proteins: plug and play! Sci. STKE 2003, RE7
5. Tonikian, R., Zhang, Y., Sazinsky, S. L., Currell, B., Yeh, J. H., Reva, B., Held, H. A., Appleton, B. A., Evangelista, M., Wu, Y., Xin, X., Chan, A. C., Seshagiri, S., Lasky, L. A., Sander, C., Boone, C., Bader, G. D., and Sidhu, S. S. (2008) A specificity map for the PDZ domain family. PLoS Biol. 6, e239
6. Roh, M. H., and Margolis, B. (2003) Composition and function of PDZ protein complexes during cell polarization. Am. J. Physiol. Renal Physiol. 285, F377-F387 (Pubitemid 37010848)
7. Bilder, D. (2001) PDZ proteins and polarity: functions from the fly. Trends Genet. 17, 511-519 (Pubitemid 32763049)
8. Kim, E., Niethammer, M., Rothschild, A., Jan, Y. N., and Sheng, M. (1995) Clustering of Shaker-Type K-channels by interaction with a family of membrane-Associated guanylate kinases. Nature 378, 85-88
9. Javier, R. T. (2008) Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene 27, 7031-7046
10. Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., and Humbert, P. O. (2011) SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. J. Clin. Invest. 121, 4257-4267
11. Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., and Muthuswamy, S. K. (2008) Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135, 865-878
12. Javier, R. T., and Rice, A. P. (2011) Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J. Virol. 85, 11544-11556
13. Spanos, W. C., Hoover, A., Harris, G. F., Wu, S., Strand, G. L., Anderson, M. E., Klingelhutz, A. J., Hendriks, W., Bossler, A. D., and Lee, J. H. (2008) The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth. J. Virol. 82, 2493-2500 (Pubitemid 351293550)
14. Thomas, M., Narayan, N., Pim, D., Tomaic, V., Massimi, P., Nagasaka, K., Kranjec, C., Gammoh, N., and Banks, L. (2008) Human papillomaviruses, cervical cancer and cell polarity. Oncogene 27, 7018-7030
15. Doyle, D. A., Lee, A., Lewis, J., Kim, E., Sheng, M., and MacKinnon, R. (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85, 1067-1076 (Pubitemid 26231173)
16. Morais Cabral, J. H., Petosa, C., Sutcliffe, M. J., Raza, S., Byron, O., Poy, F., Marfatia, S. M., Chishti, A. H., and Liddington, R. C. (1996) Crystal structure of a PDZ domain. Nature 382, 649-652
17. Harris, B. Z., and Lim, W. A. (2001) Mechanism and role of PDZ domains in signaling complex assembly. J. Cell Sci. 114, 3219-3231 (Pubitemid 32998900)
18. Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., and Cantley, L. C. (1997) Recognition of unique carboxyl-Terminal motifs by distinct PDZ domains. Science 275, 73-77 (Pubitemid 27020310)
19. Giallourakis, C., Cao, Z., Green, T., Wachtel, H., Xie, X., Lopez-Illasaca, M., Daly, M., Rioux, J., and Xavier, R. (2006) A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands. Genome Res. 16, 1056-1072 (Pubitemid 44162265)
20. Stiffler, M. A., Chen, J. R., Grantcharova, V. P., Lei, Y., Fuchs, D., Allen, J. E., Zaslavskaia, L. A., and MacBeath, G. (2007) PDZ domain binding selectivity is optimized across the mouse proteome. Science 317, 364-369
21. te Velthuis, A. J., Sakalis, P. A., Fowler, D. A., and Bagowski, C. P. (2011) Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network. PLoS One 6, e16047
22. Bezprozvanny, I., and Maximov, A. (2001) Classification of PDZ domains. FEBS Lett. 509, 457-462 (Pubitemid 34031978)
23. Lenfant, N., Polanowska, J., Bamps, S., Omi, S., Borg, J. P., and Reboul, J. (2010) A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. BMC Genomics 11, 671
