Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils

European Journal of Pharmacology

Volumn 615, Issue 1-3, 2009, Pages 207-217

  Chang, Ling Chu ^a   Lin, Ruey Hseng ^a   Huang, Li Jiau ^b   Chang, Chi Sen ^c   Kuo, Sheng Chu ^b   Wang, Jih Pyang ^b,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Akt; Neutrophil; p21 Activated kinase; p47phox; Protein kinase C; Superoxide anion

Indexed keywords

2 BENZYL 3 (4 HYDROXYMETHYLPHENYL)INDAZOLE; ARACHIDONIC ACID; CALCIUM ION; CHS 111; CYCLIC AMP; CYCLIC GMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C ZETA; PROTEIN P22; PROTEIN P40; PROTEIN P67; RAC PROTEIN; RAC2 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL FREE SYSTEM; CELL MIGRATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR CALCIUM; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NEUTROPHIL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL-FREE SYSTEM; CYCLIC AMP; CYCLIC GMP; INDAZOLES; NADPH OXIDASE; NEUTROPHILS; P21-ACTIVATED KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 67449143194     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.050     Document Type: Article

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