The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 6, 2012, Pages 1058-1067

  Pangon, Laurent ^a   Van Kralingen, Christa ^a   Abas, Melissa ^a   Daly, Roger J ^a,b   Musgrove, Elizabeth A ^a,b   Kohonen Corish, Maija R J ^a,b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Lamellipodia; MCC; Myosin IIB; PDZ; PDZ binding motif; Scrib

Indexed keywords

CELL PROTEIN; MUTATED IN COLORECTAL CANCER PROTEIN; MYOSIN IIB; PROTEIN SCRIB; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL MEMBRANE; COLON MUCOSA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LAMELLIPODIUM; PDZ BINDING MOTIF; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; CELL MEMBRANE; CELL POLARITY; COLON; EPITHELIAL CELLS; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; NONMUSCLE MYOSIN TYPE IIB; PDZ DOMAINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN TRANSPORT; PSEUDOPODIA; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TUMOR SUPPRESSOR PROTEINS;

EID: 84860312399     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.03.011     Document Type: Article

References (27)

1. Arnaud C., Sebbagh M., Nola S., Audebert S., Bidaut G., Hermant A., Gayet O., Dusetti N.J., Ollendorff V., Santoni M.J., Borg J.P., Lecine P. MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS Lett. 2009, 583:2326-2332.
2. Fukuyama R., Niculaita R., Ng K.P., Obusez E., Sanchez J., Kalady M., Aung P.P., Casey G., Sizemore N. Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription. Oncogene 2008, 27:6044-6055.
3. Bouwmeester T., Bauch A., Ruffner H., Angrand P.O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A.M., Schirle M., Schlegl J., Schwab M., Stein M.A., Bauer A., Casari G., Drewes G., Gavin A.C., Jackson D.B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol. 2004, 6:97-105.
4. Sigglekow N.D., Pangon L., Brummer T., Molloy M., Hawkins N.J., Ward R.L., Musgrove E.A., Kohonen-Corish M.R. Mutated in colorectal cancer protein modulates the NFκB pathway. Anticancer Res. 2012, 32:73-79.
5. Pangon L., Sigglekow N.D., Larance M., Al-Sohaily S., Mladenova D.N., Selinger C.I., Musgrove E.A., Kohonen-Corish M.R. The "mutated in colorectal cancer" protein is a novel target of the UV-induced DNA damage checkpoint. Genes Cancer 2010, 1:917-926.
6. Matsumine A., Senda T., Baeg G.H., Roy B.C., Nakamura Y., Noda M., Toyoshima K., Akiyama T. MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. J. Biol. Chem. 1996, 271:10341-10346.
7. Schultz J., Milpetz F., Bork P., Ponting C.P. SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:5857-5864.
8. Jelen F., Oleksy A., Smietana K., Otlewski J. PDZ domains - common players in the cell signaling. Acta Biochim. Pol. 2003, 50:985-1017.
9. Dow L.E., Kauffman J.S., Caddy J., Zarbalis K., Peterson A.S., Jane S.M., Russell S.M., Humbert P.O. The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 2007, 26:2272-2282.
10. Nola S., Sebbagh M., Marchetto S., Osmani N., Nourry C., Audebert S., Navarro C., Rachel R., Montcouquiol M., Sans N., Etienne-Manneville S., Borg J.P., Santoni M.J. Scrib regulates PAK activity during the cell migration process. Hum. Mol. Genet. 2008, 17:3552-3565.
11. Nourry C., Grant S.G., Borg J.P. PDZ domain proteins: plug and play!. Sci. STKE 2003, 2003:RE7.
12. Kohonen-Corish M.R., Sigglekow N.D., Susanto J., Chapuis P.H., Bokey E.L., Dent O.F., Chan C., Lin B.P., Seng T.J., Laird P.W., Young J., Leggett B.A., Jass J.R., Sutherland R.L. Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogene 2007, 26:4435-4441.
13. Morris J.R., Pangon L., Boutell C., Katagiri T., Keep N.H., Solomon E. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. Hum. Mol. Genet. 2006, 15:599-606.
14. Lee H.J., Zheng J.J. PDZ domains and their binding partners: structure, specificity, and modification. Cell Commun. Signal. 2010, 8:8.
15. Zhang Y., Yeh S., Appleton B.A., Held H.A., Kausalya P.J., Phua D.C., Wong W.L., Lasky L.A., Wiesmann C., Hunziker W., Sidhu S.S. Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families. J. Biol. Chem. 2006, 281:22299-22311.
16. Fuh G., Pisabarro M.T., Li Y., Quan C., Lasky L.A., Sidhu S.S. Analysis of PDZ domain-ligand interactions using carboxyl-terminal phage display. J. Biol. Chem. 2000, 275:21486-21491.
17. Helwani F.M., Kovacs E.M., Paterson A.D., Verma S., Ali R.G., Fanning A.S., Weed S.A., Yap A.S. Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization. J. Cell Biol. 2004, 164:899-910.
18. Betapudi V. Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading. PLoS One 2010, 5:e8560.
19. Ewing R.M., Chu P., Elisma F., Li H., Taylor P., Climie S., McBroom-Cerajewski L., Robinson M.D., O'Connor L., Li M., Taylor R., Dharsee M., Ho Y., Heilbut A., Moore L., Zhang S., Ornatsky O., Bukhman Y.V., Ethier M., Sheng Y., Vasilescu J., Abu-Farha M., Lambert J.P., Duewel H.S., Stewart I.I., Kuehl B., Hogue K., Colwill K., Gladwish K., Muskat B., Kinach R., Adams S.L., Moran M.F., Morin G.B., Topaloglou T., Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol. Syst. Biol. 2007, 3:89.
20. Even-Faitelson L., Rosenberg M., Ravid S. PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis. Cell. Signal. 2005, 17:1137-1148.
21. Even-Faitelson L., Ravid S. PAK1 and aPKCzeta regulate myosin II-B phosphorylation: a novel signaling pathway regulating filament assembly. Mol. Biol. Cell 2006, 17:2869-2881.
22. Vicente-Manzanares M., Horwitz A.R. Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells. Biochem. Biophys. Res. Commun. 2010, 402:537-542.
23. Doyle D.A., Lee A., Lewis J., Kim E., Sheng M., MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996, 85:1067-1076.
24. Wang S., Raab R.W., Schatz P.J., Guggino W.B., Li M. Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett. 1998, 427:103-108.
25. + exchanger regulatory factor interaction with the β2 adrenergic and platelet-derived growth factor receptors. J. Biol. Chem. 2002, 277:18973-18978.
26. Songyang Z., Fanning A.S., Fu C., Xu J., Marfatia S.M., Chishti A.H., Crompton A., Chan A.C., Anderson J.M., Cantley L.C. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 1997, 275:73-77.
27. + exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 2001, 276:19683-19686.