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Volumn 140, Issue 2, 2013, Pages 143-152

Kinase AKT controls innate immune cell development and function

Author keywords

Homeostasis; Immunity; Innate immunity; Kinase AKT; Modulation; Molecular mechanisms

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84883799660     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12123     Document Type: Article
Times cited : (80)

References (92)
  • 1
    • 33748460821 scopus 로고    scopus 로고
    • TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
    • King CG, Kobayashi T, Cejas PJ et al. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 2006; 12:1088-92.
    • (2006) Nat Med , vol.12 , pp. 1088-1092
    • King, C.G.1    Kobayashi, T.2    Cejas, P.J.3
  • 2
    • 73349107789 scopus 로고    scopus 로고
    • mTOR signal pathway and its inhibitors in antitumor therapy: a review
    • Huang JJ, Lin TY. mTOR signal pathway and its inhibitors in antitumor therapy: a review. Ai Zheng 2007; 26:1397-403.
    • (2007) Ai Zheng , vol.26 , pp. 1397-1403
    • Huang, J.J.1    Lin, T.Y.2
  • 3
    • 67651100822 scopus 로고    scopus 로고
    • Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD)
    • Fischer DC, Jacoby U, Pape L et al. Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD). Nephrol Dial Transplant 2009; 24:1819-27.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1819-1827
    • Fischer, D.C.1    Jacoby, U.2    Pape, L.3
  • 4
    • 84887320759 scopus 로고    scopus 로고
    • AKT/GSK3 signaling pathway and schizophrenia
    • Emamian ES. AKT/GSK3 signaling pathway and schizophrenia. Front Mol Neurosci 2008; 5:33.
    • (2008) Front Mol Neurosci , vol.5 , pp. 33
    • Emamian, E.S.1
  • 5
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    • Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004; 11:1060-7.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 6
    • 70149085910 scopus 로고    scopus 로고
    • Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1-dependent pathway
    • Chiu YC, Lin CY, Chen CP et al. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1-dependent pathway. J Immunol 2009; 183:2785-92.
    • (2009) J Immunol , vol.183 , pp. 2785-2792
    • Chiu, Y.C.1    Lin, C.Y.2    Chen, C.P.3
  • 7
    • 34249951624 scopus 로고    scopus 로고
    • Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
    • Chang JD, Sukhova GK, Libby P et al. Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis. Proc Natl Acad Sci USA 2007; 104:8077-82.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8077-8082
    • Chang, J.D.1    Sukhova, G.K.2    Libby, P.3
  • 8
    • 79956196180 scopus 로고    scopus 로고
    • RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism
    • Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism. Am J Respir Crit Care Med 2012; 183:1322-35.
    • (2012) Am J Respir Crit Care Med , vol.183 , pp. 1322-1335
    • Ma, B.1    Dela Cruz, C.S.2    Hartl, D.3    Kang, M.J.4    Takyar, S.5    Homer, R.J.6    Lee, C.G.7    Elias, J.A.8
  • 9
    • 69749097391 scopus 로고    scopus 로고
    • Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
    • Mortaz E, Lazar Z, Koenderman L, Kraneveld AD, Nijkamp FP, Folkerts G. Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respir Res 2009; 10:47.
    • (2009) Respir Res , vol.10 , pp. 47
    • Mortaz, E.1    Lazar, Z.2    Koenderman, L.3    Kraneveld, A.D.4    Nijkamp, F.P.5    Folkerts, G.6
  • 10
    • 84864301912 scopus 로고    scopus 로고
    • The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury
    • Lai Y, Li D, Li C et al. The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury. Immunity 2013; 37:74-84.
    • (2013) Immunity , vol.37 , pp. 74-84
    • Lai, Y.1    Li, D.2    Li, C.3
  • 11
    • 0037044792 scopus 로고    scopus 로고
    • Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo
    • Bozinovski S, Jones JE, Vlahos R, Hamilton JA, Anderson GP. Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFκB and AP-1 in vivo. J Biol Chem 2002; 277:42808-14.