24. Penkert, R. R., DiVittorio, H. M., and Prehoda, K. E. (2004) Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex. Nat. Struct. Mol. Biol. 11, 1122-1127 (Pubitemid 39453342)
25. Zhang, Y., Appleton, B. A., Wiesmann, C., Lau, T., Costa, M., Hannoush, R. N., and Sidhu, S. S. (2009) Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat. Chem. Biol. 5, 217-219
26. Zhang, Y., Appleton, B. A., Wu, P., Wiesmann, C., and Sidhu, S. S. (2007) Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain. Protein Sci. 16, 1738-1750 (Pubitemid 47195700)
27. van den Berk, L. C., Landi, E., Walma, T., Vuister, G. W., Dente, L., and Hendriks, W. J. (2007) An allosteric intramolecular PDZ-PDZ interaction modulates PTP-BL PDZ2 binding specificity. Biochemistry 46, 13629-13637 (Pubitemid 350209958)
28. Chen, Y., Sheng, R., Kallberg, M., Silkov, A., Tun, M. P., Bhardwaj, N., Kurilova, S., Hall, R. A., Honig, B., Lu, H., and Cho, W. (2012) Genomewide functional annotation of dual-specificity protein-And lipid-binding modules that regulate protein interactions. Mol. Cell, 46, 226-237
29. Zimmermann, P., Meerschaert, K., Reekmans, G., Leenaerts, I., Small, J. V., Vandekerckhove, J., David, G., and Gettemans, J. (2002) PIP(2)-PDZ domain binding controls the association of syntenin with the plasma membrane. Mol. Cell 9, 1215-1225 (Pubitemid 34722301)
30. Schultz, J., Copley, R. R., Doerks, T., Ponting, C. P., and Bork, P. (2000) SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res. 28, 231-234 (Pubitemid 30047767)
31. Hillier, L., and Green, P. (1991) OSP: a computer program for choosing PCR and DNA sequencing primers. PCR Methods Appl. 1, 124-128
32. Hartley, J. L., Temple, G. F., and Brasch, M. A. (2000) DNA cloning using in vitro site-specific recombination. Genome Res. 10, 1788-1795
33. Walhout, A. J., Temple, G. F., Brasch, M. A., Hartley, J. L., Lorson, M. A., van den Heuvel, S., and Vidal, M. (2000) GATEWAY recombinational cloning: application to the cloning of large numbers of open reading frames or ORFeomes. Methods Enzymol. 328, 575-592
34. Belotti, E., Puvirajesinghe, T. M., Audebert, S., Baudelet, E., Camoin, L., Pierres, M., Lasvaux, L., Ferracci, G., Montcouquiol, M., and Borg, J. P. (2012) Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes. PLoS One 7, e46213
35. Joubert, L., Hanson, B., Barthet, G., Sebben, M., Claeysen, S., Hong, W., Marin, P., Dumuis, A., and Bockaert, J. (2004) New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J. Cell Sci. 117, 5367-5379 (Pubitemid 39562498)
36. Audebert, S., Navarro, C., Nourry, C., Chasserot-Golaz, S., Lecine, P., Bellaiche, Y., Dupont, J. L., Premont, R. T., Sempere, C., Strub, J. M., Van Dorsselaer, A., Vitale, N., and Borg, J. P. (2004) Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr. Biol. 14, 987-995 (Pubitemid 38722613)
37. Nola, S., Sebbagh, M., Marchetto, S., Osmani, N., Nourry, C., Audebert, S., Navarro, C., Rachel, R., Montcouquiol, M., Sans, N., Etienne-Manneville, S., Borg, J. P., and Santoni, M. J. (2008) Scrib regulates PAK activity during the cell migration process. Hum. Mol. Genet. 17, 3552-3565
38. Marchal, L., Luxardi, G., Thome, V., and Kodjabachian, L. (2009) BMP inhibition initiates neural induction via FGF signaling and Zic genes. Proc. Natl. Acad. Sci. U.S.A. 106, 17437-17442
