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Volumn 61, Issue 8, 2012, Pages 853-862

AKT-mediated regulation of polarization in differentiated human neutrophil-like HL-60 cells

Author keywords

AKT; Cell polarization; Differentiated HL 60; FMLP

Indexed keywords

DIMETHYL SULFOXIDE; F ACTIN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GLUTATHIONE TRANSFERASE; PHALLOIDIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAC2 PROTEIN; RHODAMINE;

EID: 84865108747     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0478-y     Document Type: Article
Times cited : (6)

References (54)
  • 1
    • 52449120635 scopus 로고    scopus 로고
    • Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration
    • Inoue T, Meyer T. Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS ONE. 2008;3:e3068.
    • (2008) PLoS ONE , vol.3
    • Inoue, T.1    Meyer, T.2
  • 2
    • 33748457564 scopus 로고    scopus 로고
    • DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
    • Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, et al. DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis. J Cell Biol. 2006;174:647-52.
    • (2006) J Cell Biol , vol.174 , pp. 647-652
    • Kunisaki, Y.1    Nishikimi, A.2    Tanaka, Y.3    Takii, R.4    Noda, M.5    Inayoshi, A.6
  • 3
    • 0142124454 scopus 로고    scopus 로고
    • Signaling to migration in neutrophils: Importance of localized pathways
    • DOI 10.1016/S1357-2725(03)00144-4
    • Niggli V. Signaling to migration in neutrophils: importance of localized pathways. Int J biochem Cell Biol. 2003;35:1619-38. (Pubitemid 37297409)
    • (2003) International Journal of Biochemistry and Cell Biology , vol.35 , Issue.12 , pp. 1619-1638
    • Niggli, V.1
  • 4
    • 33947620706 scopus 로고    scopus 로고
    • The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts
    • DOI 10.1111/j.1365-2443.2007.01071.x
    • Onishi K, Higuchi M, Asakura T, Masuyama N, Gotoh Y. The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts. Genes Cells. 2007;12:535-46. (Pubitemid 46488588)
    • (2007) Genes to Cells , vol.12 , Issue.4 , pp. 535-546
    • Onishi, K.1    Higuchi, M.2    Asakura, T.3    Masuyama, N.4    Gotoh, Y.5
  • 5
    • 0141455957 scopus 로고    scopus 로고
    • Novel pathways of F-actin polymerization in the human neutrophil
    • DOI 10.1182/blood-2002-09-2936
    • Chodniewicz D, Zhelev DV. Novel pathways of F-actin polymerization in the human neutrophil. Blood. 2003;102:2251-8. (Pubitemid 37122407)
    • (2003) Blood , vol.102 , Issue.6 , pp. 2251-2258
    • Chodniewicz, D.1    Zhelev, D.V.2
  • 6
    • 55549147533 scopus 로고    scopus 로고
    • Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis
    • Sai J, Raman D, Liu Y, Wikswo J, Richmond A. Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. J Biol Chem. 2008;283:26538-47.
    • (2008) J Biol Chem , vol.283 , pp. 26538-26547
    • Sai, J.1    Raman, D.2    Liu, Y.3    Wikswo, J.4    Richmond, A.5
  • 7
    • 0036223113 scopus 로고    scopus 로고
    • Differentiated HL-60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis
    • DOI 10.1016/S1357-2725(02)00010-9, PII S1357272502000109
    • Hauert AB, Martinelli S, Marone C, Niggli V. Differentiated HL- 60 cells are a valid model system for the analysis of human neutrophil migration and chemotaxis. Int J Biochem Cell Biol. 2002;34:838-54. (Pubitemid 34304172)
    • (2002) International Journal of Biochemistry and Cell Biology , vol.34 , Issue.7 , pp. 838-854
    • Hauert, A.B.1    Martinelli, S.2    Marone, C.3    Niggli, V.4
  • 8
    • 34249719445 scopus 로고    scopus 로고
    • 2
    • DOI 10.1189/jlb.0406256
    • Burelout C, Naccache PH, Bourgoin SG. Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils-effect of prostaglandin E2. J Leukoc Biol. 2007;81:1523-34. (Pubitemid 46827975)
    • (2007) Journal of Leukocyte Biology , vol.81 , Issue.6 , pp. 1523-1534
    • Burelout, C.1    Naccache, P.H.2    Bourgoin, S.G.3
  • 9
  • 10
    • 0037862006 scopus 로고    scopus 로고
    • Unravelling the activation mechanisms of protein kinase B/Akt
    • DOI 10.1016/S0014-5793(03)00562-3
    • Scheid MP, Woodgett Jr. Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 2003;546:108-12. (Pubitemid 36782290)
    • (2003) FEBS Letters , vol.546 , Issue.1 , pp. 108-112
    • Scheid, M.P.1    Woodgett, J.R.2
  • 12