    • (2002) J Biol Chem , vol.277 , pp. 42808-42814
    • Bozinovski, S.1    Jones, J.E.2    Vlahos, R.3    Hamilton, J.A.4    Anderson, G.P.5
  • 13
    • 67649185215 scopus 로고    scopus 로고
    • The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
    • Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 2009; 10:769-77.
    • (2009) Nat Immunol , vol.10 , pp. 769-777
    • Liu, G.1    Burns, S.2    Huang, G.3    Boyd, K.4    Proia, R.L.5    Flavell, R.A.6    Chi, H.7
  • 15
    • 67649182934 scopus 로고    scopus 로고
    • A novel modifier of regulatory T cells
    • Ohkura N, Sakaguchi S. A novel modifier of regulatory T cells. Nat Immunol 2009; 10:685-6.
    • (2009) Nat Immunol , vol.10 , pp. 685-686
    • Ohkura, N.1    Sakaguchi, S.2
  • 16
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, Kole TP, Zheng Y et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009; 30:832-44.
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3
  • 17
    • 77951678634 scopus 로고    scopus 로고
    • The role of mTOR in memory CD8 T-cell differentiation
    • Araki K, Youngblood B, Ahmed R. The role of mTOR in memory CD8 T-cell differentiation. Immunol Rev 2007; 235:234-43.
    • (2007) Immunol Rev , vol.235 , pp. 234-243
    • Araki, K.1    Youngblood, B.2    Ahmed, R.3
  • 18
    • 83655211587 scopus 로고    scopus 로고
    • mTOR regulates T-cell differentiation and activation in immunity and autoimmunity
    • Bi Y, Liu G, Yang R. mTOR regulates T-cell differentiation and activation in immunity and autoimmunity. Crit Rev Eukaryot Gene Expr 2012; 21:313-22.
    • (2012) Crit Rev Eukaryot Gene Expr , vol.21 , pp. 313-322
    • Bi, Y.1    Liu, G.2    Yang, R.3
  • 19
    • 84857398190 scopus 로고    scopus 로고
    • + T cell survival and homeostasis in mice
    • + T cell survival and homeostasis in mice. PLoS One 2011; 7:e30592.
    • (2011) PLoS One , vol.7
    • Zhang, L.1    Zhang, H.2    Li, L.3
  • 20
    • 36248994733 scopus 로고    scopus 로고
    • Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils
    • Sandoval AJ, Riquelme JP, Carretta MD, Hancke JL, Hidalgo MA, Burgos RA. Store-operated calcium entry mediates intracellular alkalinization, ERK1/2, and Akt/PKB phosphorylation in bovine neutrophils. J Leukoc Biol 2007; 82:1266-77.
    • (2007) J Leukoc Biol , vol.82 , pp. 1266-1277
    • Sandoval, A.J.1    Riquelme, J.P.2    Carretta, M.D.3    Hancke, J.L.4    Hidalgo, M.A.5    Burgos, R.A.6
  • 21
    • 84866157114 scopus 로고    scopus 로고
    • TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway
    • Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol 2012; 189:2768-73.
    • (2012) J Immunol , vol.189 , pp. 2768-2773
    • Sun, H.1    Zhuang, G.2    Chai, L.3    Wang, Z.4    Johnson, D.5    Ma, Y.6    Chen, Y.H.7
  • 22
    • 60849134015 scopus 로고    scopus 로고
    • BK channels in innate immune functions of neutrophils and macrophages
    • Essin K, Gollasch M, Rolle S et al. BK channels in innate immune functions of neutrophils and macrophages. Blood 2009; 113:1326-31.
    • (2009) Blood , vol.113 , pp. 1326-1331
    • Essin, K.1    Gollasch, M.2    Rolle, S.3
  • 23
    • 34249814066 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils
    • Wong CK, Cheung PF, Ip WK, Lam CW. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol 2007; 37:85-96.