39. Mitchell, B., Stubbs, J. L., Huisman, F., Taborek, P., Yu, C., and Kintner, C. (2009) The PCP pathway instructs the planar orientation of ciliated cells in the Xenopus larval skin. Curr. Biol. 19, 924-929
40. Heasman, J., Kofron, M., and Wylie, C. (2000) Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. Dev. Biol. 222, 124-134 (Pubitemid 30387734)
41. Nakagawa, S., and Huibregtse, J. M. (2000) Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol. Cell. Biol. 20, 8244-8253
42. Thomas, M., Massimi, P., Navarro, C., Borg, J. P., and Banks, L. (2005) The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins. Oncogene 24, 6222-6230 (Pubitemid 43080045)
43. Storrs, C. H., and Silverstein, S. J. (2007) PATJ, a tight junction-Associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6. J. Virol. 81, 4080-4090 (Pubitemid 46586903)
44. Lee, S. S., Glaunsinger, B., Mantovani, F., Banks, L., and Javier, R. T. (2000) Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. J. Virol. 74, 9680-9693
45. Li, S., Armstrong, C. M., Bertin, N., Ge, H., Milstein, S., Boxem, M., Vidalain, P. O., Han, J. D., Chesneau, A., Hao, T., Goldberg, D. S., Li, N., Martinez, M., Rual, J. F., Lamesch, P., Xu, L., Tewari, M., Wong, S. L., Zhang, L. V., Berriz, G. F., Jacotot, L., Vaglio, P., Reboul, J., Hirozane-Kishikawa, T., Li, Q., Gabel, H. W., Elewa, A., Baumgartner, B., Rose, D. J., Yu, H., Bosak, S., Sequerra, R., Fraser, A., Mango, S. E., Saxton, W. M., Strome, S., Van Den Heuvel, S., Piano, F., Vandenhaute, J., Sardet, C., Gerstein, M., Doucette-Stamm, L., Gunsalus, K. C., Harper, J. W., Cusick, M. E., Roth, F. P., Hill, D. E., and Vidal, M. (2004) A map of the interactome network of the metazoan C. elegans. Science 303, 540-543 (Pubitemid 38120855)
46. Venkatesan, K., Rual, J. F., Vazquez, A., Stelzl, U., Lemmens, I., Hirozane-Kishikawa, T., Hao, T., Zenkner, M., Xin, X., Goh, K. I., Yildirim, M. A., Simonis, N., Heinzmann, K., Gebreab, F., Sahalie, J. M., Cevik, S., Simon, C., de Smet, A. S., Dann, E., Smolyar, A., Vinayagam, A., Yu, H., Szeto, D., Borick, H., Dricot, A., Klitgord, N., Murray, R. R., Lin, C., Lalowski, M., Timm, J., Rau, K., Boone, C., Braun, P., Cusick, M. E., Roth, F. P., Hill, D. E., Tavernier, J., Wanker, E. E., Barabasi, A. L., and Vidal, M. (2009) An empirical framework for binary interactome mapping. Nat. Methods 6, 83-90
47. Favre-Bonvin, A., Reynaud, C., Kretz-Remy, C., and Jalinot, P. (2005) Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome. J. Virol. 79, 4229-4237 (Pubitemid 40388361)
48. Jeong, K. W., Kim, H. Z., Kim, S., Kim, Y. S., and Choe, J. (2007) Human papillomavirus type 16 E6 protein interacts with cystic fibrosis transmembrane regulator-Associated ligand and promotes E6-Associated protein-mediated ubiquitination and proteasomal degradation. Oncogene 26, 487-499 (Pubitemid 46160963)
49. Caruana, G. (2002) Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int. J. Dev. Biol. 46, 511-518 (Pubitemid 36841019)
50. Blake, D. J., Hawkes, R., Benson, M. A., and Beesley, P. W. (1999) Different dystrophin-like complexes are expressed in neurons and glia. J. Cell Biol. 147, 645-658
51. Sugihara-Mizuno, Y., Adachi, M., Kobayashi, Y., Hamazaki, Y., Nishimura, M., Imai, T., Furuse, M., and Tsukita, S. (2007) Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells 12, 473-486 (Pubitemid 46488583)
52. Garcia, R. A., Vasudevan, K., and Buonanno, A. (2000) The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc. Natl. Acad. Sci. U.S.A. 97, 3596-3601 (Pubitemid 30183348)