    • 33748376922 scopus 로고    scopus 로고
    • Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR
    • DOI 10.1016/j.ejcb.2006.04.007, PII S017193350600077X, A special issue dedicated to Guenter Gerisch on the occasion of his 75th birthday
    • Sasaki AT, Firtel RA. Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR. Eur J Cell Biol. 2006;85:873-95. (Pubitemid 44334734)
    • (2006) European Journal of Cell Biology , vol.85 , Issue.9-10 , pp. 873-895
    • Sasaki, A.T.1    Firtel, R.A.2
  • 13
    • 42149177825 scopus 로고    scopus 로고
    • The regulation of cell motility and chemotaxis by phospholipid signaling
    • DOI 10.1242/jcs.023333
    • Kolsch V, Charest PG, Firtel RA. The regulation of cell motility and chemotaxis by phospholipid signaling. J Cell Sci. 2008; 121:551-9. (Pubitemid 351524153)
    • (2008) Journal of Cell Science , vol.121 , Issue.5 , pp. 551-559
    • Kolsch, V.1    Charest, P.G.2    Firtel, R.A.3
  • 17
    • 0037078334 scopus 로고    scopus 로고
    • An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients
    • DOI 10.1083/jcb.200202114
    • Heit B, Tavener S, Raharjo E, Kubes P. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J Cell Biol. 2002;159:91-102. (Pubitemid 35191521)
    • (2002) Journal of Cell Biology , vol.159 , Issue.1 , pp. 91-102
    • Heit, B.1    Tavener, S.2    Raharjo, E.3    Kubes, P.4
  • 18
    • 77953626900 scopus 로고    scopus 로고
    • Akt isoforms differentially regulate neutrophil functions
    • Chen J, Tang H, Hay N, Xu J, Ye RD. Akt isoforms differentially regulate neutrophil functions. Blood. 2010;115:4237-46.
    • (2010) Blood , vol.115 , pp. 4237-4246
    • Chen, J.1    Tang, H.2    Hay, N.3    Xu, J.4    Ye, R.D.5
  • 20
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • DOI 10.1016/j.tibs.2004.03.006, PII S096800040400074X
    • Brazil DP, Yang ZZ, Hemmings BA. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci. 2004;29:233-42. (Pubitemid 38591317)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.5 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.-Z.2    Hemmings, B.A.3
  • 21
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. 1992;70:401-10.
    • (1992) Cell , vol.70 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 22
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81: 53-62.
    • (1995) Cell. , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 23
    • 8444239999 scopus 로고    scopus 로고
    • Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles
    • Yamauchi A, Kim C, Li S, Marchal CC, Towe J, Atkinson SJ, et al. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol. 2004;173:5971-9. (Pubitemid 39487751)
    • (2004) Journal of Immunology , vol.173 , Issue.10 , pp. 5971-5979
    • Yamauchi, A.1    Kim, C.2    Li, S.3    Marchal, C.C.4    Towe, J.5    Atkinson, S.J.6    Dinauer, M.C.7
  • 24
    • 45549089809 scopus 로고    scopus 로고
    • Isolation of human neutrophils from venous blood
    • Nauseef WM. Isolation of human neutrophils from venous blood. Methods Mol Biol. 2007;412:15-20.
    • (2007) Methods Mol Biol , vol.412 , pp. 15-20
    • Nauseef, W.M.1
  • 25
    • 38949147037 scopus 로고    scopus 로고
    • PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP
    • DOI 10.1242/jcs.020412
    • Heit B, Liu L, Colarusso P, Puri KD, Kubes P. PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP. J Cell Sci. 2008;121:205-14. (Pubitemid 351228453)
    • (2008) Journal of Cell Science , vol.121 , Issue.2 , pp. 205-214
    • Heit, B.1    Liu, L.2    Colarusso, P.3    Puri, K.D.4    Kubes, P.5
  • 26
    • 0026070365 scopus 로고
    • Studies of chemotactic factor-induced polarity in human neutrophils. Lipid mobility, receptor distribution and the time-sequence of polarization
    • McKay DA, Kusel JR, Wilkinson PC. Studies of chemotactic factor-induced polarity in human neutrophils. Lipid mobility, receptor distribution and the time-sequence of polarization. J Cell Sci. 1991;100(Pt 3):473-9.
    • (1991) J Cell Sci , vol.100 , Issue.PART 3 , pp. 473-479
    • McKay, D.A.1    Kusel, J.R.2    Wilkinson, P.C.3
  • 27
    • 58349088327 scopus 로고    scopus 로고
    • Temperature pretreatment alters the polarization response of human neutrophils to the chemoattractant N-formyl-Met-Leu-Phe