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 85-96
    • Wong, C.K.1    Cheung, P.F.2    Ip, W.K.3    Lam, C.W.4
  • 24
    • 0035793574 scopus 로고    scopus 로고
    • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
    • Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem 2001; 276:3517-23.
    • (2001) J Biol Chem , vol.276 , pp. 3517-3523
    • Rane, M.J.1    Coxon, P.Y.2    Powell, D.W.3    Webster, R.4    Klein, J.B.5    Pierce, W.6    Ping, P.7    McLeish, K.R.8
  • 25
    • 59249107053 scopus 로고    scopus 로고
    • Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium
    • Beaver LM, Stemmy EJ, Constant SL et al. Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium. Toxicol Appl Pharmacol 2009; 235:47-56.
    • (2009) Toxicol Appl Pharmacol , vol.235 , pp. 47-56
    • Beaver, L.M.1    Stemmy, E.J.2    Constant, S.L.3
  • 26
    • 67449143194 scopus 로고    scopus 로고
    • Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils
    • Chang LC, Lin RH, Huang LJ, Chang CS, Kuo SC, Wang JP. Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils. Eur J Pharmacol 2009; 615:207-17.
    • (2009) Eur J Pharmacol , vol.615 , pp. 207-217
    • Chang, L.C.1    Lin, R.H.2    Huang, L.J.3    Chang, C.S.4    Kuo, S.C.5    Wang, J.P.6
  • 27
    • 42449122333 scopus 로고    scopus 로고
    • Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
    • Jia Y, Loison F, Hattori H et al. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci USA 2008; 105:4739-44.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 4739-4744
    • Jia, Y.1    Loison, F.2    Hattori, H.3
  • 28
    • 0035800662 scopus 로고    scopus 로고
    • p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils
    • De Mesquita DD, Zhan Q, Crossley L, Badwey JA. p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils. FEBS Lett 2001; 502:84-8.
    • (2001) FEBS Lett , vol.502 , pp. 84-88
    • De Mesquita, D.D.1    Zhan, Q.2    Crossley, L.3    Badwey, J.A.4
  • 29
    • 34548381779 scopus 로고    scopus 로고
    • Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis
    • Magalhaes MA, Zhu F, Sarantis H, Gray-Owen SD, Ellen RP, Glogauer M. Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis. J Leukoc Biol 2007; 82:559-66.
    • (2007) J Leukoc Biol , vol.82 , pp. 559-566
    • Magalhaes, M.A.1    Zhu, F.2    Sarantis, H.3    Gray-Owen, S.D.4    Ellen, R.P.5    Glogauer, M.6
  • 30
    • 2442681877 scopus 로고    scopus 로고
    • Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
    • Gardai SJ, Hildeman DA, Frankel SK et al. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 2004; 279:21085-95.
    • (2004) J Biol Chem , vol.279 , pp. 21085-21095
    • Gardai, S.J.1    Hildeman, D.A.2    Frankel, S.K.3
  • 31
    • 84857743749 scopus 로고    scopus 로고
    • Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils
    • Blomgran R, Patcha Brodin V, Verma D et al. Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils. PLoS One 2012; 7:e31326.
    • (2012) PLoS One , vol.7
    • Blomgran, R.1    Patcha Brodin, V.2    Verma, D.3
  • 32
    • 77649262734 scopus 로고    scopus 로고
    • Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kγ, ROS, and actin
    • Xu Y, Loison F, Luo HR. Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kγ, ROS, and actin. Proc Natl Acad Sci USA 2010; 107:2950-5.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 2950-2955
    • Xu, Y.1    Loison, F.2    Luo, H.R.3
  • 33
    • 84860797888 scopus 로고    scopus 로고
    • Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes
    • Sarkar A, Hellberg L, Bhattacharyya A et al. Infection with Anaplasma phagocytophilum activates the phosphatidylinositol 3-Kinase/Akt and NF-κB survival pathways in neutrophil granulocytes. Infect Immun 2011; 80:1615-23.
