Comparison of nephelometric, UV-spectroscopic, and HPLC methods for High-throughput determination of aqueous drug solubility in microtiter plates

Analytical Chemistry

Volumn 81, Issue 8, 2009, Pages 3165-3172

  Hoelke, Bettina ^a   Gieringer, Sabine ^a   Arlt, Michael ^b   Saal, Christoph ^a  

^a MERCK KGAA   (Germany)

^b EMD SERONO INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CO SOLVENTS; CONCENTRATION OF; DETECTION LIMITS; DRUG SOLUBILITIES; HIGH THROUGHPUTS; HIGH-THROUGHPUT SCREENINGS; HPLC METHODS; INFORMATION CONTENTS; MICROTITER PLATES; PHARMACEUTICAL INDUSTRIES; SOLUBILITY STUDIES; THERMODYNAMIC SOLUBILITIES;

ASSAYS; DRUG PRODUCTS PLANTS; ELECTRIC BATTERIES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE SUPERCONDUCTORS; TERNARY SYSTEMS;

SOLUBILITY;

SODIUM CHLORIDE; SOLVENT;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL PARAMETERS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; INCUBATION TIME; INFORMATION; INTERMETHOD COMPARISON; KINETICS; MICROTITER PLATE ASSAY; NEPHELOMETRY; THERMODYNAMICS; ULTRAVIOLET SPECTROSCOPY;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHYL SULFOXIDE; KINETICS; NEPHELOMETRY AND TURBIDIMETRY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TIME FACTORS; WATER;

EID: 65249098311     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9000089     Document Type: Article

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