    • Zhao D, Meng X, Cai C, Yuan C, Zou F. Temperature pretreatment alters the polarization response of human neutrophils to the chemoattractant N-formyl-Met-Leu-Phe. Inflammation. 2009;32: 47-56.
    • (2009) Inflammation , vol.32 , pp. 47-56
    • Zhao, D.1    Meng, X.2    Cai, C.3    Yuan, C.4    Zou, F.5
  • 28
    • 10344222155 scopus 로고    scopus 로고
    • How cells coordinate growth and division
    • DOI 10.1016/j.cub.2004.11.027, PII S0960982204008954
    • Jorgensen P, Tyers M. How cells coordinate growth and division. Curr Biol. 2004;14:R1014-27. (Pubitemid 39623187)
    • (2004) Current Biology , vol.14 , Issue.23
    • Jorgensen, P.1    Tyers, M.2
  • 30
    • 38549110300 scopus 로고    scopus 로고
    • Small molecule disruption of G protein βγ subunit signaling inhibits neutrophil chemotaxis and inflammation
    • DOI 10.1124/mol.107.041780
    • Lehmann DM, Seneviratne AM, Smrcka AV. Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation. Mol Pharmacol. 2008;73:410-8. (Pubitemid 351159211)
    • (2008) Molecular Pharmacology , vol.73 , Issue.2 , pp. 410-418
    • Lehmann, D.M.1    Seneviratne, A.M.P.B.2    Smrcka, A.V.3
  • 32
    • 21644448126 scopus 로고    scopus 로고
    • The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes
    • DOI 10.1002/jcp.20323
    • Schymeinsky J, Then C, Walzog B. The non-receptor tyrosine kinase Syk regulates lamellipodium formation and site-directed migration of human leukocytes. J Cell Physiol. 2005;204:614-22. (Pubitemid 40934657)
    • (2005) Journal of Cellular Physiology , vol.204 , Issue.2 , pp. 614-622
    • Schymeinsky, J.1    Then, C.2    Walzog, B.3
  • 34
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • DOI 10.1126/science.287.5455.1037
    • Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science. 2000;287:1037-40. (Pubitemid 30094359)
    • (2000) Science , vol.287 , Issue.5455 , pp. 1037-1040
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 35
    • 0037415640 scopus 로고    scopus 로고
    • Rac and Cdc42 play distinct roles in regulating PI(3, 45)P3 and polarity during neutrophil chemotaxis
    • Srinivasan S,Wang F,Glavas S,OttA,Hofmann F,AktoriesK, et al. Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. JCell Biol. 2003;160:375-85.
    • (2003) JCell Biol , vol.160 , pp. 375-385
    • Srinivasan, S.1    Wang, F.2    Glavas, S.3    Ott, A.4    Hofmann, F.5    Aktories, K.6
  • 36
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    • DOI 10.1146/annurev.biochem.68.1.965
    • Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem. 1999;68:965-1014. (Pubitemid 29449213)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 37
    • 0032189381 scopus 로고    scopus 로고
    • Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
    • Coffer PJ, Jin J, Woodgett Jr. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J. 1998;335(Pt 1):1-13. (Pubitemid 28477043)
    • (1998) Biochemical Journal , vol.335 , Issue.1 , pp. 1-13
    • Coffer, P.J.1    Jin, J.2    Woodgett, J.R.3
  • 38
    • 77953408308 scopus 로고    scopus 로고
    • Physiological regulation of Akt activity and stability
    • Liao Y, Hung MC. Physiological regulation of Akt activity and stability. Am J Transl Res; 2:19-42.
    • Am J Transl Res , vol.2 , pp. 19-42
    • Liao, Y.1    Hung, M.C.2
  • 39
    • 0037369696 scopus 로고    scopus 로고
    • Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
    • Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003;170:2647-54. (Pubitemid 36245657)
    • (2003) Journal of Immunology , vol.170 , Issue.5 , pp. 2647-2654
    • Sadhu, C.1    Masinovsky, B.2    Dick, K.3    Sowell, C.G.4    Staunton, D.E.5
  • 40
    • 33744926913 scopus 로고    scopus 로고
    • A phosphatidylinositide 3-kinases, rather than p110γ, regulate formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis and superoxide production in differentiated neutrophil-like PLB-985 cells
    • Boulven I, Levasseur S, Marois S, Pare G, Rollet-Labelle E, Naccache PH. Class IA phosphatidylinositide 3-kinases, rather than p110 gamma, regulate formyl-methionyl-leucyl-phenylalanine- stimulated chemotaxis and superoxide production in differentiated neutrophil-like PLB-985 cells. J Immunol. 2006; 176:7621-7. (Pubitemid 43849062)
    • (2006) Journal of Immunology , vol.176 , Issue.12 , pp. 7621-7627
    • Boulven, I.1    Levasseur, S.2    Marois, S.3    Pare, G.4    Rollet-Labelle, E.5    Naccache, P.H.6
