Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells

European Journal of Cell Biology

Volumn 88, Issue 12, 2009, Pages 753-763

  Boronkai, Arpad ^a   Bellyei, Szabolcs ^a   Szigeti, Andras ^a   Pozsgai, Eva ^a   Bognar, Zita ^a   Sumegi, Balazs ^a   Gallyas Jr , Ferenc ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

AIF; Akt; Apoptosis; Ask 1; Cytoprotection; ERK; Galectin 13; JNK; MAPK; Taxol

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; GALECTIN; GALECTIN 13; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CELL VIABILITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; ENZYME ACTIVATION; GALECTINS; HUMANS; IMMUNOBLOTTING; MACROPHAGES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PACLITAXEL; PREGNANCY PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSFECTION; U937 CELLS;

MAMMALIA;

EID: 70350059183     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcb.2009.07.005     Document Type: Article

References (45)

1. Akahani S., Nangia-Makker P., Inohara H., Kim H.R., and Raz A. Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res. 57 (1997) 5272-5276
2. Baum L.G., Pang M., Perillo N.L., Wu T., Delegeane A., Uittenbogaart C.H., Fukuda M., and Seilhamer J.J. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J. Exp. Med. 181 (1995) 877-887
3. Bernerd F., Sarasin A., and Magnaldo T. Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 11329-11334
4. Blagosklonny M.V., Schulte T., Nguyen P., Trepel J., and Neckers L.M. Taxol-induced apoptosis and phosphorylation of Bcl-2 proteins involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway. Cancer Res. 56 (1996) 1851-1854
5. Cai J., and Jones D.P. Mitochondrial redox signaling during apoptosis. J. Bioenerg. Biomembr. 31 (1999) 327-334
6. Cooper D.N., and Barondes S.H. God must love galectins; he made so many of them. Glycobiology 9 (1999) 979-984
7. Cooper D.N., Massa S.M., and Barondes S.H. Endogenous muscle lectin inhibits myoblast adhesion to laminin. J. Cell Biol. 115 (1991) 1437-1448
8. Elad-Sfadia G., Haklai R., Ballan E., Gabius H.J., and Kloog Y. Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J. Biol. Chem. 277 (2002) 37169-37175
9. Elad-Sfadia G., Haklai R., Balan E., and Kloog Y. Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J. Biol. Chem. 279 (2004) 34922-34930
10. Ellerhorst J., Nguyen T., Cooper D.N., Estrov Y., Lotan D., and Lotan R. Induction of differentiation and apoptosis in the prostate cancer cell line LNCaP by sodium butyrate and galectin-1. Int. J. Oncol. 14 (1999) 225-232
11. Elola M.T., Chiesa M.E., Alberti A.F., Mordoh J., and Fink N.E. Galectin-1 receptors in different cell types. J. Biomed. Sci. 12 (2005) 13-29
12. Emi M., Kim R., Tanabe K., Uchida Y., and Toge T. Targeted therapy against Bcl-2-related proteins in breast cancer cells. Breast Cancer Res. 7 (2005) 940-952
13. Fajka-Boja R., Szemes M., Ion G., Legradi A., Caron M., and Monostori E. Receptor tyrosine phosphatase, CD45 binds galectin-1 but does not mediate its apoptotic signal in T cell lines. Immunol. Lett. 82 (2002) 149-154
14. Farley N., Pedraza-Alva G., Serrano-Gomez D., Nagaleekar V., Aronshtam A., Krahl T., Thornton T., and Rincón M. P38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells. Mol. Cell. Biol. 26 (2006) 2118-2129
15. Fischer C., Sanchez-Ruderisch H., Welzel M., Wiedenmann B., Sakai T., André S., Gabius H.J., Khachigian L., Detjen K.M., and Rosewicz S. Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27. J. Biol. Chem. 280 (2005) 37266-37277
16. Gray C.A., Adelson D.L., Bazer F.W., Burghardt R.C., Meeusen E.N., and Spencer T.E. Discovery and characterization of an epithelial-specific galectin in the endometrium that forms crystals in the trophectoderm. Proc. Natl. Acad. Sci. USA 101 (2004) 7982-7987
17. Hadari Y.R., Arbel-Goren R., Levy Y., Amsterdam A., Alon R., Zakut R., and Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. J. Cell Sci. 113 (2000) 2385-2397
18. Haldar S., Chintapalli J., and Croce C.M. Taxol induces bcl-2 phosphorylation and death of prostate cancer cell. Cancer Res. 58 (1996) 1253-1255
19. Hughes R.C. Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim. Biophys. Acta 1473 (1999) 172-185
