The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells

Blood

Volumn 96, Issue 3, 2000, Pages 1039-1046

  Ardeshna, Kirit M ^a   Pizzey, Arnold R ^a   Devereux, Stephen ^a   Khwaja, Asim ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD1 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CELL SURFACE MARKER; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANTIGEN PRESENTING CELL; ARTICLE; CELL MATURATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MONOCYTE; PINOCYTOSIS; PRIORITY JOURNAL;

EID: 0034254811     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.1039.015k04_1039_1046     Document Type: Article

References (49)

1. The dendritic cell system and its role in immunogenicity
2. Dendritic cells and the control of immunity
3. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
4. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
5. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
6. Fc-gamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization
7. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA
8. Activation of human dendritic celts through CD40 cross-linking
9. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
10. Regulation of dendritic cell numbers and maturation by lipo- polysaccharide in vivo
11. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
12. ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
13. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
14. The stress-activated protein kinase subfamily of c-Jun kinases
15. AMAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
16. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
17. Mechanisms and consequences of activation of protein kinase B/Akt
18. Signal transduction through NF-kappa B
19. Monocyte-derived dendritic cells do not proliferate and are not susceptible to retroviral transduction
20. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide- stimulated macrophages
21. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages
22. PD 098059 is a specific inhibitor of the activation of mitogen- activated protein kinase kinase in vitro and in vivo
23. A specific inhibitor of phosphatidytinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
24. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
25. Multifocal defects in immune responses in ReIB-deficient mice
26. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages
27. Activation of the transcription factor NF-kappaB in lipopolysaccharide-stimulated U937 cells
28. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a ceil membrane-permeable motif and nuclear localization sequence
29. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
30. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells
31. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
32. Supression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
33. Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor
34. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
35. Regulation of neuronal survival by the serine-threonine protein kinase Akt
36. Dendritic cell survival and maturation are regulated by different signaling pathways
37. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
38. Identification of a promoter element that regulates tissue-specific expression of the human CD80 (B7.1) gene
39. Intrathymic signals in thymocytes are mediated by p38 mitogen- activated protein kinase
40. T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation
41. P38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes
42. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
43. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
44. Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic ceils
45. Signaling events induced by lipopolysaccharide activated toll-like receptor 2
46. Expression of reIB transcripts during lymphoid organ development: Specific expression in dendritic antigen-presenting ceils
47. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
48. Suppression of TNF-alpha-induced apoptosis by NF-kappaB [see comments]
49. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB