Common genetic variations in the NALP3 inflammasome are associated with delayed apoptosis of human neutrophils

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Blomgran, Robert ^a   Brodin, Veronika Patcha ^a   Verma, Deepti ^a   Bergström, Ida ^a   Söderkvist, Peter ^a   Sjöwall, Christopher ^a   Eriksson, Per ^a   Lerm, Maria ^a,c   Stendahl, Olle ^a   Särndahl, Eva ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ÖREBRO UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 INTEGRIN; C REACTIVE PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER; CARD8 PROTEIN, HUMAN; CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CD18 ANTIGEN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NLRP3 PROTEIN, HUMAN; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; AUTOINFLAMMATORY DISEASE; CARD 8 GENE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GENE; GENE FUNCTION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INNATE IMMUNITY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NALP3 GENE; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN INTERACTION; WESTERN BLOTTING; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; SECRETION; STAPHYLOCOCCUS AUREUS; TIME;

ADULT; AGED; ANTIGENS, CD18; APOPTOSIS; BIOLOGICAL MARKERS; CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CASPASE 1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMASOMES; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NEUTROPHILS; POLYMORPHISM, GENETIC; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; STAPHYLOCOCCUS AUREUS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84857743749     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031326     Document Type: Article

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