    • (2011) Infect Immun , vol.80 , pp. 1615-1623
    • Sarkar, A.1    Hellberg, L.2    Bhattacharyya, A.3
  • 34
    • 84887318251 scopus 로고    scopus 로고
    • G-CSF activation of AKT is not sufficient to prolong neutrophil survival
    • Souza LR, Silva E, Calloway E, Cabrera C, McLemore ML. G-CSF activation of AKT is not sufficient to prolong neutrophil survival. J Leukoc Biol 2013; 53:1235-9.
    • (2013) J Leukoc Biol , vol.53 , pp. 1235-1239
    • Souza, L.R.1    Silva, E.2    Calloway, E.3    Cabrera, C.4    McLemore, M.L.5
  • 35
    • 79953818388 scopus 로고    scopus 로고
    • G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis
    • Jun HS, Lee YM, Song KD, Mansfield BC, Chou JY. G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. Blood 2011; 117:3881-92.
    • (2011) Blood , vol.117 , pp. 3881-3892
    • Jun, H.S.1    Lee, Y.M.2    Song, K.D.3    Mansfield, B.C.4    Chou, J.Y.5
  • 36
    • 57349138458 scopus 로고    scopus 로고
    • An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption
    • Herrera BS, Ohira T, Gao L et al. An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Br J Pharmacol 2008; 155:1214-23.
    • (2008) Br J Pharmacol , vol.155 , pp. 1214-1223
    • Herrera, B.S.1    Ohira, T.2    Gao, L.3
  • 37
    • 0037133606 scopus 로고    scopus 로고
    • Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
    • Hannigan M, Zhan L, Li Z, Ai Y, Wu D, Huang CK. Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis. Proc Natl Acad Sci USA 2002; 99:3603-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3603-3608
    • Hannigan, M.1    Zhan, L.2    Li, Z.3    Ai, Y.4    Wu, D.5    Huang, C.K.6
  • 38
    • 0034635452 scopus 로고    scopus 로고
    • Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
    • Hirsch E, Katanaev VL, Garlanda C et al. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science 2000; 287:1049-53.
    • (2000) Science , vol.287 , pp. 1049-1053
    • Hirsch, E.1    Katanaev, V.L.2    Garlanda, C.3
  • 39
    • 56749156696 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications
    • Weichhart T, Saemann MD. The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis 2008; 67(Suppl. 3):iii70-4.
    • (2008) Ann Rheum Dis , vol.67 , Issue.SUPPL. 3
    • Weichhart, T.1    Saemann, M.D.2
  • 40
    • 83055161506 scopus 로고    scopus 로고
    • Rac regulates PtdInsP(3) signaling and the chemotactic compass through a redox-mediated feedback loop
    • Kuiper JW, Sun C, Magalhaes MA, Glogauer M. Rac regulates PtdInsP(3) signaling and the chemotactic compass through a redox-mediated feedback loop. Blood 2009; 118:6164-71.
    • (2009) Blood , vol.118 , pp. 6164-6171
    • Kuiper, J.W.1    Sun, C.2    Magalhaes, M.A.3    Glogauer, M.4
  • 41
    • 33845889090 scopus 로고    scopus 로고
    • Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
    • Nishio M, Watanabe K, Sasaki J et al. Control of cell polarity and motility by the PtdIns(3, 4, 5)P3 phosphatase SHIP1. Nat Cell Biol 2007; 9:36-44.
    • (2007) Nat Cell Biol , vol.9 , pp. 36-44
    • Nishio, M.1    Watanabe, K.2    Sasaki, J.3
  • 43
    • 33344461473 scopus 로고    scopus 로고
    • G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth
    • Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood 2006; 107:1847-56.
