G0LPH3 modulates mTOR signalling and rapamydn sensitivity in cancer

Nature

Volumn 459, Issue 7250, 2009, Pages 1085-1090

  Scott, Kenneth L ^a   Kabbarah, Omar ^a   Liang, Mei Chih ^a,d   Ivanova, Elena ^b   Anagnostou, Valsamo ^e   Wu, Joyce ^a   Dhakal, Sabin ^a   Wu, Min ^a   Chen, Shujuan ^a   Feinberg, Tamar ^a   Huang, Joseph ^a   Saci, Abdel ^f   Widlund, Hans R ^c,f   Fisher, David E ^c,g   Xiao, Yonghong ^b   Rimm, David L ^e   Protopopov, Alexei ^b   Wong, Kwok Kin ^a,d   Chin, Lynda ^a,b,f  

^a Department of Medical Oncology ^*  (United States)

^b Belfer Institute for Innovative Cancer Science   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d DANA FARBER HARVARD CANCER CENTER   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GOLGI LOCALIZING PROTEIN 3; MAMMALIAN TARGET OF RAPAMYCIN; ONCOPROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DNA BINDING PROTEIN; GOLPH3 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE; RAPAMYCIN; SUB1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

BIOMECHANICS; CANCER; CELL ORGANELLE; DISEASE TREATMENT; DRUG; GENOME; HOMINID; PROTEIN; YEAST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER CELL; CELL SIZE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE NUMBER; GENETIC ANALYSIS; GOLGI COMPLEX; HUMAN; HUMAN CELL; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; YEAST; ANIMAL; DRUG EFFECT; FEMALE; GENE SILENCING; GENETICS; METABOLISM; NEOPLASM; NUDE MOUSE; PATHOPHYSIOLOGY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASMS; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS;

EID: 67649500009     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08109     Document Type: Article

References (33)

1. Manning, B. D. & Cantioy, L. C. AKT/PKB signaling: navigating downstream, Cell 129,1261-1274(2007).
2. Wuilschleger, S., Loowith, R. & Hall, M. N/ TOR signaling in growth and metabolism, Cell 124, 471 -484 (2006).
3. 56k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBOJ. 17, 6649-6659 (1998).
4. Montagne, J, et al. Drosophila S6 kinase: a regulator of ce:l size, Science 285, 2126-2129 (1999).
5. Oldham, S., Montagne, J., Radimorski, T., Thomas, G. & Hafen, E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin, Genes Dev. 14, 2689, 2694 (2000).
6. Zhang, H., Stalock, J. P., Ng, J, C., Reinhard, C., & Neufeld, T. P. Regulation of celiuar growth by the Drosophila target of rapamycin dTOR, Genes Dev. 14, 2712-2724 (2000).
7. Fingar, D. C., & Blenis, J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of ce;i growth and cell cycle progression, Oncogene 23, 3151 -3171 (2004).
8. Guertin, D. A.&Sabatini, D. M. Defining the role of mTOR in cancer, Cancer Cell 12, 9-22 (2007).
9. Yang, Q. & Guan, K. L. Expanding mTOR signaling. Cell Res. 17, 666 681 (2007).
10. Abraham, R. T. & Wiederrecht, G. J. lmmunopharmacology of rapamycin, .Annu, Rev. Immunol. 14, 483-510 (1996).
11. Sabatini, D. M. mTOR and cancerl insights into a complex relationship, Nature Rev. Cancer 6, 729-734 (2006).
12. Garraway, L. A. et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant moianoma. Nalure 436,117-122 (2005).
13. Wu, C., C., et al. GMx33: a novel family of trans-Golgi proteins identified by proteomics, Traffic 1, 963 975 (2000).
14. Bell, A. W. et al Proteomics characterization of abundant Golgi membrane proteins, J. Biol. Chem. 276, 5152-5165 (2001).
15. Snyder, C., M., Mardones, G. A., Ladinsky, M. S, & Howell, K. E. GMx33 associates with the Irans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi. Mol. Biol. Cell 17, 511-524 (2006).
16. Bonifacino, J. S. & Hurley, J. H. Retrorner. Curr. Opin. Cell Biol. 20,427-4 36 (2008).
17. Xie, M. W. et al. Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method, Proc, Natl Acad. Sci. USA 102, 7215 7220(2005).
18. Camp, R. L., Chung, G. G. & Rimm, D. L. Automated subcellular localization and quantification of protein expression in tissue nrcroarrays. Nature Med. 8, 1323-1327(2002).
19. Fingar, D. C., Salama, S., Tsou, C, Harlow, E & Blenis, J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/elF4E, Genes Dev. 16,1472 -1487 (2002).
20. Burnett, P. E., Barrow, R., K., Cohen, N. A., Snyder, S. H. & Sabatini, D. M. RAFT1 phosphorylation of the translatiorial regulators p70 S6 kinase and 4 E-BPl, Proc, Natl. Acad. Sci. USA 95,1432-1437 (1998).
21. Isotani, S. et al. Immunopurified mammalian target of rapamycin phosphoryiates and activates p70 S6 kinase m in vitro. J. Biol. Chem. 274, 34493-34498 (1999).
22. 473 kinase for Akt/protein kinase B in 3T3 LI adipocytes, J. Biol. Chem. 280, 40406 40416 (2005).
23. Sarbassov, D, D., Guertin, D, A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex, Science 307,1098-1101 (2005).
24. Chiu, V. K. et al. Ras signaling on the endoplasmic reticulum and the Golgi, Nature Cell Biol. 4, 343-350(2002).
25. Eaton, S. Retromor retrieves wntiess, Dev. Cell 14, 4-6 (2008).
26. Korolchuk, V. I. et al. Drosophila Vps35 function is necessary for norma endocytic trafficking and actin cytoskeleton organisation, J. Cell Sci. 120, 4367-4376 (2007).
27. Schmitz, K, R, et al. Golgi localization of giycosyitransferases requires a Vps74p oligomer. Dev. Cell 14, 523-534 (2008).
28. Tu, L. Tai, W. C. Chen, L. & Banfieid, D. K. Signal-mediated dynamic retention of glycosy transferases in the Golgi, Science 321, 404-407 (2008).
29. Ohtsubo, K. & Marth. J. D. G:ycosyiation in cellular mechanisms of health and disease, Cell 126, 855-867 (2006).
30. Takahashi, M., Tsuda, T., lkeda, Y., Honke, K. & Taniguchi, N. Role of N-glycans in growth factor signaling, Glyeoeonj. J. 20, 207-212 (2004).
31. Maser, R. S. et al. Chromosomal y unstable mouse tumours have genomic alterations similar to divers-e human cancers, Nature 447, 966-971 (2007).
32. Satyamoorthy, K. et al. Melanoma cellines from different stages of progression and their biologica and molecular analyses, Melanoma Res. 7 (suppl.2), S35-S42 (1997).
33. Tonon, G. el al. High-resolution genomic profiles of human ung cancer. Proc. Natl Acad. Sci. USA 102, 9625-9630 (2005).