20. Inohara H., Akahani S., Koths K., and Raz A. Interactions between galectin-3 and Mac-2-binding protein mediate cell-cell adhesion. Cancer Res. 56 (1996) 4530-4534
21. Kasai K., and Hirabayashi J. Galectins: a family of animal lectins that decipher glycocodes. J. Biochem. 119 (1996) 1-8
22. Kim H.R., Lin H.M., Biliran H., and Raz A. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res. 59 (1999) 4148-4154
23. Kuwabara I., and Liu F.T. Galectin-3 promotes adhesion of human neutrophils to laminin. J. Immunol. 156 (1996) 3939-3944
24. Kuwabara I., Kuwabara Y., Yang R.Y., Schuler M., Green D.R., Zuraw B.L., Hsu D.K., and Liu F.T. Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J. Biol. Chem. 277 (2002) 3487-3497
25. Lee Y.J., Song Y.K., Song J.J., Siervo-Sassi R.R., Kim H.R., Li L., Spitz D.R., Lokshin A., and Kim J.H. Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. Exp. Cell Res. 288 (2003) 21-34
26. Levy Y., Ronen D., Bershadsky A.D., and Zick Y. Sustained induction of ERK, protein kinase B, and p70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin. J. Biol. Chem. 278 (2003) 14533-14542
27. Liu F.T. Galectins: a new family of regulators of inflammation. Clin. Immunol. 97 (2000) 79-88
28. Liu F.T., Patterson R.J., and Wang J.L. Intracellular functions of galectins. Biochim. Biophys. Acta 1572 (2002) 263-273
29. Matarrese P., Fusco O., Tinari N., Natoli C., Liu F.T., Semeraro M.L., Malorni W., and Iacobelli S. Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties. Int. J. Cancer 85 (2000) 545-554
30. Matarrese P., Tinari A., Mormone E., Bianco G.A., Toscano M.A., Ascione B., Rabinovich G.A., and Malorni W. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J. Biol. Chem. 280 (2005) 6969-6985
31. Moon B.K., Lee Y.J., Battle P., Jessup J.M., Raz A., and Kim H.R. Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: implication of galectin-3 function during metastasis. Am. J. Pathol. 159 (2001) 1055-1060
32. Oka N., Nakahara S., Takenaka Y., Fukumori T., Hogan V., Kanayama H.O., Yanagawa T., and Raz A. Galectin-3 inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by activating Akt in human bladder carcinoma cells. Cancer Res. 65 (2005) 7546-7553
33. Paz A., Haklai R., Elad-Sfadia G., Ballan E., and Kloog Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20 (2001) 7486-7493
34. Perillo N.L., Pace K.E., Seilhamer J.J., and Baum L.G. Apoptosis of T cells mediated by galectin-1. Nature 378 (1995) 736-739
35. Perillo N.L., Uittenbogaart C.H., Nguyen J.T., and Baum L.G. Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes. J. Exp. Med. 185 (1997) 1851-1858
36. Perillo N.L., Marcus M.E., and Baum L.G. Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J. Mol. Med. 76 (1998) 402-412
37. Schiff P.B., Fant J., and Horwitz S.B. Promotion of microtubule assembly in vitro by taxol. Nature 277 (1979) 665-667
38. Shalom-Feuerstein R., Cooks T., Raz A., and Kloog Y. Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells. Cancer Res. 65 (2005) 7292-7300
39. Tapodi A., Debreceni B., Hanto K., Bognar Z., Wittmann I., Gallyas Jr. F., Varbiro G., and Sumegi B. Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J. Biol. Chem. 280 (2005) 35767-35775
40. Than N.G., Pick E., Bellyei S., Szigeti A., Burger O., Berente Z., Janaky T., Boronkai A., Kliman H., Meiri H., Bohn H., Than G.N., and Sumegi B. Functional analyses of placental protein 13/galectin-13. Eur. J. Biochem. 271 (2004) 1065-1078
41. Tobiume K., Matsuzawa A., Takahashi T., Nishitoh H., Morita K., Takeda K., Minowa O., Miyazono K., Noda T., and Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2 (2001) 222-228
42. Visegrády B., Than N.G., Kilár F., Sömegi B., Than G.N., and Bohn H. Homology modelling and molecular dynamics studies of human placental tissue protein 13 (galectin-13). Protein Eng. 14 (2001) 875-880
43. Xu Y., Huang S., Liu Z.G., and Han J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J. Biol. Chem. 281 (2006) 8788-8795
44. Yang R.Y., Hsu D.K., and Liu F.T. Expression of galectin-3 modulates T-cell growth and apoptosis. Proc. Natl. Acad. Sci. USA 93 (1996) 6737-6742
45. Zha H., Aime-Sempe C., Sato T., and Reed J.C. Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem. 271 (1996) 7440-7444