    • (2006) Blood , vol.107 , pp. 1847-1856
    • Zhu, Q.S.1    Xia, L.2    Mills, G.B.3    Lowell, C.A.4    Touw, I.P.5    Corey, S.J.6
  • 44
    • 0034655090 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways
    • Klein JB, Rane MJ, Scherzer JA, Coxon PY, Kettritz R, Mathiesen JM, Buridi A, McLeish KR. Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways. J Immunol 2000; 164:4286-91.
    • (2000) J Immunol , vol.164 , pp. 4286-4291
    • Klein, J.B.1    Rane, M.J.2    Scherzer, J.A.3    Coxon, P.Y.4    Kettritz, R.5    Mathiesen, J.M.6    Buridi, A.7    McLeish, K.R.8
  • 45
    • 52449120635 scopus 로고    scopus 로고
    • Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
    • Inoue T, Meyer T. Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS One 2008; 3:e3068.
    • (2008) PLoS One , vol.3
    • Inoue, T.1    Meyer, T.2
  • 46
    • 77953626900 scopus 로고    scopus 로고
    • Akt isoforms differentially regulate neutrophil functions
    • Chen J, Tang H, Hay N, Xu J, Ye RD. Akt isoforms differentially regulate neutrophil functions. Blood 2010; 115:4237-46.
    • (2010) Blood , vol.115 , pp. 4237-4246
    • Chen, J.1    Tang, H.2    Hay, N.3    Xu, J.4    Ye, R.D.5
  • 47
    • 21044446798 scopus 로고    scopus 로고
    • Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion
    • Rane MJ, Gozal D, Butt W et al. Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion. J Immunol 2005; 174:7242-9.
    • (2005) J Immunol , vol.174 , pp. 7242-7249
    • Rane, M.J.1    Gozal, D.2    Butt, W.3
  • 48
    • 84865108747 scopus 로고    scopus 로고
    • AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells
    • Zou W, Chu X, Cai C, Zou M, Meng X, Chen H, Zou F. AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells. Inflamm Res 2013; 61:853-62.
    • (2013) Inflamm Res , vol.61 , pp. 853-862
    • Zou, W.1    Chu, X.2    Cai, C.3    Zou, M.4    Meng, X.5    Chen, H.6    Zou, F.7
  • 49
    • 84872593818 scopus 로고    scopus 로고
    • Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1
    • Liu G, Hu X, Sun B, Yang T, Shi J, Zhang L, Zhao Y. Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood 2013; 121:519-29.
    • (2013) Blood , vol.121 , pp. 519-529
    • Liu, G.1    Hu, X.2    Sun, B.3    Yang, T.4    Shi, J.5    Zhang, L.6    Zhao, Y.7
  • 50
    • 20444412722 scopus 로고    scopus 로고
    • Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury
    • Strassheim D, Kim JY, Park JS, Mitra S, Abraham E. Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol 2005; 174:8064-71.
    • (2005) J Immunol , vol.174 , pp. 8064-8071
    • Strassheim, D.1    Kim, J.Y.2    Park, J.S.3    Mitra, S.4    Abraham, E.5
  • 51
    • 2142652249 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils
    • Strassheim D, Asehnoune K, Park JS et al. Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol 2004; 172:5727-33.
    • (2004) J Immunol , vol.172 , pp. 5727-5733
    • Strassheim, D.1    Asehnoune, K.2    Park, J.S.3
  • 52
    • 0037883614 scopus 로고    scopus 로고
    • Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils
    • Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, McLeish KR. Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol 2003; 170:5302-8.
    • (2003) J Immunol , vol.170 , pp. 5302-5308
    • Chen, Q.1    Powell, D.W.2    Rane, M.J.3    Singh, S.4    Butt, W.5    Klein, J.B.6    McLeish, K.R.7
  • 53
    • 33748457564 scopus 로고    scopus 로고
    • DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
    • Kunisaki Y, Nishikimi A, Tanaka Y et al. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol 2006; 174:647-52.
