Predicting intrinsic aqueous solubility by a thermodynamic cycle

Molecular Pharmaceutics

Volumn 5, Issue 2, 2008, Pages 266-279

  Palmer, David S ^a   Llinàs, Antonio ^a   Morao, Iñaki ^b   Day, Graeme M ^a   Goodman, Jonathan M ^a   Glen, Robert C ^a   Mitchell, John B O ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

ADME; Crystal; Lattice energy; Pharmacokinetics; QSPR; Solvation

Indexed keywords

1 NAPHTHOL; ACETANILIDE; ADENOSINE; ALCLOFENAC; ALLOPURINOL; ALPRAZOLAM; AMINOSALICYLIC ACID; BENZAMIDE; BENZOCAINE; BENZOIC ACID; CHLORPROTHIXENE; CHLORZOXAZONE; CIMETIDINE; CLOZAPINE; COCAINE; DICLOFENAC; FLUFENAMIC ACID; IBUPROFEN; INDOPROFEN; MEFENAMIC ACID; METOCLOPRAMIDE; NAPHTHALENE; NAPROXEN; NICOTINIC ACID; NITROFURANTOIN; ORGANIC COMPOUND; PAPAVERINE; PARACETAMOL; PHENOBARBITAL; UNINDEXED DRUG;

AB INITIO CALCULATION; ACCURACY; AQUEOUS SOLUTION; ARTICLE; CRYSTAL; CRYSTALLOGRAPHY; DRUG SOLUBILITY; MOLECULAR INTERACTION; MOLECULE; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGRESSION ANALYSIS; SOLID STATE; SOLVATION; THEORETICAL STUDY; THERMODYNAMICS;

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOLUBILITY; THERMODYNAMICS;

EID: 42549147181     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp7000878     Document Type: Article

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