Estimation of the aqueous solubility of weak electrolytes

International Journal of Pharmaceutics

Volumn 319, Issue 1-2, 2006, Pages 169-171

  Jain, Neera ^b   Yang, Gang ^c   Machatha, Stephen G ^a   Yalkowsky, Samuel H ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b PFIZER INC   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

GSE; pKa; Solubility; Weak electrolytes

Indexed keywords

ACID; ELECTROLYTE;

AQUEOUS SOLUTION; ARTICLE; ASSAY; PKA; PRIORITY JOURNAL; SOLUBILITY;

ELECTROLYTES; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; SOLUBILITY; SOLUTIONS; TRANSITION TEMPERATURE;

EID: 33745898815     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.04.022     Document Type: Article

References (3)

1. Biobyte Corp., 1999. ClogP, version 4.0.
2. Jain N., and Yalkowsky S.H. Estimation of the aqueous solubility. I. Application to organic non-electrolytes. J. Pharm. Sci. 90 (2001) 234-252
3. Ran Y., and Yalkowsky S.H. Prediction of drug solubility by the general solubility equation (GSE). J. Chem. Inf. Comput. Sci. 41 (2001) 354-357