    • (2006) J Cell Biol , vol.174 , pp. 647-652
    • Kunisaki, Y.1    Nishikimi, A.2    Tanaka, Y.3
  • 54
    • 0033764726 scopus 로고    scopus 로고
    • Intraperitoneal macrophages and tumor immunity: a review
    • Jackson PG, Evans SR. Intraperitoneal macrophages and tumor immunity: a review. J Surg Oncol 2000; 75:146-54.
    • (2000) J Surg Oncol , vol.75 , pp. 146-154
    • Jackson, P.G.1    Evans, S.R.2
  • 55
    • 0037100507 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2
    • Reddy SM, Hsiao KH, Abernethy VE et al. Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2. J Immunol 2002; 169:702-13.
    • (2002) J Immunol , vol.169 , pp. 702-713
    • Reddy, S.M.1    Hsiao, K.H.2    Abernethy, V.E.3
  • 56
    • 84866179288 scopus 로고    scopus 로고
    • The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin
    • Gantner BN, Jin H, Qian F, Hay N, He B, Ye RD. The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin. J Immunol 2012; 189:3104-11.
    • (2012) J Immunol , vol.189 , pp. 3104-3111
    • Gantner, B.N.1    Jin, H.2    Qian, F.3    Hay, N.4    He, B.5    Ye, R.D.6
  • 57
    • 84873706806 scopus 로고    scopus 로고
    • Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1
    • Mukherjee B, Mukhopadhyay R, Bannerjee B et al. Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1. Proc Natl Acad Sci USA 2012; 110:E575-82.
    • (2012) Proc Natl Acad Sci USA , vol.110
    • Mukherjee, B.1    Mukhopadhyay, R.2    Bannerjee, B.3
  • 58
    • 0037613604 scopus 로고    scopus 로고
    • C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt
    • Koide N, Sugiyama T, Mori I, Mu MM, Yoshida T, Yokochi T. C2-ceramide inhibits LPS-induced nitric oxide production in RAW 264.7 macrophage cells through down-regulating the activation of Akt. J Endotoxin Res 2003; 9:85-90.
    • (2003) J Endotoxin Res , vol.9 , pp. 85-90
    • Koide, N.1    Sugiyama, T.2    Mori, I.3    Mu, M.M.4    Yoshida, T.5    Yokochi, T.6
  • 59
    • 84866179288 scopus 로고    scopus 로고
    • The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin
    • Gantner BN, Jin H, Qian F, Hay N, He B, Ye RD. The Akt1 isoform is required for optimal IFN-β transcription through direct phosphorylation of β-catenin. J Immunol 2012; 189:3104-11.
    • (2012) J Immunol , vol.189 , pp. 3104-3111
    • Gantner, B.N.1    Jin, H.2    Qian, F.3    Hay, N.4    He, B.5    Ye, R.D.6
  • 60
    • 20144385204 scopus 로고    scopus 로고
    • Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages
    • Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol 2005; 25:1213-9.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1213-1219
    • Miller, Y.I.1    Viriyakosol, S.2    Worrall, D.S.3    Boullier, A.4    Butler, S.5    Witztum, J.L.6
  • 61
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki A, Iliopoulos D, Arranz A et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009; 31:220-31.
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1    Iliopoulos, D.2    Arranz, A.3
  • 62
    • 84863254048 scopus 로고    scopus 로고
    • PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress
    • Kim SY, Jeong E, Joung SM, Lee JY. PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress. Biochem Biophys Res Commun 2012; 419:466-71.
    • (2012) Biochem Biophys Res Commun , vol.419 , pp. 466-471
    • Kim, S.Y.1    Jeong, E.2    Joung, S.M.3    Lee, J.Y.4
  • 65
    • 84862187485 scopus 로고    scopus 로고
    • Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
    • Arranz A, Doxaki C, Vergadi E et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA 2012; 109:9517-22.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 9517-9522
    • Arranz, A.1    Doxaki, C.2    Vergadi, E.3
  • 67
    • 33846416534 scopus 로고    scopus 로고
    • Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
    • Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007; 67:167-77.