53. Maudsley, S., Zamah, A. M., Rahman, N., Blitzer, J. T., Luttrell, L. M., Lefkowitz, R. J., and Hall, R. A. (2000) Platelet-derived growth factor receptor association with Na/H exchanger regulatory factor potentiates receptor activity. Mol. Cell. Biol. 20, 8352-8363
54. Park, M., and Moon, R. T. (2002) The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat. Cell Biol. 4, 20-25 (Pubitemid 34071976)
55. Wolff, T., and Rubin, G. M. (1998) Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development 125, 1149-1159 (Pubitemid 28171209)
56. Montcouquiol, M., Rachel, R. A., Lanford, P. J., Copeland, N. G., Jenkins, N. A., and Kelley, M. W. (2003) Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423, 173-177 (Pubitemid 36569540)
57. Torban, E., Kor, C., and Gros, P. (2004) Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates. Trends Genet. 20, 570-577 (Pubitemid 39314565)
58. Torban, E., Wang, H. J., Groulx, N., and Gros, P. (2004) Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J. Biol. Chem. 279, 52703-52713 (Pubitemid 39656646)
59. Wallingford, J. B., and Mitchell, B. (2011) Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev. 25, 201-213
60. Kallay, L. M., McNickle, A., Brennwald, P. J., Hubbard, A. L., and Braiterman, L. T. (2006) Scribble associates with two polarity proteins, Lgl2 and Vangl2, via distinct molecular domains. J. Cell. Biochem. 99, 647-664 (Pubitemid 44435580)
61. Babayeva, S., Zilber, Y., and Torban, E. (2011) Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am. J. Physiol. Renal Physiol. 300, F549-F560
62. Lauffer, B. E., Melero, C., Temkin, P., Lei, C., Hong, W., Kortemme, T., and von Zastrow, M. (2010) SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J. Cell Biol. 190, 565-574
63. Temkin, P., Lauffer, B., Jager, S., Cimermancic, P., Krogan, N. J., and von Zastrow, M. (2011) SNX27 mediates retromer tubule entry and endosome-To-plasma membrane trafficking of signalling receptors. Nat. Cell Biol. 13, 715-721
64. Valdembri, D., Caswell, P. T., Anderson, K. I., Schwarz, J. P., Konig, I., Astanina, E., Caccavari, F., Norman, J. C., Humphries, M. J., Bussolino, F., and Serini, G. (2009) Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol. 7, e25
65. Angers, S., Thorpe, C. J., Biechele, T. L., Goldenberg, S. J., Zheng, N., MacCoss, M. J., and Moon, R. T. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat. Cell Biol. 8, 348-357
66. Daulat, A. M., Maurice, P., Froment, C., Guillaume, J. L., Broussard, C., Monsarrat, B., Delagrange, P., and Jockers, R. (2007) Purification and identification of G protein-coupled receptor protein complexes under native conditions. Mol. Cell. Proteomics 6, 835-844 (Pubitemid 46831935)
67. Bilder, D., and Perrimon, N. (2000) Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403, 676-680 (Pubitemid 30104011)
68. Dow, L. E., Kauffman, J. S., Caddy, J., Zarbalis, K., Peterson, A. S., Jane, S. M., Russell, S. M., and Humbert, P. O. (2007) The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26, 2272-2282 (Pubitemid 46572809)
69. Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., Murdoch, J., Warchol, M. E., Wenthold, R. J., and Kelley, M. W. (2006) Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J. Neurosci. 26, 5265-5275 (Pubitemid 44315309)