  • 42
    • 33644805719 scopus 로고    scopus 로고
    • Finding the way: Directional sensing and cell polarization through Ras signalling
    • discussion 87-91 223-30
    • Sasaki AT, Firtel RA. Finding the way: directional sensing and cell polarization through Ras signalling. Novartis Foundation symposium 2005; 269:73-87 (discussion 87-91, 223-30).
    • (2005) Novartis Foundation Symposium , vol.269 , pp. 73-87
    • Sasaki, A.T.1    Firtel, R.A.2
  • 44
    • 34249111428 scopus 로고    scopus 로고
    • Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling
    • DOI 10.1083/jcb.200611046
    • Keizer-Gunnink I, Kortholt A, Van Haastert PJ. Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling. J Cell Biol. 2007;177: 579-85. (Pubitemid 46799830)
    • (2007) Journal of Cell Biology , vol.177 , Issue.4 , pp. 579-585
    • Keizer-Gunnink, I.1    Kortholt, A.2    Van Haastert, P.J.M.3
  • 45
    • 39549108299 scopus 로고    scopus 로고
    • APKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region
    • Takahama S, Hirose T, Ohno S. aPKC restricts the basolateral determinant PtdIns(3,4,5)P3 to the basal region. Biochem Biophys Res Commun. 2008;368:249-55.
    • (2008) Biochem Biophys Res Commun , vol.368 , pp. 249-255
    • Takahama, S.1    Hirose, T.2    Ohno, S.3
  • 47
    • 70149115733 scopus 로고    scopus 로고
    • Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2
    • Zhang H, Sun C, Glogauer M, Bokoch GM. Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol. 2009;183:2718-28.
    • (2009) J Immunol , vol.183 , pp. 2718-2728
    • Zhang, H.1    Sun, C.2    Glogauer, M.3    Bokoch, G.M.4
  • 48
    • 35548972598 scopus 로고    scopus 로고
    • Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor
    • DOI 10.1083/jcb.200705122
    • Sun CX, Magalhaes MA, Glogauer M. Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol. 2007;179:239-45. (Pubitemid 350004888)
    • (2007) Journal of Cell Biology , vol.179 , Issue.2 , pp. 239-245
    • Chun, X.S.1    Magalhaes, M.A.O.2    Glogauer, M.3
  • 49
    • 20144387139 scopus 로고    scopus 로고
    • Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
    • Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, Harris C, et al. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol. 2005;174:4613-20.
    • (2005) J Immunol , vol.174 , pp. 4613-4620
    • Carstanjen, D.1    Yamauchi, A.2    Koornneef, A.3    Zang, H.4    Filippi, M.D.5    Harris, C.6
  • 50
    • 3242799065 scopus 로고    scopus 로고
    • Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
    • DOI 10.1038/ni1081
    • Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, Williams DA. Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol. 2004;5:744-51. (Pubitemid 39023307)
    • (2004) Nature Immunology , vol.5 , Issue.7 , pp. 744-751
    • Filippi, M.-D.1    Harris, C.E.2    Meller, J.3    Gu, Y.4    Zheng, Y.5    Williams, D.A.6
  • 52
    • 33845873342 scopus 로고    scopus 로고
    • 3 and directed migration
    • DOI 10.1038/ncb0107-15, PII NCB0107-15
    • Franca-Koh J, Kamimura Y, Devreotes PN. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nat Cell Biol. 2007;9:15-7. (Pubitemid 46024189)
    • (2007) Nature Cell Biology , vol.9 , Issue.1 , pp. 15-17
    • Franca-Koh, J.1    Kamimura, Y.2    Devreotes, P.N.3
  • 53
    • 0033912699 scopus 로고    scopus 로고
    • The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase
    • DOI 10.1128/MCB.20.15.5469-5478.2000
    • Genot EM, Arrieumerlou C, Ku G, Burgering BM, Weiss A, Kramer IM. The T-cell receptor regulates Akt (protein kinase B) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol Cell Biol. 2000;20:5469-78. (Pubitemid 30482884)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.15 , pp. 5469-5478
    • Genot, E.M.1    Arrieumerlou, C.2    Ku, G.3    Burgering, B.M.T.4    Weiss, A.5    Kramer, I.M.6
  • 54
    • 65249117435 scopus 로고    scopus 로고
    • Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis
    • Nishikimi A, Fukuhara H, SuW, Hongu T, Takasuga S, Mihara H, et al. Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis. Science. 2009;324:384-7.
    • (2009) Science. , vol.324 , pp. 384-387
    • Nishikimi, A.1    Fukuhara, H.2    Suw Hongu, T.3    Takasuga, S.4    Mihara, H.5


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