    • (2007) Cancer Res , vol.67 , pp. 167-177
    • Maroulakou, I.G.1    Oemler, W.2    Naber, S.P.3    Tsichlis, P.N.4
  • 68
    • 84856806021 scopus 로고    scopus 로고
    • Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development
    • Mukherjee A, Rotwein P. Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development. Mol Cell Biol 2011; 32:490-500.
    • (2011) Mol Cell Biol , vol.32 , pp. 490-500
    • Mukherjee, A.1    Rotwein, P.2
  • 69
    • 33750580557 scopus 로고    scopus 로고
    • Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    • Yang FC, Chen S, Robling AG et al. Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions. J Clin Invest 2006; 116:2880-91.
    • (2006) J Clin Invest , vol.116 , pp. 2880-2891
    • Yang, F.C.1    Chen, S.2    Robling, A.G.3
  • 70
    • 58049129497 scopus 로고    scopus 로고
    • AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways
    • Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, Lee ZH. AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways. Mol Cells 2008; 26:436-42.
    • (2008) Mol Cells , vol.26 , pp. 436-442
    • Kwak, H.B.1    Sun, H.M.2    Ha, H.3    Lee, J.H.4    Kim, H.N.5    Lee, Z.H.6
  • 71
    • 46749113860 scopus 로고    scopus 로고
    • MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis
    • Kong L, Ge BX. MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis. Cell Res 2008; 18:745-55.
    • (2008) Cell Res , vol.18 , pp. 745-755
    • Kong, L.1    Ge, B.X.2
  • 73
    • 79952598936 scopus 로고    scopus 로고
    • Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity
    • Zhou Q, Leeman SE, Amar S. Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc Natl Acad Sci USA 2011; 108:2867-72.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2867-2872
    • Zhou, Q.1    Leeman, S.E.2    Amar, S.3
  • 75
    • 84875640226 scopus 로고    scopus 로고
    • Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity
    • Liu G, Bi Y, Wang R, Wang X. Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity. J Leukoc Biol 2013; 93:511-9.
    • (2013) J Leukoc Biol , vol.93 , pp. 511-519
    • Liu, G.1    Bi, Y.2    Wang, R.3    Wang, X.4
  • 77
    • 76949085146 scopus 로고    scopus 로고
    • Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response
    • Wang W, Wang J, Dong SF et al. Immunomodulatory activity of andrographolide on macrophage activation and specific antibody response. Acta Pharmacol Sin 2010; 31:191-201.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 191-201
    • Wang, W.1    Wang, J.2    Dong, S.F.3
  • 78
    • 70350059183 scopus 로고    scopus 로고
    • Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells
    • Boronkai A, Bellyei S, Szigeti A, Pozsgai E, Bognar Z, Sumegi B, Gallyas F Jr. Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells. Eur J Cell Biol 2009; 88:753-63.
    • (2009) Eur J Cell Biol , vol.88 , pp. 753-763
    • Boronkai, A.1    Bellyei, S.2    Szigeti, A.3    Pozsgai, E.4    Bognar, Z.5    Sumegi, B.6    Gallyas Jr, F.7
  • 79
    • 36749030024 scopus 로고    scopus 로고
    • Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
    • Kuijl C, Savage ND, Marsman M et al. Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature 2007; 450:725-30.
    • (2007) Nature , vol.450 , pp. 725-730
    • Kuijl, C.1    Savage, N.D.2    Marsman, M.3
  • 80
    • 16344368251 scopus 로고    scopus 로고
    • Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-κB and Akt signaling pathways
    • Appel S, Rupf A, Weck MM, Schoor O, Brummendorf TH, Weinschenk T, Grunebach F, Brossart P. Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-κB and Akt signaling pathways. Clin Cancer Res 2005; 11:1928-40.