70. Wallingford, J. B., Niswander, L. A., Shaw, G. M., and Finnell, R. H. (2013) The continuing challenge of understanding, preventing, and treating neural tube defects. Science 339, 1222002
71. Wallingford, J. B., and Harland, R. M. (2002) Neural tube closure requires Dishevelled-dependent convergent extension of the midline. Development 129, 5815-5825 (Pubitemid 36054623)
72. Ohno, S. (2001) Intercellular junctions and cellular polarity: the PAR-APKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr. Opin. Cell Biol. 13, 641-648 (Pubitemid 32817025)
73. Etienne-Manneville, S. (2004) Cdc42-The centre of polarity. J. Cell Sci. 117, 1291-1300
74. McCaffrey, L. M., and Macara, I. G. (2011) Epithelial organization, cell polarity and tumorigenesis. Trends Cell Biol. 21, 727-735
75. Kingston, D., Chang, H., Ensser, A., Lee, H. R., Lee, J., Lee, S. H., Jung, J. U., and Cho, N. H. (2011) Inhibition of retromer activity by herpesvirus saimiri tip leads to CD4 downregulation and efficient T cell transformation. J. Virol. 85, 10627-10638
76. Scott, K. L., Kabbarah, O., Liang, M. C., Ivanova, E., Anagnostou, V., Wu, J., Dhakal, S., Wu, M., Chen, S., Feinberg, T., Huang, J., Saci, A., Widlund, H. R., Fisher, D. E., Xiao, Y., Rimm, D. L., Protopopov, A., Wong, K. K., and Chin, L. (2009) GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 459, 1085-1090
77. Mukherjee, K., Sharma, M., Urlaub, H., Bourenkov, G. P., Jahn, R., Sudhof, T. C., and Wahl, M. C. (2008) CASK functions as a Mg2-independent neurexin kinase. Cell 133, 328-339 (Pubitemid 351508303)
78. Anastas, J. N., Biechele, T. L., Robitaille, M., Muster, J., Allison, K. H., Angers, S., and Moon, R. T. (2012) A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene 31, 3696-3708
79. Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., and Wrana, J. L. (2012) Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 151, 1542-1556
80. Williams, B. B., Cantrell, V. A., Mundell, N. A., Bennett, A. C., Quick, R. E., and Jessen, J. R. (2012) VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration. J. Cell Sci. 125 (Pt9), 2141-2147
81. Wansleeben, C., Feitsma, H., Montcouquiol, M., Kroon, C., Cuppen, E., and Meijlink, F. (2010) Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b. Development 137, 1067-1073
82. Cai, L., Loo, L. S., Atlashkin, V., Hanson, B. J., and Hong, W. (2011) Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-Aspartate receptor 2C (NR2C). Mol. Cell. Biol. 31, 1734-1747
83. Giese, A. P., Ezan, J., Wang, L., Lasvaux, L., Lembo, F., Mazzocco, C., Richard, E., Reboul, J., Borg, J. P., Kelley, M. W., Sans, N., Brigande, J., and Montcouquiol, M. (2012) Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development 139, 3775-3785
84. Pangon, L., Van Kralingen, C., Abas, M., Daly, R. J., Musgrove, E. A., and Kohonen-Corish, M. R. (2012) The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. Biochim. Biophys. Acta 1823, 1058-1067
85. Grootjans, J. J., Reekmans, G., Ceulemans, H., and David, G. (2000) Syntenin-syndecan binding requires syndecan-synteny and the co-operation of both PDZ domains of syntenin. J. Biol. Chem. 275, 19933-19941 (Pubitemid 30441599)
86. Ivarsson, Y., Wawrzyniak, A. M., Kashyap, R., Polanowska, J., Betzi, S., Lembo, F., Vermeiren, E., Chiheb, D., Lenfant, N., Morelli, X., Borg, J. P., Reboul, J., and Zimmermann, P. (2013) Prevalence, specificity and determinants of lipid-interacting PDZ domains from an in-cell screen and in vitro binding experiments. PLoS One 8, e54581