    • (2005) Clin Cancer Res , vol.11 , pp. 1928-1940
    • Appel, S.1    Rupf, A.2    Weck, M.M.3    Schoor, O.4    Brummendorf, T.H.5    Weinschenk, T.6    Grunebach, F.7    Brossart, P.8
  • 81
    • 77953643797 scopus 로고    scopus 로고
    • Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling
    • van de Laar L, Buitenhuis M, Wensveen FM, Janssen HL, Coffer PJ, Woltman AM. Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling. J Immunol 2010; 184:6600-11.
    • (2010) J Immunol , vol.184 , pp. 6600-6611
    • van de Laar, L.1    Buitenhuis, M.2    Wensveen, F.M.3    Janssen, H.L.4    Coffer, P.J.5    Woltman, A.M.6
  • 83
    • 84870533821 scopus 로고    scopus 로고
    • HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells
    • Florentin J, Aouar B, Dental C et al. HCV glycoprotein E2 is a novel BDCA-2 ligand and acts as an inhibitor of IFN production by plasmacytoid dendritic cells. Blood 2010; 120:4544-51.
    • (2010) Blood , vol.120 , pp. 4544-4551
    • Florentin, J.1    Aouar, B.2    Dental, C.3
  • 84
    • 0034254811 scopus 로고    scopus 로고
    • The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells
    • Ardeshna KM, Pizzey AR, Devereux S, Khwaja A. The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 2000; 96:1039-46.
    • (2000) Blood , vol.96 , pp. 1039-1046
    • Ardeshna, K.M.1    Pizzey, A.R.2    Devereux, S.3    Khwaja, A.4
  • 85
    • 62849114121 scopus 로고    scopus 로고
    • Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway
    • Mattioli B, Giordani L, Quaranta MG, Viora M. Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. FEBS Lett 2009; 583:1102-6.
    • (2009) FEBS Lett , vol.583 , pp. 1102-1106
    • Mattioli, B.1    Giordani, L.2    Quaranta, M.G.3    Viora, M.4
  • 87
    • 0035839450 scopus 로고    scopus 로고
    • A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation
    • Arron JR, Vologodskaia M, Wong BR, Naramura M, Kim N, Gu H, Choi Y. A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation. J Biol Chem 2001; 276:30011-7.
    • (2001) J Biol Chem , vol.276 , pp. 30011-30017
    • Arron, J.R.1    Vologodskaia, M.2    Wong, B.R.3    Naramura, M.4    Kim, N.5    Gu, H.6    Choi, Y.7
  • 88
    • 77951251910 scopus 로고    scopus 로고
    • Nuclear factor (NF)-κB-dependent thyroid hormone receptor β1 expression controls dendritic cell function via Akt signaling
    • Mascanfroni ID, Montesinos Mdel M, Alamino VA et al. Nuclear factor (NF)-κB-dependent thyroid hormone receptor β1 expression controls dendritic cell function via Akt signaling. J Biol Chem 2009; 285:9569-82.
    • (2009) J Biol Chem , vol.285 , pp. 9569-9582
    • Mascanfroni, I.D.1    Montesinos, M.M.2    Alamino, V.A.3
  • 91
    • 0025322445 scopus 로고
    • Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses: theoretical assignment of functional domains
    • Poch O, Blumberg BM, Bougueleret L, Tordo N. Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses: theoretical assignment of functional domains. J Gen Virol 1990; 71(Pt 5):1153-62.
    • (1990) J Gen Virol , vol.71 , Issue.PART 5 , pp. 1153-1162
    • Poch, O.1    Blumberg, B.M.2    Bougueleret, L.3    Tordo, N.4
  • 92
    • 55249122957 scopus 로고    scopus 로고
    • AKT1-dependent activation of NF-κB by the L protein of parainfluenza virus 5
    • Luthra P, Sun D, Wolfgang M, He B. AKT1-dependent activation of NF-κB by the L protein of parainfluenza virus 5. J Virol 2008; 82:10887-95.
    • (2008) J Virol , vol.82 , pp. 10887-10895
    • Luthra, P.1    Sun, D.2    Wolfgang, M.3    He, B.4


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